| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J J Lambert, D Belell. Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors: commentary on Brown et al. British journal of pharmacology. vol 136. issue 7. 2003-03-31. PMID:12145094. |
pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta gaba(a) receptors: commentary on brown et al. |
2003-03-31 |
2023-08-12 |
human |
| N Brown, J Kerby, T P Bonnert, P J Whiting, K A Waffor. Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors. British journal of pharmacology. vol 136. issue 7. 2003-03-31. PMID:12145096. |
pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta gaba(a) receptors. |
2003-03-31 |
2023-08-12 |
human |
| N Brown, J Kerby, T P Bonnert, P J Whiting, K A Waffor. Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors. British journal of pharmacology. vol 136. issue 7. 2003-03-31. PMID:12145096. |
1: the pharmacology of the stable cell line expressing human alpha(4)beta(3)delta gaba(a) receptor was investigated using whole-cell patch-clamp techniques. |
2003-03-31 |
2023-08-12 |
human |
| N Brown, J Kerby, T P Bonnert, P J Whiting, K A Waffor. Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors. British journal of pharmacology. vol 136. issue 7. 2003-03-31. PMID:12145096. |
2: alpha(4)beta(3)delta receptors exhibited increased sensitivity to gaba when compared to alpha(4)beta(3)gamma(2) receptors, with ec(50)'s of 0.50 (0.46, 0.53) microm and 2.6 (2.5, 2.6) microm respectively. |
2003-03-31 |
2023-08-12 |
human |
| N Brown, J Kerby, T P Bonnert, P J Whiting, K A Waffor. Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors. British journal of pharmacology. vol 136. issue 7. 2003-03-31. PMID:12145096. |
additionally, the gaba partial agonists piperidine-4-sulphonate (p4s) and 4,5,6,7-tetrahydroisothiazolo-[5,4-c]pyridin-3-ol (thip) displayed markedly higher efficacy at alpha(4)beta(3)delta receptors, indeed thip demonstrated greater efficacy than gaba at these receptors. |
2003-03-31 |
2023-08-12 |
human |
| N Brown, J Kerby, T P Bonnert, P J Whiting, K A Waffor. Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors. British journal of pharmacology. vol 136. issue 7. 2003-03-31. PMID:12145096. |
3: the delta subunit conferred slow desensitization to gaba, with rate constants of 4.8+/-0.5 s for alpha(4)beta(3)delta and 2.5+/-0.2 s for alpha(4)beta(3)gamma(2). |
2003-03-31 |
2023-08-12 |
human |
| N Brown, J Kerby, T P Bonnert, P J Whiting, K A Waffor. Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors. British journal of pharmacology. vol 136. issue 7. 2003-03-31. PMID:12145096. |
4: alpha(4)beta(3)delta and alpha(4)beta(3)gamma(2) demonstrated equal sensitivity to inhibition by the cation zinc (2-3 microm ic(50)). |
2003-03-31 |
2023-08-12 |
human |
| N Brown, J Kerby, T P Bonnert, P J Whiting, K A Waffor. Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors. British journal of pharmacology. vol 136. issue 7. 2003-03-31. PMID:12145096. |
however, alpha(4)beta(3)delta receptors demonstrated greater sensitivity to inhibition by lanthanum. |
2003-03-31 |
2023-08-12 |
human |
| N Brown, J Kerby, T P Bonnert, P J Whiting, K A Waffor. Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors. British journal of pharmacology. vol 136. issue 7. 2003-03-31. PMID:12145096. |
the ic(50) for gaba antagonists sr-95531 and picrotoxin, was similar for alpha(4)beta(3)delta and alpha(4)beta(3)gamma(2). |
2003-03-31 |
2023-08-12 |
human |
| N Brown, J Kerby, T P Bonnert, P J Whiting, K A Waffor. Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors. British journal of pharmacology. vol 136. issue 7. 2003-03-31. PMID:12145096. |
5: alpha(4)beta(3)delta receptors were insensitive to modulation by benzodiazepine ligands. |
2003-03-31 |
2023-08-12 |
human |
| N Brown, J Kerby, T P Bonnert, P J Whiting, K A Waffor. Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors. British journal of pharmacology. vol 136. issue 7. 2003-03-31. PMID:12145096. |
6: the efficacy of neurosteroids at alpha(4)beta(3)delta receptors was greatly enhanced over that observed at alpha(4)beta(3)gamma(2) receptors. |
