| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Takahashi, N Miyamoto, T Oki, N Kajiwara, K Furuya, K Yanai Taniguchi, K Yagami, T Niidome, I Tanaka, K Katayam. Neuron-specific expression of reporter gene in transgenic mice carrying the 5'-upstream region of mouse P/Q-type Ca2+ channel alpha 1A subunit gene fused to E. coli lacZ reporter gene. Brain research. vol 850. issue 1-2. 2000-02-03. PMID:10629747. |
in the cerebellum, the expression of the reporter gene was induced by the 3.0-kb region in granule cells, whereas it was induced by the 6.3-kb region in purkinje cells. |
2000-02-03 |
2023-08-12 |
mouse |
| E K Kwack, D J Kim, T I Park, K R Cho, I H Kwon, Y K Soh. Neural toxicity induced by accidental intrathecal vincristine administration. Journal of Korean medical science. vol 14. issue 6. 2000-02-03. PMID:10642952. |
the upstream portion of the spinal cord (brain stem, cerebellum, cerebrum) showed patchy loss of neurons, especially purkinje cells and granular cells of the cerebellar cortex. |
2000-02-03 |
2023-08-12 |
Not clear |
| S Aono, H Keino, T Ono, Y Yasuda, Y Tokita, F Matsui, M Taniguchi, S Sonta, A Oohir. Genomic organization and expression pattern of mouse neuroglycan C in the cerebellar development. The Journal of biological chemistry. vol 275. issue 1. 2000-01-31. PMID:10617623. |
immunohistochemical studies showed that only the purkinje cells were immunopositive in the cerebellum. |
2000-01-31 |
2023-08-12 |
mouse |
| T Tomoda, R S Bhatt, H Kuroyanagi, T Shirasawa, M E Hatte. A mouse serine/threonine kinase homologous to C. elegans UNC51 functions in parallel fiber formation of cerebellar granule neurons. Neuron. vol 24. issue 4. 2000-01-27. PMID:10624947. |
the formation of the cerebellar circuitry depends on the outgrowth of connections between the two principal classes of neurons, granule neurons and purkinje neurons. |
2000-01-27 |
2023-08-12 |
mouse |
| K Ishihara, M Sas. [The function of sigma receptors--electrophysiological approach]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 114. issue 1. 2000-01-21. PMID:10562967. |
in the cerebellum, however, activities of purkinje cells were suppressed by locally applied dtg, with probable involvement of the catecholaminergic system. |
2000-01-21 |
2023-08-12 |
Not clear |
| D B Campbell, J B North, E J Hes. Tottering mouse motor dysfunction is abolished on the Purkinje cell degeneration (pcd) mutant background. Experimental neurology. vol 160. issue 1. 2000-01-21. PMID:10630211. |
these dystonic episodes induce c-fos mrna expression in the cerebellar circuitry, including cerebellar granule and purkinje neurons, deep cerebellar nuclei, and the postsynaptic targets of the deep nuclei. |
2000-01-21 |
2023-08-12 |
mouse |
| G A Bishop, J S Kin. Corticotropin releasing factor in the embryonic mouse cerebellum. Experimental neurology. vol 160. issue 2. 2000-01-14. PMID:10619566. |
in conclusion, crf-positive punctate elements derived from an as yet unknown source are present in the embryonic cerebellum just prior to and during the birth of purkinje cells and nuclear neurons. |
2000-01-14 |
2023-08-12 |
mouse |
| L J Martin, F E Sieber, R J Traystma. Apoptosis and necrosis occur in separate neuronal populations in hippocampus and cerebellum after ischemia and are associated with differential alterations in metabotropic glutamate receptor signaling pathways. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 20. issue 1. 2000-01-13. PMID:10616804. |
it was concluded that neuronal death after global ischemia exists as two distinct, temporally overlapping forms in hippocampus and cerebellum: necrosis of pyramidal neurons and purkinje cells and apoptosis of granule neurons. |
2000-01-13 |
2023-08-12 |
dog |
| M R Smith, A L Goldi. A mutation that causes ataxia shifts the voltage-dependence of the Scn8a sodium channel. Neuroreport. vol 10. issue 14. 2000-01-04. PMID:10549817. |
the shift in the voltage dependence of activation observed for the mutant channel would reduce the spontaneous activity of purkinje cells and lead to a decrease in output from the cerebellum, which is consistent with the phenotype of cerebellar ataxia observed in med(jo) mice. |
2000-01-04 |
2023-08-12 |
mouse |
| D H Rowitch, A Kispert, A P McMaho. Pax-2 regulatory sequences that direct transgene expression in the developing neural plate and external granule cell layer of the cerebellum. Brain research. Developmental brain research. vol 117. issue 1. 1999-12-28. PMID:10536237. |
in the fetal and neonatal brain, pax-2-lacz activity was confined largely to purkinje cells and the external granule cell layer (egl) of the cerebellum. |
1999-12-28 |
