| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C J Helke, J A Quest, R A Gilli. Effects of serotonin antagonists on digitalis-induced ventricular arrhythmias. European journal of pharmacology. vol 47. issue 4. 1978-05-24. PMID:147176. |
these data indicate that serotonin antagonists are effective in counteracting digitalis-induced ventricular arrhythmias and support the notion that a serotonergic mechanism may be mediating the arrhythmogenic effect of digitalis. |
1978-05-24 |
2023-08-11 |
Not clear |
| S M Stahl, H Y Meltze. A kinetic and pharmacologic analysis of 5-hydroxytryptamine transport by human platelets and platelet storage granules: comparison with central serotonergic neurons. The Journal of pharmacology and experimental therapeutics. vol 205. issue 1. 1978-05-24. PMID:633077. |
a kinetic and pharmacologic analysis of 5-hydroxytryptamine transport by human platelets and platelet storage granules: comparison with central serotonergic neurons. |
1978-05-24 |
2023-08-11 |
human |
| J J Clancy, D F Caldwell, D Oberleas, S Sangiah, M J Villeneuv. Effect of a chronic tryptophan dietary deficiency on the rat's sleep-wake cycle. Brain research bulletin. vol 3. issue 1. 1978-05-08. PMID:204399. |
the results do not support the suggested relationship between reduced serotonin levels and the occurrence of insomnia, questioning the serotonergic theory of sleep. |
1978-05-08 |
2023-08-11 |
rat |
| D Tsang, S La. Effect of monoamine receptor agonists and antagonists on cyclic AMP accumulation in human cerebral cortex slices. Canadian journal of physiology and pharmacology. vol 55. issue 6. 1978-03-29. PMID:23211. |
chlorpromazine blocked the increase of cyclic amp formation induced by noradrenaline, dopamine or serotonin, while cyproheptadine, a putative central serotonergic antagonist, was ineffective. |
1978-03-29 |
2023-08-11 |
human |
| A H Dickenso. Specific responses of rat raphé neurones to skin temperature. The Journal of physiology. vol 273. issue 1. 1978-03-10. PMID:599422. |
the results suggest that any involvement of 5-ht in central thermo-regulation is in terms of an afferent thermal pathway mediated by serotonergic raphé neurones. |
1978-03-10 |
2023-08-11 |
rat |
| J E Goldman, J H Schwart. Metabolism of [3H]serotonin in the marine mollusc, Aplysia californica. Brain research. vol 136. issue 1. 1978-02-18. PMID:589448. |
when [3h]serotonin was injected directly into cell bodies of identified neurons, both serotonergic and non-serotonergic, only the conjugate which behaved as the glucuronide was formed. |
1978-02-18 |
2023-08-11 |
aplysia |
| Rita B Messing, Loy D Lytl. Serotonin-containing neurons: their possible role in pain and analgesia. Pain. vol 4. issue 1. 1978-01-27. PMID:22060. |
this evidence, based on studies employing pharmacological, surgical, electrophysiological, and dietary manipulations of central nervous system serotonergic neurotransmission, suggests that increases in the activity of brain and spinal cord serotonin neurons are associated with analgesia and enhanced antinociceptive drug potency, whereas decreases in the activities of these neurons correlate with hyperalgesia and diminished analgesic drug potency. |
1978-01-27 |
2023-08-11 |
Not clear |
| J H Growdo. Postural changes, tremor, and myoclonus in the rat immediately following injections of p-chloromaphetamine. Neurology. vol 27. issue 11. 1978-01-27. PMID:563003. |
pretreatment with drugs that interfere with the uptake of p-chloroamphetamine into terminals of serotonergic neurons (fluoxetine), depress brain serotonin levels (p-chlorophenylalanine), or block serotonin receptors (methiothepin or methergoline) suppressed this syndrome, whereas drugs that antagonize the effects of dopamine, norepinephrine, and acetylcholine did not. |
1978-01-27 |
2023-08-11 |
rat |
| A Michanek, B J Meyerso. A comparative study of different amphetamines on copulatory behavior and stereotype activity in the female rat. Psychopharmacology. vol 53. issue 2. 1977-10-20. PMID:408843. |
lordosis response in the female rat has been shown to be inhibited by increased central nervous serotonergic (5-ht) as well as dopaminergic (da) activity. |
1977-10-20 |
2023-08-11 |
rat |
| V M Pickel, T H Joh, D J Rei. A serotonergic innervation of noradrenergic neurons in nucleus locus coeruleus: demonstration by immunocytochemical localization of the transmitter specific enzymes tyrosine and tryptophan hydroxylase. Brain research. vol 131. issue 2. 1977-10-14. PMID:19125. |
immunocytochemical localization of the neurotransmitter synthesizing enzymes, tyrosine and tryptophan hydroxylase, was used to determine whether the noradrenergic neurons in the nucleus locus coeruleus of the rat are innervated by serotonergic (5-ht) neurons. |
