| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I E Dori, A Dinopoulos, J G Parnavela. The development of the synaptic organization of the serotonergic system differs in brain areas with different functions. Experimental neurology. vol 154. issue 1. 1999-01-19. PMID:9875273. |
considering these results together with data from our previous studies, we speculate that the regional heterogeneity in the synaptic organization of the serotonergic system may reflect a differential role of 5-ht in the development of brain areas with different functions. |
1999-01-19 |
2023-08-12 |
rat |
| P J Goodnick, B J Goldstei. Selective serotonin reuptake inhibitors in affective disorders--I. Basic pharmacology. Journal of psychopharmacology (Oxford, England). vol 12. issue 3 Suppl B. 1999-01-15. PMID:9808077. |
the ssris selectively and powerfully inhibit serotonin reuptake and result in a potentiation of serotonergic neurotransmission. |
1999-01-15 |
2023-08-12 |
Not clear |
| M Pasqualetti, M Ori, I Nardi, M Castagna, G B Cassano, D Marazzit. Distribution of the 5-HT5A serotonin receptor mRNA in the human brain. Brain research. Molecular brain research. vol 56. issue 1-2. 1999-01-14. PMID:9602024. |
since the cerebellum receives diffuse serotonergic afferents, this finding suggests that the 5-ht5a receptor may have an important role in mediating the effects of 5-ht on cerebellar functions. |
1999-01-14 |
2023-08-12 |
human |
| H M van Praa. Anxiety and increased aggression as pacemakers of depression. Acta psychiatrica Scandinavica. Supplementum. vol 393. 1999-01-14. PMID:9777052. |
anti-aggressive drugs) that act via normalization of serotonergic circuits will exert an antidepressant effect in 5-ht related depression, in addition to their therapeutic actions in anxiety disorders and states of increased aggressiveness, respectively. |
1999-01-14 |
2023-08-12 |
Not clear |
| S J Kim, K H K. Abnormal central serotonergic activities in spontaneously hypertensive rats (SHR). Methods and findings in experimental and clinical pharmacology. vol 20. issue 6. 1999-01-12. PMID:9789871. |
the activities of serotonergic nervous system were assessed by measuring the serotonin turnover rates in rats treated with probenecid. |
1999-01-12 |
2023-08-12 |
rat |
| P Bonaventure, X Langlois, J E Leyse. Co-localization of 5-HT1B- and 5-HT1D receptor mRNA in serotonergic cell bodies in guinea pig dorsal raphé nucleus: a double labeling in situ hybridization histochemistry study. Neuroscience letters. vol 254. issue 2. 1999-01-08. PMID:9779933. |
in order to provide further details on the cellular localization of 5-ht1b- and 5-ht1d receptor mrna in the dorsal raphé nucleus, we performed, in the same sections of guinea-pig dorsal raphé nucleus, double labeling in situ hybridization histochemistry for: (1) 5-ht1b receptor mrna and 5-ht1d receptor mrna, (2) 5-ht1b receptor mrna and 5-ht transporter (5-htt) mrna as marker for serotonergic neurons and (3) 5-ht1d receptor mrna and 5-htt mrna. |
1999-01-08 |
2023-08-12 |
Not clear |
| A C Trillat, I Malagié, M Mathe-Allainmat, M C Anmella, C Jacquot, M Langlois, A M Gardie. Synergistic neurochemical and behavioral effects of fluoxetine and 5-HT1A receptor antagonists. European journal of pharmacology. vol 357. issue 2-3. 1999-01-07. PMID:9797034. |
thus, fluoxetine increased [5-ht(ext)] in serotonergic nerve terminal areas and consequently, induced hypophagia, both effects being limited by indirect activation of somatodendritic 5-ht1a autoreceptors. |
1999-01-07 |
2023-08-12 |
rat |
| B S Chan, A Graudins, I M Whyte, A H Dawson, G Braitberg, G G Duggi. Serotonin syndrome resulting from drug interactions. The Medical journal of Australia. vol 169. issue 10. 1999-01-07. PMID:9861909. |
we describe six patients diagnosed with serotonin syndrome after exposure to drugs with serotonergic activity. |
1999-01-07 |
2023-08-12 |
Not clear |
| J K Staley, R T Malison, R B Inni. Imaging of the serotonergic system: interactions of neuroanatomical and functional abnormalities of depression. Biological psychiatry. vol 44. issue 7. 1999-01-06. PMID:9787877. |
with the rapid development of novel pet and spect radiotracers, future studies of the serotonergic system that evaluate presynaptic (5-ht transporter) and postsynaptic (5-ht1a and 5-ht2a receptors) markers and the interaction of synaptic levels of 5-ht with these sites will make profound contributions to the understanding of the role of the serotonergic synapse in the pathophysiology of depression. |
1999-01-06 |
2023-08-12 |
human |
| A J Cleare, R M Murray, V O'Kean. Assessment of serotonergic function in major depression using d-fenfluramine: relation to clinical variables and antidepressant response. Biological psychiatry. vol 44. issue 7. 1999-01-06. PMID:9787879. |
