| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Skoglösa, C Patrone, D Lindhol. Pituitary adenylate cyclase activating polypepetide is expressed by developing rat Purkinje cells and decreases the number of cerebellar gamma-amino butyric acid positive neurons in culture. Neuroscience letters. vol 265. issue 3. 1999-07-01. PMID:10327167. |
during prenatal cerebellar development, pacap mrna was present in developing purkinje cells and some deep cerebellar nuclei, whilst pri mrna was expressed by adjacent cells in the purkinje cell layer (pcl). |
1999-07-01 |
2023-08-12 |
rat |
| R A French, R W VanHoy, R Chizzonite, J F Zachary, R Dantzer, P Parnet, R M Bluthé, K W Kelle. Expression and localization of p80 and p68 interleukin-1 receptor proteins in the brain of adult mice. Journal of neuroimmunology. vol 93. issue 1-2. 1999-07-01. PMID:10378883. |
both isoforms are expressed in the cns, particularly in neuronal soma of the granular layer of the dentate gyrus and pyramidal cells of fields ca1-ca4 of ammon's horn of the hippocampus, in epithelial cells of the choroid plexus and ependymal layer, and in neuronal soma of purkinje cells of the cerebellum. |
1999-07-01 |
2023-08-12 |
mouse |
| S E Maier, J A Miller, J M Blackwell, J R Wes. Fetal alcohol exposure and temporal vulnerability: regional differences in cell loss as a function of the timing of binge-like alcohol exposure during brain development. Alcoholism, clinical and experimental research. vol 23. issue 4. 1999-06-28. PMID:10235310. |
total cell numbers in the cerebellum (purkinje and granule cells) and the olfactory bulb (mitral and granule cells) were estimated by the unbiased stereological technique, the optical disector. |
1999-06-28 |
2023-08-12 |
rat |
| K Goto, H Kond. Diacylglycerol kinase in the central nervous system--molecular heterogeneity and gene expression. Chemistry and physics of lipids. vol 98. issue 1-2. 1999-06-28. PMID:10358933. |
interestingly, it is revealed that the mrna for each isozyme is expressed in a distinct pattern in the brain; dgk alpha is expressed in oligodendrocytes, glial cells that form myelin; dgk beta in neurons of the caudate-putamen; dgk gamma predominantly in the cerebellar purkinje cells; and dgk zeta in the cerebellar and cerebral cortices. |
1999-06-28 |
2023-08-12 |
rat |
| L Schmued, W Slikker, P Clausing, J Bowye. d-Fenfluramine produces neuronal degeneration in localized regions of the cortex, thalamus, and cerebellum of the rat. Toxicological sciences : an official journal of the Society of Toxicology. vol 48. issue 1. 1999-06-18. PMID:10330689. |
cerebellar damage occurred primarily in medial purkinje cells and occasionally in granule cells or basket cells. |
1999-06-18 |
2023-08-12 |
rat |
| A E Clatworthy, W Stockinger, R H Christie, W J Schneider, J Nimpf, B T Hyman, G W Rebec. Expression and alternate splicing of apolipoprotein E receptor 2 in brain. Neuroscience. vol 90. issue 3. 1999-06-14. PMID:10218790. |
immunohistochemistry of mouse brain showed that apolipoprotein e receptor 2 was expressed in neurons throughout the brain, with strong expression in pyramidal neurons of the hippocampus, granule cells of the dentate gyrus, cortical neurons and purkinje cells of the cerebellum. |
1999-06-14 |
2023-08-12 |
mouse |
| W Y Ong, C P Lau, S K Leong, U Kumar, S Suresh, S C Pate. Apolipoprotein D gene expression in the rat brain and light and electron microscopic immunocytochemistry of apolipoprotein D expression in the cerebellum of neonatal, immature and adult rats. Neuroscience. vol 90. issue 3. 1999-06-14. PMID:10218791. |
these results reveal a maturation-associated induction of apolipoprotein d gene expression in the rat brain, and expression of apolipoprotein d in glial (immature oligodendrocyte) cells in the immature cerebellum, followed by specific expression of apolipoprotein d in purkinje neurons. |
1999-06-14 |
2023-08-12 |
rat |
| W S Seo, J H Shin, C K Su. 4-Aminopyridine (4-AP) augments Ca(2+)-dependent action potential and changes oscillatory firing patterns in rat cerebellar Purkinje cells. Yonsei medical journal. vol 40. issue 2. 1999-06-14. PMID:10333713. |
intracellular recordings in cerebellar slice preparation showed that applications of 4-ap altered the pattern of oscillatory firing activity in purkinje cells (pcs), especially yielding pronounced changes in action potential shape. |
1999-06-14 |
2023-08-12 |
rat |
| J C Strahlendorf, H K Strahlendor. Enduring changes in Purkinje cell electrophysiology following transient exposure to AMPA: correlates to dark cell degeneration. Neuroscience research. vol 33. issue 2. 1999-06-07. PMID:10211781. |
the whole-cell configuration of the patch clamp technique was used to record spontaneous electrical activity and ionic currents of purkinje neurons from cerebellar slices using an experimental paradigm known to produce dcd in response to ampa. |
1999-06-07 |
2023-08-12 |
Not clear |
