| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vaughn L Culbertson, Shaikh E Rahman, Grayson C Bosen, Matthew L Caylor, Megan M Echevarria, Dong X. Implications of Off-Target Serotoninergic Drug Activity: An Analysis of Serotonin Syndrome Reports Using a Systematic Bioinformatics Approach. Pharmacotherapy. vol 38. issue 9. 2019-06-13. PMID:29972695. |
no systematic process currently exists for evaluating cumulative 5-ht and off-target toxicity of serotonergic drugs. |
2019-06-13 |
2023-08-13 |
Not clear |
| Vaughn L Culbertson, Shaikh E Rahman, Grayson C Bosen, Matthew L Caylor, Megan M Echevarria, Dong X. Implications of Off-Target Serotoninergic Drug Activity: An Analysis of Serotonin Syndrome Reports Using a Systematic Bioinformatics Approach. Pharmacotherapy. vol 38. issue 9. 2019-06-13. PMID:29972695. |
the primary study aim was to create a serotonergic expanded bioactivity matrix (sebm) by using a molecular bioinformatics, polypharmacologic approach for assessment of the participation of individual 5-ht drugs in serotonin syndrome (ss) reports. |
2019-06-13 |
2023-08-13 |
Not clear |
| Iliyan Ivanov, Janine Flory, Jeffrey H Newcorn, Jeffrey M Halperi. Childhood serotonergic function and early adult outcomes in youth with ADHD: A 15-year follow-up study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 28. issue 12. 2019-06-12. PMID:30454909. |
despite existing evidence for the purported role of abnormal serotonergic function in aggressive youth and adults, little evidence exists on the role of serotonin in the progression from childhood disruptive behavior disorders to adult psychopathology, including aspd. |
2019-06-12 |
2023-08-13 |
human |
| Elina T L'Estrade, Hanne D Hansen, Maria Erlandsson, Tomas G Ohlsson, Gitte M Knudsen, Matthias M Hert. Classics in Neuroimaging: The Serotonergic 2A Receptor System-from Discovery to Modern Molecular Imaging. ACS chemical neuroscience. vol 9. issue 6. 2019-06-11. PMID:29763291. |
it was used not only to antagonize biological effects of serotonin and to study the system itself, but also to identify serotonergic subtype receptors. |
2019-06-11 |
2023-08-13 |
Not clear |
| Sonali N Reisinger, Thomas Wanek, Oliver Langer, Daniela D Polla. PET imaging of the mouse brain reveals a dynamic regulation of SERT density in a chronic stress model. Translational psychiatry. vol 9. issue 1. 2019-06-10. PMID:30745564. |
the serotonin transporter (sert, slc6a4) plays an important role in the regulation of serotonergic neurotransmission and its aberrant expression has been linked to several psychiatric conditions. |
2019-06-10 |
2023-08-13 |
mouse |
| Faheem Hyder Pottoo, Md Noushad Javed, Md Abul Barkat, Md Sabir Alam, Javaid Ashraf Nowshehri, Dhafer Mahdi Alshayban, Mohammad Azam Ansar. Estrogen and Serotonin: Complexity of Interactions and Implications for Epileptic Seizures and Epileptogenesis. Current neuropharmacology. vol 17. issue 3. 2019-06-03. PMID:29956631. |
serotonin modulates epileptiform activity in either direction i.e administration of 5-ht agonists or reuptake inhibitors leads to the activation of 5-ht3 and 5-ht1a receptors tending to impede focal and generalized seizures, while depletion of brain 5-ht along with the destruction of serotonergic terminals leads to expanded neuronal excitability hence abatement of seizure threshold in experimental animal models. |
2019-06-03 |
2023-08-13 |
Not clear |
| Faheem Hyder Pottoo, Md Noushad Javed, Md Abul Barkat, Md Sabir Alam, Javaid Ashraf Nowshehri, Dhafer Mahdi Alshayban, Mohammad Azam Ansar. Estrogen and Serotonin: Complexity of Interactions and Implications for Epileptic Seizures and Epileptogenesis. Current neuropharmacology. vol 17. issue 3. 2019-06-03. PMID:29956631. |
