| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Louis J Kolling, Michael S Chimenti, Catherine A Marcinkiewc. Spatial differences in gene expression across the dorsal raphe nucleus in a model of early Alzheimer's disease. Journal of Alzheimer's disease : JAD. 2024-11-25. PMID:39584353. |
these early symptoms can be driven by changes in the serotonergic (5-ht) nuclei of the brainstem, particularly the dorsal raphe nucleus (drn). |
2024-11-25 |
2024-11-27 |
Not clear |
| Osmar Henrique Dos Santos Junior, Severina Cassia de Andrade Silva, Maria Daniele Teixeira Beltrão de Lemos, Thyago de Oliveira Rodrigues, Aline Isabel da Silva, Claudia J Lagranh. Effects of serotonergic manipulation in the brainstem and hypothalamus of overnourished rats during lactation. Life sciences. 2024-11-03. PMID:39490520. |
effects of serotonergic manipulation in the brainstem and hypothalamus of overnourished rats during lactation. |
2024-11-03 |
2024-11-06 |
rat |
| Sara J Fenstermacher, Ann Vonasek, Hannah Gattuso, Corryn Chaimowitz, Susan M Dymecki, Thomas M Jessell, Jeremy S Dase. Potentiation of active locomotor state by spinal-projecting serotonergic neurons. bioRxiv : the preprint server for biology. 2024-10-10. PMID:39386605. |
discrete populations of serotonergic (5-ht) neurons target circuits in the brainstem and spinal cord, but their role in the control of motor behavior is unclear. |
2024-10-10 |
2024-10-12 |
Not clear |
| C Saiz-Masvidal, V De la Peña-Arteaga, S Bertolín, I Martínez-Zalacaín, A Juaneda-Seguí, P Chavarría-Elizondo, M Subirà, J M Menchón, M A Fullana, C Soriano-Ma. Uncovering the correlation between neurotransmitter-specific functional connectivity and multidimensional anxiety in a non-clinical cohort. European archives of psychiatry and clinical neuroscience. 2024-08-27. PMID:39190041. |
resting-state functional magnetic resonance imaging data were acquired, focusing on seven brainstem regions representing serotonergic, dopaminergic, and noradrenergic nuclei, with their fc patterns voxel-wise correlated with the scales. |
2024-08-27 |
2024-08-30 |
human |
| Seoyeon Kim, Kyung Ah Woo, Hongyoon Choi, Jung Hwan Shin, Han-Joon Ki. Monoaminergic degeneration, cognition, and autonomic symptom trajectory in early Parkinson's disease. Parkinsonism & related disorders. vol 127. 2024-08-08. PMID:39116636. |
this study aimed to investigate the associations between cognitive and autonomic symptoms and the degeneration of brainstem monoaminergic nuclei, particularly the serotonergic and noradrenergic nuclei, in a prospective cohort of early pd patients. |
2024-08-08 |
2024-08-12 |
Not clear |
| Anders Björklund, Bengt Mattsso. The AAV-α-Synuclein Model of Parkinson's Disease: An Update. Journal of Parkinson's disease. 2024-07-20. PMID:39031386. |
in recent years, however, the aav-α-synuclein model has become more widely used to induce parkinson-like synuclein pathology in other relevant neuronal systems, such as the brainstem noradrenergic and serotonergic neurons, the vagal motor neurons, as well as in oligodendrocytes, the prime target relevant to the pathology seen in multiple system atrophy. |
2024-07-20 |
2024-07-24 |
mouse |
| Sylvana I S Rendeiro de Noronha, Lauro Angelo Gonçalves de Moraes, James E Hassell, Christopher E Stamper, Mathew R Arnold, Jared D Heinze, Christine L Foxx, Margaret M Lieb, Kristin E Cler, Bree L Karns, Sophia Jaekel, Kelsey M Loupy, Fernanda C S Silva, Deoclécio Alves Chianca-Jr, Christopher A Lowry, Rodrigo Cunha de Meneze. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological research. vol 57. issue 1. 2024-05-05. PMID:38705984. |
here we conducted a nine-week hfd protocol in male rats, followed by an analysis of the gut microbiome diversity and community composition, brainstem serotonergic gene expression (tph2, htr1a, and slc6a4), and anxiety-related defensive behavioral responses. |
