| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takako Gotohda, Itsuo Tokunaga, Shin-ichi Kubo, Osamu Kitamura, Akiko Ishigam. Toluene inhalation induces glial cell line-derived neurotrophic factor, transforming growth factor and tumor necrosis factor in rat cerebellum. Legal medicine (Tokyo, Japan). vol 4. issue 1. 2003-12-05. PMID:12935687. |
in the cerebellum, tnf-alpha was induced only in the granule cells, while gdnf expression was enhanced in the purkinje cells. |
2003-12-05 |
2023-08-12 |
rat |
| Takako Gotohda, Itsuo Tokunaga, Shin-ichi Kubo, Osamu Kitamura, Akiko Ishigam. Toluene inhalation induces glial cell line-derived neurotrophic factor, transforming growth factor and tumor necrosis factor in rat cerebellum. Legal medicine (Tokyo, Japan). vol 4. issue 1. 2003-12-05. PMID:12935687. |
these data suggest that toluene induces astrocyte activation through tgf-beta1 upregulation, which then induces gdnf in the purkinje cells and tnf-alpha in the granule cells of the cerebellum. |
2003-12-05 |
2023-08-12 |
rat |
| Wei-Jung A Chen, Russell B Edward. Prenatal nicotine exposure does not cause Purkinje cell loss in the developing rat cerebellar vermis. Neurotoxicology and teratology. vol 25. issue 5. 2003-12-05. PMID:12972077. |
one pup from each litter was sacrificed on postnatal day (pd) 10 and the cerebellar vermis was processed for stereological cell counting of purkinje cells. |
2003-12-05 |
2023-08-12 |
rat |
| Osamu Saitoh, Megumi Odagir. RGS8 expression in developing cerebellar Purkinje cells. Biochemical and biophysical research communications. vol 309. issue 4. 2003-12-04. PMID:13679049. |
rgs8 belongs to b/r4 subfamily of rgs proteins and is specifically expressed in purkinje cells of adult cerebellum. |
2003-12-04 |
2023-08-12 |
Not clear |
| Robert Feil, Jana Hartmann, Chongde Luo, Wiebke Wolfsgruber, Karl Schilling, Susanne Feil, Jaroslaw J Barski, Michael Meyer, Arthur Konnerth, Chris I De Zeeuw, Franz Hofman. Impairment of LTD and cerebellar learning by Purkinje cell-specific ablation of cGMP-dependent protein kinase I. The Journal of cell biology. vol 163. issue 2. 2003-12-03. PMID:14568994. |
impairment of ltd and cerebellar learning by purkinje cell-specific ablation of cgmp-dependent protein kinase i. |
2003-12-03 |
2023-08-12 |
mouse |
| Nathalie Griffon, Freddy Jeanneteau, Fanny Prieur, Jorge Diaz, Pierre Sokolof. CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors. Brain research. Molecular brain research. vol 117. issue 1. 2003-12-01. PMID:14499480. |
in adult rat brain, clic6 mrna expression was restricted to the choroid plexus, the striatal proliferative subventricular zone and the cerebellum where it is co-expressed with the d(3)r in the purkinje cells of the lobules ix and x. clic6 mrna was also detected in the pituitary in the posterior lobe and in cells co-expressing the d(2)r at the border between the intermediate and anterior lobes. |
2003-12-01 |
2023-08-12 |
human |
| Toshiko Nagashima, Yasuyuki Mizutani, Hiromasa Kawahara, Shiro Maguchi, Yoshihiko Terayama, Toshiya Shinohara, Yasuko Orba, Takayo Chuma, Yukio Mano, Tomoo Itoh, Hirofumi Sawa, Koichiro Sakai, Masakatsu Motomura, Kazuo Nagashim. Anti-Hu paraneoplastic syndrome presenting with brainstem-cerebellar symptoms and Lambert-Eaton myasthenic syndrome. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 23. issue 3. 2003-11-28. PMID:14570293. |
in the cerebellum, there was a slight loss of purkinje cells with torpedo formation but without apparent lymphocytic infiltration. |
