| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S L Walsh, K A Cunningha. Serotonergic mechanisms involved in the discriminative stimulus, reinforcing and subjective effects of cocaine. Psychopharmacology. vol 130. issue 1. 1997-07-18. PMID:9089847. |
in summary, while the functional significance of 5-ht receptors has not been fully elucidated, these data suggest that changes in serotonergic activity can modulate the effects of cocaine in both animals and humans under a variety of experimental conditions. |
1997-07-18 |
2023-08-12 |
Not clear |
| E Challet, P Pévet, A Mala. Lesion of the serotonergic terminals in the suprachiasmatic nuclei limits the phase advance of body temperature rhythm in food-restricted rats fed during daytime. Journal of biological rhythms. vol 12. issue 3. 1997-07-18. PMID:9181435. |
a lesion of serotonergic (5-htergic) terminals in the suprachiasmatic nuclei (scn)-the endogenous circadian clock(s)-was performed by microinjection of the 5-ht neurotoxin 5,7-dihydroxytryptamine (5,7-dht). |
1997-07-18 |
2023-08-12 |
rat |
| R Volpi, P Caffarra, A Scaglioni, S Boni, A Saginario, P Chiodera, V Coir. Defective 5-HT 1-receptor-mediated neurotransmission in the control of growth hormone secretion in Parkinson's disease. Neuropsychobiology. vol 35. issue 2. 1997-07-16. PMID:9097298. |
in order to gain a better insight in the serotonergic disorder affecting the parkinsonian brain, the growth hormone (gh) response to the 5-ht 1 serotonergic receptor agonist sumatriptan was tested. |
1997-07-16 |
2023-08-12 |
human |
| M Z Wrona, J Waskiewicz, Q P Han, J Han, H Li, G Dryhurs. Putative oxidative metabolites of 1-methyl-6-hydroxy-1,2,3,4-tetrahydro-beta-carboline of potential relevance to the addictive and neurodegenerative consequences of ethanol abuse. Alcohol (Fayetteville, N.Y.). vol 14. issue 3. 1997-07-10. PMID:9160798. |
within the cytoplasm of serotonergic axon terminals these metabolic pathways together provide conditions for the endogenous synthesis of 1-methyl-6-hydroxy-1,2,3,4-tetrahydro-beta-carboline (1), by reaction of acetaldehyde with unbound 5-hydroxytryptamine (5-ht), and for the oxygen radical-mediated oxidation of this alkaloid. |
1997-07-10 |
2023-08-12 |
mouse |
| N Nakata, H Suda, J Izumi, Y Tanaka, Y Ikeda, H Kato, Y Itoyama, K Kogur. Role of hippocampal serotonergic neurons in ischemic neuronal death. Behavioural brain research. vol 83. issue 1-2. 1997-07-09. PMID:9062688. |
to clarify the serotonergic mechanisms involved in the protection against ischemic neuronal damage, zd-211 (citalopram hbr), a serotonin (5-hydroxytryptamine; 5-ht) re-uptake inhibitor, or buspirone, a 5-ht1a agonist, was locally administered into the hippocampus of gerbils. |
1997-07-09 |
2023-08-12 |
Not clear |
| D Bengel, A Heils, S Petri, M Seemann, K Glatz, A Andrews, D L Murphy, K P Lesc. Gene structure and 5'-flanking regulatory region of the murine serotonin transporter. Brain research. Molecular brain research. vol 44. issue 2. 1997-07-08. PMID:9073170. |
by modulating the magnitude and duration of postsynaptic responses, carrier-facilitated serotonin (5-ht) transport into and release from the presynaptic neuron is central to the fine tuning of serotonergic neurotransmission. |
1997-07-08 |
2023-08-12 |
Not clear |
| C Maudhuit, E Prévot, L Dangoumau, P Martin, M Hamon, J Adrie. Antidepressant treatment in helpless rats: effect on the electrophysiological activity of raphe dorsalis serotonergic neurons. Psychopharmacology. vol 130. issue 3. 1997-07-07. PMID:9151362. |
chronic treatment with antidepressants renders serotonergic neuronal firing less sensitive to the inhibitory effect of serotonin (5-ht) reuptake blockers in the rat, and this has been considered as a major correlate of the therapeutic action of these drugs. |
1997-07-07 |
2023-08-12 |
rat |
| J M Horowitz, M B Kristal, G Torre. Differential behavioral responses to cocaethylene of Long-Evans and Sprague-Dawley rats: role of serotonin. Synapse (New York, N.Y.). vol 26. issue 1. 1997-06-27. PMID:9097401. |
to relate these behavioral differences to possible structural differences in the neuronal density of dopaminergic or serotonergic neurons, long-evans and sprague-dawley brains were evaluated for tyrosine hydroxylase and 5-ht immunocytochemistry. |
1997-06-27 |
2023-08-12 |
rat |
| N Singewald, S Kaehler, R Hemeida, A Philipp. Release of serotonin in the rat locus coeruleus: effects of cardiovascular, stressful and noxious stimuli. The European journal of neuroscience. vol 9. issue 3. 1997-06-27. PMID:9104597. |
to investigate the function of serotonergic neurons within the locus coeruleus, this brain nucleus of conscious, freely moving rats was superfused with artificial cerebrospinal fluid through a push-pull cannula and the extracellular concentration of serotonin was determined in the superfusate. |
1997-06-27 |
2023-08-12 |
rat |
