| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Niraj Kumar Singh, Pranjul Singh, Prachi Varshney, Ashini Singh, Bharat Bhusha. Multimodal action of phosphodiesterase 5 inhibitors against neurodegenerative disorders: An update review. Journal of biochemical and molecular toxicology. vol 38. issue 11. 2024-10-19. PMID:39425458. |
phosphodiesterase type 5 (pde5) is an enzyme primarily found in the smooth muscle of the corpus cavernosum and also highly expressed in the substantia nigra, cerebellum, caudate, hippocampal regions and cerebellar purkinje cells, responsible for selectively breaking down cyclic guanosine monophosphate (cgmp) into 5'-gmp and regulate intracellular cgmp levels. |
2024-10-19 |
2024-10-21 |
Not clear |
| Mustafa Ozkaraca, Selcuk Ozdemir, Selim Comakli, Mehmet Ozkan Timurka. Roles of apoptosis and autophagy in natural rabies infections. Veterinarni medicina. vol 67. issue 1. 2024-08-22. PMID:39169958. |
lc3b immunopositivity was detected in the cytoplasm of the purkinje cells in the cerebellum of the cows, horses and donkeys, and also in the cytoplasm of the neurons in the cornu ammonis of the dogs and cats. |
2024-08-22 |
2024-08-24 |
Not clear |
| Shuangchan Wu, Pingting Liu, Marija Cvetanovic, Wensheng Li. Endoplasmic reticulum associated degradation preserves neurons viability by maintaining endoplasmic reticulum homeostasis. Frontiers in neuroscience. vol 18. 2024-08-14. PMID:39135735. |
moreover, we found that cerebellar and hippocampal atrophy in these mice resulted from degeneration of purkinje neurons and hippocampal neurons, respectively. |
2024-08-14 |
2024-08-16 |
mouse |
| Aïda Padilla-Ferrer, Alex Carrete, Anne Simon, Delphine Meffre, Mehrnaz Jafarian-Tehran. A disintegrin and Metalloprotease 10 expression within the murine central nervous system. Brain research. 2024-03-28. PMID:38548249. |
we observed adam10 expression through the whole cns, with a strong expression in the hippocampus, in the hypothalamus and in the cerebral and piriform cortex in the brain, in the purkinje and in granular cell layers in the cerebellum and in the spinal cord to a lower extent. |
2024-03-28 |
2024-03-31 |
mouse |
| Moritz Groden, Hannah M Moessinger, Barbara Schaffran, Javier DeFelipe, Ruth Benavides-Piccione, Hermann Cuntz, Peter Jedlick. A biologically inspired repair mechanism for neuronal reconstructions with a focus on human dendrites. PLoS computational biology. vol 20. issue 2. 2024-02-23. PMID:38394339. |
importantly, we show that such repairs also apply to other neuron types including hippocampal granule cells and cerebellar purkinje cells. |
2024-02-23 |
2024-02-26 |
mouse |
| Hou Liu, Guicheng Wang, Jin Zhang, Bingjie Lu, Dan Li, Jianmin Che. Inhalation of diesel exhaust particulate matter induces locomotor hyperactivity and its relationship with brain and gut metabolism. Environment international. vol 183. 2023-12-06. PMID:38056096. |
exposure to depm disrupted motor behavior generation related cerebellar purkinje cells, induced widespread reduction of neurotransmitters in the frontal cortex, and downregulated expression of genes encoding brain-derived neurotrophic factor (bdnf) and involved in the brain-blood-barrier (bbb) in the hippocampus. |
2023-12-06 |
2023-12-10 |
mouse |
| Sumit S Rathod, Yogeeta O Agrawal, Kartik T Nakhate, M F Nagoor Meeran, Shreesh Ojha, Sameer N Goya. Neuroinflammation in the Central Nervous System: Exploring the Evolving Influence of Endocannabinoid System. Biomedicines. vol 11. issue 10. 2023-10-30. PMID:37893016. |
the presence of cb2 receptors in certain brain components, like cultured cerebellar granular cells, purkinje fibers, and microglia, as well as in the areas like the cerebral cortex, hippocampus, and cerebellum is also evidenced by immunoblotting assays, radioligand binding, and autoradiography studies. |
