| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Punita Bhalla, D K Dhawa. Protective role of lithium in ameliorating the aluminium-induced oxidative stress and histological changes in rat brain. Cellular and molecular neurobiology. vol 29. issue 4. 2009-08-24. PMID:19184412. |
similarly, the loss of purkinje cells was also evident in cerebellum. |
2009-08-24 |
2023-08-12 |
rat |
| Michael J Urbanski, Flora E Kovacs, Bela Szab. Depolarizing GABAergic synaptic input triggers endocannabinoid-mediated retrograde synaptic signaling. Synapse (New York, N.Y.). vol 63. issue 8. 2009-08-19. PMID:19347961. |
spontaneous gabaergic inhibitory postsynaptic currents (sipscs) were recorded in purkinje cells in mouse cerebellar slices with patch-clamp pipettes containing 151 mm chloride (a usual recording mode). |
2009-08-19 |
2023-08-12 |
mouse |
| Jin Tao, Yuan Zhang, Hua Huang, Xinghong Jian. Activation of corticotropin-releasing factor 2 receptor inhibits Purkinje neuron P-type calcium currents via G(o)alpha-dependent PKC epsilon pathway. Cellular signalling. vol 21. issue 9. 2009-08-14. PMID:19439178. |
in addition, ucn2 significantly increases spontaneous firing frequency of purkinje neurons in cerebellar slices. |
2009-08-14 |
2023-08-12 |
rat |
| Jin Tao, Yuan Zhang, Hua Huang, Xinghong Jian. Activation of corticotropin-releasing factor 2 receptor inhibits Purkinje neuron P-type calcium currents via G(o)alpha-dependent PKC epsilon pathway. Cellular signalling. vol 21. issue 9. 2009-08-14. PMID:19439178. |
in summary, activation of crfr2 inhibits p-currents in purkinje neurons via g(o)alpha-dependent plc/pkcepsilon pathway, which might contribute to its physiological functions in the cerebellum. |
2009-08-14 |
2023-08-12 |
rat |
| Kazushi Ichikawa, Saoko Takeshita, Shuichi Ito, Atsuo Nez. Rasmussen syndrome combined with IgA deficiency and membranous nephropathy. Pediatric neurology. vol 40. issue 6. 2009-08-10. PMID:19433284. |
the boy died at the age of 14 years, and autopsy revealed diffuse brain atrophy with neuronal loss, infiltration of glial cells in the cerebrum, and loss of purkinje cells in the cerebellum. |
2009-08-10 |
2023-08-12 |
Not clear |
| Ruth Morona, Agustin Gonzále. Immunohistochemical localization of calbindin-D28k and calretinin in the brainstem of anuran and urodele amphibians. The Journal of comparative neurology. vol 515. issue 5. 2009-08-10. PMID:19479990. |
in the cerebellum, cb labeled purkinje cells in all species, whereas cr was mainly found in fibers and labeled purkinje cells only in rana. |
2009-08-10 |
2023-08-12 |
xenopus_laevis |
| Francesca Maltecca, Raffaella Magnoni, Federica Cerri, Gregory A Cox, Angelo Quattrini, Giorgio Casar. Haploinsufficiency of AFG3L2, the gene responsible for spinocerebellar ataxia type 28, causes mitochondria-mediated Purkinje cell dark degeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 29. 2009-08-10. PMID:19625515. |
furthermore, we propose a pathogenetic mechanism in which respiratory chain dysfunction and increased reactive oxygen species production caused by afg3l2 haploinsufficiency lead to dark degeneration of purkinje cells and cerebellar dysfunction. |
2009-08-10 |
2023-08-12 |
mouse |
| Simon R Schultz, Kazuo Kitamura, Arthur Post-Uiterweer, Julija Krupic, Michael Häusse. Spatial pattern coding of sensory information by climbing fiber-evoked calcium signals in networks of neighboring cerebellar Purkinje cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 25. 2009-08-04. PMID:19553440. |
spontaneous synchrony of calcium transients between individual purkinje cells falls off over approximately 200 microm mediolaterally, consistent with the presence of cerebellar microzones organized by climbing fiber input. |
2009-08-04 |
2023-08-12 |
Not clear |
| Nathan D Jorgensen, J Michael Andresen, Sara Lagalwar, Ben Armstrong, Sam Stevens, Courtney E Byam, Lisa A Duvick, Shaojuan Lai, Paymaan Jafar-Nejad, Huda Y Zoghbi, H Brent Clark, Harry T Or. Phosphorylation of ATXN1 at Ser776 in the cerebellum. Journal of neurochemistry. vol 110. issue 2. 2009-07-31. PMID:19500214. |
we found that while phosphorylation of s776 is associated with a stabilization of atxn1 in purkinje cells, inhibition of akt either in vivo or in a cerebellar extract-based phosphorylation assay did not decrease the phosphorylation of atxn1-s776. |
2009-07-31 |
2023-08-12 |
mouse |
| Andre Teigler, Dorde Komljenovic, Andreas Draguhn, Karin Gorgas, Wilhelm W Jus. Defects in myelination, paranode organization and Purkinje cell innervation in the ether lipid-deficient mouse cerebellum. Human molecular genetics. vol 18. issue 11. 2009-07-30. PMID:19270340. |
investigating the cerebellum of these mice, we observed: (i) defects in foliation patterning and delay in precursor granule cell migration, (ii) defects in myelination and concomitant reduction in the level of myelin basic protein, (iii) disturbances in paranode organization by extending the caspr distribution and disrupting axo-glial septate-like junctions, (iv) impaired innervation of purkinje cells by both parallel fibers and climbing fibers and (v) formation of axon swellings by the accumulation of inositol-tris-phosphate receptor 1 containing smooth er-like tubuli. |
