| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Evan D Paul, Philip L Johnson, Anantha Shekhar, Christopher A Lowr. The Deakin/Graeff hypothesis: focus on serotonergic inhibition of panic. Neuroscience and biobehavioral reviews. vol 46 Pt 3. 2015-07-17. PMID:24661986. |
the deakin/graeff hypothesis proposes that different subpopulations of serotonergic neurons through topographically organized projections to forebrain and brainstem structures modulate the response to acute and chronic stressors, and that dysfunction of these neurons increases vulnerability to affective and anxiety disorders, including panic disorder. |
2015-07-17 |
2023-08-12 |
Not clear |
| Giampaolo Perna, Giuseppe Guerriero, Paolo Brambilla, Daniela Caldirol. Panic and the brainstem: clues from neuroimaging studies. CNS & neurological disorders drug targets. vol 13. issue 6. 2015-05-19. PMID:24923341. |
however, preliminary evidence of a role of the brainstem in pd can be found and, secondly, the brainstem serotonergic system seems to be involved in panic modulation with indications of both altered serotonergic receptors and 5-ht transporter bindings. |
2015-05-19 |
2023-08-13 |
Not clear |
| Giampaolo Perna, Giuseppe Guerriero, Paolo Brambilla, Daniela Caldirol. Panic and the brainstem: clues from neuroimaging studies. CNS & neurological disorders drug targets. vol 13. issue 6. 2015-05-19. PMID:24923341. |
in conclusion, our review suggests that the brainstem may be involved in psychopathology of pd and supports the relevant role of subcortical serotonergic system in panic pathogenesis. |
2015-05-19 |
2023-08-13 |
Not clear |
| You-Qing Cai, Wei Wang, Yuan-Yuan Hou, Zhizhong Z Pa. Optogenetic activation of brainstem serotonergic neurons induces persistent pain sensitization. Molecular pain. vol 10. 2015-03-12. PMID:25410898. |
optogenetic activation of brainstem serotonergic neurons induces persistent pain sensitization. |
2015-03-12 |
2023-08-13 |
Not clear |
| Zhong-Qiu Zhao, Xian-Yu Liu, Joseph Jeffry, W K Ajith Karunarathne, Jin-Lian Li, Admire Munanairi, Xuan-Yi Zhou, Hui Li, Yan-Gang Sun, Li Wan, Zhen-Yu Wu, Seungil Kim, Fu-Quan Huo, Ping Mo, Devin M Barry, Chun-Kui Zhang, Ji-Young Kim, N Gautam, Kenneth J Renner, Yun-Qing Li, Zhou-Feng Che. Descending control of itch transmission by the serotonergic system via 5-HT1A-facilitated GRP-GRPR signaling. Neuron. vol 84. issue 4. 2015-02-10. PMID:25453842. |
here we report that enhancing serotonergic tone via administration of 5-ht potentiates itch sensation, whereas mice lacking 5-ht or serotonergic neurons in the brainstem exhibit markedly reduced scratching behavior. |
2015-02-10 |
2023-08-13 |
mouse |
| Iskra Pollak Dorocic, Daniel Fürth, Yang Xuan, Yvonne Johansson, Laura Pozzi, Gilad Silberberg, Marie Carlén, Konstantinos Meleti. A whole-brain atlas of inputs to serotonergic neurons of the dorsal and median raphe nuclei. Neuron. vol 83. issue 3. 2014-12-29. PMID:25102561. |
we identified discrete inputs onto serotonergic neurons from forebrain and brainstem neurons, with specific inputs from hypothalamus, cortex, basal ganglia, and midbrain, displaying a greater than anticipated complexity and diversity in cell-type-specific connectivity. |
2014-12-29 |
2023-08-13 |
Not clear |
| He Liu, Wei-Wei Yan, Xiao-Xing Lu, Xiu-Li Zhang, Jing-Qiu Wei, Xiao-Yu Wang, Tiao Wang, Tong Wu, Jing Cao, Cui-Jie Shao, Fang Zhou, Hong-Xing Zhang, Peng Zhang, Ting Zang, Xian-Fu Lu, Jun-Li Cao, Hai-Lei Ding, Li-Cai Zhan. Role of the cerebrospinal fluid-contacting nucleus in the descending inhibition of spinal pain transmission. Experimental neurology. vol 261. 2014-12-17. PMID:25108066. |