2024-05-05 |
2024-05-08 |
rat |
| Jarek Wegiel, Kathryn Chadman, Eric London, Thomas Wisniewski, Jerzy Wegie. Contribution of the serotonergic system to developmental brain abnormalities in autism spectrum disorder. Autism research : official journal of the International Society for Autism Research. 2024-03-19. PMID:38500252. |
this review highlights a key role of the serotonergic system in brain development and in distortions of normal brain development in early stages of fetal life resulting in cascades of abnormalities, including defects of neurogenesis, neuronal migration, neuronal growth, differentiation, and arborization, as well as defective neuronal circuit formation in the cortex, subcortical structures, brainstem, and cerebellum of autistic subjects. |
2024-03-19 |
2024-03-21 |
human |
| Jarek Wegiel, Kathryn Chadman, Eric London, Thomas Wisniewski, Jerzy Wegie. Contribution of the serotonergic system to developmental brain abnormalities in autism spectrum disorder. Autism research : official journal of the International Society for Autism Research. 2024-03-19. PMID:38500252. |
there is a discrepancy between more than 500 reports demonstrating the contribution of the serotonergic system to autism's behavioral anomalies, highlighted by lack of studies of autistic subjects' brainstem raphe nuclei, the center of brain serotonergic innervation, and of the contribution of the serotonergic system to the diagnostic features of autism spectrum disorder (asd). |
2024-03-19 |
2024-03-21 |
human |
| Bedia Samanci, Sonny Tan, Stijn Michielse, Mark L Kuijf, Yasin Teme. THE HABENULA IN PARKINSON'S DISEASE: ANATOMY, FUNCTION, AND IMPLICATIONS FOR MOOD DISORDERS - A NARRATIVE REVIEW. Journal of chemical neuroanatomy. 2024-01-18. PMID:38237746. |
degeneration of serotonergic neurons in brainstem raphe nuclei have been linked to depression and anxiety. |
2024-01-18 |
2024-01-21 |
Not clear |
| Ifat Israel-Elgali, Hope Pan, Keren Oved, Nir Pillar, Gilad Levy, Boaz Barak, Ana Carneiro, David Gurwitz, Noam Shomro. Impaired myelin ultrastructure is reversed by citalopram treatment in a mouse model for major depressive disorder. Journal of psychiatric research. vol 166. 2023-09-27. PMID:37757703. |
the raphe nuclei (rn), located in the brain stem, consist of clusters of serotonergic (5-ht) neurons that project to almost all regions of the brain. |
2023-09-27 |
2023-10-07 |
mouse |
| Nicolas Delestrée, Evangelia Semizoglou, John G Pagiazitis, Aleksandra Vukojicic, Estelle Drobac, Vasilissa Paushkin, George Z Menti. Serotonergic dysfunction impairs locomotor coordination in spinal muscular atrophy. Brain : a journal of neurology. 2023-09-07. PMID:37678880. |
we also demonstrate that the 5-ht dysfunction is caused by smn deficiency in serotonergic neurons in the raphe nuclei of the brainstem. |
2023-09-07 |
2023-10-07 |
mouse |
| Simon Levinson, Michelle Miller, Ahmed Iftekhar, Monica Justo, Daniel Arriola, Wenxin Wei, Saman Hazany, Josue M Avecillas-Chasin, Taylor P Kuhn, Andreas Horn, Ausaf A Bar. A structural connectivity atlas of limbic brainstem nuclei. Frontiers in neuroimaging. vol 1. 2023-08-09. PMID:37555163. |
several brainstem nuclei have been identified as the primary central nervous system (cns) source of important monoaminergic ascending fibers including the noradrenergic locus coeruleus, serotonergic dorsal raphe nucleus, and dopaminergic ventral tegmental area. |
2023-08-09 |
2023-08-16 |
Not clear |
| Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Koichi J Homma, Shinji Yamaguch. Molecular biology of serotonergic systems in avian brains. Frontiers in molecular neuroscience. vol 16. 2023-08-04. PMID:37538316. |
