| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sung-min Park, Esra Tara, Kamran Khodakha. Efficient generation of reciprocal signals by inhibition. Journal of neurophysiology. vol 107. issue 9. 2013-02-11. PMID:22298833. |
in addition to exciting purkinje cells positioned immediately above it, the activity of a mossy fiber is relayed to laterally positioned purkinje cells by a disynaptic granule cell → molecular layer interneuron pathway. |
2013-02-11 |
2023-08-12 |
Not clear |
| Ruth M Empson, Thomas Knöpfe. Functional integration of calcium regulatory mechanisms at Purkinje neuron synapses. Cerebellum (London, England). vol 11. issue 3. 2012-12-11. PMID:20596808. |
cerebellar purkinje neurons receive synaptic inputs from three different sources: the excitatory parallel fibre and climbing fibre synapses as well as the inhibitory synapses from molecular layer stellate and basket cells. |
2012-12-11 |
2023-08-12 |
Not clear |
| Isabelle Dusart, Frederic Flaman. Profound morphological and functional changes of rodent Purkinje cells between the first and the second postnatal weeks: a metamorphosis? Frontiers in neuroanatomy. vol 6. 2012-10-02. PMID:22514522. |
during the first postnatal week, they are multi-innervated by climbing fibers and numerous collateral branches sprout from their axons, whereas from the second postnatal week, the regression of climbing fiber multi-innervation begins, and purkinje cells become innervated by parallel fibers and inhibitory molecular layer interneurons. |
2012-10-02 |
2023-08-12 |
mouse |
| Alexander R Bottini, Richard A Gatti, Martin Wirenfeldt, Harry V Vinter. Heterotopic Purkinje cells in ataxia-telangiectasia. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 32. issue 1. 2012-05-17. PMID:21978196. |
using the anti-calbindin d-28k antibody to label purkinje cells in cerebellar tissue from five a-t patients and five age- and sex-matched controls, the study found calbindin-positive heterotopic purkinje cells in the molecular layer occurring at a significantly higher rate in a-t patients than in controls (p = 0.012). |
2012-05-17 |
2023-08-12 |
Not clear |
| Milena Laure-Kamionowska, Danuta Maślińsk. Cerebellar cortical neurons misplaced in the white matter due to disturbed migration during development of human brain. Folia neuropathologica. vol 49. issue 4. 2012-05-03. PMID:22212918. |
clusters of grey matter reflecting the cerebellar cortical pattern with well-defined molecular layer and altered granular and purkinje cells were most frequently observed. |
2012-05-03 |
2023-08-12 |
human |
| Lars Schack Kruse, Morten Møller, Christina Kruus. Distribution of PDE8A in the nervous system of the Sprague-Dawley rat. Journal of chemical neuroanatomy. vol 42. issue 3. 2012-04-02. PMID:21821118. |
in cerebellum pde8a immunoreactivity was located not only in the purkinje cells, but also in the granular cells as well as the parallel fibres in the molecular layer. |
2012-04-02 |
2023-08-12 |
rat |
| Yuanzheng Gao, Emma M Perkins, Yvonne L Clarkson, Steven Tobia, Alastair R Lyndon, Mandy Jackson, Jeffrey D Rothstei. β-III spectrin is critical for development of purkinje cell dendritic tree and spine morphogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 46. 2012-01-12. PMID:22090485. |
mutations in the gene encoding β-iii spectrin give rise to spinocerebellar ataxia type 5, a neurodegenerative disease characterized by progressive thinning of the molecular layer, loss of purkinje cells and increasing motor deficits. |
2012-01-12 |
2023-08-12 |
mouse |
| Yuanzheng Gao, Emma M Perkins, Yvonne L Clarkson, Steven Tobia, Alastair R Lyndon, Mandy Jackson, Jeffrey D Rothstei. β-III spectrin is critical for development of purkinje cell dendritic tree and spine morphogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 46. 2012-01-12. PMID:22090485. |
this study confirms that thinning of the molecular layer associated with disease pathogenesis is a consequence of purkinje cell dendritic degeneration, as purkinje cells from 8-month-old β-iii⁻/⁻ mice have drastically reduced dendritic volumes, surface areas and total dendritic lengths compared with 5- to 6-week-old β-iii⁻/⁻ mice. |
2012-01-12 |
2023-08-12 |
mouse |
| Ming-Wai Poon, Wan-Hong Tsang, Mary Miu-Yee Waye, Sun-On Cha. Distribution of Kiaa0319-like immunoreactivity in the adult mouse brain--a novel protein encoded by the putative dyslexia susceptibility gene KIAA0319-like. Histology and histopathology. vol 26. issue 8. 2011-10-13. PMID:21692029. |
in the cerebellum, the protein was observed in the molecular layer and a fraction of purkinje neurons. |
2011-10-13 |
2023-08-12 |
mouse |
| Maria Johanna Dizon, Kamran Khodakha. The role of interneurons in shaping Purkinje cell responses in the cerebellar cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 29. 2011-09-16. PMID:21775592. |
the well established anatomy of the cerebellar cortex has led to suggestions that cerebellar molecular layer interneurons laterally inhibit purkinje cells. |
