| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sonali N Reisinger, Spyros Sideromenos, Orsolya Horvath, Sophia Derdak, Ana Cicvaric, Francisco J Monje, Martin Bilban, Martin Häring, Micaela Glat, Daniela D Polla. STAT3 in the dorsal raphe gates behavioural reactivity and regulates gene networks associated with psychopathology. Molecular psychiatry. vol 26. issue 7. 2021-10-16. PMID:33046834. |
here, we focused on the midbrain serotonergic system, a central hub for the regulation of emotions, to examine the relevance of stat3 signalling for emotional behaviour in mice by selectively knocking down raphe stat3 expression using germline genetic (stat3 ko) and viral-mediated approaches. |
2021-10-16 |
2023-08-13 |
mouse |
| Sonali N Reisinger, Spyros Sideromenos, Orsolya Horvath, Sophia Derdak, Ana Cicvaric, Francisco J Monje, Martin Bilban, Martin Häring, Micaela Glat, Daniela D Polla. STAT3 in the dorsal raphe gates behavioural reactivity and regulates gene networks associated with psychopathology. Molecular psychiatry. vol 26. issue 7. 2021-10-16. PMID:33046834. |
mice lacking serotonergic stat3 presented with reduced negative behavioural reactivity and a blunted response to the sensitising effects of amphetamine, alongside alterations in midbrain neuronal firing activity of serotonergic neurons and transcriptional control of gene networks relevant for neuropsychiatric disorders. |
2021-10-16 |
2023-08-13 |
mouse |
| Yaxin Yang, Jian Liu, Yixuan Wang, Xiang Wu, Libo Li, Guanyun Bian, Wenjuan Li, Haifeng Yuan, Qiaojun Zhan. Blockade of pre-synaptic and post-synaptic GABA Neuropharmacology. vol 196. 2021-10-01. PMID:34246684. |
blockade of pre-synaptic and post-synaptic gaba although the output of the lateral habenula (lhb) controls the activity of midbrain dopaminergic and serotonergic systems, which are implicated in the pathophysiology of anxiety, it is not known how blockade of gaba |
2021-10-01 |
2023-08-13 |
Not clear |
| Victoria M Williams, Adhil Bhagwandin, Jordan Swiegers, Mads F Bertelsen, Therese Hård, Thomas C Thannickal, Jerome M Siegel, Chet C Sherwood, Paul R Mange. Nuclear organization of orexinergic neurons in the hypothalamus of a lar gibbon and a chimpanzee. Anatomical record (Hoboken, N.J. : 2007). 2021-09-23. PMID:34535040. |
while orexinergic terminal networks were observed throughout the brain, high density terminal networks were observed within the hypothalamus, medial and intralaminar nuclei of the dorsal thalamus, and within the serotonergic and noradrenergic regions of the midbrain and pons, which is typical for mammals. |
2021-09-23 |
2023-08-13 |
human |
| Arianna Gentile Polese, Sunny Nigam, Laura M Hurle. 5-HT1A Receptors Alter Temporal Responses to Broadband Vocalizations in the Mouse Inferior Colliculus Through Response Suppression. Frontiers in neural circuits. vol 15. 2021-09-14. PMID:34512276. |
to address this issue, we measured the influence of the serotonergic system on the responses of neurons in a mouse auditory midbrain nucleus, the inferior colliculus (ic), to vocal signals. |
2021-09-14 |
2023-08-13 |
mouse |
| Jennyfer M Payet, Kira-Elise Wilson, Adrian M Russo, Anthony Angiolino, William Kavanagh-Ryan, Stephen Kent, Christopher A Lowry, Matthew W Hal. Involvement of dorsal raphe nucleus serotonergic systems in social approach-avoidance behaviour and in the response to fluoxetine treatment in peri-adolescent female BALB/c mice. Behavioural brain research. vol 408. 2021-09-02. PMID:33811952. |
the midbrain dorsal raphe nucleus (dr), which is a major serotonergic nucleus and main source of serotonergic innervation of the forebrain, has been proposed as an important target for ssris, although evidence in females is lacking. |
