| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ronald L Cowa. Neuroimaging research in human MDMA users: a review. Psychopharmacology. vol 189. issue 4. 2007-03-02. PMID:16847678. |
because findings from the animal literature have indicated that specific dosage regimens of mdma can produce long-lasting alterations in serotonergic function, existing studies of mdma effects in humans have examined brain serotonin (5-ht) transporters (5-htt) and receptors or have examined brain structures or functions potentially affected by mdma. |
2007-03-02 |
2023-08-12 |
human |
| Carolyn B Boylan, Mary E Blue, Christine F Hohman. Modeling early cortical serotonergic deficits in autism. Behavioural brain research. vol 176. issue 1. 2007-03-01. PMID:17034875. |
serotonin is involved in neuronal growth and plasticity and these actions are likely mediated via serotonergic and glutamatergic receptors. |
2007-03-01 |
2023-08-12 |
mouse |
| Carolyn B Boylan, Mary E Blue, Christine F Hohman. Modeling early cortical serotonergic deficits in autism. Behavioural brain research. vol 176. issue 1. 2007-03-01. PMID:17034875. |
newborn male and female mice were depleted of forebrain 5-ht with injections of the serotonergic neurotoxin, 5,7-dihydroxytryptamine (5,7-dht), into the bilateral medial forebrain bundle (mfb). |
2007-03-01 |
2023-08-12 |
mouse |
| Eric Bush, Carol Miller, Irwin Friedma. A case of serotonin syndrome and mutism associated with methadone. Journal of palliative medicine. vol 9. issue 6. 2007-03-01. PMID:17187532. |
serotonin syndrome is not an idiopathic drug reaction; it is a predictable consequence of excess serotonergic agonism of central nervous system (cns) receptors and peripheral serotonergic receptors. |
2007-03-01 |
2023-08-12 |
Not clear |
| Robert Philibert, Anup Madan, Allan Andersen, Remi Cadoret, Hans Packer, Harinder Sandh. Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 1. 2007-02-27. PMID:16958039. |
the serotonin reuptake transporter (5htt) is thought to be the principal regulator of serotonergic activity and epigenetic effects at this locus are thought to be important moderators of vulnerability to neuropsychiatric illness. |
2007-02-27 |
2023-08-12 |
Not clear |
| Natalia Alenina, Saleh Bashammakh, Michael Bade. Specification and differentiation of serotonergic neurons. Stem cell reviews. vol 2. issue 1. 2007-02-27. PMID:17142880. |
because serotonin is a relevant pathophysiological factor in several neurological diseases such as bipolar disorder and depression tools to generate or maintain serotonergic neurons might be of therapeutic value. |
2007-02-27 |
2023-08-12 |
mouse |
| Olivia F O'Leary, Anita J Bechtholt, James J Crowley, Rita J Valentino, Irwin Luck. The role of noradrenergic tone in the dorsal raphe nucleus of the mouse in the acute behavioral effects of antidepressant drugs. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 17. issue 3. 2007-02-26. PMID:16997535. |
thus, afferent noradrenergic input to the drn could modify the antidepressant effects of selective serotonin reuptake inhibitors (ssris) by regulating serotonergic transmission. |
2007-02-26 |
2023-08-12 |
mouse |
| Olivia F O'Leary, Anita J Bechtholt, James J Crowley, Rita J Valentino, Irwin Luck. The role of noradrenergic tone in the dorsal raphe nucleus of the mouse in the acute behavioral effects of antidepressant drugs. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 17. issue 3. 2007-02-26. PMID:16997535. |
thus, afferent noradrenergic activity at the level of the drn can modulate serotonergic transmission in forebrain structures and the behavioral effects of ssris, such as fluoxetine, which use noradrenergic input to the drn to increase forebrain serotonin. |
2007-02-26 |
2023-08-12 |
mouse |
| Danuta Wasserman, Thomas Geijer, Marcus Sokolowski, Amos Frisch, Elena Michaelovsky, Abraham Weizman, Vsevolod Rozanov, Jerzy Wasserma. Association of the serotonin transporter promotor polymorphism with suicide attempters with a high medical damage. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 17. issue 3. 2007-02-26. PMID:17029913. |
serotonergic neurotransmission has been implicated in suicidal behavior, including inconsistent results concerning the serotonin transporter promoter polymorphism (5-httlpr). |
2007-02-26 |
2023-08-12 |
Not clear |
| Rebecca Segrave, Rodney J Croft, Susan Illic, K Luan Phan, Pradeep J Natha. Pindolol does not augment central serotonin function increases to citalopram in humans: an auditory evoked potential investigation. Pharmacology, biochemistry, and behavior. vol 85. issue 1. 2007-02-23. PMID:16904172. |
animal studies have demonstrated that the co-administration of pindolol and selective serotonin reuptake inhibitors (ssris) potentiate serotonergic functioning to a greater degree than ssris alone. |
2007-02-23 |
2023-08-12 |
human |
| N N Dygalo, G T Shishkina, T S Kalinina, A M Yudina, E S Ovchinnikov. Effect of repeated treatment with fluoxetine on tryptophan hydroxylase-2 gene expression in the rat brainstem. Pharmacology, biochemistry, and behavior. vol 85. issue 1. 2007-02-23. PMID:16982082. |