furthermore, immunohistochemical experiments showed that the csf-contacting nucleus was a cluster of 5-ht-containing neurons in the brainstem, and the spinal projection of serotonergic axons originating from the csf-contacting nucleus constituted the descending 5-ht pathway to the spinal cord. |
2014-12-17 |
2023-08-13 |
rat |
| Olivier Flabeau, Wassilios G Meissner, Annaig Ozier, Patrick Berger, François Tison, Pierre-Olivier Fernagu. Breathing variability and brainstem serotonergic loss in a genetic model of multiple system atrophy. Movement disorders : official journal of the Movement Disorder Society. vol 29. issue 3. 2014-12-01. PMID:24442757. |
breathing variability and brainstem serotonergic loss in a genetic model of multiple system atrophy. |
2014-12-01 |
2023-08-12 |
mouse |
| Juan Jose Ramos-Rodriguez, Sara Molina-Gil, Raquel Rey-Brea, Esther Berrocoso, Monica Garcia-Alloz. Specific serotonergic denervation affects tau pathology and cognition without altering senile plaques deposition in APP/PS1 mice. PloS one. vol 8. issue 11. 2014-09-23. PMID:24278223. |
on the other hand brainstem neurodegeneration has been suggested as an initial event in ad, and serotonergic dysfunction, as well as reductions in raphe neurones density, have been reported in ad patients. |
2014-09-23 |
2023-08-12 |
mouse |
| Yuriko Nishizaki, Tsuyoshi Takagi, Fumiko Matsui, Yujiro Higash. SIP1 expression patterns in brain investigated by generating a SIP1-EGFP reporter knock-in mouse. Genesis (New York, N.Y. : 2000). vol 52. issue 1. 2014-09-22. PMID:24243579. |
we further observed sip1-egfp expression in oligodendrocytes of the corpus callosum and fimbria, bergmann glial cells of the cerebellum, the olfactory bulb, and in the serotonergic and dopaminergic neurons of the raphe nuclei in the brainstem. |
2014-09-22 |
2023-08-12 |
mouse |
| John Jacob, Vanessa Ribes, Steven Moore, Sean C Constable, Noriaki Sasai, Sebastian S Gerety, Darren J Martin, Chris P Sergeant, David G Wilkinson, James Brisco. Valproic acid silencing of ascl1b/Ascl1 results in the failure of serotonergic differentiation in a zebrafish model of fetal valproate syndrome. Disease models & mechanisms. vol 7. issue 1. 2014-09-08. PMID:24135485. |
it does so by downregulating the proneural gene ascl1b, an ortholog of mammalian ascl1, which is a known determinant of serotonergic identity in the mammalian brainstem. |
2014-09-08 |
2023-08-12 |
zebrafish |
| Elisabet Cuyas, Patricia Robledo, Nieves Pizarro, Magí Farré, Elena Puerta, Norberto Aguirre, Rafael de la Torr. 3,4-methylenedioxymethamphetamine induces gene expression changes in rats related to serotonergic and dopaminergic systems, but not to neurotoxicity. Neurotoxicity research. vol 25. issue 2. 2014-09-07. PMID:23949956. |
in order to further clarify this issue, we used quantitative pcr to study the long-term changes induced by acute administration of mdma (5 mg/kg × 3) in the expression of genes related to serotonergic and dopaminergic systems, as well as those related to cellular toxicity in the cortex, hippocampus, striatum, and brain stem of rats. |
2014-09-07 |
2023-08-12 |
human |
| Giulia Cartocci, Giuseppe Attanasio, Francesco Fattapposta, Nicoletta Locuratolo, Daniela Mannarelli, Roberto Filip. An electrophysiological approach to tinnitus interpretation. The international tinnitus journal. vol 17. issue 2. 2014-08-12. PMID:24333887. |
auditory brainstem responses (abr) examine the auditory system functionality from the periphery and through the brainstem, where serotonergic projections have been identified. |
2014-08-12 |
2023-08-12 |