2021-09-02 |
2023-08-13 |
mouse |
| Shawn Zheng Kai Tan, Yasin Temel, Ariel Yovela Chan, Andrea Tsz Ching Mok, Jose Angelo Udal Perucho, Arjan Blokland, Luca Aquili, Wei Ling Lim, Lee Wei Li. Serotonergic treatment normalizes midbrain dopaminergic neuron increase after periaqueductal gray stimulation. Brain structure & function. vol 225. issue 7. 2021-07-06. PMID:32594260. |
serotonergic treatment normalizes midbrain dopaminergic neuron increase after periaqueductal gray stimulation. |
2021-07-06 |
2023-08-13 |
rat |
| Zachary A Grieb, Joseph S Lonstei. Oxytocin receptor expression in the midbrain dorsal raphe is dynamic across female reproduction in rats. Journal of neuroendocrinology. vol 33. issue 2. 2021-06-15. PMID:33427399. |
changes in central otr expression across female reproduction have often been studied, but almost all of such research has focused on the forebrain, ignoring hormone-sensitive midbrain sites such as the serotonergic dorsal raphe (dr) that are also critical for postpartum behaviours. |
2021-06-15 |
2023-08-13 |
rat |
| Christopher L Petersen, Alexander Koo, Bhumi Patel, Laura M Hurle. Serotonergic innervation of the auditory midbrain: dorsal raphe subregions differentially project to the auditory midbrain in male and female mice. Brain structure & function. vol 225. issue 6. 2021-03-24. PMID:32556584. |
serotonergic innervation of the auditory midbrain: dorsal raphe subregions differentially project to the auditory midbrain in male and female mice. |
2021-03-24 |
2023-08-13 |
mouse |
| Nikolay N Dygalo, Tatyana S Kalinina, Galina T Shishkin. Stress-induced expression pattern of glutamate signaling genes associated with anhedonia. Stress (Amsterdam, Netherlands). vol 23. issue 6. 2021-03-24. PMID:32814471. |
the decrease in expression of these subunits in the midbrain may attenuate glutamatergic drive on the serotonergic neurons promoting a shift of excitation/inhibition balance between glutamate and gaba in the forebrain regions resulting in anhedonia. |
2021-03-24 |
2023-08-13 |
human |
| Enaam Chleilat, Abhishek Pethe, Dietmar Pfeifer, Kerstin Krieglstein, Eleni Rouss. TGF-β Signaling Regulates SLC8A3 Expression and Prevents Oxidative Stress in Developing Midbrain Dopaminergic and Dorsal Raphe Serotonergic Neurons. International journal of molecular sciences. vol 21. issue 8. 2021-02-08. PMID:32326436. |
tgf-β signaling regulates slc8a3 expression and prevents oxidative stress in developing midbrain dopaminergic and dorsal raphe serotonergic neurons. |
2021-02-08 |
2023-08-13 |
Not clear |
| Justin K Siemann, Piper Williams, Turnee N Malik, Chad R Jackson, Noah H Green, Ronald B Emeson, Pat Levitt, Douglas G McMaho. Photoperiodic effects on monoamine signaling and gene expression throughout development in the serotonin and dopamine systems. Scientific reports. vol 10. issue 1. 2020-12-15. PMID:32963273. |
hence, we evaluated, at multiple stages of postnatal development, the expression of key dopaminergic (th) and serotonergic (tph2, sert, and pet-1) genes, and midbrain monoamine content in mice raised under control equinox (ld 12:12), short winter-like (ld 8:16), or long summer-like (ld 16:8) photoperiods. |
2020-12-15 |
2023-08-13 |
mouse |
| Justin K Siemann, Piper Williams, Turnee N Malik, Chad R Jackson, Noah H Green, Ronald B Emeson, Pat Levitt, Douglas G McMaho. Photoperiodic effects on monoamine signaling and gene expression throughout development in the serotonin and dopamine systems. Scientific reports. vol 10. issue 1. 2020-12-15. PMID:32963273. |