2023-10-30 |
2023-11-08 |
Not clear |
| Ferit Durankuş, Korkut Budak, Yakup Albayrak, İbrahim H Sever, Bahattin Özkul, Yigit Uyanıkgil, Neslihan Albayrak, Oytun Erba. Atorvastatin Improves the Propionic Acid-Induced Autism in Rats: The Roles of Sphingosine-1-Phosphate and Anti-inflammatory Action. Cureus. vol 15. issue 3. 2023-05-01. PMID:37123681. |
in histopathology assessments, the ppa+atorvastatin group was found to have significantly higher neuronal counts of ca1 and ca2 in the hippocampus, and purkinje cells in the cerebellum. |
2023-05-01 |
2023-08-14 |
rat |
| Akie Toya, Masahide Fukada, Eiko Aoki, Tohru Matsuki, Masashi Ueda, Shima Eda, Yoshio Hashizume, Akio Iio, Shigeo Masaki, Atsuo Nakayam. The distribution of neuroligin4, an autism-related postsynaptic molecule, in the human brain. Molecular brain. vol 16. issue 1. 2023-02-07. PMID:36747195. |
nlgn4 signals in other large neurons, such as pyramidal cells in the cerebral cortex and hippocampus as well as neurons in the locus coeruleus and the raphe nucleus, were also remarkable, clearly contrasting with no or scarce signals in purkinje cells. |
2023-02-07 |
2023-08-14 |
human |
| Gabriel G Cataldi, Setiembre D Elorza, Ana Toledano-Zaragoza, Soledad de Olmos, Andrea B Cragnolini, Mauricio G Martí. Cholesterol-24-hydroxylase (CYP46) in the old brain: Analysis of positive populations and factors triggering its expression in astrocytes. The Journal of comparative neurology. 2022-12-01. PMID:36453552. |
we found that cyp46 is localized in the same neuronal populations in young and old brains, mainly in the hippocampus, in cortical layers, and in purkinje neurons of the cerebellum. |
2022-12-01 |
2023-08-14 |
mouse |
| Nanako Hamada, Ikuko Iwamoto, Mariko Noda, Masashi Nishikawa, Koh-Ichi Nagat. Expression analyses of polo-like kinase 4 (Plk4), a gene product responsible for autosomal recessive microcephaly and Seckel syndrome, during mouse brain development. Developmental neuroscience. 2022-09-06. PMID:36067731. |
plk4 was then diffusely distributed in the cell body of cortical neurons at p7 while it was enriched in the neuropil as well as soma of excitatory neurons in cerebral cortex and hippocampus, and purkinje cells in the cerebellum at p30. |
2022-09-06 |
2023-08-14 |
mouse |
| Anastasia Rumyantseva, Milica Popovic, Aleksandra Trifunovi. CLPP deficiency ameliorates neurodegeneration caused by impaired mitochondrial protein synthesis. Brain : a journal of neurology. 2022-03-03. PMID:35240691. |
here, we build upon this finding by showing that clpp depletion is indeed beneficial in vivo for various types of neuronal populations, including purkinje cells in the cerebellum and cortical and hippocampal neurons in the forebrain, as it strongly improves distinct phenotypes of mitochondria encephalopathy, driven by the deficiency of the mitochondrial aspartyl trna synthase dars2. |
2022-03-03 |
2023-08-13 |
mouse |
| Yu Liu, Samuel S McAfee, Meike E Van Der Heijden, Mukesh Dhamala, Roy V Sillitoe, Detlef H Hec. Causal Evidence for a Role of Cerebellar Lobulus Simplex in Prefrontal-Hippocampal Interaction in Spatial Working Memory Decision-Making. Cerebellum (London, England). 2022-02-26. PMID:35218525. |
with recent evidence that purkinje cells in the cerebellar lobulus simplex (ls) represent information about the phase and phase differences of gamma oscillations in the mpfc and dorsal hippocampus, we hypothesized that ls might be involved in the modulation of mpfc-hippocampal gamma coherence. |
2022-02-26 |
2023-08-13 |
mouse |