2003-11-28 |
2023-08-12 |
Not clear |
| Hesham S Elsabbagh, Said Z Moussa, Osama S El-tawi. Neurotoxicologic sequelae of tributyltin intoxication in rats. Pharmacological research. vol 45. issue 3. 2003-11-25. PMID:11884216. |
histopathological changes in brain included hyperaemia, focal haemorrhages in vacuolated myelinated fibres, chromatolysis, or complete necrosis of neurons, degenerative changes, or complete absence of purkinje cells in the cerebellum. |
2003-11-25 |
2023-08-12 |
rat |
| Michael B Porter, Robert J MacKay, Elizabeth Uhl, Simon R Platt, Alexander de Lahunt. Neurologic disease putatively associated with ingestion of Solanum viarum in goats. Journal of the American Veterinary Medical Association. vol 223. issue 4. 2003-11-24. PMID:12930090. |
histologic examination of cerebellar tissues revealed extensive vacuolation within the cytoplasm of purkinje cells. |
2003-11-24 |
2023-08-12 |
cattle |
| Tiziana Sacco, Alessandro Bruno, Enzo Wanke, Filippo Tempi. Functional roles of an ERG current isolated in cerebellar Purkinje neurons. Journal of neurophysiology. vol 90. issue 3. 2003-11-19. PMID:12750425. |
by patch-clamp whole cell recording from purkinje neurons in slices of young (5-9 days old) mouse cerebellum we have been able to isolate a tail current [ik(erg)] with the same characteristics as previously described for erg channels. |
2003-11-19 |
2023-08-12 |
mouse |
| Shogo Endo, Thomas Laune. Nitric oxide activates extracellular signal-regulated kinase 1/2 and enhances declustering of ionotropic glutamate receptor subunit 2/3 in rat cerebellar Purkinje cells. Neuroscience letters. vol 350. issue 2. 2003-11-06. PMID:12972168. |
to address the physiological role of no-induced erk activation in purkinje cells, we examined the effects of no and 8-bromoadenosine 3', 5'-cyclic monophosphate (8-br-cgmp) on pkc-dependent receptor declustering, which underlies cerebellar long-term depression. |
2003-11-06 |
2023-08-12 |
rat |
| Frederique Zindy, Lisa M Nilsson, Luc Nguyen, Cecile Meunier, Richard J Smeyne, Jerold E Rehg, Charles Eberhart, Charles J Sherr, Martine F Rousse. Hemangiosarcomas, medulloblastomas, and other tumors in Ink4c/p53-null mice. Cancer research. vol 63. issue 17. 2003-11-06. PMID:14500377. |
in situ hybridization revealed that, in newborn mice, ink4c is detected in the pia mater and in an adjacent layer of rapidly dividing cells within the cerebellar external granule layer (egl), whereas ink4d is primarily expressed in purkinje neurons. |
2003-11-06 |
2023-08-12 |
mouse |
| Frederique Zindy, Lisa M Nilsson, Luc Nguyen, Cecile Meunier, Richard J Smeyne, Jerold E Rehg, Charles Eberhart, Charles J Sherr, Martine F Rousse. Hemangiosarcomas, medulloblastomas, and other tumors in Ink4c/p53-null mice. Cancer research. vol 63. issue 17. 2003-11-06. PMID:14500377. |
because the pia mater and purkinje cells sandwich the cerebellar egl from which medulloblastomas are presumed to arise, ink4 proteins might function in a cell-autonomous manner in governing neuronal cell cycle exit as well as in a non-cell-autonomous manner in controlling the production of diffusible mitogens and chemokines that influence postnatal development of the cerebellar egl. |
2003-11-06 |
2023-08-12 |
mouse |
