| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vural Ozdemir, Leif Bertilsson, Jun Miura, Erin Carpenter, Christopher Reist, Patricia Harper, Jolanta Widén, Jan-Olof Svensson, Lawrence J Albers, James L Kennedy, Laszlo Endrenyi, Werner Kalo. CYP2D6 genotype in relation to perphenazine concentration and pituitary pharmacodynamic tissue sensitivity in Asians: CYP2D6-serotonin-dopamine crosstalk revisited. Pharmacogenetics and genomics. vol 17. issue 5. 2007-05-29. PMID:17429316. |
as dopaminergic neurotransmission is subject to regulation by serotonin, cyp2d6 may exert a nuanced (serotonergic) influence on dopaminergic tone in the pituitary. |
2007-05-29 |
2023-08-12 |
human |
| G Rudnic. Structure/function relationships in serotonin transporter: new insights from the structure of a bacterial transporter. Handbook of experimental pharmacology. issue 175. 2007-05-23. PMID:16722230. |
serotonin transporter (sert) serves the important function of taking up serotonin (5-ht) released during serotonergic neurotransmission. |
2007-05-23 |
2023-08-12 |
Not clear |
| Christine Lochner, Sian Hemmings, Soraya Seedat, Craig Kinnear, Renata Schoeman, Kristina Annerbrink, Marie Olsson, Elias Eriksson, Johanna Moolman-Smook, Christer Allgulander, Dan J Stei. Genetics and personality traits in patients with social anxiety disorder: a case-control study in South Africa. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 17. issue 5. 2007-05-22. PMID:16899354. |
to genotype a subgroup of these participants to investigate the role of genes encoding components of serotonergic (5-ht) and dopaminergic (da) pathways in patients with sad and iii.) |
2007-05-22 |
2023-08-12 |
human |
| Lori Asarian, Brigitte S Kopf, Nori Geary, Wolfgang Langhan. Pharmacological, but not genetic, disruptions in 5-HT(2C) receptor function attenuate LPS anorexia in mice. Pharmacology, biochemistry, and behavior. vol 86. issue 3. 2007-05-22. PMID:17307246. |
there is strong evidence that antagonism of serotonergic activity at 2c receptors (5-ht(2c)r) attenuates lps anorexia in rats. |
2007-05-22 |
2023-08-12 |
mouse |
| Jill A Kreiling, Robert Creton, Carol Reinisc. Early embryonic exposure to polychlorinated biphenyls disrupts heat-shock protein 70 cognate expression in zebrafish. Journal of toxicology and environmental health. Part A. vol 70. issue 12. 2007-05-17. PMID:17497411. |
the serotonergic neurons in the developing diencephalon showed a 34% reduction in fluorescence when labeled with a serotonin antibody following pcb exposure, corresponding to a reduction in serotonin concentration in the neurons. |
2007-05-17 |
2023-08-12 |
zebrafish |
| Debra E Weese-Mayer, Michael J Ackerman, Mary L Marazita, Elizabeth M Berry-Kravi. Sudden Infant Death Syndrome: review of implicated genetic factors. American journal of medical genetics. Part A. vol 143A. issue 8. 2007-05-16. PMID:17340630. |
genetic studies in sudden infant death syndrome (sids) have been motivated by clinical, epidemiological, and/or neuropathological observations in sids victims, with subsequent pursuit of candidate genes in five categories: (1) genes for ion channel proteins based on electrocardiographic evidence of prolonged qt intervals in sids victims, (2) gene for serotonin transporter based on decreased serotonergic receptor binding in brainstems of sids victims, (3) genes pertinent to the early embryology of the autonomic nervous system (ans) (and with a link to the 5-ht system) based on reports of ans dysregulation in sids victims, (4) genes for nicotine metabolizing enzymes based on evidence of cigarette smoking as a modifiable risk factor for sids, and (5) genes regulating inflammation, energy production, hypoglycemia, and thermal regulation based on reports of postnatal infection, low birth weight, and/or overheating in sids victims. |
