| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M J Eaton, J K Staley, M Y Globus, S R Whittemor. Developmental regulation of early serotonergic neuronal differentiation: the role of brain-derived neurotrophic factor and membrane depolarization. Developmental biology. vol 170. issue 1. 1995-08-07. PMID:7601307. |
collectively these data indicate that distinct aspects of serotonin metabolism are differentially regulated during development and suggest that 5ht may function as a developmental signal in an autocrine loop during early serotonergic differentiation. |
1995-08-07 |
2023-08-12 |
rat |
| G W Lambert, D M Kaye, H S Cox, M Vaz, A G Turner, G L Jennings, M D Esle. Regional 5-hydroxyindoleacetic acid production in humans. Life sciences. vol 57. issue 3. 1995-08-03. PMID:7541101. |
the source of 5-hiaa stemming from these regional beds remains unknown, it may derive from serotonin taken up by and deaminated in ubiquitous endothelial cells, enterochromaffin cells of the gut, peripheral serotonergic nerves, serotonin turnover in platelets or perhaps the metabolism of serotonin taken up by sympathetic nerves. |
1995-08-03 |
2023-08-12 |
human |
| M Rafieian-Kopaei, A M Gray, P S Spencer, R D Sewel. Contrasting actions of acute or chronic paroxetine and fluvoxamine on morphine withdrawal-induced place conditioning. European journal of pharmacology. vol 275. issue 2. 1995-08-03. PMID:7796854. |
it is suggested therefore that acute fluvoxamine may have decreased withdrawal aversion, probably through serotonin and also, in part, via an opioid-like mechanism whereas chronic paroxetine decreased withdrawal aversion by a serotonergic mechanism, but it is not clear whether opioid systems play any role in the action of paroxetine. |
1995-08-03 |
2023-08-12 |
rat |
| M J Gitli. Effects of depression and antidepressants on sexual functioning. Bulletin of the Menninger Clinic. vol 59. issue 2. 1995-08-01. PMID:7795566. |
it is likely that antidepressants with strong serotonergic effects--selective serotonin reuptake inhibitors, clomipramine, and monoamine oxidase inhibitors--are associated with higher rates of sexual side effects, compared to other antidepressant classes. |
1995-08-01 |
2023-08-12 |
Not clear |
| G Halliday, K Baker, C Harpe. Serotonin and alcohol-related brain damage. Metabolic brain disease. vol 10. issue 1. 1995-07-31. PMID:7596326. |
preliminary results from the immunohistochemical examination of the brainstems of chronic alcoholics, suggest that alcohol may have a role in damage to the principal serotonergic (5ht) nuclei. |
1995-07-31 |
2023-08-12 |
rat |
| J C Pecknold, L Luthe, L Iny, D Ramdoya. Fluoxetine in panic disorder: pharmacologic and tritiated platelet imipramine and paroxetine binding study. Journal of psychiatry & neuroscience : JPN. vol 20. issue 3. 1995-07-27. PMID:7786880. |
serotonergic implication in panic disorder has been demonstrated by the efficacy of serotonin reuptake blockers in treatment. |
1995-07-27 |
2023-08-12 |
Not clear |
| U Halbreich, N Rojansky, S Palter, H Tworek, P Hissin, K Wan. Estrogen augments serotonergic activity in postmenopausal women. Biological psychiatry. vol 37. issue 7. 1995-07-27. PMID:7786956. |
to investigate the influence of estrogen replacement on serotonergic activity in postmenopausal women, the serotonin agonist meta-chlorophenylpiperazine (m-cpp) (0.5 mg/kg) was given orally to 18 normal postmenopausal women, 11 of whom were also tested following 30 days' treatment with estrogen transdermal patches (estraderm 0.1 mg). |
1995-07-27 |
2023-08-12 |
Not clear |
| R Jackisch, B Neufang, G Hertting, H Jeltsch, C Kelche, B Will, J C Casse. Sympathetic sprouting: time course of changes of noradrenergic, cholinergic, and serotonergic markers in the denervated rat hippocampus. Journal of neurochemistry. vol 65. issue 1. 1995-07-26. PMID:7540665. |
however, whereas the cholinergic (choline uptake and choline acetyltransferase activity) and the serotonergic (concentrations of serotonin and 5-hydroxyindoleacetic acid) markers remained significantly reduced for up to 40 weeks, both noradrenergic markers recovered to near-normal (noradrenaline uptake) or even supranormal (noradrenaline concentration) levels, although with clear-cut differences in the time course and the regional characteristics. |
1995-07-26 |
2023-08-12 |
rat |
| E Le Poul, L Lima, A M Laporte, C Even, E Doucet, C M Fattaccini, N Laaris, M Hamon, L Lanfume. [Central serotonin receptors and chronic treatment with selective serotonin reuptake inhibitors in the rat: comparative effects of fluoxetine and paroxetine]. L'Encephale. vol 21. issue 2. 1995-07-20. PMID:7781583. |
the hypothesis that a dysfunction of serotonergic neurotransmission is implicated in depression is supported by the clinical efficiency of selective serotonin (5-hydroxytryptamine, 5-ht) reuptake inhibitors (ssris) in the treatment of depressive disorders. |
1995-07-20 |
2023-08-12 |
rat |
| E Le Poul, L Lima, A M Laporte, C Even, E Doucet, C M Fattaccini, N Laaris, M Hamon, L Lanfume. [Central serotonin receptors and chronic treatment with selective serotonin reuptake inhibitors in the rat: comparative effects of fluoxetine and paroxetine]. L'Encephale. vol 21. issue 2. 1995-07-20. PMID:7781583. |
