| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dragos Niculescu, Wiebke Hirdes, Sönke Hornig, Olaf Pongs, Jürgen R Schwar. Erg potassium currents of neonatal mouse Purkinje cells exhibit fast gating kinetics and are inhibited by mGluR1 activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 42. 2013-12-10. PMID:24133274. |
action potentials recorded from purkinje cells in cerebellar slices exhibited a decreased threshold potential and increased frequency of spontaneous and repetitive activity following application of the specific erg channel blocker e-4031. |
2013-12-10 |
2023-08-12 |
mouse |
| Erik L de Graaf, Wilbert P Vermeij, Monique C de Waard, Yvonne Rijksen, Ingrid van der Pluijm, Casper C Hoogenraad, Jan H J Hoeijmakers, A F Maarten Altelaar, Albert J R Hec. Spatio-temporal analysis of molecular determinants of neuronal degeneration in the aging mouse cerebellum. Molecular & cellular proteomics : MCP. vol 12. issue 5. 2013-12-09. PMID:23399551. |
here, we used the purkinje cell-specific ercc1 dna-repair knock-out mouse model to study aging in the mouse cerebellum. |
2013-12-09 |
2023-08-12 |
mouse |
| Elisa J Cops, Maithili Sashindranath, Maria Daglas, Kieran M Short, Candida da Fonseca Pereira, Terence Y Pang, Roger H Lijnen, Ian M Smyth, Anthony J Hannan, Andre L Samson, Robert L Medcal. Tissue-type plasminogen activator is an extracellular mediator of Purkinje cell damage and altered gait. Experimental neurology. vol 249. 2013-12-09. PMID:23939410. |
a correlation between purkinje degeneration and excess cerebellar levels of tissue-type plasminogen activator (tpa) has been observed in multiple genetically-distinct models of ataxia. |
2013-12-09 |
2023-08-12 |
mouse |
| Elisa J Cops, Maithili Sashindranath, Maria Daglas, Kieran M Short, Candida da Fonseca Pereira, Terence Y Pang, Roger H Lijnen, Ian M Smyth, Anthony J Hannan, Andre L Samson, Robert L Medcal. Tissue-type plasminogen activator is an extracellular mediator of Purkinje cell damage and altered gait. Experimental neurology. vol 249. 2013-12-09. PMID:23939410. |
here we show that purkinje loss in a mouse model of huntington's disease also correlates with a 200% increase in cerebellar tpa activity. |
2013-12-09 |
2023-08-12 |
mouse |
| Elisa J Cops, Maithili Sashindranath, Maria Daglas, Kieran M Short, Candida da Fonseca Pereira, Terence Y Pang, Roger H Lijnen, Ian M Smyth, Anthony J Hannan, Andre L Samson, Robert L Medcal. Tissue-type plasminogen activator is an extracellular mediator of Purkinje cell damage and altered gait. Experimental neurology. vol 249. 2013-12-09. PMID:23939410. |
to address the specific contribution of tpa to cerebellar dysfunction we studied the t4 mice line that overexpresses murine tpa in postnatal neurons through the thy1.2 gene promoter, which directs preferential expression to purkinje cells within the cerebellum. |
2013-12-09 |
2023-08-12 |
mouse |
| Jinbin Tian, Chhavy Tep, Michael X Zhu, Sung Ok Yoo. Changes in Spontaneous firing patterns of cerebellar Purkinje cells in p75 knockout mice. Cerebellum (London, England). vol 12. issue 3. 2013-12-04. PMID:23307658. |
in young mice, p75 is present in both granular cells and purkinje cells of the cerebellum. |
2013-12-04 |
2023-08-12 |
mouse |
| Jinbin Tian, Chhavy Tep, Michael X Zhu, Sung Ok Yoo. Changes in Spontaneous firing patterns of cerebellar Purkinje cells in p75 knockout mice. Cerebellum (London, England). vol 12. issue 3. 2013-12-04. PMID:23307658. |