it is further established that ovarian steroids bring induction of dendritic spine proliferation on serotonin neurons thus thawing a profound effect on serotonergic transmission. |
2019-06-03 |
2023-08-13 |
Not clear |
| Yun Liu, Hailong Yang, Fei He, Peng Xu, Hanwen Tong, Yao Liu, Jie Ni, Qiulin Zhang, Jun Wan. An atypical case of serotonin syndrome with normal dose of selective serotonin inhibitors: A case report. Medicine. vol 98. issue 19. 2019-05-30. PMID:31083217. |
as increasing frequency of serotonergic drug use, ss (serotonin syndrome) occurred more than ever. |
2019-05-30 |
2023-08-13 |
Not clear |
| Yun Liu, Hailong Yang, Fei He, Peng Xu, Hanwen Tong, Yao Liu, Jie Ni, Qiulin Zhang, Jun Wan. An atypical case of serotonin syndrome with normal dose of selective serotonin inhibitors: A case report. Medicine. vol 98. issue 19. 2019-05-30. PMID:31083217. |
ss is usually caused by the increased serotonin activity in the central nervous system which may due to a serotonergic agent overdose or the concomitant use of 2 or more serotonergic antidepressants. |
2019-05-30 |
2023-08-13 |
Not clear |
| Francis Delicata, Cristiano Bombardi, Massimo Pierucci, Roberto Di Maio, Philippe De Deurwaerdère, Giuseppe Di Giovann. Preferential modulation of the lateral habenula activity by serotonin-2A rather than -2C receptors: Electrophysiological and neuroanatomical evidence. CNS neuroscience & therapeutics. vol 24. issue 8. 2019-05-29. PMID:29479825. |
serotonergic (5-ht) modulation of the lateral habenula (lhb) activity is central in normal and pathologic conditions such as mood disorders. |
2019-05-29 |
2023-08-13 |
Not clear |
| Ana María Cruz-Martínez, Juan Gabriel Tejas-Juárez, Juan Manuel Mancilla-Díaz, Benjamín Florán-Garduño, Verónica Elsa López-Alonso, Rodrigo Erick Escartín-Pére. CB1 receptors in the paraventricular nucleus of the hypothalamus modulate the release of 5-HT and GABA to stimulate food intake in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 28. issue 11. 2019-05-29. PMID:30217553. |
cb1r mrna is expressed in serotonergic neurons that innervate the pvn, and activation of 5-ht receptors in the pvn constitutes an important satiety signal. |
2019-05-29 |
2023-08-13 |
rat |
| Ana María Cruz-Martínez, Juan Gabriel Tejas-Juárez, Juan Manuel Mancilla-Díaz, Benjamín Florán-Garduño, Verónica Elsa López-Alonso, Rodrigo Erick Escartín-Pére. CB1 receptors in the paraventricular nucleus of the hypothalamus modulate the release of 5-HT and GABA to stimulate food intake in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 28. issue 11. 2019-05-29. PMID:30217553. |
some gabaergic terminals are negatively influenced by 5-ht, suggesting that the hyperphagic effect of cb1r activation could involve changes in serotonergic and gabaergic signaling in the pvn. |
2019-05-29 |
2023-08-13 |
rat |
| Ana María Cruz-Martínez, Juan Gabriel Tejas-Juárez, Juan Manuel Mancilla-Díaz, Benjamín Florán-Garduño, Verónica Elsa López-Alonso, Rodrigo Erick Escartín-Pére. CB1 receptors in the paraventricular nucleus of the hypothalamus modulate the release of 5-HT and GABA to stimulate food intake in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 28. issue 11. 2019-05-29. PMID:30217553. |
here, we have found that the neurochemical mechanisms activated by stimulation of cb1 receptors in the pvn involve inhibition of 5-ht release, resulting in a decrease of serotonergic activity mediated by 5-ht |
2019-05-29 |
2023-08-13 |
rat |
| Saeed Alghamdi, Yehya Seddeq, Hussein Algahtani, Bader Shira. Fatal serotonin syndrome in a patient with Marchiafava-Bignami disease: Combined neurological and psychiatric emergency. Neurologia i neurochirurgia polska. vol 52. issue 2. 2019-05-24. PMID:29169770. |