in the central serotonergic system of vertebrate species examined so far, serotonergic neurons have been confirmed to exist in clusters in the brainstem. |
2023-08-04 |
2023-08-14 |
chicken |
| Arman Hajikarim-Hamedani, Amirhossein Heidari, Mitra-Sadat Sadat-Shirazi, Sarah Mahboubi, Samira Raminfard, Solmaz Khalifeh, Mohammad-Reza Zarrindas. The role of lateral habenula NMDA receptors in tramadol-induced conditioning. Behavioural pharmacology. 2023-07-04. PMID:37401401. |
the role of the lateral habenula (lhb) as a hub for receiving and relaying signals from the limbic system to serotonergic, dopaminergic, and norepinephrinergic regions in the brainstem makes this area a critical region in the control of reward and addiction. |
2023-07-04 |
2023-08-14 |
rat |
| Kanza M Khan, Nagalakshmi Balasubramanian, Gabriel Gaudencio, Ruixiang Wang, Govindhasamy Pushpavathi Selvakumar, Louis Kolling, Samantha Pierson, Satya M Tadinada, Ted Abel, Marco Hefti, Catherine A Marcinkiewc. Human tau-overexpressing mice recapitulate brainstem involvement and neuropsychiatric features of early Alzheimer's disease. Acta neuropathologica communications. vol 11. issue 1. 2023-04-03. PMID:37009893. |
in total, these results suggest that tau pathology in brainstem monoaminergic nuclei and the resulting loss of serotonergic and/or noradrenergic drive may underpin depressive- and anxiety-like behaviors in the early stages of ad. |
2023-04-03 |
2023-08-14 |
mouse |
| Carl L Faingold, Hua-Jun Fen. A unified hypothesis of SUDEP: Seizure-induced respiratory depression induced by adenosine may lead to SUDEP but can be prevented by autoresuscitation and other restorative respiratory response mechanisms mediated by the action of serotonin on the periaqueductal gray. Epilepsia. 2023-01-30. PMID:36715572. |
this effect of serotonergic drugs may be mediated, in part, by actions on brainstem sites that modulate respiration, including the pag. |
2023-01-30 |
2023-08-14 |
human |
| Carl L Faingold, Hua-Jun Fen. A unified hypothesis of SUDEP: Seizure-induced respiratory depression induced by adenosine may lead to SUDEP but can be prevented by autoresuscitation and other restorative respiratory response mechanisms mediated by the action of serotonin on the periaqueductal gray. Epilepsia. 2023-01-30. PMID:36715572. |
therefore, we hypothesize that serotonergic or direct activation of this brainstem site may be a useful approach for sudep prevention. |
2023-01-30 |
2023-08-14 |
human |
| Carlos Aparecido da Silva Junior, Danuzia A Marques, Luís Gustavo A Patrone, Vivian Biancardi, Kênia C Bícego, Luciane H Gargaglion. Intra-uterine diazepam exposure decreases the number of catecholaminergic and serotoninergic neurons of neonate rats. Neuroscience letters. 2022-12-15. PMID:36521643. |
thus, we sought to evaluate the effects of intrauterine exposure to dzp on the number of brainstem's catecholaminergic and serotonergic neurons, implicated in respiratory control, in male and female rats on postnatal (p) day 12-13, using immunofluorescence labeling for tyrosine-hydroxylase (th) and serotonin (5-ht). |
2022-12-15 |
2023-08-14 |
rat |
| Lindsay J Agostinelli, Scott C Seaman, Clifford B Saper, Dustin Fykstra, Marco M Hefti, Timothy R Koscik, Brian J Dlouhy, Alexander G Bassu. Human Brainstem and Cerebellum Atlas- Chemoarchitecture and Cytoarchitecture Paired to MRI. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-11-28. PMID:36442999. |
here, we report a high resolution (200 μm) 7t mri of a cadaveric male human brainstem and cerebellum paired with detailed, coregistered histology (at 2 μm single cell resolution) of the immunohistochemically stained cholinergic, serotonergic, and catecholaminergic (dopaminergic noradrenergic and adrenergic) neurons, in relationship to each other and to the cerebellum. |
2022-11-28 |
2023-08-14 |
human |