| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sameer Hassamal, Karen Miotto, William Dale, Itai Danovitc. Tramadol: Understanding the Risk of Serotonin Syndrome and Seizures. The American journal of medicine. vol 131. issue 11. 2019-09-09. PMID:29752906. |
various risk factors such as medical comorbidities, use or abuse of supratherapeutic doses of tramadol, and concomitant administration of proconvulsant serotonergic cytochrome p-450 inhibitors will help clinicians identify individuals at an elevated risk for serotonin toxicity and seizures. |
2019-09-09 |
2023-08-13 |
Not clear |
| Emilie Faggiani, Frederic Naudet, Marcus L F Janssen, Yasin Temel, Abdelhamid Benazzou. Serotonergic neurons mediate the anxiolytic effect of l-DOPA: Neuronal correlates in the amygdala. Neurobiology of disease. vol 110. 2019-09-06. PMID:29108985. |
our data provide the first evidence of the key and positive role of the serotonergic system in the combined efficacy of l-dopa on anxiety and the paralleled bla neuronal activity, suggesting that the enhancement of the activity of serotonin neurons may boost the anxiolytic action of l-dopa. |
2019-09-06 |
2023-08-13 |
rat |
| James Francescangeli, Kunal Karamchandani, Meghan Powell, Anthony Bonavi. The Serotonin Syndrome: From Molecular Mechanisms to Clinical Practice. International journal of molecular sciences. vol 20. issue 9. 2019-09-03. PMID:31075831. |
the serotonin syndrome is a medication-induced condition resulting from serotonergic hyperactivity, usually involving antidepressant medications. |
2019-09-03 |
2023-08-13 |
Not clear |
| Elda G Cargnel, Patricia C Cardoso, Julián Irigoyen, Sol García Puglis. [An unintended diagnosis: Serotonergic toxicity secondary to drug interactions. Case reports]. Archivos argentinos de pediatria. vol 116. issue 1. 2019-08-22. PMID:29333835. |
serotonin toxicity is a potentially life-threatening condition associated with increased serotonergic activity in the central nervous system. |
2019-08-22 |
2023-08-13 |
Not clear |
| Fabiola Hernández-Vázquez, Julieta Garduño, Salvador Hernández-Lópe. GABAergic modulation of serotonergic neurons in the dorsal raphe nucleus. Reviews in the neurosciences. vol 30. issue 3. 2019-08-21. PMID:30173207. |
gabaergic neurons regulate the excitability of drn serotonergic neurons and the serotonin release in different brain areas. |
2019-08-21 |
2023-08-13 |
Not clear |
| Yu Miyahara, Hideki Funahashi, Rumi Naono-Nakayama, Ayaka Haruta-Tsukamoto, Toshikazu Nishimori, Yasushi Ishid. Role of serotonin and noradrenaline in the acute itch processing in mice. European journal of pharmacology. vol 850. 2019-08-06. PMID:30763572. |
the pretreatment with milnacipran, a serotonin and noradrenaline reuptake inhibitor, and mirtazapine, a noradrenergic and specific serotonergic antidepressant, attenuated the induction of scratching behavior by chloroquine, a representative pruritogen, indicating the involvement of serotonin and/or noradrenaline in the modulation of pruriceptive processing. |
2019-08-06 |
2023-08-13 |
mouse |
| Samar M Koura, Mohamed Salama, Mahmoud El-Hussiny, Mahmoud El-Sayed Awad Khalil, Ahmed Lotfy, Samia Ahmed Hassan, Seham Aly Gad Elhak, Mohamed A Sob. Fluoxetine induces direct inhibitory effects on mesenchymal stem cell‑derived osteoprogenitor cells independent of serotonin concentration. Molecular medicine reports. vol 19. issue 4. 2019-08-01. PMID:30720108. |
furthermore, the expression levels of serotonergic genes, including serotonin 1b receptor, serotonin 2a receptor (htr2a), serotonin 2b receptor and serotonin transporter, were down regulated; of these genes, htr2a exhibited the highest expression levels. |
2019-08-01 |
2023-08-13 |
rat |
| Ryosuke Morinaga, Nobuaki Nakamuta, Yoshio Yamamot. Serotonergic projections to the ventral respiratory column from raphe nuclei in rats. Neuroscience research. vol 143. 2019-07-23. PMID:29803764. |
serotonergic nerve fibers are densely distributed in the rostral to caudal vrc and serotonin would be one of the important modulators for the respiratory control in the vrc. |
2019-07-23 |
2023-08-13 |
rat |
| Arvind Negi, Ciaran O Reilly, Dilip V Jarikote, Jian Zhou, Paul V Murph. Multi-targeting protein-protein interaction inhibitors: Evolution of macrocyclic ligands with embedded carbohydrates (MECs) to improve selectivity. European journal of medicinal chemistry. vol 176. 2019-07-22. PMID:31112891. |
firstly, retroscreening of the previously reported eannaphane-40 (e40, 40), a mec presenting two pharmacophoric groups, against a set of 55 receptor-subtypes led to a finding of sub-micromolar inhibitory activity for e40 against three serotonergic isoforms (5ht |
2019-07-22 |
2023-08-13 |
Not clear |
| Ewa Bromek, Marta Rysz, Anna Haduch, Władysława A Danie. Serotonin Receptors of 5-HT Drug metabolism and disposition: the biological fate of chemicals. vol 47. issue 2. 2019-07-18. PMID:30518657. |
serotonin receptors of 5-ht our recent study carried out after local injection of the serotonergic neurotoxin 5,7-dihydroxytryptamine into the arcuate nucleus (arc) of the hypothalamus suggested a positive influence of the serotonergic innervation of the arc on growth hormone (gh) secretion and gh-dependent expression of cytochrome p450. |