using extracellular recordings of spontaneous firing of purkinje neurons in cerebellar slices prepared from wild type and p75 knockout mice, we measured intrinsic firing properties in the presence of fast synaptic blockers of more than 200 purkinje cells, each for a period of 5 min, for each genotype. |
2013-12-04 |
2023-08-12 |
mouse |
| Sang Jeong Ki. TRPC3 channel underlies cerebellar long-term depression. Cerebellum (London, England). vol 12. issue 3. 2013-12-04. PMID:23408143. |
metabotropic glutamate receptor type 1 (mglur1)-dependent signaling in purkinje cells is critically involved in the induction of cerebellar ltd. |
2013-12-04 |
2023-08-12 |
Not clear |
| Sang Jeong Ki. TRPC3 channel underlies cerebellar long-term depression. Cerebellum (London, England). vol 12. issue 3. 2013-12-04. PMID:23408143. |
here, we hypothesized that trpc3, which is reported to be responsible for mglur1-evoked slow currents, mediates the induction of the cerebellar ltd. purkinje cells were loaded with antibodies which act against a cytoplasmic epitope of trpc3 channels, acting as a specific antagonist of trpc3. |
2013-12-04 |
2023-08-12 |
Not clear |
| Joseph Chaumont, Nicolas Guyon, Antoine M Valera, Guillaume P Dugué, Daniela Popa, Paikan Marcaggi, Vanessa Gautheron, Sophie Reibel-Foisset, Stéphane Dieudonné, Aline Stephan, Michel Barrot, Jean-Christophe Cassel, Jean-Luc Dupont, Frédéric Doussau, Bernard Poulain, Fekrije Selimi, Clément Léna, Philippe Isop. Clusters of cerebellar Purkinje cells control their afferent climbing fiber discharge. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 40. 2013-12-03. PMID:24046366. |
purkinje cells target the deep cerebellar nuclei, which are the output of the cerebellum and include an inhibitory gabaergic projection to the inferior olive. |
2013-12-03 |
2023-08-12 |
mouse |
| Joseph Chaumont, Nicolas Guyon, Antoine M Valera, Guillaume P Dugué, Daniela Popa, Paikan Marcaggi, Vanessa Gautheron, Sophie Reibel-Foisset, Stéphane Dieudonné, Aline Stephan, Michel Barrot, Jean-Christophe Cassel, Jean-Luc Dupont, Frédéric Doussau, Bernard Poulain, Fekrije Selimi, Clément Léna, Philippe Isop. Clusters of cerebellar Purkinje cells control their afferent climbing fiber discharge. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 40. 2013-12-03. PMID:24046366. |
tetrode recordings in the cerebellar nuclei demonstrate that focal stimulations of purkinje cells strongly inhibit spatially restricted sets of cerebellar nuclear neurons. |
2013-12-03 |
2023-08-12 |
mouse |
| Joseph Chaumont, Nicolas Guyon, Antoine M Valera, Guillaume P Dugué, Daniela Popa, Paikan Marcaggi, Vanessa Gautheron, Sophie Reibel-Foisset, Stéphane Dieudonné, Aline Stephan, Michel Barrot, Jean-Christophe Cassel, Jean-Luc Dupont, Frédéric Doussau, Bernard Poulain, Fekrije Selimi, Clément Léna, Philippe Isop. Clusters of cerebellar Purkinje cells control their afferent climbing fiber discharge. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 40. 2013-12-03. PMID:24046366. |
therefore, our results demonstrate that purkinje cells phasically control the discharge of their own olivary afferents and thus might participate in the regulation of cerebellar motor learning. |
2013-12-03 |
2023-08-12 |
mouse |
| Junko Sato, Satoshi Sasaki, Naoaki Yamada, Minoru Tsuchitan. Early morphological changes of hereditary cerebellar cortical abiotrophy in rabbits. The Journal of veterinary medical science. vol 75. issue 4. 2013-12-02. PMID:23182865. |
