| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M D Mauk, N H Donega. A model of Pavlovian eyelid conditioning based on the synaptic organization of the cerebellum. Learning & memory (Cold Spring Harbor, N.Y.). vol 4. issue 1. 1999-09-15. PMID:10456059. |
the theory is based on four primary hypotheses: (1) two cerebellar sites of plasticity are involved in conditioning: (a) bidirectional long-term depression/potentiation at granule cell synapses onto purkinje cells (gr-->pkj) in the cerebellar cortex and (b) bidirectional plasticity in the interpositus nucleus that is controlled by inhibitory inputs from purkinje cells; (2) climbing fiber activity is regulated to an equilibrium level at which the net strength of gr-->pkj synapses remains constant unless an unexpected unconditioned stimulus (us) is presented or an expected us is omitted; (3) a time-varying representation of the conditioned stimulus (cs) in the cerebellar cortex permits the temporal discrimination required for conditioned response timing; and (4) the ability of a particular segment of the cs to be represented consistently across trials varies as a function of time since cs onset. |
1999-09-15 |
2023-08-12 |
Not clear |
| V Lev-Ram, Z Nebyelul, M H Ellisman, P L Huang, R Y Tsie. Absence of cerebellar long-term depression in mice lacking neuronal nitric oxide synthase. Learning & memory (Cold Spring Harbor, N.Y.). vol 4. issue 1. 1999-09-15. PMID:10456061. |
extensive pharmacological evidence suggests that nitric oxide (no) is a crucial transmitter for cerebellar long-term depression (ltd), a long-lasting decrease in efficacy of the synapses from parallel fibers onto purkinje neurons, triggered by coincident presynaptic activity and postsynaptic depolarization. |
1999-09-15 |
2023-08-12 |
mouse |
| V Lev-Ram, Z Nebyelul, M H Ellisman, P L Huang, R Y Tsie. Absence of cerebellar long-term depression in mice lacking neuronal nitric oxide synthase. Learning & memory (Cold Spring Harbor, N.Y.). vol 4. issue 1. 1999-09-15. PMID:10456061. |
we now show that ltd cannot be induced in purkinje neurons under whole-cell patch clamp in cerebellar slices from young adult mice genetically lacking neuronal nitric oxide synthase (nnos). |
1999-09-15 |
2023-08-12 |
mouse |
| Y Ando, N Ichihara, S Takeshita, M Nagata, T Kimura, H Tanase, T Kikuch. A new neurological mutant rat with symmetrical calcification of Purkinje cells in cerebellum. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 221. issue 4. 1999-09-10. PMID:10460698. |
a new neurological mutant rat with symmetrical calcification of purkinje cells in cerebellum. |
1999-09-10 |
2023-08-12 |
rat |
| H Tashiro, S O Suzuki, T Hitotsumatsu, T Iwak. An autopsy case of spinocerebellar ataxia type 6 with mental symptoms of schizophrenia and dementia. Clinical neuropathology. vol 18. issue 4. 1999-09-09. PMID:10442462. |
the number of purkinje cells in our case had decreased severely in comparison to that in either opca or age-matched control cases, and the purkinje cells in the cerebellar hemisphere were more affected than those in the cerebellar vermis. |
1999-09-09 |
2023-08-12 |
Not clear |
| J M Powers, T P Kenjarski, A B Moser, H W Mose. Cerebellar atrophy in chronic rhizomelic chondrodysplasia punctata: a potential role for phytanic acid and calcium in the death of its Purkinje cells. Acta neuropathologica. vol 98. issue 2. 1999-09-09. PMID:10442551. |
cerebellar atrophy in chronic rhizomelic chondrodysplasia punctata: a potential role for phytanic acid and calcium in the death of its purkinje cells. |
1999-09-09 |
2023-08-12 |
Not clear |
| J M Powers, T P Kenjarski, A B Moser, H W Mose. Cerebellar atrophy in chronic rhizomelic chondrodysplasia punctata: a potential role for phytanic acid and calcium in the death of its Purkinje cells. Acta neuropathologica. vol 98. issue 2. 1999-09-09. PMID:10442551. |
cerebellar atrophy, consequent to the postdevelopmental degeneration and loss of purkinje cells and granular neurons, has been identified in three patients with rhizomelic chondrodysplasia punctata (rcdp). |
1999-09-09 |
2023-08-12 |
Not clear |
| H Grabsch, A Pereverzev, M Weiergräber, M Schramm, M Henry, R Vajna, R E Beattie, S G Volsen, U Klöckner, J Hescheler, T Schneide. Immunohistochemical detection of alpha1E voltage-gated Ca(2+) channel isoforms in cerebellum, INS-1 cells, and neuroendocrine cells of the digestive system. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 47. issue 8. 1999-09-08. PMID:10424882. |
similarily, in rat cerebellum, which was used as a reference system, the anti-e-spec serum stained somata and dendrites of purkinje cells. |
1999-09-08 |
2023-08-12 |
human |
| S Bischoff, S Leonhard, N Reymann, V Schuler, R Shigemoto, K Kaupmann, B Bettle. Spatial distribution of GABA(B)R1 receptor mRNA and binding sites in the rat brain. The Journal of comparative neurology. vol 412. issue 1. 1999-09-01. PMID:10440706. |
a typical example is the cerebellum with an almost exclusive expression of r1b in the purkinje cells and of r1a in the granule, stellate, and basket cells. |
1999-09-01 |
2023-08-12 |
human |
| D J Sammin, D Butler, G J Atkins, B J Sheaha. Cell death mechanisms in the olfactory bulb of rats infected intranasally with Semliki forest virus. Neuropathology and applied neurobiology. vol 25. issue 3. 1999-08-26. PMID:10417665. |