| Kamel Khalili, Luis Del Valle, Vandhana Muralidharan, William J Gault, Nune Darbinian, Jessica Otte, Ellen Meier, Edward M Johnson, Dianne C Daniel, Yayoi Kinoshita, Shohreh Amini, Jennifer Gordo. Puralpha is essential for postnatal brain development and developmentally coupled cellular proliferation as revealed by genetic inactivation in the mouse. Molecular and cellular biology. vol 23. issue 19. 2003-11-04. PMID:12972605. |
at postnatal day 5, a critical time for cerebellar development, puralpha and cdk5 were both at peak levels in bodies and dendrites of purkinje cells of pura(+/+) mice, but both were absent in dendrites of pura(-/-) mice. |
2003-11-04 |
2023-08-12 |
mouse |
| Jeremy R Edgerton, Peter H Reinhar. Distinct contributions of small and large conductance Ca2+-activated K+ channels to rat Purkinje neuron function. The Journal of physiology. vol 548. issue Pt 1. 2003-10-30. PMID:12576503. |
in every case, information flowing through the cerebellum passes through purkinje neurons, which receive input from the two primary cerebellar afferents and generate continuous streams of action potentials that constitute the sole output from the cerebellar cortex to the deep nuclei. |
2003-10-30 |
2023-08-12 |
rat |
| Jeremy R Edgerton, Peter H Reinhar. Distinct contributions of small and large conductance Ca2+-activated K+ channels to rat Purkinje neuron function. The Journal of physiology. vol 548. issue Pt 1. 2003-10-30. PMID:12576503. |
in order to better understand the ionic mechanisms that control the behaviour of these neurons, we investigated the effects of different ca2+ channel and kca channel antagonists on purkinje neurons in acute slices of rat cerebellum. |
2003-10-30 |
2023-08-12 |
rat |
| Erin C Jacobs, Ernesto R Bongarzone, Celia W Campagnoni, Kathy Kampf, Anthony T Campagnon. Soma-restricted products of the myelin proteolipid gene are expressed primarily in neurons in the developing mouse nervous system. Developmental neuroscience. vol 25. issue 2-4. 2003-10-30. PMID:12966208. |
robust staining persisted in many neuronal populations including nuclei in the hindbrain, purkinje and granule neurons in the cerebellum, pyramidal cells in the cortex and mitral cells in the olfactory bulb. |
2003-10-30 |
2023-08-12 |
mouse |
| Hirotaka Sakamoto, Yukio Mezaki, Hanako Shikimi, Kazuyoshi Ukena, Kazuyoshi Tsutsu. Dendritic growth and spine formation in response to estrogen in the developing Purkinje cell. Endocrinology. vol 144. issue 10. 2003-10-29. PMID:12960093. |
estradiol as well as progesterone may contribute to the growth of purkinje cells during the cerebellar cortical formation. |
2003-10-29 |
2023-08-12 |
rat |
| M Sh Avrushchenko, I V Samorukova, V V Moroz, A V Volkov, I V Nazarenko, N A Gorenkov. [Development of postresuscitation morphological changes of hippocampal and cerebellar neurons: common regularities and specific features]. Patologicheskaia fiziologiia i eksperimental'naia terapiia. issue 2. 2003-10-17. PMID:12838772. |
a comparative morphometric study of postresuscitation changes in the neuronal populations of the pyramidal cells from hyppocampal sector ca1 and purkinje cells of the lateral cerebellar region in the course of postresuscitation period after 12-minute cardiac arrest in rats has shown that the changes differ in severity and pattern. |
2003-10-17 |
2023-08-12 |
rat |
| John Speciale, Alexander de Lahunt. Cerebellar degeneration in a mature Staffordshire terrier. Journal of the American Animal Hospital Association. vol 39. issue 5. 2003-10-17. PMID:14518653. |
purkinje cells were most depleted, but granular cells and the molecular layer of cerebellum were also depleted. |
2003-10-17 |
2023-08-12 |
dog |