as synapse abnormality preceded the degeneration or reduction of purkinje and granular cells at early stages, we concluded that the pathogenesis of the present cerebellar lesion was caused by failed synaptogenesis during postnatal cerebellar development. |
2013-12-02 |
2023-08-12 |
rabbit |
| Marianna Szemes, Rachel L Davies, Claire Lp Garden, Maria M Usowic. Weaker control of the electrical properties of cerebellar granule cells by tonically active GABAA receptors in the Ts65Dn mouse model of Down's syndrome. Molecular brain. vol 6. 2013-11-27. PMID:23870245. |
gcs process sensory information entering the cerebellum via mossy fibres and pass it on to purkinje cells and inhibitory interneurons. |
2013-11-27 |
2023-08-12 |
mouse |
| E Zoons, M A J Tijsse. Pathologic changes in the brain in cervical dystonia pre- and post-mortem - a commentary with a special focus on the cerebellum. Experimental neurology. vol 247. 2013-11-26. PMID:23597638. |
their most important finding was a patchy loss of cerebellar purkinje cells in the cerebellum. |
2013-11-26 |
2023-08-12 |
Not clear |
| Victor Anggono, Yeliz Koç-Schmitz, Jocelyn Widagdo, Jan Kormann, Annie Quan, Chih-Ming Chen, Phillip J Robinson, Se-Young Choi, David J Linden, Markus Plomann, Richard L Hugani. PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 34. 2013-11-26. PMID:23918399. |
genetic deletion of pacsin2, which is highly expressed in purkinje cells, eliminates cerebellar long-term depression. |
2013-11-26 |
2023-08-12 |
Not clear |
| Tatyana A Yakusheva, Pablo M Blazquez, Aihua Chen, Dora E Angelak. Spatiotemporal properties of optic flow and vestibular tuning in the cerebellar nodulus and uvula. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 38. 2013-11-26. PMID:24048845. |
many purkinje cells in vermal lobules 10 (nodulus) and 9 (uvula) of the macaque cerebellum are tuned to vestibular translation stimuli, yet little is known about their visual motion responsiveness. |
2013-11-26 |
2023-08-12 |
monkey |
| Mark J Hackett, Ferenc Borondics, Devin Brown, Carol Hirschmugl, Shari E Smith, Phyllis G Paterson, Helen Nichol, Ingrid J Pickering, Graham N Georg. Subcellular biochemical investigation of purkinje neurons using synchrotron radiation fourier transform infrared spectroscopic imaging with a focal plane array detector. ACS chemical neuroscience. vol 4. issue 7. 2013-11-25. PMID:23638613. |
with this approach, accurate correlation between infrared images and histology of the same section revealed that purkinje neurons in the cerebellum are rich in cytosolic proteins and not depleted as once thought. |
2013-11-25 |
2023-08-12 |
Not clear |
| S L Dun, R-M Lyu, Y-H Chen, J-K Chang, J J Luo, N J Du. Irisin-immunoreactivity in neural and non-neural cells of the rodent. Neuroscience. vol 240. 2013-11-13. PMID:23470775. |
in the rats and mice, immunohistochemical studies with an antiserum against irisin peptide fragment (42-112), revealed that irisin-immunoreactivity (irirn) was detected in three types of cells; namely, skeletal muscle cells, cardiomyocytes, and purkinje cells of the cerebellum. |
2013-11-13 |
2023-08-12 |
mouse |
| S L Dun, R-M Lyu, Y-H Chen, J-K Chang, J J Luo, N J Du. Irisin-immunoreactivity in neural and non-neural cells of the rodent. Neuroscience. vol 240. 2013-11-13. PMID:23470775. |
double-labeling of cerebellar sections with irisin antiserum and glutamate decarboxylase (gad) antibody showed that nearly all irirn purkinje cells were gad-positive. |
2013-11-13 |
2023-08-12 |
mouse |