1977-10-14 |
2023-08-11 |
rat |
| M L Cohen, K S Wile. Neuronal uptake inhibitors, nisoxetine and fluoxetine on rat vascular contractions. European journal of pharmacology. vol 44. issue 3. 1977-10-14. PMID:891602. |
furthermore, these data provide indirect evidence against a functionally important serotonergic uptake process in rat blood vessels and suggest that neuronal uptake of serotonin does not exert a major role in terminating the vascular action of this biogenic amine. |
1977-10-14 |
2023-08-11 |
rat |
| J K Wan. Antinociceptive effect of intrathecally administered serotonin. Anesthesiology. vol 47. issue 3. 1977-09-29. PMID:578085. |
it is assumed that serotonin molecules penetrate the spinal cord tissue and activate the antinociceptive serotonergic pathyways. |
1977-09-29 |
2023-08-11 |
Not clear |
| M Palkovits, J M Saavedra, D M Jacoboqitz, J S Kizer, L Záborszky, M J Brownstei. Serotonergic innervation of the forebrain: effect of lesions on serotonin and tryptophan hydroxylase levels. Brain research. vol 130. issue 1. 1977-09-22. PMID:884514. |
serotonergic innervation of the forebrain: effect of lesions on serotonin and tryptophan hydroxylase levels. |
1977-09-22 |
2023-08-11 |
Not clear |
| A J Mandell, S Knap. Regulation of serotonin biosynthesis in brain: role of the high affinity uptake of tryptophan into serotonergic neurons. Federation proceedings. vol 36. issue 8. 1977-08-25. PMID:872948. |
regulation of serotonin biosynthesis in brain: role of the high affinity uptake of tryptophan into serotonergic neurons. |
1977-08-25 |
2023-08-11 |
Not clear |
| S M Stah. The human platelet. A diagnostic and research tool for the study of biogenic amines in psychiatric and neurologic disorders. Archives of general psychiatry. vol 34. issue 5. 1977-06-30. PMID:140632. |
comparison of the properties of blood platelets and serotonergic synaptosomes suggests that the human platelet can serve as an appropriate model for the transport, metabolism, and release of serotonin (5-ht) by cns serotonergic neurons. |
1977-06-30 |
2023-08-11 |
human |
| B L Jacobs, S M Simon, D D Ruimy, M E Trulso. A quantitative rotational model for studying serotonergic function in the rat. Brain research. vol 124. issue 2. 1977-05-20. PMID:139194. |
these data indicate that the turning response of rats with unilateral destruction of brain serotonin nerve terminals provides a sensitive tool for quantifiably studying changes in serotonergic function. |
1977-05-20 |
2023-08-11 |
rat |
| J Blasig, R Papeschi, C Gramsch, A Her. Central serotonergic mechanisms and development of morphine dependence. Drug and alcohol dependence. vol 1. issue 3. 1977-04-25. PMID:138583. |
since chronic reduction of 5-ht level during the whole time of morphine exposure changed withdrawal symptomatology in nearly the same way as did a decrease in 5-ht level during the time of withdrawal only, it is suggested that serotonergic mechanisms are not linked to the basic processes underlying dependence development but that they are only involved in the nervous pathways mediating the expression of some withdrawal signs. |
1977-04-25 |
2023-08-11 |
rat |
| S S Mosko, D Haubrich, B L Jacob. Serotonergic afferents to the dorsal raphe nucleus: evdience from HRP and synaptosomal uptake studies. Brain research. vol 119. issue 2. 1977-02-26. PMID:830388. |
a serotonergic innervation of the dorsal raphe was also demonstrated by the presence of high affinity uptake of [3h]5-ht (km=0.17 mum) into synaptosomal suspensions of the dorsal raphe nucleus. |
1977-02-26 |
2023-08-11 |
rat |
| S S Mosko, D Haubrich, B L Jacob. Serotonergic afferents to the dorsal raphe nucleus: evdience from HRP and synaptosomal uptake studies. Brain research. vol 119. issue 2. 1977-02-26. PMID:830388. |
synaptosomal uptake of [3h]5-ht was blocked by selective destruction of serotonergic axon terminals induced by the intraventricular injection of 200 mug of 5,7-dihydroxytryptamine following desipramine hcl pretreatment, but not by destruction of catecholaminergic axon terminals induced by intraventricularly injected 6-hydroxydopamine (2 x 250 mug). |
1977-02-26 |
2023-08-11 |
rat |
| R A Green, J D Barchas, G R Elliott, J S Carman, R J Wyat. The tryptolines: effect of intraventricular administration on spontaneous motor activity of rats. Pharmacology, biochemistry, and behavior. vol 5. issue 4. 1977-02-26. PMID:1005486. |
since both the tryptolines and tryptamines have been shown to be inhibitors of 5-hydroxytryptamine uptake, it may be possible that these compounds are acting indirectly throught an effect on the serotonergic system. |
1977-02-26 |
2023-08-11 |
rat |