2007-05-16 |
2023-08-12 |
Not clear |
| Michael Stern, Sabine Knipp, Gerd Bicke. Embryonic differentiation of serotonin-containing neurons in the enteric nervous system of the locust (Locusta migratoria). The Journal of comparative neurology. vol 501. issue 1. 2007-05-08. PMID:17206618. |
cells developing to serotonergic phenotype express the serotonin uptake transporter (sert) significantly earlier, beginning at 40% of development. |
2007-05-08 |
2023-08-12 |
Not clear |
| Christine F Hohmann, Ellen M Walker, Carolyn B Boylan, Mary E Blu. Neonatal serotonin depletion alters behavioral responses to spatial change and novelty. Brain research. vol 1139. 2007-05-08. PMID:17296168. |
we report significant decreases in the serotonergic (5-ht) innervation to cortex and hippocampus, but not to subcortical forebrain structures in 5,7-dht-lesioned mice. |
2007-05-08 |
2023-08-12 |
mouse |
| Hannah C Kinney, Richard A Belliveau, Felicia L Trachtenberg, Luciana A Rava, David S Paterso. The development of the medullary serotonergic system in early human life. Autonomic neuroscience : basic & clinical. vol 132. issue 1-2. 2007-05-04. PMID:17236817. |
the serotonergic (5-ht) neurons of the medulla oblongata are postulated to comprise a system that modulates homeostatic function in response to metabolic imbalances in the internal milieu in a state-dependent manner. |
2007-05-04 |
2023-08-12 |
human |
| Elisabetta Cervio, Mariangela Rondanelli, Barbara Balestra, Antonio Dellabianca, Alessandro Agazzi, Attilio Giacosa, Marcello Tonin. [Recent insights into the pathogenesis of abdominal symptoms in functional bowel disorders]. Recenti progressi in medicina. vol 98. issue 2. 2007-05-04. PMID:17439064. |
in the gut, 5-ht acts as a paracrine signalling molecule released by enterochromaffin cells and as a transmitter released by some descending serotonergic interneurons. |
2007-05-04 |
2023-08-12 |
Not clear |
| Elisabetta Cervio, Mariangela Rondanelli, Barbara Balestra, Antonio Dellabianca, Alessandro Agazzi, Attilio Giacosa, Marcello Tonin. [Recent insights into the pathogenesis of abdominal symptoms in functional bowel disorders]. Recenti progressi in medicina. vol 98. issue 2. 2007-05-04. PMID:17439064. |
among all 5-ht receptors, those belonging to the 5-ht3 (a ionotropic receptor) and 5-ht4 (a metabotropic receptor) type are the most extensively studied in gastroenterology, resulting in commercially available (although not worldwide) serotonergic agents for the treatment of ibs and functional dyspepsia. |
2007-05-04 |
2023-08-12 |
Not clear |
| Arturo Zazpe, Inés Artaiz, Luis Labeaga, María Luisa Lucero, Aurelio Orjale. Reversal of learned helplessness by selective serotonin reuptake inhibitors in rats is not dependent on 5-HT availability. Neuropharmacology. vol 52. issue 3. 2007-05-01. PMID:17141811. |
the involvement of serotonergic mechanisms in the antidepressant-like effect of these agents was investigated using the selective 5-ht(1a) receptor antagonist way 100,635 and the 5-ht synthesis inhibitor p-chlorophenylalanine (pcpa). |
2007-05-01 |
2023-08-12 |
human |
| Lei Wang, Lan Yu, Guang He, Jing Zhang, Ai-Ping Zhang, Jing Du, Rui-Qi Tang, Xin-Zhi Zhao, Jie Ma, Jie-Kun Xuan, Yue Xiao, Niu-Fan Gu, Guo-Ying Feng, Ming-Qing Xu, Qing-He Xing, Lin H. Response of risperidone treatment may be associated with polymorphisms of HTT gene in Chinese schizophrenia patients. Neuroscience letters. vol 414. issue 1. 2007-04-27. PMID:17287080. |
serotonin transporter (5-htt) is a key component of the serotonergic neurotransmitter system. |
2007-04-27 |
2023-08-12 |
Not clear |