| X Y Lu, M B Ghasemzadeh, P W Kaliva. Regional distribution and cellular localization of gamma-aminobutyric acid subtype 1 receptor mRNA in the rat brain. The Journal of comparative neurology. vol 407. issue 2. 1999-06-07. PMID:10213089. |
areas where the majority of neurons expressed a high density of mrna included the medial habenula; the septohippocampal, periventricular, suprachiasmatic, and supraoptic nuclei; purkinje cells in the cerebellum; and pyramidal and granule cells of the hippocampus and dentate gyrus, respectively. |
1999-06-07 |
2023-08-12 |
rat |
| U Wüllner, M Weller, J B Schulz, S Krajewski, J C Reed, T Klockgethe. Bcl-2, Bax and Bcl-x expression in neuronal apoptosis: a study of mutant weaver and lurcher mice. Acta neuropathologica. vol 96. issue 3. 1999-06-02. PMID:9754955. |
lurcher purkinje cells and weaver germinal (granule neuron progenitor) cells both die via apoptosis during the postnatal cerebellar development. |
1999-06-02 |
2023-08-12 |
mouse |
| R Drake-Baumann, F J Sei. Influence of functional glia on the electrophysiology of Purkinje cells in organotypic cerebellar cultures. Neuroscience. vol 88. issue 2. 1999-06-01. PMID:10197771. |
influence of functional glia on the electrophysiology of purkinje cells in organotypic cerebellar cultures. |
1999-06-01 |
2023-08-12 |
Not clear |
| D Woodbury, D G Schaar, L Ramakrishnan, I B Blac. Novel structure of the human GDNF gene. Brain research. vol 803. issue 1-2. 1999-05-26. PMID:9729303. |
glial cell line-derived neurotrophic factor (gdnf) is the most potent known survival factor for substantia nigra neurons, which degenerate in parkinson's disease, for spinal motoneurons, which die in lou gehrig's disease (als), and for purkinje neurons, the critical outflow cells of the cerebellum. |
1999-05-26 |
2023-08-12 |
human |
| E Vaudano, G Campbell, S P Hunt, A R Lieberma. Axonal injury and peripheral nerve grafting in the thalamus and cerebellum of the adult rat: upregulation of c-jun and correlation with regenerative potential. The European journal of neuroscience. vol 10. issue 8. 1999-05-26. PMID:9767394. |
by comparison, injured purkinje cells of the cerebellum which do not regenerate their axons along a graft, do not upregulate either c-jun or gap-43, although they increase their expression of p75. |
1999-05-26 |
2023-08-12 |
rat |
| F Mahmood, M D King, O P Smyth, M A Farrel. Familial cerebellar hypoplasia and pancytopenia without chromosomal breakages. Neuropediatrics. vol 29. issue 6. 1999-05-24. PMID:10029349. |
one sibling died from sepsis and the cerebellum demonstrated reduced cellularity of the molecular and granular layers with relative preservation of purkinje cells and minimal gliosis. |
1999-05-24 |
2023-08-12 |
Not clear |
| T J Gould, K Chadman, P C Bickfor. Antioxidant protection of cerebellar beta-adrenergic receptor function in aged F344 rats. Neuroscience letters. vol 250. issue 3. 1999-05-19. PMID:9708858. |
cerebellar beta-adrenergic receptor function was assessed using extracellular recordings of purkinje cells during iontophoresis of gaba and isoproterenol (iso). |
1999-05-19 |
2023-08-12 |
rat |
| D G Walker, P L McGee. Vitronectin expression in Purkinje cells in the human cerebellum. Neuroscience letters. vol 251. issue 2. 1999-05-19. PMID:9718986. |
vitronectin expression in purkinje cells in the human cerebellum. |
1999-05-19 |
2023-08-12 |
human |
| M Miyata, D Okada, K Hashimoto, M Kano, M It. Corticotropin-releasing factor plays a permissive role in cerebellar long-term depression. Neuron. vol 22. issue 4. 1999-05-19. PMID:10230796. |
this study of rat cerebellar slices yielded two lines of evidence indicating that the corticotropin-releasing factor (crf) found in climbing fibers (cfs) is critical for the induction of long-term depression (ltd) at the parallel fiber (pf) synapses of purkinje cells (pcs) by their conjunctive activation with either stimulation of cfs or depolarization of pcs. |
1999-05-19 |
2023-08-12 |
rat |
| M Pumarola, D Fondevila, D Borrás, N Majó, I Ferre. Neuronal vacuolation in young Rottweiler dogs. Acta neuropathologica. vol 97. issue 2. 1999-05-18. PMID:9928831. |
neuronal vacuolation, involving the cerebellar roof nuclei, purkinje cells, selected nuclei of the brain stem, thalamus, clarke's column, anterior and posterior horns of the spinal cord, visceral autonomic ganglia and myenteric plexus, as well as axonal degeneration of the white matter of the brain stem, cerebellar pedunculi, dorsolateral columns of the spinal cord and ventral roots of the spinal cord, were observed in two young rottweiler dogs which were clinically afflicted with hind limb weakness progressing to paraparesia, ataxia, intention tremor, and difficulty in swallowing and barking. |
1999-05-18 |
2023-08-12 |
Not clear |
| R Nakamura, K Kurita, T Kawanami, T Kat. An immunohistochemical study of Purkinje cells in a case of hereditary cerebellar cortical atrophy. Acta neuropathologica. vol 97. issue 2. 1999-05-18. PMID:9928832. |
an immunohistochemical study of purkinje cells in a case of hereditary cerebellar cortical atrophy. |
1999-05-18 |
2023-08-12 |
Not clear |