2003-03-31 |
2023-08-12 |
human |
| N Brown, J Kerby, T P Bonnert, P J Whiting, K A Waffor. Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors. British journal of pharmacology. vol 136. issue 7. 2003-03-31. PMID:12145096. |
the greatest effect was observed using thdoc with 524+/-71.6% potentiation at alpha(4)beta(3)delta and 297.9+/-49.7% at alpha(4)beta(3)gamma(2) receptors. |
2003-03-31 |
2023-08-12 |
human |
| N Brown, J Kerby, T P Bonnert, P J Whiting, K A Waffor. Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors. British journal of pharmacology. vol 136. issue 7. 2003-03-31. PMID:12145096. |
the efficacy of both pentobarbitone and propofol was slightly augmented and etomidate greatly enhanced at alpha(4)beta(3)delta receptors versus alpha(4)beta(3)gamma(2) receptors. |
2003-03-31 |
2023-08-12 |
human |
| N Brown, J Kerby, T P Bonnert, P J Whiting, K A Waffor. Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors. British journal of pharmacology. vol 136. issue 7. 2003-03-31. PMID:12145096. |
7: we show that the alpha(4)beta(3)delta receptor has a distinct pharmacology and kinetic profile. |
2003-03-31 |
2023-08-12 |
human |
| Feng Chu, Nancy E Ward, Catherine A O'Bria. PKC isozyme S-cysteinylation by cystine stimulates the pro-apoptotic isozyme PKC delta and inactivates the oncogenic isozyme PKC epsilon. Carcinogenesis. vol 24. issue 2. 2003-03-31. PMID:12584183. |
we report that pkc delta is stimulated 2.0-2.5 fold by gssg, (cys-gly)(2) and cystine, under conditions where pkc gamma and pkc epsilon are fully inactivated by cystine, and pkc alpha activity is affected marginally or not at all by the disulfides. |
2003-03-31 |
2023-08-12 |
mouse |
| Patrick C Reading, Julian A Symons, Geoffrey L Smit. A soluble chemokine-binding protein from vaccinia virus reduces virus virulence and the inflammatory response to infection. Journal of immunology (Baltimore, Md. : 1950). vol 170. issue 3. 2003-03-27. PMID:12538705. |
cells infected with v delta b8r-35k secreted a 35-kda protein that bound the cc chemokine macrophage-inflammatory protein 1 alpha. |
2003-03-27 |
2023-08-12 |
mouse |
| Maria C Hansson, Håkan Wittzell, Kerstin Persson, Torbjörn von Schant. Characterization of two distinct aryl hydrocarbon receptor (AhR2) genes in Atlantic salmon (Salmo salar) and evidence for multiple AhR2 gene lineages in salmonid fish. Gene. vol 303. 2003-03-24. PMID:12559581. |
interestingly, they are not orthologs of the rainbow trout (oncorhynchus mykiss) ahr2 alpha and beta genes and the new salmon loci are therefore here designated ahr2 gamma and ahr2 delta. |
2003-03-24 |
2023-08-12 |
Not clear |
| Tamotsu Kanai, Sota Ito, Tadayuki Imanak. Characterization of a cytosolic NiFe-hydrogenase from the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1. Journal of bacteriology. vol 185. issue 5. 2003-03-24. PMID:12591889. |
the purified t. kodakaraensis hydrogenase was composed of four subunits (beta, gamma, delta, and alpha), corresponding to the products of hyhbgsl(tk), respectively. |
2003-03-24 |
2023-08-12 |
Not clear |
| Shinsaku Togo, Toshibumi Shimokawa, Yoshinosuke Fukuchi, Chisei R. Alternative splicing of myeloid IgA Fc receptor (Fc alpha R, CD89) transcripts in inflammatory responses. FEBS letters. vol 535. issue 1-3. 2003-03-21. PMID:12560105. |
in this study, we quantified fc alpha r splice transcripts delta ec2 and delta 66 ec2, which lack the entire and a part of the homologous immunoglobulin-like extracellular domain 2 (ec2), respectively. |
2003-03-21 |
2023-08-12 |
human |
| T Saito, Y Matsuno, R Tanosaki, T Watanabe, Y Kobayashi, K Tobina. Gamma delta T-cell neoplasms: a clinicopathological study of 11 cases. Annals of oncology : official journal of the European Society for Medical Oncology. vol 13. issue 11. 2003-03-20. PMID:12419753. |
the majority of t-cell neoplasms express t-cell antigen receptor (tcr) alpha beta on their cell surface, and a few cases show the tcr gamma delta phenotype. |
2003-03-20 |
2023-08-12 |
Not clear |