| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D W Gallager, G K Aghajania. Effect of antipsychotic drugs on the firing of dorsal raphe cells. I. Role of adrenergic system. European journal of pharmacology. vol 39. issue 2. 1977-01-03. PMID:10173. |
the activity of serotonergic (5ht) neurons in the dorsal raphe nucleus was inhibited by the i.v. |
1977-01-03 |
2023-08-11 |
Not clear |
| D W Gallager, G K Aghajania. Effect of antipsychotic drugs on the firing of dorsal raphe cells. II. Reversal by picrotoxin. European journal of pharmacology. vol 39. issue 2. 1977-01-03. PMID:10174. |
as reported in the preceding study, the ability of certain antipsychotic and adrenolytic agents to inhibit the spontaneous firing of serotonergic 5ht neurons in the dorsal raphe nucleus appeared to be related to adrenergic blocking efficacy. |
1977-01-03 |
2023-08-11 |
Not clear |
| J H Schwartz, J E Goldman, R T Ambron, D J Goldber. Axonal transport of vesicles carrying (3H)serotonin in the metacerebral neuron of Aplysia californica. Cold Spring Harbor symposia on quantitative biology. vol 40. 1976-09-25. PMID:59657. |
because the serotonergic vesicle appears to be more stable to isolation than the cholinergic vesicle and because serotonin, like other transmitter molecules with primary amino groups, can be fixed into tissue with aldehyde fixatives, we were able to show that serotonergic vesicles, originating from the cell body, are transported in both branches of the axon by fast axonal transport. |
1976-09-25 |
2023-08-11 |
aplysia |
| M E Trulso. Biological bases for the integration of appetitive and consummatory grooming behaviors in the cat: a review. Pharmacology, biochemistry, and behavior. vol 4. issue 3. 1976-08-23. PMID:1084531. |
systemic administration of 5-hydroxytryptophan or monoamine oxidase inhibition plus tryptophan administration abolishes the abnormal grooming behavior in each group of cats, and microinjections of 5-hydroxytryptophan or serotonin into the superior colliculi has the same effect, indicating that the change in a serotonergic system is a critical aspect of the abnormal behavior in cats with lesions and that a serotonergic system may also be involved in the genesis of the abnormal grooming behavior in thyroidectomized cats. |
1976-08-23 |
2023-08-11 |
cat |
| T Magnusson, A Carlsson, G H Fisher, D Chang, K Folker. Effect of synthetic substance P on monoaminergic mechanisms in brain. Journal of neural transmission. vol 38. issue 2. 1976-08-02. PMID:5576. |
a similar stimulation of noradrenaline and 5-hydroxytryptamine indicate a similar transmitter role for noradrenergic and serotonergic neurons. |
1976-08-02 |
2023-08-11 |
Not clear |
| G K Aghajanian, H J Hailgle. Hallucinogenic indoleamines: Preferential action upon presynaptic serotonin receptors. Psychopharmacology communications. vol 1. issue 6. 1976-07-06. PMID:1063421. |
the results support the hypothesis that low doses of indoleamine halluciogens act preferentially upon presynaptic serotonin receptors to inhibit raphe neurons, thus releasing postsynaptic neurons from a tonic inhibitory serotonergic influence. |
1976-07-06 |
2023-08-11 |
rat |
| N Toda, S Hayashi, W L Fu, Y Nagasak. Serotonin antagonism in isolated canine cerebral arteries. Japanese journal of pharmacology. issue 1. 1976-07-06. PMID:1263357. |
it may be concluded that an alpha-adrenergic mechanism is not involved in the genesis of serotonin-induced contractions and that serotonin acts directly on serotonergic receptors in canine cerebral arteries. |
1976-07-06 |
2023-08-11 |
Not clear |
| H Tamir, M M Rappor. Is the serotonin binding protein (SBP) a soluble storage form for serotonin? Research communications in chemical pathology and pharmacology. vol 13. issue 2. 1976-06-02. PMID:1257610. |
the binding of serotonin to a soluble, high affinity binding protein (sbp) present in synaptosomes and assoicated with serotonergic tracts, has now been studied for the effect of drugs and, in particular, drugs interacting with contractile proteins. |
1976-06-02 |
2023-08-11 |
Not clear |
| L M Yunger, J A Harve. Behavioral effects of L-5-hydroxytryptophan after destruction of ascending serotonergic pathways in the rat: the role of catecholaminergic neurons. The Journal of pharmacology and experimental therapeutics. vol 196. issue 2. 1976-05-10. PMID:1255478. |
it was concluded that l-5-htp can be decarboxylated to 5-ht in serotonergic and catecholaminergic neurons and that the behavioral effects of l-5-htp in lesioned rats may be due to the formation of 5-ht in catecholaminergic neurons where it may act as a "false-transmitter." |
1976-05-10 |
2023-08-11 |
rat |
| E K Orenberg, S R Vandenberg, J D Barchas, M M Herma. Neurochemical studies in a mouse teratoma with neuroepithelial differentiation. Presence of cyclic AMP, serotonin and enzymes of the serotonergic, adrenergic and cholinergic systems. Brain research. vol 101. issue 2. 1976-03-20. PMID:1140. |