serotonin syndrome is a rare but potentially fatal side effect of antidepressants that results from overstimulation of both central and peripheral serotonergic receptors. |
2019-05-24 |
2023-08-13 |
Not clear |
| Adam Henke, Yekaterina Kovalyova, Matthew Dunn, Dominik Dreier, Niko G Gubernator, Iva Dincheva, Christopher Hwu, Peter Šebej, Mark S Ansorge, David Sulzer, Dalibor Same. Toward Serotonin Fluorescent False Neurotransmitters: Development of Fluorescent Dual Serotonin and Vesicular Monoamine Transporter Substrates for Visualizing Serotonin Neurons. ACS chemical neuroscience. vol 9. issue 5. 2019-05-21. PMID:29281252. |
while we found only minor ffn246 accumulation in serotonergic axons in murine brain tissue, ffn246 effectively traces serotonin uptake and packaging in the soma of serotonergic neurons with improved photophysical properties and loading parameters compared to known serotonin-based fluorescent tracers. |
2019-05-21 |
2023-08-13 |
mouse |
| Luis Jiménez-Treviño, Pilar Alejandra Saiz, Maria Paz García-Portilla, Hilario Blasco-Fontecilla, Vladimir Carli, Miriam Iosue, Isabelle Jaussent, Jorge López-Castroman, Concepcion Vaquero-Lorenzo, Marco Sarchiapone, Enrique Baca-García, Philippe Courtet, Julio Bobe. 5-HTTLPR-brain-derived neurotrophic factor (BDNF) gene interactions and early adverse life events effect on impulsivity in suicide attempters. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 20. issue 2. 2019-05-14. PMID:28914102. |
serotonergic genes such as the promoter region of the serotonin transporter gene (5-httlpr) have been associated both with impulsivity in suicide attempts and reactivity to environmental stress exposure. |
2019-05-14 |
2023-08-13 |
Not clear |
| Valentina R Garbarino, Taylor A Santos, Anastassia R Nelson, Wynne Q Zhang, Corey M Smolik, Martin A Javors, Lynette C Daws, Georgianna G Goul. Prenatal metformin exposure or organic cation transporter 3 knock-out curbs social interaction preference in male mice. Pharmacological research. vol 140. 2019-05-13. PMID:30423430. |
yet no gross alterations in serotonergic function were evident by measure of serotonin transporter density in oct3, or serotonin turnover in metformin-exposed offspring brains. |
2019-05-13 |
2023-08-13 |
mouse |
| Ingvar R Möller, Marika Slivacka, Anne Kathrine Nielsen, Søren G F Rasmussen, Ulrik Gether, Claus J Loland, Kasper D Ran. Conformational dynamics of the human serotonin transporter during substrate and drug binding. Nature communications. vol 10. issue 1. 2019-05-08. PMID:30976000. |
the serotonin transporter (sert), a member of the neurotransmitter:sodium symporter family, is responsible for termination of serotonergic signaling by re-uptake of serotonin (5-ht) into the presynaptic neuron. |
2019-05-08 |
2023-08-13 |
human |
| Mun Fai Loke, Eng Guan Chua, Han Ming Gan, Kumar Thulasi, Jane W Wanyiri, Iyadorai Thevambiga, Khean Lee Goh, Won Fen Wong, Jamuna Vadivel. Metabolomics and 16S rRNA sequencing of human colorectal cancers and adjacent mucosa. PloS one. vol 13. issue 12. 2019-05-07. PMID:30576312. |
metabolites involved in serotonergic synapse/ tryptophan metabolism (serotonin and 5-hydroxy-3-indoleacetic acid [5-hiaa]) were only detected in normal tissue samples. |
2019-05-07 |
2023-08-13 |
human |
| L Aparicio-Nava, R Tellez, R Gonzalez, G Liy-Salmeron, A Menese. Intrahippocampal administration of 5-HT Behavioural brain research. vol 359. 2019-04-23. PMID:30452930. |
intrahippocampal administration of 5-ht to our knowledge the intrahippocampal serotonergic 5-ht |
2019-04-23 |
2023-08-13 |
Not clear |