| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Ohmori, H Ogura, M Yasuda, S Nakamura, T Hatta, K Kawano, T Michikawa, K Yamashita, K Mikoshib. Developmental neurotoxicity of phenytoin on granule cells and Purkinje cells in mouse cerebellum. Journal of neurochemistry. vol 72. issue 4. 1999-04-13. PMID:10098854. |
these findings indicate that pht induces neurotoxic damage to granule cells and purkinje cells in the developing cerebellum and impairs selected aspects of motor coordination ability. |
1999-04-13 |
2023-08-12 |
mouse |
| G P Reynolds, C F Dalton, C L Tillery, L Mangiarini, S W Davies, G P Bate. Brain neurotransmitter deficits in mice transgenic for the Huntington's disease mutation. Journal of neurochemistry. vol 72. issue 4. 1999-04-13. PMID:10098889. |
in contrast to the findings in hd, striatal gaba was unaffected, although a deficit was observed in the cerebellum, consistent with a dysfunction of purkinje cells. |
1999-04-13 |
2023-08-12 |
mouse |
| R J Cork, M L Perrone, D Bridges, J Wandell, C A Scheiner, R R Miz. A web-accessible digital atlas of the distribution of nitric oxide synthase in the mouse brain. Progress in brain research. vol 118. 1999-04-07. PMID:9932433. |
other points of interest arising from this project include the apparent lack of nadphd labeling in the ca1 pyramidal cells of the hippocampus or the purkinje neurons in the cerebellum. |
1999-04-07 |
2023-08-12 |
mouse |
| Y Yuan, W D Atchiso. Comparative effects of methylmercury on parallel-fiber and climbing-fiber responses of rat cerebellar slices. The Journal of pharmacology and experimental therapeutics. vol 288. issue 3. 1999-04-01. PMID:10027838. |
in the present study, effects of acute exposure to mehg on synaptic transmission between parallel fibers or climbing fibers and purkinje cells were compared in 300- to 350-microm cerebellar slices by using extracellular and intracellular microelectrode-recording techniques. |
1999-04-01 |
2023-08-12 |
rat |
| K Tanji, T H Vu, E A Schon, S DiMauro, E Bonill. Kearns-Sayre syndrome: unusual pattern of expression of subunits of the respiratory chain in the cerebellar system. Annals of neurology. vol 45. issue 3. 1999-03-29. PMID:10072053. |
we suggest that mitochondrial abnormalities in the dentate nucleus in conjunction with loss of purkinje cells and spongiform degeneration of the cerebellar white matter may be important factors in the genesis of the cerebellar dysfunction in kss. |
1999-03-29 |
2023-08-12 |
Not clear |
| O Warr, M Takahashi, D Attwel. Modulation of extracellular glutamate concentration in rat brain slices by cystine-glutamate exchange. The Journal of physiology. vol 514 ( Pt 3). 1999-03-26. PMID:9882750. |
applying cystine to cerebellar slices generated a membrane current in purkinje cells which was abolished by glutamate receptor blockers. |
1999-03-26 |
2023-08-12 |
rat |
| A P Southan, B Robertso. Modulation of inhibitory post-synaptic currents (IPSCs) in mouse cerebellar Purkinje and basket cells by snake and scorpion toxin K+ channel blockers. British journal of pharmacology. vol 125. issue 6. 1999-03-25. PMID:9863670. |
using an in vitro mouse cerebellar slice preparation and whole-cell electrophysiological recording techniques we have characterized purkinje and basket cell inhibitory post-synaptic currents (ipscs), and examined the effects of a number of selective peptidergic k+ channel blockers. |
1999-03-25 |
2023-08-12 |
mouse |
| M G Nunzi, M Grillo, F L Margolis, E Mugnain. Compartmental organization of Purkinje cells in the mature and developing mouse cerebellum as revealed by an olfactory marker protein-lacZ transgene. The Journal of comparative neurology. vol 404. issue 1. 1999-03-22. PMID:9886028. |
compartmental organization of purkinje cells in the mature and developing mouse cerebellum as revealed by an olfactory marker protein-lacz transgene. |
1999-03-22 |
2023-08-12 |
mouse |
| M G Nunzi, M Grillo, F L Margolis, E Mugnain. Compartmental organization of Purkinje cells in the mature and developing mouse cerebellum as revealed by an olfactory marker protein-lacZ transgene. The Journal of comparative neurology. vol 404. issue 1. 1999-03-22. PMID:9886028. |
in a line of transgenic mice (hpy-1), the pattern of expression of an olfactory marker protein (omp)-lacz fusion gene was analyzed in the cerebellum, where, in adult mice, omp-lacz was expressed primarily in purkinje cells (pcs) of the posterior lobe. |
1999-03-22 |
2023-08-12 |
mouse |
| L C Triarho. Rate of neuronal fallout in a transsynaptic cerebellar model. Brain research bulletin. vol 47. issue 3. 1999-03-18. PMID:9865853. |