it is proposed that 5-ht reuptake inhibitors exert their therapeutic activity by increasing serotonergic neurotransmission; therefore, the aim of the present study was to investigate the effects of repeated treatment with fluoxetine (25 mg/kg/day p.o., 14 days) on expression of genes coding for proteins that involved in the synthesis and reuptake of 5-ht. |
2007-02-23 |
2023-08-12 |
human |
| Ilan A Kerman, Cyrus Shabrang, Larry Taylor, Huda Akil, Stanley J Watso. Relationship of presympathetic-premotor neurons to the serotonergic transmitter system in the rat brainstem. The Journal of comparative neurology. vol 499. issue 6. 2007-02-23. PMID:17072838. |
overactivity of these serotonergic sympatho-somatomotor circuits may also play a role in the pathophysiology of serotonin syndrome. |
2007-02-23 |
2023-08-12 |
rat |
| Christophe Wersinger, Alexis Jeannotte, Anita Sidh. Attenuation of the norepinephrine transporter activity and trafficking via interactions with alpha-synuclein. The European journal of neuroscience. vol 24. issue 11. 2007-02-23. PMID:17156375. |
we have shown that alpha-syn regulates the homeostasis of dopaminergic and serotonergic synapses, through trafficking of the dopamine and serotonin transporter, respectively. |
2007-02-23 |
2023-08-12 |
Not clear |
| Karl J Loope. Potential medical and surgical complications of serotonergic antidepressant medications. Psychosomatics. vol 48. issue 1. 2007-02-22. PMID:17209143. |
this article reviews the association of serotonergic antidepressants and the following medical complications: syndrome of inappropriate antidiuretic hormone secretion, bleeding, serotonin syndrome, serotonin-discontinuation syndrome, and adverse pregnancy and neonatal effects. |
2007-02-22 |
2023-08-12 |
Not clear |
| Ying Qu, Lisa Chang, Justin Klaff, Ruth Seemann, Deanna Greenstein, Stanley I Rapopor. Chronic fluoxetine upregulates arachidonic acid incorporation into the brain of unanesthetized rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 16. issue 8. 2007-02-20. PMID:16517130. |
serotonergic 5-ht(2a/2c) receptors can be coupled to phospholipase a(2) (pla(2)) activation to release the second messenger, arachidonic acid (aa), from membrane phospholipids. |
2007-02-20 |
2023-08-12 |
human |
| Michio Nomura, Yasuyuki Nomur. Psychological, neuroimaging, and biochemical studies on functional association between impulsive behavior and the 5-HT2A receptor gene polymorphism in humans. Annals of the New York Academy of Sciences. vol 1086. 2007-02-13. PMID:17185512. |
it has been suggested that impulsive behavior is caused by dysfunctional serotonergic 5-ht neurotransmission in the central nervous system (cns). |
2007-02-13 |
2023-08-12 |
human |
| Vincenzo Micale, Gian Marco Leggio, Carmen Mazzola, Filippo Drag. Cognitive effects of SL65.0155, a serotonin 5-HT4 receptor partial agonist, in animal models of amnesia. Brain research. vol 1121. issue 1. 2007-02-12. PMID:17011531. |
given that several data suggest the involvement of serotonergic (5-ht) system, particularly the serotonin 5-ht(4) receptors, in memory processes; this study was undertaken to investigate the role of serotonin 5-ht(4) receptors in different experimental models of amnesia in male swiss mice or in male sprague-dawley rats, tested in learning and memory tasks. |
2007-02-12 |
2023-08-12 |
mouse |
| Hristina Jovanovic, Asta Cerin, Per Karlsson, Johan Lundberg, Christer Halldin, Anna-Lena Nordströ. A PET study of 5-HT1A receptors at different phases of the menstrual cycle in women with premenstrual dysphoria. Psychiatry research. vol 148. issue 2-3. 2007-02-12. PMID:17085022. |
the results are in concordance with previously reported challenge studies of 5-ht(1a) receptor-mediated effects indicating different serotonergic responses between women with pmdd and controls. |
2007-02-12 |
2023-08-12 |
human |
| Elizabeth C Finger, Abigail A Marsh, Beata Buzas, Niveen Kamel, Rebecca Rhodes, Meena Vythilingham, Daniel S Pine, David Goldman, James R Blai. The impact of tryptophan depletion and 5-HTTLPR genotype on passive avoidance and response reversal instrumental learning tasks. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 1. 2007-02-09. PMID:16900105. |
transient reductions in serotonin levels during tryptophan depletion (td) are thought to impair reward processing in healthy volunteers, while another facet of the serotonergic system, the serotonin transporter (5-httlpr) short allele polymorphism, is implicated in augmented processing of aversive stimuli. |
2007-02-09 |
2023-08-12 |
human |
| Francine Côté, Cécile Fligny, Elisa Bayard, Jean-Marie Launay, Michael D Gershon, Jacques Mallet, Guilan Vodjdan. Maternal serotonin is crucial for murine embryonic development. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 1. 2007-02-07. PMID:17182745. |
observations provide the first clear evidence that (i) maternal serotonin is involved in the control of morphogenesis during developmental stages that precede the appearance of serotonergic neurons and (ii) serotonin is critical for normal murine development. |
2007-02-07 |
2023-08-12 |
mouse |