2011-09-16 |
2023-08-12 |
rat |
| Maria Johanna Dizon, Kamran Khodakha. The role of interneurons in shaping Purkinje cell responses in the cerebellar cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 29. 2011-09-16. PMID:21775592. |
to extend these observations, we mapped the functional connectivity between granule cells, molecular layer interneurons, and purkinje cells in rats. |
2011-09-16 |
2023-08-12 |
rat |
| Maria Johanna Dizon, Kamran Khodakha. The role of interneurons in shaping Purkinje cell responses in the cerebellar cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 29. 2011-09-16. PMID:21775592. |
independent of the location of granule cells, within the 480 μm lateral distance examined, molecular layer interneurons reduced the strength of granule cell inputs to purkinje cells to a comparable extent. |
2011-09-16 |
2023-08-12 |
rat |
| Koen Tahon, Mike Wijnants, Erik De Schutter, Reinoud Mae. Current source density correlates of cerebellar Golgi and Purkinje cell responses to tactile input. Journal of neurophysiology. vol 105. issue 3. 2011-07-22. PMID:21228303. |
a dip in simple-spike activity of coregistered purkinje cells correlated with a current source deep in the molecular layer, probably generated by basket cell synapses, interspersed between sparse early sinks presumably generated by synapses from granule cells. |
2011-07-22 |
2023-08-12 |
rat |
| William Wisden, Andrew J Murray, Christina McClure, Peer Wulf. Studying Cerebellar Circuits by Remote Control of Selected Neuronal Types with GABA(A) Receptors. Frontiers in molecular neuroscience. vol 2. 2011-07-14. PMID:20076763. |
although gaba(a) receptor-mediated inhibition of cerebellar purkinje cells by molecular layer interneurons (mlis) has been studied intensely at the cellular level, it has remained unclear how this inhibition regulates cerebellum-dependent behaviour. |
2011-07-14 |
2023-08-12 |
mouse |
| William H Hoffman, Sandra L Siedlak, Yang Wang, Rudy J Castellani, Mark A Smit. Oxidative damage is present in the fatal brain edema of diabetic ketoacidosis. Brain research. vol 1369. 2011-04-21. PMID:21040714. |
however, in the cerebellum, only 8ohg was increased in the purkinje cells and other cells of the molecular layer. |
2011-04-21 |
2023-08-12 |
Not clear |
| Denisa Ioana Creţu, Alina Sovrea, R M Ignat, Adriana Filip, Cristina Bidian, Aurica Creţ. Morpho-pathological and physiological changes of the brain and liver after ozone exposure. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 51. issue 4. 2011-04-07. PMID:21103629. |
therefore, cerebral edema was discovered in the brain hemispheres and the cerebellum indicating necrotic signs accompanied by a reduction in the molecular layer and purkinje cells with pale core. |
2011-04-07 |
2023-08-12 |
human |
| Markus Damme, Stijn Stroobants, Steven U Walkley, Renate Lüllmann-Rauch, Rudi D'Hooge, Jens Fogh, Paul Saftig, Torben Lübke, Judith Blan. Cerebellar alterations and gait defects as therapeutic outcome measures for enzyme replacement therapy in α-mannosidosis. Journal of neuropathology and experimental neurology. vol 70. issue 1. 2011-03-07. PMID:21157375. |
in the cerebellar molecular layer, α-mannosidosis mice display clusters of activated bergman glia, infiltration of phagocytic macrophages, and accumulation of free cholesterol and gangliosides (gm1), notably in regions lacking purkinje cells. |
2011-03-07 |
2023-08-12 |
mouse |
| Hiroshi Ishii, Koichi Nakajo, Yuchio Yanagawa, Yoshihiro Kub. Identification and characterization of Cs(+) -permeable K(+) channel current in mouse cerebellar Purkinje cells in lobules 9 and 10 evoked by molecular layer stimulation. The European journal of neuroscience. vol 32. issue 5. 2011-03-01. PMID:20673313. |
identification and characterization of cs(+) -permeable k(+) channel current in mouse cerebellar purkinje cells in lobules 9 and 10 evoked by molecular layer stimulation. |
2011-03-01 |
2023-08-12 |
mouse |
| Douglas J Swanson, Ekaterina Y Steshina, Paul Wakenight, Kimberly A Aldinger, Dan Goldowitz, Kathleen J Millen, Victor V Chizhiko. Phenotypic and genetic analysis of the cerebellar mutant tmgc26, a new ENU-induced ROR-alpha allele. The European journal of neuroscience. vol 32. issue 5. 2011-03-01. PMID:20722722. |
chimera studies suggested a cell-autonomous effect of the tmgc26 mutation in purkinje cells and molecular layer interneurons, and a non-cell-autonomous effect in granule cells. |
2011-03-01 |
2023-08-12 |
mouse |
| Jason R Pugh, Craig E Jah. Axonal GABAA receptors increase cerebellar granule cell excitability and synaptic activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 2. 2011-02-22. PMID:21228165. |
these results describe a positive feedback mechanism whereby transmission from granule cells to purkinje cells and molecular layer interneurons will be strengthened during granule cell spike bursts evoked by sensory stimulation. |
2011-02-22 |
2023-08-12 |
Not clear |