bcl-2 staining was similar in infected and control rats and was most intense in randomly distributed purkinje cells in the cerebellum; neurons in the olfactory bulbs were unstained. |
1999-08-26 |
2023-08-12 |
mouse |
| K K de Balogh, A P Dimande, J J van der Lugt, R J Molyneux, T W Naudé, W G Welma. A lysosomal storage disease induced by Ipomoea carnea in goats in Mozambique. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. vol 11. issue 3. 1999-08-24. PMID:10353359. |
residual alterations in the brain in chronic cases revealed predominantly cerebellar lesions characterized by loss of purkinje neurons and gliosis of the purkinje cell layer. |
1999-08-24 |
2023-08-12 |
Not clear |
| J M Sluck, R C Lin, L I Katolik, A Y Jeng, J C Lehman. Endothelin converting enzyme-1-, endothelin-1-, and endothelin-3-like immunoreactivity in the rat brain. Neuroscience. vol 91. issue 4. 1999-08-24. PMID:10391453. |
in the cerebellum, purkinje cells were stained. |
1999-08-24 |
2023-08-12 |
rat |
| J G Netzeband, C Trotter, J N Caguioa, D L Gruo. Chronic ethanol exposure enhances AMPA-elicited Ca2+ signals in the somatic and dendritic regions of cerebellar Purkinje neurons. Neurochemistry international. vol 35. issue 2. 1999-08-24. PMID:10406000. |
intracellular ca2+ signals produced by the glutamate receptor agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (ampa; 5 microm) were measured in the somatic and dendritic regions of cerebellar purkinje neurons in mature cerebellar control cultures (> or = 20 days in vitro) and cultures chronically treated with 32 mm ethanol (146 mg%; 8-11 days). |
1999-08-24 |
2023-08-12 |
Not clear |
| G Schmid, R Chittolini, L Raiteri, G Bonann. Differential effects of zinc on native GABA(A) receptor function in rat hippocampus and cerebellum. Neurochemistry international. vol 34. issue 5. 1999-08-19. PMID:10397368. |
changes in sensitivity to zn2+ inhibition consequent to mutations in cerebellar granule cell gaba(a) receptor subunits may lead to changes in glutamate release from parallel fibers onto purkinje cells and may play important roles in cerebellar dysfunctions. |
1999-08-19 |
2023-08-12 |
rat |
| J C Lin, C L Cepk. Biphasic dispersion of clones containing Purkinje cells and glia in the developing chick cerebellum. Developmental biology. vol 211. issue 2. 1999-08-18. PMID:10395781. |
biphasic dispersion of clones containing purkinje cells and glia in the developing chick cerebellum. |
1999-08-18 |
2023-08-12 |
chicken |
| A Pisani, W N Ros. Weak effect of neuromodulators on climbing fiber-activated [Ca(2+)](i) increases in rat cerebellar Purkinje neurons. Brain research. vol 831. issue 1-2. 1999-08-18. PMID:10411989. |
the effect of several neuromodulators (carbachol (cch), serotonin (5-ht), noradrenaline (ne), and dopamine (da)) on the climbing fiber (cf)-induced [ca(2+)](i) increase in the dendrites of cerebellar purkinje cells was examined in slices from the rat cerebellum. |
1999-08-18 |
2023-08-12 |
rat |
| C M Anderson, W Xiong, J D Geiger, J D Young, C E Cass, S A Baldwin, F E Parkinso. Distribution of equilibrative, nitrobenzylthioinosine-sensitive nucleoside transporters (ENT1) in brain. Journal of neurochemistry. vol 73. issue 2. 1999-08-13. PMID:10428086. |
35s-labeled sense and antisense riboprobes, transcribed from a 153-bp segment of rent1, were hybridized to fresh frozen coronal sections from adult rat brain and revealed widespread rent1 mrna in pyramidal neurons of the hippocampus, granule neurons of the dentate gyrus, purkinje and granule neurons of the cerebellum, and cortical and striatal neurons. |
1999-08-13 |
2023-08-12 |
human |
| U Grüsser-Cornehls, C Grüsser, J Bäurl. Vermectomy enhances parvalbumin expression and improves motor performance in weaver mutant mice: an animal model for cerebellar ataxia. Neuroscience. vol 91. issue 1. 1999-08-02. PMID:10336081. |
in purkinje cell degeneration mice (pcd/pcd) lacking nearly all purkinje cells and displaying milder motor deficiencies than wv, in comparison to wild-type mice, a strong increase in parvalbumin- and (co-localized with parvalbumin) glycine-immunopositive somata in the deep cerebellar and vestibular nuclei has recently been found. |
1999-08-02 |
2023-08-12 |
mouse |
| I J Rhyu, S Oda, C S Uhm, H Kim, Y S Suh, L C Abbot. Morphologic investigation of rolling mouse Nagoya (tg(rol)/tg(rol)) cerebellar Purkinje cells: an ataxic mutant, revisited. Neuroscience letters. vol 266. issue 1. 1999-08-02. PMID:10336181. |
no specific light and electron microscopic findings have been reported for the rolling mouse cerebellum except a decreased number of granule cells, while altered purkinje cell/parallel fiber synapses have been observed in tottering and leaner cerebella. |
1999-08-02 |
2023-08-12 |
mouse |
| K Sawada, S Komatsu, H Haga, X Z Sun, S Hisano, Y Fuku. Abnormal expression of tyrosine hydroxylase immunoreactivity in cerebellar cortex of ataxic mutant mice. Brain research. vol 829. issue 1-2. 1999-08-02. PMID:10350535. |
in adult rmn, th-positive purkinje cells were found in all lobules of the cerebellum. |
1999-08-02 |
2023-08-12 |
mouse |