| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Gerin, A Legrand, A Priva. Study of 5-HT release with a chronically implanted microdialysis probe in the ventral horn of the spinal cord of unrestrained rats during exercise on a treadmill. Journal of neuroscience methods. vol 52. issue 2. 1994-12-14. PMID:7967717. |
detailed histological and immunocytochemical analysis based on glial fibrillary acidic protein and 5-ht immunocytochemistry showed minimal gliosis and the presence of serotonergic varicose fibers, respectively, at the probe contact. |
1994-12-14 |
2023-08-12 |
rat |
| D Marazziti, U Bonuccelli, A Nuti, C Toni, S Pedri, L Palego, N Pavese, C Lucetti, A Muratorio, G B Cassan. Platelet 3H-imipramine binding and sulphotransferase activity in primary headache. Cephalalgia : an international journal of headache. vol 14. issue 3. 1994-12-08. PMID:7954741. |
the decreased number of platelet 3h-imi binding sites is suggestive of a presynaptic serotonergic dysfunction and confirms the involvement of 5ht in primary headaches. |
1994-12-08 |
2023-08-12 |
Not clear |
| S O Huh, D H Park, J Y Cho, T H Joh, J H So. A 6.1 kb 5' upstream region of the mouse tryptophan hydroxylase gene directs expression of E. coli lacZ to major serotonergic brain regions and pineal gland in transgenic mice. Brain research. Molecular brain research. vol 24. issue 1-4. 1994-12-07. PMID:7968351. |
tryptophan hydroxylase (tph) catalyzes the first step of serotonin biosynthesis in serotonergic neurons and neuroendocrine cells. |
1994-12-07 |
2023-08-12 |
mouse |
| M A Lee, H Y Meltze. Blunted oral body temperature response to MK-212 in cocaine addicts. Drug and alcohol dependence. vol 35. issue 3. 1994-11-29. PMID:7956751. |
previous studies have suggested that chronic cocaine administration may affect serotonergic function and that serotonin (5-ht) may be of importance in cocaine craving. |
1994-11-29 |
2023-08-12 |
Not clear |
| L Lima, P Matus, M Urbin. Serotonin inhibits outgrowth of goldfish retina and impairs the trophic effect of taurine. Journal of neuroscience research. vol 38. issue 4. 1994-11-23. PMID:7523693. |
in the present work we evaluated the effect of serotonin and some serotonergic agonists on the neuritic outgrowth from goldfish retinal explants. |
1994-11-23 |
2023-08-12 |
Not clear |
| C M Portas, R W McCarle. Behavioral state-related changes of extracellular serotonin concentration in the dorsal raphe nucleus: a microdialysis study in the freely moving cat. Brain research. vol 648. issue 2. 1994-11-21. PMID:7922546. |
these data, to our knowledge the first direct drn 5-ht measurements during behavioral state changes, directly parallel the levels of serotonergic neuronal action potential activity and suggest that drn extracellular 5-ht is determined by this action potential activity through synaptic release by recurrent axonal collaterals in the drn. |
1994-11-21 |
2023-08-12 |
cat |
| S W Ying, B Rusa. Effects of serotonergic agonists on firing rates of photically responsive cells in the hamster suprachiasmatic nucleus. Brain research. vol 651. issue 1-2. 1994-11-16. PMID:7922588. |
application of metergoline alone, a non-selective 5-ht antagonist, slightly increased firing rates during darkness and light exposure, suggesting a tonic serotonergic suppression of scn activity. |
1994-11-16 |
2023-08-12 |
Not clear |
| A Anand, D S Charney, P L Delgado, C J McDougle, G R Heninger, L H Pric. Neuroendocrine and behavioral responses to intravenous m-chlorophenylpiperazine (mCPP) in depressed patients and healthy comparison subjects. The American journal of psychiatry. vol 151. issue 11. 1994-11-15. PMID:7943451. |
this double-blind study was undertaken to compare central serotonergic function in depressed patients and healthy comparison subjects by examining neuroendocrine and mood responses to intravenous infusion of the serotonin agonist m-chlorophenylpiperazine (mcpp). |
1994-11-15 |
2023-08-12 |
human |
| T Honda, K Semb. Serotonergic synaptic input to cholinergic neurons in the rat mesopontine tegmentum. Brain research. vol 647. issue 2. 1994-11-10. PMID:7922506. |
the presence of serotonergic synapses onto tegmental cholinergic neurons is consistent with previous behavioral and electrophysiological findings suggesting an inhibitory role of serotonin in the induction of rapid eye movement sleep and its phenomenology through an action on cholinergic neurons in the mesopontine tegmentum. |
1994-11-10 |
2023-08-12 |
rat |
| C Chen, D G Rainnie, R W Greene, S Tonegaw. Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II. Science (New York, N.Y.). vol 266. issue 5183. 1994-11-08. PMID:7939668. |