these drugs, such as fluoxetine and paroxetine, exert their antidepressant activity by increasing 5-ht concentration in the synaptic cleft and thus enhancing serotonergic neurotransmission. |
1995-07-20 |
2023-08-12 |
rat |
| T Steckler, A Sahga. The role of serotonergic-cholinergic interactions in the mediation of cognitive behaviour. Behavioural brain research. vol 67. issue 2. 1995-07-19. PMID:7779290. |
whether serotonin alters accuracy or bias, however, may also depend on the cognitive process under investigation: it is suggested that attention, stimulus processing and/or arousal can be influenced by both cholinergic and serotonergic systems independently from each other. |
1995-07-19 |
2023-08-12 |
Not clear |
| S Hjorth, C S Suchowski, M P Gallowa. Evidence for 5-HT autoreceptor-mediated, nerve impulse-independent, control of 5-HT synthesis in the rat brain. Synapse (New York, N.Y.). vol 19. issue 3. 1995-07-18. PMID:7784957. |
to gain further insight into the operation of 5-ht autoreceptor-mediated feedback control of 5-ht biosynthesis in serotonergic nerve terminal areas, the effect of the 5-ht1b and the 5-ht1a receptor agonists, tfmpp and 8-oh-dpat, respectively, were investigated in the rat central nervous system (cns) using in vivo and in vitro neurochemical approaches. |
1995-07-18 |
2023-08-12 |
rat |
| S Hjorth, C S Suchowski, M P Gallowa. Evidence for 5-HT autoreceptor-mediated, nerve impulse-independent, control of 5-HT synthesis in the rat brain. Synapse (New York, N.Y.). vol 19. issue 3. 1995-07-18. PMID:7784957. |
specifically, our data indicate: (1) that the reduction of rat brain 5-ht synthesis after tfmpp is mediated by 5-ht1b autoreceptors located on the serotonergic axon terminals, and (2) that the effect is directly mediated and occurs independently of 5-ht neuronal firing and intact monoamine stores. |
1995-07-18 |
2023-08-12 |
rat |
| J A Den Boer, I M van Vliet, H G Westenber. Recent developments in the psychopharmacology of social phobia. European archives of psychiatry and clinical neuroscience. vol 244. issue 6. 1995-07-07. PMID:7772614. |
drugs exerting selective and specific actions on certain components of, for example, the serotonergic system, can now be studied, and it is hoped that the role of 5-hydroxytryptamine) and other neuronal systems in social phobia can be elucidated. |
1995-07-07 |
2023-08-12 |
Not clear |
| A Breie. Serotonin, schizophrenia and antipsychotic drug action. Schizophrenia research. vol 14. issue 3. 1995-07-06. PMID:7539288. |
a rapidly growing body of data suggests that dysfunction in serotonergic (5-ht) function may be involved in the pathophysiology of schizophrenia, and that pharmacologic agents for this illness have their therapeutic effects mediated through serotonergic mechanisms. |
1995-07-06 |
2023-08-12 |
Not clear |
| L Sundin, G E Nilsson, M Block, C O Löfma. Control of gill filament blood flow by serotonin in the rainbow trout, Oncorhynchus mykiss. The American journal of physiology. vol 268. issue 5 Pt 2. 1995-07-06. PMID:7771583. |
after treatment with the serotonergic receptor antagonist methysergide, the vasoconstrictor effect of serotonin on the filamental vasculature was eliminated, while a decrease in pca was still observed. |
1995-07-06 |
2023-08-12 |
Not clear |
| K G Koski, L Lanoue, S N Youn. Maternal dietary carbohydrate restriction influences the developmental profile of postnatal rat brain indoleamine metabolism. Biology of the neonate. vol 67. issue 2. 1995-07-05. PMID:7539298. |
however, the reemergence of a significant difference in brain 5-ht content at day 15 postpartum indicates that even when energy intake is adequate the level of carbohydrate in the maternal diet may continue to play a role in modulating serotonergic neurotransmitter levels later in development. |
1995-07-05 |
2023-08-12 |
rat |
| J A Lawrence, A R Charters, S P Butcher, J S Kelly, H J Olverma. 5-HT transporter antibodies as a tool in serotonergic synaptosomal isolation. Biochemical Society transactions. vol 23. issue 1. 1995-06-26. PMID:7758676. |
5-ht transporter antibodies as a tool in serotonergic synaptosomal isolation. |
1995-06-26 |
2023-08-12 |
Not clear |
| A C Lahti, C A Tamming. Recent developments in the neuropharmacology of schizophrenia. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. vol 52. issue 3 Suppl 1. 1995-06-22. PMID:7749964. |
antagonists of dopa-mine and serotonin receptors were developed on the basis of the discovery that dopa-minergic and serotonergic systems in the mammalian central nervous system functionally interact; balanced antagonism of these receptors may provide an enhanced antipsychotic effect. |
1995-06-22 |
2023-08-12 |
Not clear |
| D J Kim, S D Rope. Localization of serotonin in taste buds: a comparative study in four vertebrates. The Journal of comparative neurology. vol 353. issue 3. 1995-06-21. PMID:7751436. |
based on the position of serotonergic cells in the taste bud and on recent physiological studies on the actions of serotonin in taste buds, we postulate that serotonin functions as a neuromodulator or neurotransmitter in vertebrate taste buds. |
1995-06-21 |
2023-08-12 |
mouse |