| N Singewald, S Kaehler, R Hemeida, A Philipp. Release of serotonin in the rat locus coeruleus: effects of cardiovascular, stressful and noxious stimuli. The European journal of neuroscience. vol 9. issue 3. 1997-06-27. PMID:9104597. |
the findings demonstrate that neuronal serotonin release in the locus coeruleus responds to cardiovascular and sensory stimuli, suggesting a function of serotonergic neurons in central blood pressure regulation, as well as in the modulation of locus coeruleus activity by stress and noxious stimuli. |
1997-06-27 |
2023-08-12 |
rat |
| M C Buho. Serotonin receptors in cognitive behaviors. Current opinion in neurobiology. vol 7. issue 2. 1997-06-27. PMID:9142756. |
the serotonergic system appears to play a role in behaviors that involve a high cognitive demand and in memory improvement or recovery from impaired cognitive performance, as made evident after administration of serotonin 5-ht2a/5-ht2c or 5-ht4 receptor agonists or 5-ht1a or 5-ht3 receptor antagonists. |
1997-06-27 |
2023-08-12 |
mouse |
| H J van Megen, H G Westenberg, J A den Boer, B Slaap, A Scheepmaker. Effect of the selective serotonin reuptake inhibitor fluvoxamine on CCK-4 induced panic attacks. Psychopharmacology. vol 129. issue 4. 1997-06-19. PMID:9085405. |
data from animal studies suggest a functional relationship between the cholecystokinin-ergic (cck) and the serotonergic (5-ht) system. |
1997-06-19 |
2023-08-12 |
human |
| S Beckett, C A Marsde. The effect of central and systemic injection of the 5-HT1A receptor agonist 8-OHDPAT and the 5-HT1A receptor antagonist WAY100635 on periaqueductal grey-induced defence behaviour. Journal of psychopharmacology (Oxford, England). vol 11. issue 1. 1997-06-19. PMID:9097891. |
these data support previous findings which indicate that serotonergic modulation of aversive behaviours such as defence can be mediated by 5-ht(1a) receptors. |
1997-06-19 |
2023-08-12 |
rat |
| M J Owen. Molecular and cellular mechanisms of antidepressant drugs. Depression and anxiety. vol 4. issue 4. 1997-06-18. PMID:9166647. |
serotonin transporter antagonists enhance serotonergic neurotransmission by decreasing the functional activity of the 5-ht1a and 5-ht1b autoreceptors. |
1997-06-18 |
2023-08-12 |
Not clear |
| M J Owen. Molecular and cellular mechanisms of antidepressant drugs. Depression and anxiety. vol 4. issue 4. 1997-06-18. PMID:9166647. |
monoamine oxidase inhibitors and the 5-ht1a agonists increase serotonergic function by desensitizing the somatodendritic autoreceptor; the terminal 5-ht autoreceptor is not affected by these agents. |
1997-06-18 |
2023-08-12 |
Not clear |
| R T Miller, S S Lau, T J Monk. 2,5-Bis-(glutathion-S-yl)-alpha-methyldopamine, a putative metabolite of (+/-)-3,4-methylenedioxyamphetamine, decreases brain serotonin concentrations. European journal of pharmacology. vol 323. issue 2-3. 1997-06-16. PMID:9128836. |
the effects of 2,5-bis-(glutathion-s-yl)-alpha-methyldopamine were also selective for serotonergic nerve terminal fields, in that 5-ht levels were unaffected in regions of the cell bodies. |
1997-06-16 |
2023-08-12 |
rat |
| M Strittmatter, M Grauer, E Isenberg, G Hamann, C Fischer, K H Hoffmann, F Blaes, K Schimrig. Cerebrospinal fluid neuropeptides and monoaminergic transmitters in patients with trigeminal neuralgia. Headache. vol 37. issue 4. 1997-06-16. PMID:9150615. |
as a marker for the serotonergic system, we measured cerebrospinal fluid levels of the serotonin metabolite, 5-hydroxyindoleacetic acid. |
1997-06-16 |
2023-08-12 |
Not clear |
| P Maso. Physiological identification of pontomedullary serotonergic neurons in the rat. Journal of neurophysiology. vol 77. issue 3. 1997-06-13. PMID:9084584. |
establishing the electrophysiological properties of serotonergic bulbospinal neurons in the pontomedullary raphe and reticular formation is critical to understanding the physiological role of serotonin in the spinal cord. |
1997-06-13 |
2023-08-12 |
rat |
| D A Bayliss, Y W Li, E M Talle. Effects of serotonin on caudal raphe neurons: activation of an inwardly rectifying potassium conductance. Journal of neurophysiology. vol 77. issue 3. 1997-06-13. PMID:9084602. |
the overwhelming majority of identified serotonergic neurons was hyperpolarized by bath-applied 5-ht (94%; n = 32 of 34); conversely, most cells in this sample that were hyperpolarized by 5-ht were serotonergic (78%; n= 32 of 41). |
1997-06-13 |
2023-08-12 |
rat |
| D A Bayliss, Y W Li, E M Talle. Effects of serotonin on caudal raphe neurons: inhibition of N- and P/Q-type calcium channels and the afterhyperpolarization. Journal of neurophysiology. vol 77. issue 3. 1997-06-13. PMID:9084603. |
a subpopulation of recorded neurons was recovered after staining for tryptophan hydroxylase (tph), the 5-ht synthesizing enzyme (n = 21); of those cells, 86% were tph immunoreactive, suggesting that the majority of recorded neurons was serotonergic. |
1997-06-13 |
2023-08-12 |
rat |