focusing in early adulthood, we evaluated the midbrain levels of these serotonergic genes, and also assayed these gene levels in the dorsal raphe nucleus (drn) with rnascope. |
2020-12-15 |
2023-08-13 |
mouse |
| Philip W Gold, Bashkim Kadri. A Major Role for the Lateral Habenula in Depressive Illness: Physiologic and Molecular Mechanisms. Frontiers in psychiatry. vol 10. 2020-10-01. PMID:31231247. |
lack of perceived reward experienced during the adverse outcomes also precipitates lateral habenula firing, while outcomes that meet or exceed expectations decrease lateral habenula firing and, in turn, increase midbrain dopaminergic and serotonergic neurotransmission. |
2020-10-01 |
2023-08-13 |
Not clear |
| Daniel Richter, Dirk Woitalla, Siegfried Muhlack, Ralf Gold, Lars Tönges, Christos Krogia. Brainstem Raphe Alterations in TCS: A Biomarker for Depression and Apathy in Parkinson's Disease Patients. Frontiers in neurology. vol 9. 2020-09-30. PMID:30131761. |
furthermore, the br has only been investigated using a singular axial tcs examination plane, although coronal tcs examination allows a much more accurate evaluation of the craniocaudal formation of serotonergic raphe structures in the midbrain area. |
2020-09-30 |
2023-08-13 |
Not clear |
| b' A Yamamotov\\xc3\\xa. Endogenous antinociceptive system and potential ways to influence It. Physiological research. vol 68. issue Suppl 3. 2020-07-08. PMID:31928038.' |
its anatomical substrate ranges from the periaqueductal gray matter of the midbrain, through the noradrenergic and serotonergic nuclei of the brain stem to the spinal neurons, which receive "pain" information from nociceptors. |
2020-07-08 |
2023-08-13 |
Not clear |
| Hailan Hu, Yihui Cui, Yan Yan. Circuits and functions of the lateral habenula in health and in disease. Nature reviews. Neuroscience. vol 21. issue 5. 2020-05-11. PMID:32269316. |
the lhb, sometimes referred to as the brain's 'antireward centre', receives inputs from diverse limbic forebrain and basal ganglia structures, and targets essentially all midbrain neuromodulatory systems, including the noradrenergic, serotonergic and dopaminergic systems. |
2020-05-11 |
2023-08-13 |
Not clear |
| Klaus Peter Lesch, Armin Heil. Serotonergic gene transcriptional control regions: targets for antidepressant drug development? The international journal of neuropsychopharmacology. vol 3. issue 1. 2019-11-20. PMID:11343581. |
in the adult brain, midbrain raphe serotonergic neurons project to a variety of brain regions and modulate a wide range of physiological functions. |
2019-11-20 |
2023-08-12 |
Not clear |
| Pau Celada, M. Victoria Puig, Raúl Martín-Ruiz, Josep M. Casanovas, Francesc Artiga. Control of the serotonergic system by the medial prefrontal cortex: potential role in the etiology of PTSD and depressive disorders. Neurotoxicity research. vol 4. issue 5-6. 2019-11-20. PMID:12754155. |
serotonergic neurons of the midbrain rapbe nuclei innervate the prefrontal cortex and are the cellular target for drugs used to treat mood disorders such as the selective serotonin (5-ht) reuptake inhibitors. |
2019-11-20 |
2023-08-12 |
Not clear |
| Sarah M Keesom, Mitchell D Morningstar, Rebecca Sandlain, Bradley M Wise, Laura M Hurle. Social isolation reduces serotonergic fiber density in the inferior colliculus of female, but not male, mice. Brain research. vol 1694. 2019-07-11. PMID:29763575. |
here, we assess whether 4 weeks of post-weaning individual housing alters serotonergic fiber density in the inferior colliculus (ic), an auditory midbrain nucleus in which serotonin alters auditory-evoked activity. |
2019-07-11 |
2023-08-13 |
mouse |