quantitative analyses of transsynaptic granule cell death subsequent to the genetically determined degeneration of purkinje cells in the cerebellum of pcd/pcd mutant mice show that granule neuron fallout follows a typical mathematical pattern of elemental decay. |
1999-03-18 |
2023-08-12 |
mouse |
| S Balijepalli, P S Tirumalai, K V Swamy, M R Boyd, J J Mieyal, V Ravindranat. Rat brain thioltransferase: regional distribution, immunological characterization, and localization by fluorescent in situ hybridization. Journal of neurochemistry. vol 72. issue 3. 1999-03-18. PMID:10037490. |
ttase mrna was also present in purkinje cells in the cerebellum, in giant reticular neurons in the midbrain, and in the striatal and thalamic neurons. |
1999-03-18 |
2023-08-12 |
human |
| S Yanagitani, H Miyazaki, Y Nakahashi, K Kuno, Y Ueno, M Matsushita, Y Naitoh, S Taketani, K Inou. Ischemia induces metallothionein III expression in neurons of rat brain. Life sciences. vol 64. issue 8. 1999-03-18. PMID:10069533. |
immunohistochemical analysis revealed that mt-iii in normal brain is localized abundantly in neuronal cell bodies in ca1-3 regions of hippocampus, dentate gyrus, cerebral cortex, olfactory bulb and purkinje cells in cerebellum. |
1999-03-18 |
2023-08-12 |
rat |
| J A Meaney, V J Balcar, J D Rothstein, P L Jeffre. Glutamate transport in cultures from developing avian cerebellum: presence of GLT-1 immunoreactivity in Purkinje neurons. Journal of neuroscience research. vol 54. issue 5. 1999-03-11. PMID:9843150. |
glutamate transport in cultures from developing avian cerebellum: presence of glt-1 immunoreactivity in purkinje neurons. |
1999-03-11 |
2023-08-12 |
human |
| J A Meaney, V J Balcar, J D Rothstein, P L Jeffre. Glutamate transport in cultures from developing avian cerebellum: presence of GLT-1 immunoreactivity in Purkinje neurons. Journal of neuroscience research. vol 54. issue 5. 1999-03-11. PMID:9843150. |
immunocytochemical studies indicated that purkinje cells cultured from chick embryonic cerebellum (embryonic day 8) strongly express a glutamate transporter eaat2 cloned from human brain (glt-1 in rat brain). |
1999-03-11 |
2023-08-12 |
human |
| J C Strahlendorf, T Brandon, R Miles, H K Strahlendor. AMPA receptor-mediated alterations of intracellular calcium homeostasis in rat cerebellar Purkinje cells in vitro: correlates to dark cell degeneration. Neurochemical research. vol 23. issue 11. 1999-03-08. PMID:9814545. |
in the rat cerebellar slice preparation in vitro, excessive dl-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (ampa)-receptor activation elicits a characteristic type of excitotoxicity of purkinje cells (pcs) known as dark cell degeneration (dcd). |
1999-03-08 |
2023-08-12 |
rat |
| E Gallagher, B W Howell, P Soriano, J A Cooper, R Hawke. Cerebellar abnormalities in the disabled (mdab1-1) mouse. The Journal of comparative neurology. vol 402. issue 2. 1999-03-08. PMID:9845246. |
the purkinje cells, identified by anti-zebrin ii in the adult or anti-calbindin in the new born mdab1-1 mutant cerebellum, form a parasagittal banding pattern, similar to but distorted compared with the wild-type design. |
1999-03-08 |
2023-08-12 |
mouse |
| A L Prieto, J L Weber, S Tracy, M J Heeb, C La. Gas6, a ligand for the receptor protein-tyrosine kinase Tyro-3, is widely expressed in the central nervous system. Brain research. vol 816. issue 2. 1999-03-04. PMID:9878891. |
in the cerebellum, it is expressed in purkinje neurons and deep cerebellar nuclei. |
1999-03-04 |
2023-08-12 |
rat |
| Y Etzion, Y Grossma. Spontaneous Na+ and Ca2+ spike firing of cerebellar Purkinje neurons at high pressure. Pflugers Archiv : European journal of physiology. vol 437. issue 2. 1999-03-03. PMID:9929570. |
the effects of high pressure (up to 10.1 mpa) on the spontaneous firing of purkinje neurons in guinea-pig cerebellar slices were studied using the macropatch clamp technique. |
1999-03-03 |
2023-08-12 |
Not clear |
| E Kowalska, T Marcinkowsk. The amount of DNA in cells of the granular layer of the cerebellum and their susceptibility to hypoxia. Medical hypotheses. vol 51. issue 5. 1999-03-02. PMID:9848476. |
purkinje cells of the cerebellum are particularly susceptible to hypoxia. |
1999-03-02 |
2023-08-12 |
Not clear |
| M Hamamura, H Ozawa, Y Kimuro, J Okouchi, K Higasa, A Iwaki, Y Fukumak. Differential decreases in c-fos and aldolase C mRNA expression in the rat cerebellum after repeated administration of methamphetamine. Brain research. Molecular brain research. vol 64. issue 1. 1999-03-02. PMID:9889345. |
therefore, differential decreases in c-fos mrna and aldolase c mrna expression after repeated methamphetamine administration depend upon the localization of purkinje cells in the cerebellum. |
1999-03-02 |
2023-08-12 |
rat |