| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Schonewille, A Belmeguenai, S K Koekkoek, S H Houtman, H J Boele, B J van Beugen, Z Gao, A Badura, G Ohtsuki, W E Amerika, E Hosy, F E Hoebeek, Y Elgersma, C Hansel, C I De Zeeu. Purkinje cell-specific knockout of the protein phosphatase PP2B impairs potentiation and cerebellar motor learning. Neuron. vol 67. issue 4. 2010-09-27. PMID:20797538. |
thus, our data indicate that pp2b may indeed mediate potentiation in purkinje cells and contribute prominently to cerebellar motor learning. |
2010-09-27 |
2023-08-12 |
Not clear |
| Celia Quevedo, Vincent Sauzeau, Mauricio Menacho-Márquez, Antonio Castro-Castro, Xosé R Bustel. Vav3-deficient mice exhibit a transient delay in cerebellar development. Molecular biology of the cell. vol 21. issue 6. 2010-09-08. PMID:20089829. |
we report here that vav3 is expressed at high levels in purkinje and granule cells, suggesting additional roles for this protein in the cerebellum. |
2010-09-08 |
2023-08-12 |
mouse |
| Kong-Yan Wu, Xiu-Ping Zhou, Zhen-Ge Lu. Geranylgeranyltransferase I is essential for dendritic development of cerebellar Purkinje cells. Molecular brain. vol 3. 2010-08-31. PMID:20540740. |
during cerebellar development, purkinje cells (pcs) form the most elaborate dendritic trees among neurons in the brain, but the mechanism regulating pc arborization remains largely unknown. |
2010-08-31 |
2023-08-12 |
Not clear |
| V V Grigor'ev, I V Serkov, B K Beznosko, T A Ivanova, N M Gretskaia, V V Bezuglov, S O Bachuri. [Influence of derivatives of arachidonic and docosohexaenic acids on AMPA receptors in Purkinje neurons and cognitive functions in mice]. Izvestiia Akademii nauk. Seriia biologicheskaia. issue 3. 2010-08-31. PMID:20583621. |
the effect of derivatives of arachidonic and docosahexaenoic acids on ampa receptors in purkinje cells from the rat cerebellum was studied using the patch-clamp electrophysiological method. |
2010-08-31 |
2023-08-12 |
mouse |
| Xiaowei Chen, Yury Kovalchuk, Helmuth Adelsberger, Horst A Henning, Matthias Sausbier, Georg Wietzorrek, Peter Ruth, Yosef Yarom, Arthur Konnert. Disruption of the olivo-cerebellar circuit by Purkinje neuron-specific ablation of BK channels. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 27. 2010-08-30. PMID:20566869. |
cellular analyses showed that a decrease in spike firing rate occurred in at least two types of cerebellar neurons, namely in purkinje neurons (pns) and in golgi cells. |
2010-08-30 |
2023-08-12 |
mouse |
| William A Catterall, Franck Kalume, John C Oakle. NaV1.1 channels and epilepsy. The Journal of physiology. vol 588. issue Pt 11. 2010-08-27. PMID:20194124. |
similarly, the sodium currents and action potential firing are also impaired in the gabaergic purkinje neurons of the cerebellum, which is likely to contribute to ataxia. |
2010-08-27 |
2023-08-12 |
mouse |
| J D Brady, C Mohr, D J Ross. Vesicular GABA release delays the onset of the Purkinje cell terminal depolarization without affecting tissue swelling in cerebellar slices during simulated ischemia. Neuroscience. vol 168. issue 1. 2010-08-20. PMID:20226232. |
here we use patch-clamp recording from purkinje cells in acutely prepared slices of rat cerebellum to determine how ischemia affects gabaergic signaling to purkinje cells. |
2010-08-20 |
2023-08-12 |
rat |
| Stephanie Schorge, Joyce van de Leemput, Andrew Singleton, Henry Houlden, John Hard. Human ataxias: a genetic dissection of inositol triphosphate receptor (ITPR1)-dependent signaling. Trends in neurosciences. vol 33. issue 5. 2010-08-16. PMID:20226542. |
we argue that the unifying feature of many genes involved in cerebellar ataxias is their impact on the signaling protein itpr1 (inositiol 1,4,5-triphosphate receptor type 1), that underlies coincidence detection in purkinje cells and could play an important role in cerebellar coordination. |
2010-08-16 |
2023-08-12 |
human |
| Hyun Lee, Jae-Sung Bae, Hee Kyung Ji. Human umbilical cord blood-derived mesenchymal stem cells improve neurological abnormalities of Niemann-Pick type C mouse by modulation of neuroinflammatory condition. The Journal of veterinary medical science. vol 72. issue 6. 2010-08-13. PMID:20124762. |
here, we show that hucb-mscs transplantation into np-c mice prevents the loss of purkinje neurons and inhibits cerebellar apoptotic cell death. |
2010-08-13 |
2023-08-12 |
mouse |
| Nadia L Cerminara, John A Rawson, Richard App. Electrophysiological characterization of the cerebellum in the arterially perfused hindbrain and upper body of the rat. Cerebellum (London, England). vol 9. issue 2. 2010-08-12. PMID:20033360. |
similarly, the spontaneous and evoked single unit activity of purkinje cells, putative golgi cells, molecular interneurones and cerebellar nuclear neurones was similar to activity patterns reported in vivo. |
2010-08-12 |
2023-08-12 |
rat |