presence of cyclic amp, serotonin and enzymes of the serotonergic, adrenergic and cholinergic systems. |
1976-03-20 |
2023-08-11 |
mouse |
| L E Hicks, J D Maser, G G Gallup, P H Edso. Possible serotonergic mediation of tonic immobility: effects of morphine and serotonin blockade. Psychopharmacologia. vol 42. issue 1. 1975-11-06. PMID:125432. |
possible serotonergic mediation of tonic immobility: effects of morphine and serotonin blockade. |
1975-11-06 |
2023-08-11 |
Not clear |
| J A Harvey, A J Schlosberg, L M Yunge. Behavioral correlates of serotonin depletion. Federation proceedings. vol 34. issue 9. 1975-11-05. PMID:125207. |
depletion of telencephalic serotonin (5-ht) content by medical forebrain bundle lesions, which interrupt the ascending serotonergic pathways or by dl-p-chlorophenylalanine produces an increased sensitivity to pain as measured by the flinch-jump, stabilimetric, or hot-plate methods. |
1975-11-05 |
2023-08-11 |
rat |
| J A Harvey, A J Schlosberg, L M Yunge. Behavioral correlates of serotonin depletion. Federation proceedings. vol 34. issue 9. 1975-11-05. PMID:125207. |
all three of these telencephalic areas are innervated by the ascending serotonergic pathways, and cells in these areas show inhibition of firing following the iontophoretic application of 5-ht. |
1975-11-05 |
2023-08-11 |
rat |
| J A Harvey, A J Schlosberg, L M Yunge. Behavioral correlates of serotonin depletion. Federation proceedings. vol 34. issue 9. 1975-11-05. PMID:125207. |
a review of a variety of behavioral effects of 5-ht depletion including an enhanced response to lysergic acid diethylamide and amphetamine suggests that the ascending serotonergic system may have a general role in the inhibition of arousal, rather than a specific role with respect to various categories of behavior. |
1975-11-05 |
2023-08-11 |
rat |
| M H Aprison, J N Hingtgen, W J McBrid. Serotonergic and cholinergic mechanisms during disruption of approach and avoidance behavior. Federation proceedings. vol 34. issue 9. 1975-11-05. PMID:1080120. |
our hypothesis to explain these two apparent opposite biochemical states which result in similar behavioral disruptions is that in both cases more 5-ht is released within certain key serotonergic synapses mediating this behavior. |
1975-11-05 |
2023-08-11 |
rat |
| M H Aprison, J N Hingtgen, W J McBrid. Serotonergic and cholinergic mechanisms during disruption of approach and avoidance behavior. Federation proceedings. vol 34. issue 9. 1975-11-05. PMID:1080120. |
tnot only are the levels of 5-ht significantly higher in preparations of nerve endings isolated from the telencephalon and diencephalon of pigeons given injections of d,l-5-htp, but in vitro studies also show that low concentrations of l-5-htp significantly increased the release of radioactive 5-ht from serotonergic nerve endings. |
1975-11-05 |
2023-08-11 |
rat |
| D W Gallager, G K Aghajania. Effects of chlorimipramine and lysergic acid diethylamide on efflux of precursor-formed 3-H-serotonin: correlations with serotonergic impulse flow. The Journal of pharmacology and experimental therapeutics. vol 193. issue 3. 1975-11-01. PMID:168347. |
the effects of d-lysergic acid diethylamide (lsd) and chlorimipramine (cimi) on the firing rate of serotonergic (5-ht) neurons and on the in vivo efflux of 5-ht were investigated in parallel. |
1975-11-01 |
2023-08-11 |
Not clear |
| D W Gallager, G K Aghajania. Effects of chlorimipramine and lysergic acid diethylamide on efflux of precursor-formed 3-H-serotonin: correlations with serotonergic impulse flow. The Journal of pharmacology and experimental therapeutics. vol 193. issue 3. 1975-11-01. PMID:168347. |
impulse flow in serotonergic neurons was monitored by single unit recording from raphe (5-ht) neurons. |
1975-11-01 |
2023-08-11 |
Not clear |
| N Tod. Analysis of the effect of 5-hydroxykynurenamine,, a serotonin metabolite, on isolated cerebral arteries, aortas and atria. The Journal of pharmacology and experimental therapeutics. vol 193. issue 2. 1975-10-10. PMID:1142096. |
it appears that 5-hk produces vascular contractions via serotonergic receptors, inhibits specifically the contractile response of arteries and aortas to serotonin and causes a tachycardia in rabbit atria by liberating catecholamines from adrenergic nerves. |
1975-10-10 |
2023-08-11 |
human |
| R G Schaub, K M Meyer. Evidence for a small functional pool of serotonin in neurohumoral transmission. Research communications in chemical pathology and pharmacology. vol 10. issue 1. 1975-07-07. PMID:235778. |
decreasing central nervous system (cns) concentrations of serotonin (5-ht) via para-chlorophenylalanine (pcpa) will profoundly increase the severity of the disease although the basic defect does not involve serotonergic neurons. |
1975-07-07 |
2023-08-11 |
Not clear |