2009-07-30 |
2023-08-12 |
mouse |
| Paola Martinelli, Veronica La Mattina, Andrea Bernacchia, Raffaella Magnoni, Federica Cerri, Gregory Cox, Angelo Quattrini, Giorgio Casari, Elena I Rugarl. Genetic interaction between the m-AAA protease isoenzymes reveals novel roles in cerebellar degeneration. Human molecular genetics. vol 18. issue 11. 2009-07-30. PMID:19289403. |
in addition, they show prominent cerebellar degeneration with loss of purkinje cells and parallel fibers, and reactive astrogliosis. |
2009-07-30 |
2023-08-12 |
mouse |
| Georgia Mandolesi, Eleonora Autuori, Roberta Cesa, Federica Premoselli, Paolo Cesare, Piergiorgio Strat. GluRdelta2 expression in the mature cerebellum of hotfoot mice promotes parallel fiber synaptogenesis and axonal competition. PloS one. vol 4. issue 4. 2009-07-30. PMID:19370152. |
glutamate receptor delta 2 (glurdelta2) is selectively expressed in the cerebellum, exclusively in the spines of the purkinje cells (pcs) that are in contact with parallel fibers (pfs). |
2009-07-30 |
2023-08-12 |
mouse |
| Hitoshi Kuwata, Kazuki Nakao, Takeshi Harada, Ikuo Matsuda, Atsu Aib. Generation of RGS8 null mutant mice by Cre/loxP system. The Kobe journal of medical sciences. vol 53. issue 6. 2009-07-29. PMID:18762722. |
histological analysis showed no apparent abnormalities in morphology of cerebellar layer or purkinje cells in rgs8 null mutant mice. |
2009-07-29 |
2023-08-12 |
mouse |
| L F Barros, R Courjaret, P Jakoby, A Loaiza, C Lohr, J W Deitme. Preferential transport and metabolism of glucose in Bergmann glia over Purkinje cells: a multiphoton study of cerebellar slices. Glia. vol 57. issue 9. 2009-07-22. PMID:19062182. |
preferential transport and metabolism of glucose in bergmann glia over purkinje cells: a multiphoton study of cerebellar slices. |
2009-07-22 |
2023-08-12 |
rat |
| L F Barros, R Courjaret, P Jakoby, A Loaiza, C Lohr, J W Deitme. Preferential transport and metabolism of glucose in Bergmann glia over Purkinje cells: a multiphoton study of cerebellar slices. Glia. vol 57. issue 9. 2009-07-22. PMID:19062182. |
our main conclusion is that in acute cerebellar slices, the glucose transport capacity and glycolytic rate of bergmann glia are several-fold higher than those of purkinje cells. |
2009-07-22 |
2023-08-12 |
rat |
| L F Barros, R Courjaret, P Jakoby, A Loaiza, C Lohr, J W Deitme. Preferential transport and metabolism of glucose in Bergmann glia over Purkinje cells: a multiphoton study of cerebellar slices. Glia. vol 57. issue 9. 2009-07-22. PMID:19062182. |
given that the cerebellum is largely fueled by glucose and purkinje neurons are estimated to spend more energy than bergmann glial cells, these results suggest substantial shuttling of an energy-rich metabolite like lactate between glial cells and neurons. |
2009-07-22 |
2023-08-12 |
rat |
| Joy T Walter, Maria-Johanna Dizon, Kamran Khodakha. The functional equivalence of ascending and parallel fiber inputs in cerebellar computation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 26. 2009-07-20. PMID:19571137. |
at the center of the computational cerebellar circuitry are purkinje cells, which integrate synaptic inputs from >150,000 granule cell inputs. |
2009-07-20 |
2023-08-12 |
Not clear |
| Joy T Walter, Maria-Johanna Dizon, Kamran Khodakha. The functional equivalence of ascending and parallel fiber inputs in cerebellar computation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 26. 2009-07-20. PMID:19571137. |
by systematically examining the efficacy of patches of granule cells with photostimulation, we found no differences in the efficacy of the two inputs in driving the activity of, or in producing postsynaptic currents in, purkinje cells in cerebellar slices in vitro. |
2009-07-20 |
2023-08-12 |
Not clear |
| Yu Shin Kim, Jung Hoon Shin, F Scott Hall, David J Linde. Dopamine signaling is required for depolarization-induced slow current in cerebellar Purkinje cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 26. 2009-07-20. PMID:19571144. |
purkinje cells in cerebellar slices derived from dat-null mice expressed disc, but this disc ran down at a significantly higher rate than littermate controls. |
2009-07-20 |
2023-08-12 |
mouse |
| Keiko Matsuda, Tetsuro Kondo, Takatoshi Iijima, Shinji Matsuda, Masahiko Watanabe, Michisuke Yuzak. Cbln1 binds to specific postsynaptic sites at parallel fiber-Purkinje cell synapses in the cerebellum. The European journal of neuroscience. vol 29. issue 4. 2009-07-13. PMID:19200061. |
immunoreactivity for the recombinant cbln1 was observed in weaver cerebellum (which lacks granule cells) but was absent in pcd cerebellum (which lacks purkinje cells), suggesting that the binding site was located on the postsynaptic sites of pf-purkinje cell synapses. |
2009-07-13 |
2023-08-12 |
Not clear |