| Renee F Ren-Patterson, Lauren W Cochran, Andrew Holmes, Klaus-Peter Lesch, Bai Lu, Dennis L Murph. Gender-dependent modulation of brain monoamines and anxiety-like behaviors in mice with genetic serotonin transporter and BDNF deficiencies. Cellular and molecular neurobiology. vol 26. issue 4-6. 2007-04-24. PMID:17029036. |
brain-derived neurotrophic factor (bdnf) supports serotonergic neuronal development and our recent study found that heterozygous mice lacking one bdnf gene allele interbred with male serotonin transporter (sert) knockout mice had greater reductions in brain tissue serotonin concentrations, greater increases in anxiety-like behaviors and greater acth responses to stress than found in the sert knockout mice alone. |
2007-04-24 |
2023-08-12 |
mouse |
| Darakhshan J Haleem, Noreen Samad, Tahira Perveen, Saida Haider, M A Halee. Role of serotonin-1A receptors in restraint-induced behavioral deficits and adaptation to repeated restraint stress in rats. The International journal of neuroscience. vol 117. issue 2. 2007-04-24. PMID:17365111. |
the results suggest that a decrease in serotonergic neurotransmission is involved in restraint-induced behavioral deficits while a normalization of serotonin neurotransmission due to desensitization of somatodendritic 5-ht-1a receptors may help cope with the stress demand to produce adaptation to stress. |
2007-04-24 |
2023-08-12 |
rat |
| Sophie Mouillet-Richard, Benoît Schneider, Elodie Pradines, Mathéa Pietri, Myriam Ermonval, Jacques Grassi, J Grayson Richards, Vincent Mutel, Jean-Marie Launay, Odile Kellerman. Cellular prion protein signaling in serotonergic neuronal cells. Annals of the New York Academy of Sciences. vol 1096. 2007-04-19. PMID:17405922. |
taking advantage of the 1c11 neuroectodermal cell line, endowed with the capacity to convert into 1c11(5-ht) serotonergic or 1c11(ne) noradrenergic neuronal cells, allowed us to ascribe a signaling function to prp(c). |
2007-04-19 |
2023-08-12 |
Not clear |
| Sophie Mouillet-Richard, Benoît Schneider, Elodie Pradines, Mathéa Pietri, Myriam Ermonval, Jacques Grassi, J Grayson Richards, Vincent Mutel, Jean-Marie Launay, Odile Kellerman. Cellular prion protein signaling in serotonergic neuronal cells. Annals of the New York Academy of Sciences. vol 1096. 2007-04-19. PMID:17405922. |
in addition to its proper signaling activity, prp(c) modulates the agonist-induced response of the three serotonergic g protein-coupled receptors present on the 1c11(5-ht) differentiated cells. |
2007-04-19 |
2023-08-12 |
Not clear |
| Sophie Mouillet-Richard, Benoît Schneider, Elodie Pradines, Mathéa Pietri, Myriam Ermonval, Jacques Grassi, J Grayson Richards, Vincent Mutel, Jean-Marie Launay, Odile Kellerman. Cellular prion protein signaling in serotonergic neuronal cells. Annals of the New York Academy of Sciences. vol 1096. 2007-04-19. PMID:17405922. |
by mobilizing transduction cascades controlling the cellular redox state and the erk1/2 kinases and by altering 5-ht receptor-mediated intracellular response, prp(c) takes part in the homeostasis of serotonergic neuronal cells. |
2007-04-19 |
2023-08-12 |
Not clear |
| Robert E Shapiro, Stewart J Teppe. The serotonin syndrome, triptans, and the potential for drug-drug interactions. Headache. vol 47. issue 2. 2007-04-17. PMID:17300366. |
the serotonin syndrome is an acute adverse reaction to medications that enhance serotonergic activity. |
2007-04-17 |
2023-08-12 |
Not clear |
| Robert E Shapiro, Stewart J Teppe. The serotonin syndrome, triptans, and the potential for drug-drug interactions. Headache. vol 47. issue 2. 2007-04-17. PMID:17300366. |
we conclude that it is currently unclear whether administration of triptans with other serotonergic medications increases the risk of serotonin syndrome. |
2007-04-17 |
2023-08-12 |
Not clear |