Not clear |
| David Baumeister, Georgina Barnes, Giovanni Giaroli, Derek Trac. Classical hallucinogens as antidepressants? A review of pharmacodynamics and putative clinical roles. Therapeutic advances in psychopharmacology. vol 4. issue 4. 2014-08-01. PMID:25083275. |
they alter the serotonergic tone of brainstem raphe nuclei that project through the brain; they interact with receptors in the prefrontal cortex altering connectivity patterns and intracellular functioning; and they disrupt inhibitory control of sensory input via the thalamus to the cortex. |
2014-08-01 |
2023-08-13 |
Not clear |
| Sarah E Van Dine, Elsaid Salem, Elizabeth George, Nga Yan Siu, Timothy Dotzler, Raddy L Ramo. Cellular and axonal diversity in molecular layer heterotopia of the rat cerebellar vermis. BioMed research international. vol 2013. 2014-06-12. PMID:24191251. |
in addition, we document the presence of myelinated, serotonergic, catecholaminergic, and cholinergic axons in heterotopia indicating possible spinal and brainstem afferent projections to heterotopic cells. |
2014-06-12 |
2023-08-12 |
rat |
| Narges Moghimi, Samden D Lhato. Sudden unexpected death in epilepsy or voodoo heart: analysis of heart/brain connections. Current cardiology reports. vol 15. issue 12. 2014-06-03. PMID:24122216. |
these, as well as serotonergic mechanisms affecting brainstem homeostasis of cardiac and respiratory function are important areas of current and future sudep research. |
2014-06-03 |
2023-08-12 |
Not clear |
| C Gorini, H Jameson, A L Woerman, D C Perry, D Mendelowit. Prenatal nicotine exposure enhances the trigeminocardiac reflex via serotonin receptor facilitation in brainstem pathways. Journal of applied physiology (Bethesda, Md. : 1985). vol 115. issue 4. 2014-05-19. PMID:23766497. |
in this study we used a rat model for prenatal nicotine exposure to test whether clinically relevant concentrations of brain nicotine and cotinine are passed from dams exposed to nicotine to her pups, whether this changes the trigeminocardiac reflex (tcr), and whether serotonergic function in the tcr brainstem circuitry is altered. |
2014-05-19 |
2023-08-12 |
rat |
| Paraskevi Mavrogiorgou, Fabio Nalato, Saskia Meves, Stefanie Luksnat, Christine Norra, Ralf Gold, Georg Juckel, Christos Krogia. Transcranial sonography in obsessive-compulsive disorder. Journal of psychiatric research. vol 47. issue 11. 2014-05-13. PMID:23932243. |
this study used tcs to examine the alterations in different parenchymal regions, especially concerning serotonergic brainstem raphe nuclei as well as basal ganglia in ocd. |
2014-05-13 |
2023-08-12 |
human |
| Paraskevi Mavrogiorgou, Fabio Nalato, Saskia Meves, Stefanie Luksnat, Christine Norra, Ralf Gold, Georg Juckel, Christos Krogia. Transcranial sonography in obsessive-compulsive disorder. Journal of psychiatric research. vol 47. issue 11. 2014-05-13. PMID:23932243. |
obsessive-compulsive disorder patients showed reduced echogenity of the serotonergic brainstem raphe nuclei (32.3%) compared with healthy controls (16.1%). |
2014-05-13 |
2023-08-12 |
human |
| Paraskevi Mavrogiorgou, Fabio Nalato, Saskia Meves, Stefanie Luksnat, Christine Norra, Ralf Gold, Georg Juckel, Christos Krogia. Transcranial sonography in obsessive-compulsive disorder. Journal of psychiatric research. vol 47. issue 11. 2014-05-13. PMID:23932243. |
patients with ocd significantly more often reveal a hypoechogenic brainstem raphe possibly reflecting altered serotonergic neurons there and a hyperechogenicity of caudate nucleus indicating structural or molecular cell changes. |
2014-05-13 |
2023-08-12 |
human |