d-fenfluramine, a specific serotonin (5-ht)-releasing agent without the catecholamine effects of d,l-fenfluramine, was used as a serotonergic neuroendocrine challenge in subjects with unipolar major depression. |
1999-01-06 |
2023-08-12 |
human |
| G R Twitchell, G L Hanna, E H Cook, H E Fitzgerald, K Y Little, R A Zucke. Overt behavior problems and serotonergic function in middle childhood among male and female offspring of alcoholic fathers. Alcoholism, clinical and experimental research. vol 22. issue 6. 1999-01-04. PMID:9756051. |
a father's alcoholism status was not significantly related to his child's 5-ht level, i.e., the child's phenotypic expression of behavioral dysregulation was more reliably connected to serotonergic function than was paternal alcoholism. |
1999-01-04 |
2023-08-12 |
Not clear |
| P S MohanKumar, S M MohanKumar, S K Quadri, J L Voog. Responsiveness of tuberoinfundibular dopaminergic neurons to 5-hydroxytryptophan: effects of aging. Endocrine. vol 9. issue 1. 1999-01-04. PMID:9798728. |
an effective way to increase serotonergic activity is to administer 5-hydroxytryptophan (5-htp), a serotonin precursor. |
1999-01-04 |
2023-08-12 |
rat |
| J E Smith, J M Lakosk. Cellular electrophysiological effects of chronic fluoxetine and duloxetine administration on serotonergic responses in the aging hippocampus. Synapse (New York, N.Y.). vol 30. issue 3. 1998-12-28. PMID:9776135. |
these results demonstrate cellular adaptive changes in serotonergic neuronal function occur following repeated exposure to 5-ht reuptake inhibitors in an age-dependent manner. |
1998-12-28 |
2023-08-12 |
rat |
| S Ramboz, R Oosting, D A Amara, H F Kung, P Blier, M Mendelsohn, J J Mann, D Brunner, R He. Serotonin receptor 1A knockout: an animal model of anxiety-related disorder. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 24. 1998-12-28. PMID:9826725. |
to investigate the contribution of individual serotonin (5-hydroxytryptamine; 5-ht) receptors to mood control, we have used homologous recombination to generate mice lacking specific serotonergic receptor subtypes. |
1998-12-28 |
2023-08-12 |
mouse |
| S Ramboz, R Oosting, D A Amara, H F Kung, P Blier, M Mendelsohn, J J Mann, D Brunner, R He. Serotonin receptor 1A knockout: an animal model of anxiety-related disorder. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 24. 1998-12-28. PMID:9826725. |
although 5-ht1a receptors are involved in controlling the activity of serotonergic neurons, 5-ht1a knockout mice had normal levels of 5-ht and 5-hydroxyindoleacetic acid, possibly because of an up-regulation of 5-ht1b autoreceptors. |
1998-12-28 |
2023-08-12 |
mouse |
| I Hervás, N Bel, A G Fernández, J M Palacios, F Artiga. In vivo control of 5-hydroxytryptamine release by terminal autoreceptors in rat brain areas differentially innervated by the dorsal and median raphe nuclei. Naunyn-Schmiedeberg's archives of pharmacology. vol 358. issue 3. 1998-12-22. PMID:9774218. |
however, despite a comparatively lower 5-ht1a-mediated inhibition of 5-ht release and a greater density of serotonergic uptake sites in hippocampus, the net elevation produced by the systemic administration of ssris is similar in various forebrain areas, regardless of the origin of serotonergic fibres. |
1998-12-22 |
2023-08-12 |
rat |
| P K Gillma. Serotonin syndrome: history and risk. Fundamental & clinical pharmacology. vol 12. issue 5. 1998-12-22. PMID:9794145. |
the various serotonergic drugs that may be implicated in serotonin syndrome are tabulated and discussed in relation to the relative risk. |
1998-12-22 |
2023-08-12 |
human |
| P K Gillma. Serotonin syndrome: history and risk. Fundamental & clinical pharmacology. vol 12. issue 5. 1998-12-22. PMID:9794145. |
it is proposed that more systematic national collection of toxicity data is essential in order to quantify the relative risk of serotonin syndrome with various combinations of serotonergic drugs. |
1998-12-22 |
2023-08-12 |
human |
| T Vermeule. Distribution of paroxetine in three postmortem cases. Journal of analytical toxicology. vol 22. issue 6. 1998-12-17. PMID:9788532. |
paroxetine potentiates serotonergic activity through the selective inhibition of serotonin reuptake in the central nervous system. |
1998-12-17 |
2023-08-12 |
Not clear |
| J M Lauder, J Liu, L Devaud, A L Morro. GABA as a trophic factor for developing monoamine neurons. Perspectives on developmental neurobiology. vol 5. issue 2-3. 1998-12-16. PMID:9777640. |
the brainstem provides a good example of this relationship, since gabaergic axons pass through the anlage of the developing raphe nuclei when serotonergic (5-ht) neurons are just beginning to differentiate and migrate away from the ventricular zone. |
1998-12-16 |
2023-08-12 |
Not clear |