| Murat C Rağbetli, Atif Aydinlioğlu, Necat Koyun, Cennet Rağbetli, Seyman Bektas, Serdar Ozdemi. The effect of mobile phone on the number of Purkinje cells: a stereological study. International journal of radiation biology. vol 86. issue 7. 2010-08-12. PMID:20545571. |
purkinje cells of the cerebellum are also sensitive to high dose microwave exposure in rats. |
2010-08-12 |
2023-08-12 |
rat |
| Murat C Rağbetli, Atif Aydinlioğlu, Necat Koyun, Cennet Rağbetli, Seyman Bektas, Serdar Ozdemi. The effect of mobile phone on the number of Purkinje cells: a stereological study. International journal of radiation biology. vol 86. issue 7. 2010-08-12. PMID:20545571. |
the present study investigated the effect of exposure to mobile phone on the number of purkinje and granule neurons in the developing cerebellum. |
2010-08-12 |
2023-08-12 |
rat |
| Vimal Kumar Paliwal, Satish Chandra, Ritu Verma, Jayantee Kalita, Usha K Misr. Clonazepam responsive opsoclonus myoclonus syndrome: additional evidence in favour of fastigial nucleus disinhibition hypothesis? Journal of neural transmission (Vienna, Austria : 1996). vol 117. issue 5. 2010-07-29. PMID:20094737. |
neural generator of opsoclonus and myoclonus is not known but evidences suggest the role of fastigial nucleus disinhibition from the loss of function of inhibitory (gabaergic) purkinje cells in the cerebellum. |
2010-07-29 |
2023-08-12 |
Not clear |
| Kosuke Kajitani, Karim Wafa, Kishore B S Pasumarthi, George S Robertso. Developmental expression of the cyclin D2 splice variant in postnatal Purkinje cells of the mouse cerebellum. Neuroscience letters. vol 477. issue 2. 2010-07-29. PMID:20433897. |
developmental expression of the cyclin d2 splice variant in postnatal purkinje cells of the mouse cerebellum. |
2010-07-29 |
2023-08-12 |
mouse |
| Jae-sung Bae, Janet E Carter, Hee Kyung Ji. Adipose tissue-derived stem cells rescue Purkinje neurons and alleviate inflammatory responses in Niemann-Pick disease type C mice. Cell and tissue research. vol 340. issue 2. 2010-07-21. PMID:20238127. |
herein, we demonstrate that adscs, when transplanted into niemann-pick disease type c (np-c) mouse cerebellum, elicit rescue of purkinje neurons and restoration of motor coordination together with alleviation of inflammatory responses as verified by immunohistochemistry and real-time pcr using glial fibrillary acidic protein (gfap), f4/80, il-1 beta, il-6, and tnf-alpha. |
2010-07-21 |
2023-08-12 |
mouse |
| Carla Fernandez, Valérie M Tatard, Nicolas Bertrand, Nadia Dahman. Differential modulation of Sonic-hedgehog-induced cerebellar granule cell precursor proliferation by the IGF signaling network. Developmental neuroscience. vol 32. issue 1. 2010-07-09. PMID:20389077. |
sonic hedgehog (shh) signaling is a major player in the regulation of cerebellar development: shh is secreted by purkinje neurons and acts on the proliferation of granule cell precursors (gcps) in the external germinal layer. |
2010-07-09 |
2023-08-12 |
mouse |
| Nan Zheng, Indira M Rama. Synaptic inhibition, excitation, and plasticity in neurons of the cerebellar nuclei. Cerebellum (London, England). vol 9. issue 1. 2010-07-02. PMID:19847585. |
the synaptic and intrinsic features of cerebellar nuclear cells are unusual in several respects, however: these neurons receive an overwhelming amount of basal and driven inhibition from purkinje neurons, but are also spontaneously active, producing action potentials even without excitation. |
2010-07-02 |
2023-08-12 |
Not clear |
| Lazaros C Triarho. Biological clues on neuronal degeneration based on theoretical fits of decay patterns: towards a mathematical neuropathology. Folia neuropathologica. vol 48. issue 1. 2010-07-02. PMID:20383806. |
in the cerebellum of pcd mice, analyses of transsynaptic granule cell death subsequent to the genetically-determined degeneration of purkinje cells show that granule neuron fallout follows a typical pattern of exponential decay. |
2010-07-02 |
2023-08-12 |
mouse |
| Jin Bao, Kerstin Reim, Takeshi Sakab. Target-dependent feedforward inhibition mediated by short-term synaptic plasticity in the cerebellum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 24. 2010-07-02. PMID:20554867. |
cerebellar feedforward inhibition (ffi) is mediated by two distinct pathways targeting different subcellular compartments of purkinje cells (pcs). |
2010-07-02 |
2023-08-12 |
mouse |
| Shan-chuan Zhong, Xue Luo, Xing-shu Chen, Qi-yan Cai, Jing Liu, Xing-hua Chen, Zhong-xiang Ya. Expression and subcellular location of alpha-synuclein during mouse-embryonic development. Cellular and molecular neurobiology. vol 30. issue 3. 2010-07-01. PMID:19885730. |
in the neocortex, expression was detected in the marginal zone (mz) in the early stages and was later condensed in the mz and in the subplate (sp); in the cerebellum, expression was initially detected in the deep cerebellar nuclei (dcn) and was later condensed in the purkinje cells. |
2010-07-01 |
2023-08-12 |
mouse |