2023-08-12 |
mouse |
| P Rivas-Manzano, C Pa. Cerebellar morphological alterations in rats induced by prenatal ozone exposure. Neuroscience letters. vol 276. issue 1. 1999-12-23. PMID:10586969. |
ozone exposed rats showed cerebellar necrotic signs at age 0, diminished area of the molecular layer with purkinje cells with pale nucleoli and perinucleolar bodies at age 12, and purkinje cells showing nuclei with unusual clumps of chromatin in the periphery at age 60. |
1999-12-23 |
2023-08-12 |
rat |
| Y Tendler, G Weisinger, R Coleman, E Diamond, S Lischinsky, H Kerner, V Rotter, O Zinde. Tissue-specific p53 expression in the nervous system. Brain research. Molecular brain research. vol 72. issue 1. 1999-12-22. PMID:10521597. |
significantly, p53 promoter-driven cat expression was visualized in the ammon horn of the hippocampus, in the purkinje cells of the cerebellum and in the cornea as well as in the retina of the eye. |
1999-12-22 |
2023-08-12 |
mouse |
| G Thomadakis, L N Ramoshebi, J Crooks, D C Rueger, U Ripamont. Immunolocalization of Bone Morphogenetic Protein-2 and -3 and Osteogenic Protein-1 during murine tooth root morphogenesis and in other craniofacial structures. European journal of oral sciences. vol 107. issue 5. 1999-12-20. PMID:10515202. |
bmp-3 was also localized in ducts of submandibular and sublingual salivary glands, acini of the lacrimal gland, purkinje cells in the cerebellum, nerve fibres of the cerebellum and brain, afferent cells of the dorsal root ganglia, inferior alveolar nerve, and peripheral processes of the vestibulocochlear nerve. |
1999-12-20 |
2023-08-12 |
mouse |
| T Kitama, T Omata, A Mizukoshi, T Ueno, Y Sat. Motor dynamics encoding in cat cerebellar flocculus middle zone during optokinetic eye movements. Journal of neurophysiology. vol 82. issue 5. 1999-12-17. PMID:10561402. |
we investigated the relationship between eye movement and simple-spike (ss) frequency of purkinje cells in the cerebellar flocculus middle zone during the optokinetic response (okr) in alert cats. |
1999-12-17 |
2023-08-12 |
cat |
| T C Nag, S Wadhw. Calbindin immunoreactivity in the developing and adult human cerebellum. Journal of chemical neuroanatomy. vol 17. issue 1. 1999-12-15. PMID:10569235. |
calb immunoreactivity was present in granule and purkinje cells throughout the cerebellum. |
1999-12-15 |
2023-08-12 |
human |
| T C Nag, S Wadhw. Calbindin immunoreactivity in the developing and adult human cerebellum. Journal of chemical neuroanatomy. vol 17. issue 1. 1999-12-15. PMID:10569235. |
in the adult cerebellum, purkinje cells were moderately immunopositive while granule cells were faintly stained; no other cells, including those of the deep nuclei were stained. |
1999-12-15 |
2023-08-12 |
human |
| W Darmanto, M Inouye, S Hayasaka, Y Takagishi, M Ogawa, K Mikoshiba, Y Murat. Disturbed Purkinje cell migration due to reduced expression of Reelin by X-irradiation in developing rat cerebellum. Uchu Seibutsu Kagaku. vol 12. issue 3. 1999-12-12. PMID:11542484. |
when rat fetuses are exposed to x-radiation in the last gestation period, abnormal foliation of the cerebellum develops with ectopic purkinje cells. |
1999-12-12 |
2023-08-12 |
rat |
| W Darmanto, M Inouye, S Hayasaka, Y Takagishi, M Ogawa, K Mikoshiba, Y Murat. Disturbed Purkinje cell migration due to reduced expression of Reelin by X-irradiation in developing rat cerebellum. Uchu Seibutsu Kagaku. vol 12. issue 3. 1999-12-12. PMID:11542484. |
the molecular mechanism that contributes to abnormal migration of purkinje cells and foliar malformation induced by x-irradiation in the cerebellum are not yet clear. |
1999-12-12 |
2023-08-12 |
rat |
| R E McAlhany, R C Miranda, R H Finnell, J R Wes. Ethanol decreases Glial-Derived Neurotrophic Factor (GDNF) protein release but not mRNA expression and increases GDNF-stimulated Shc phosphorylation in the developing cerebellum. Alcoholism, clinical and experimental research. vol 23. issue 10. 1999-11-30. PMID:10550003. |
although differentiating purkinje cells of the cerebellum are particularly vulnerable to ethanol exposure, the mechanisms underlying ethanol-induced purkinje cell loss have not been well defined. |
1999-11-30 |
2023-08-12 |
Not clear |
| E Traiffort, D Charytoniuk, L Watroba, H Faure, N Sales, M Rua. Discrete localizations of hedgehog signalling components in the developing and adult rat nervous system. The European journal of neuroscience. vol 11. issue 9. 1999-11-24. PMID:10510184. |
in the adult, shh-positive cells were mainly observed in forebrain structures, in the purkinje cells of the cerebellum and in motor neurons. |
1999-11-24 |
2023-08-12 |
rat |