at the cellular level, both extracellular and whole-cell patch clamp recordings indicated that serotonin release in putative serotonergic neurons of the dorsal raphe was reduced. |
1994-11-08 |
2023-08-12 |
mouse |
| C A Fornal, F Marrosu, C W Metzler, K Tada, B L Jacob. Effects of the putative 5-hydroxytryptamine1A antagonists BMY 7378, NAN 190 and (-)-propranolol on serotonergic dorsal raphe unit activity in behaving cats. The Journal of pharmacology and experimental therapeutics. vol 270. issue 3. 1994-11-07. PMID:7932190. |
recent evidence from our laboratory has demonstrated that blockade of somatodendritic 5-hydroxytryptamine (5-ht)1a autoreceptors by systemic administration of spiperone increases the firing rate of central serotonergic neurons in awake cats. |
1994-11-07 |
2023-08-12 |
Not clear |
| J A Den Boer, I M Van Vliet, H G Westenber. Recent advances in the psychopharmacology of social phobia. Progress in neuro-psychopharmacology & biological psychiatry. vol 18. issue 4. 1994-11-04. PMID:7938556. |
the serotonergic system can now be studied and it is hoped that the role of 5-ht and other neuronal systems in social phobia can be elucidated. |
1994-11-04 |
2023-08-12 |
Not clear |
| J E Sprague, X Huang, A Kanthasamy, D E Nichol. Attenuation of 3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity with the serotonin precursors tryptophan and 5-hydroxytryptophan. Life sciences. vol 55. issue 15. 1994-10-25. PMID:7934616. |
treatment of rats with serotonin (5-ht) precursors tryptophan (trp, 400 mg/kg) and 5-hydroxytryptophan (5-htp, 50 mg/kg) was shown to attenuate mdma (20 mg/kg) induced serotonergic neurotoxicity as measured by [3h]-paroxetine binding in the striatum, hippocampus, and frontal cortex of the rat brain. |
1994-10-25 |
2023-08-12 |
rat |
| J E Sprague, X Huang, A Kanthasamy, D E Nichol. Attenuation of 3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity with the serotonin precursors tryptophan and 5-hydroxytryptophan. Life sciences. vol 55. issue 15. 1994-10-25. PMID:7934616. |
the possible significance of this 5-ht depletion in mdma-induced serotonergic terminal degeneration is also discussed. |
1994-10-25 |
2023-08-12 |
rat |
| T S Rieg, A M Maestrello, P F Aravic. Weight cycling alters the effects of D-fenfluramine on susceptibility to activity-based anorexia. The American journal of clinical nutrition. vol 60. issue 4. 1994-10-20. PMID:8092083. |
it has been proposed that anorexia nervosa (an) is treatable with serotonergic (5-ht) agonists. |
1994-10-20 |
2023-08-12 |
rat |
| A Dedeoğlu, L A Fishe. Cardiovascular activation by serotonergic stimulation: role of corticotropin-releasing factor. The American journal of physiology. vol 267. issue 3 Pt 2. 1994-10-19. PMID:8092332. |
serotonin (5-ht) and serotonergic agonists stimulate the release of corticotropin-releasing factor (crf) from hypophysiotropic neurons and thereby activate the pituitary-adrenal axis. |
1994-10-19 |
2023-08-12 |
rat |
| J F Wedderburn, K T Silla. Modulation of rhythmic swimming activity in post-embryonic Xenopus laevis tadpoles by 5-hydroxytryptamine acting at 5HT1a receptors. Proceedings. Biological sciences. vol 257. issue 1348. 1994-10-14. PMID:8090792. |
by applying a range of agonists and antagonists against different 5ht receptor subtypes, we conclude that serotonergic modulation of swimming activity is accomplished via the activation of just one receptor type with a pharmacological profile similar to the mammalian 5ht1a receptor. |
1994-10-14 |
2023-08-12 |
xenopus_laevis |
| S L Dubovsk. Beyond the serotonin reuptake inhibitors: rationales for the development of new serotonergic agents. The Journal of clinical psychiatry. vol 55 Suppl. 1994-09-30. PMID:8077173. |
beyond the serotonin reuptake inhibitors: rationales for the development of new serotonergic agents. |
1994-09-30 |
2023-08-12 |
Not clear |
| M A Wilson, M E Mollive. Microglial response to degeneration of serotonergic axon terminals. Glia. vol 11. issue 1. 1994-09-29. PMID:8070892. |
the neurotoxic drug p-chloramphetamine (pca) causes widespread degeneration of fine, unmyelinated serotonergic (5-ht) axons in the forebrain. |
1994-09-29 |
2023-08-12 |
rat |
| J P O'Callaghan, D B Mille. Neurotoxicity profiles of substituted amphetamines in the C57BL/6J mouse. The Journal of pharmacology and experimental therapeutics. vol 270. issue 2. 1994-09-28. PMID:8071867. |
dopaminergic (da) and serotonergic (5-ht) projections to striatum and cortex have been implicated as the primary targets of substituted amphetamine (amp)-induced neurotoxicity, largely on the basis of the propensity of these compounds to cause protracted decrements in da and 5-ht rather than on the basis of amp-induced alterations of indices linked to neural damage. |
1994-09-28 |
2023-08-12 |
mouse |