2019-07-18 |
2023-08-13 |
Not clear |
| Heisy B Asusta, Erin Keyser, Patricia Dominguez, Marvin Miller, Tolulope Odedoku. Serotonin Syndrome in Obstetrics: A Case Report and Review of Management. Military medicine. vol 184. issue 1-2. 2019-07-15. PMID:29901770. |
serotonin syndrome (ss) is a life-threatening condition, usually precipitated by a combination of serotonergic agents. |
2019-07-15 |
2023-08-13 |
Not clear |
| Sarah M Keesom, Mitchell D Morningstar, Rebecca Sandlain, Bradley M Wise, Laura M Hurle. Social isolation reduces serotonergic fiber density in the inferior colliculus of female, but not male, mice. Brain research. vol 1694. 2019-07-11. PMID:29763575. |
here, we assess whether 4 weeks of post-weaning individual housing alters serotonergic fiber density in the inferior colliculus (ic), an auditory midbrain nucleus in which serotonin alters auditory-evoked activity. |
2019-07-11 |
2023-08-13 |
mouse |
| Sarah M Keesom, Mitchell D Morningstar, Rebecca Sandlain, Bradley M Wise, Laura M Hurle. Social isolation reduces serotonergic fiber density in the inferior colliculus of female, but not male, mice. Brain research. vol 1694. 2019-07-11. PMID:29763575. |
serotonergic projections were subsequently visualized with an antibody to the serotonin transporter, which labels serotonergic fibers with relatively high selectivity. |
2019-07-11 |
2023-08-13 |
mouse |
| Lidiane P Garcia, Josefine S Witteveen, Anthonieke Middelman, Josephus A van Hulten, Gerard J M Martens, Judith R Homberg, Sharon M Kol. Perturbed Developmental Serotonin Signaling Affects Prefrontal Catecholaminergic Innervation and Cortical Integrity. Molecular neurobiology. vol 56. issue 2. 2019-07-11. PMID:29948943. |
proper development of the medial prefrontal cortex (mpfc), crucial for correct cognitive functioning, requires projections from, among others, the serotonergic (5-ht) and catecholaminergic systems, but it is unclear how these systems influence each other during development. |
2019-07-11 |
2023-08-13 |
rat |
| Andrée-Anne Hudon Thibeault, J Thomas Sanderson, Cathy Vaillancour. Serotonin-estrogen interactions: What can we learn from pregnancy? Biochimie. vol 161. 2019-07-08. PMID:30946949. |
from a mechanistic point of view, we hypothesize that estrogens regulate the serotonergic system, resulting in a protective effect against 5-ht-linked diseases, but that, in turn, 5-ht affects estrogen synthesis in an attempt to retrieve homeostasis. |
2019-07-08 |
2023-08-13 |
human |
| Thomas R Barber, Ludovica Griffanti, Kinan Muhammed, Daniel S Drew, Kevin M Bradley, Daniel R McGowan, Marie Crabbe, Christine Lo, Clare E Mackay, Masud Husain, Michele T Hu, Johannes C Klei. Apathy in rapid eye movement sleep behaviour disorder is associated with serotonin depletion in the dorsal raphe nucleus. Brain : a journal of neurology. vol 141. issue 10. 2019-07-05. PMID:30212839. |
the integrity of the raphe serotonergic system can be assessed alongside dopaminergic basal ganglia imaging using the radioligand 123i-ioflupane, which binds both serotonin and dopamine transporters. |
2019-07-05 |
2023-08-13 |
Not clear |
| Dilys Lam, Marie-Laure Ancelin, Karen Ritchie, Rosanne Freak-Poli, Richard Saffery, Joanne Rya. Genotype-dependent associations between serotonin transporter gene (SLC6A4) DNA methylation and late-life depression. BMC psychiatry. vol 18. issue 1. 2019-06-25. PMID:30180828. |
disrupted serotonergic signaling is often a feature of depression and the role of the serotonin transporter gene (slc6a4), responsible for serotonin re-uptake, has received much attention in this regard. |
2019-06-25 |
2023-08-13 |
Not clear |
| Zachary D Zuschlag, Matthew W Warren, Susan K Schult. Serotonin Toxicity and Urinary Analgesics: A Case Report and Systematic Literature Review of Methylene Blue-Induced Serotonin Syndrome. Psychosomatics. vol 59. issue 6. 2019-06-24. PMID:30104021. |
serotonin syndrome (ss) is a potentially serious side effect of serotonergic drugs. |
2019-06-24 |
2023-08-13 |
Not clear |
| L Jurek, M Nourredine, B Megarbane, T d'Amato, J-M Dorey, B Rollan. [The serotonin syndrome: An updated literature review]. La Revue de medecine interne. vol 40. issue 2. 2019-06-24. PMID:30243558. |
the serotonin syndrome is a potentially deadly complication resulting from drug adverse effect, drug-drug interaction or overdose involving one or more serotonergic molecules, e.g., antidepressants, psychostimulants and sometimes an "ignored" serotonergic compound. |
2019-06-24 |
2023-08-13 |
Not clear |
| Vaughn L Culbertson, Shaikh E Rahman, Grayson C Bosen, Matthew L Caylor, Megan M Echevarria, Dong X. Implications of Off-Target Serotoninergic Drug Activity: An Analysis of Serotonin Syndrome Reports Using a Systematic Bioinformatics Approach. Pharmacotherapy. vol 38. issue 9. 2019-06-13. PMID:29972695. |
serotonergic adverse drug events (ades) are caused by enhanced intrasynaptic concentrations of 5-hydroxytryptamine (5-ht). |
2019-06-13 |
2023-08-13 |
Not clear |