| Balaji Gouda, Sukesh Narayan Sinha, Meram Chalamaiah, Validandi Vakdevi, Patangay Shashikala, Bantal Veeresh, Venkata Mullapudi Surekha, Vasudev Kasturi, Naveen Kumar Boiroj. Sex Differences in Animal Models of Sodium-Valproate-Induced Autism in Postnatal BALB/c Mice: Whole-Brain Histoarchitecture and 5-HT2A Receptor Biomarker Evidence. Biology. vol 11. issue 1. 2022-01-21. PMID:35053076. |
we observed that both male and female mice showed similar morphological changes in the prefrontal cortex, hippocampus and purkinje cells. |
2022-01-21 |
2023-08-13 |
mouse |
| Balaji Gouda, Sukesh Narayan Sinha, Meram Chalamaiah, Validandi Vakdevi, Patangay Shashikala, Bantal Veeresh, Venkata Mullapudi Surekha, Vasudev Kasturi, Naveen Kumar Boiroj. Sex Differences in Animal Models of Sodium-Valproate-Induced Autism in Postnatal BALB/c Mice: Whole-Brain Histoarchitecture and 5-HT2A Receptor Biomarker Evidence. Biology. vol 11. issue 1. 2022-01-21. PMID:35053076. |
moreover, 5-ht2a receptor protein levels were upregulated in the cerebral cortex, hippocampus and purkinje cells in vpa-treated male mice compared with control animals and vpa-treated female mice, as shown by immunohistochemical analysis. |
2022-01-21 |
2023-08-13 |
mouse |
| Sameh M Farouk, Ahmed M Abdellatif, Elsayed Metwall. Outer and inner mitochondrial membrane proteins TOMM40 and TIMM50 are intensively concentrated and localized at Purkinje and pyramidal neurons in the New Zealand white rabbit brain. Anatomical record (Hoboken, N.J. : 2007). vol 305. issue 1. 2021-12-08. PMID:34041863. |
sections from brain specimens were initially stained for cytochrome c oxidase (cox), a well-known mitochondrial marker, which was found to be homogeneously expressed in the cerebrum, but localized to the purkinje and pyramidal neurons of the cerebellum and hippocampus, respectively. |
2021-12-08 |
2023-08-13 |
rabbit |
| Sameh M Farouk, Ahmed M Abdellatif, Elsayed Metwall. Outer and inner mitochondrial membrane proteins TOMM40 and TIMM50 are intensively concentrated and localized at Purkinje and pyramidal neurons in the New Zealand white rabbit brain. Anatomical record (Hoboken, N.J. : 2007). vol 305. issue 1. 2021-12-08. PMID:34041863. |
meanwhile, purkinje cells in the cerebellum and pyramidal neurons in the hippocampus displayed higher intensities in their cytoplasm. |
2021-12-08 |
2023-08-13 |
rabbit |
| Anastasiia Bohush, Agnieszka Góral, Małgorzata Sierant, Barbara Nawrot, Wiesława Leśniak, Anna Filipe. Sgt1 Regulates α-Synuclein Subcellular Localization and Expression of Parkinson's Disease Related Genes, Biomolecules. vol 11. issue 11. 2021-11-30. PMID:34827672. |
sgt1 regulates α-synuclein subcellular localization and expression of parkinson's disease related genes, the sgt1 protein is highly expressed in the mammalian brain, particularly in neurons of the hippocampus and cortex, and in purkinje cells of the cerebellum. |
2021-11-30 |
2023-08-13 |
Not clear |
| Anshul Srivastava, Serguei Liachenko, Sumit Sarkar, Merle Paule, Natalya Sadovova, Joseph P Hani. Global Neurotoxicity: Quantitative Analysis of Rat Brain Toxicity Following Exposure to Trimethyltin. International journal of toxicology. vol 40. issue 4. 2021-10-11. PMID:33878910. |
trimethyltin toxicity was greatest in the hippocampus, olfactory area, cerebellum, pons, mammillary nucleus, inferior and superior colliculus, hypoglossal nucleus, thalamus, and cerebellar purkinje cells. |
2021-10-11 |
2023-08-13 |
rat |
| Jerrold M Ward, Andrew N Cartoceti, Martha A Delane. Brain Lesions in Aging Zoo-Housed Naked Mole-Rats ( Veterinary pathology. vol 58. issue 1. 2021-09-17. PMID:33205701. |
less severe lesions were present in cerebellar purkinje cells, medulla, and hippocampal neurons. |
2021-09-17 |
2023-08-13 |
Not clear |