| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Silvia Marino, Dennis Hoogervoorst, Sebastian Brandner, Anton Bern. Rb and p107 are required for normal cerebellar development and granule cell survival but not for Purkinje cell persistence. Development (Cambridge, England). vol 130. issue 15. 2003-09-03. PMID:12810584. |
to investigate the roles of rb and p107 in growth, differentiation and apoptosis in the developing and mature cerebellum, we selectively inactivated either rb alone or in combination with p107 in cerebellar precursor cells or in purkinje cells. |
2003-09-03 |
2023-08-12 |
mouse |
| Masami Shimizu-Albergine, Sergei D Rybalkin, Irina G Rybalkina, Robert Feil, Wiebke Wolfsgruber, Franz Hofmann, Joseph A Beav. Individual cerebellar Purkinje cells express different cGMP phosphodiesterases (PDEs): in vivo phosphorylation of cGMP-specific PDE (PDE5) as an indicator of cGMP-dependent protein kinase (PKG) activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 16. 2003-09-03. PMID:12878685. |
here we identify pde5 and pde1b as the two major cgmp-hydrolyzing pdes specifically and differentially expressed in the purkinje neurons of mouse cerebellum. |
2003-09-03 |
2023-08-12 |
mouse |
| Rachel M Sherrard, Adrian J Bowe. Climbing fiber development: do neurotrophins have a part to play? Cerebellum (London, England). vol 1. issue 4. 2003-08-22. PMID:12879965. |
subsequently, cerebellar expression of two neurotrophins, nt3 and nt4, is concurrent with olivary receptor expression and the time of olivary axonal outgrowth and this continues postnatally during early climbing fiber synaptogenesis on purkinje cells. |
2003-08-22 |
2023-08-12 |
Not clear |
| Michael W Voge. Cell death, Bcl-2, Bax, and the cerebellum. Cerebellum (London, England). vol 1. issue 4. 2003-08-22. PMID:12879966. |
both bcl-2 and bax are expressed in the developing cerebellum and recent studies of bcl-2 transgenic mice and bcl-2 or bax knock-out mutants have shown that both proteins are likely to play a role in regulating cell death among purkinje cells, granule cells and olivary neurons. |
2003-08-22 |
2023-08-12 |
mouse |
| Thomas Knöpfel, Pedro Grande. Metabotropic glutamate receptors in the cerebellum with a focus on their function in Purkinje cells. Cerebellum (London, England). vol 1. issue 1. 2003-08-22. PMID:12879970. |
metabotropic glutamate receptors in the cerebellum with a focus on their function in purkinje cells. |
2003-08-22 |
2023-08-12 |
Not clear |
| Carl-Fredrik Ekerot, Henrik Jörntel. Parallel fiber receptive fields: a key to understanding cerebellar operation and learning. Cerebellum (London, England). vol 2. issue 2. 2003-08-20. PMID:12880177. |
in several theories of the function of the cerebellum in motor control, the mossy-fiber-parallel fiber input has been suggested to provide information used in the control of ongoing movements whereas the role of climbing fibers is to induce plastic changes of parallel fiber (pf) synapses on purkinje cells. |
2003-08-20 |
2023-08-12 |
Not clear |
| Carl-Fredrik Ekerot, Henrik Jörntel. Parallel fiber receptive fields: a key to understanding cerebellar operation and learning. Cerebellum (London, England). vol 2. issue 2. 2003-08-20. PMID:12880177. |
the present review, which focuses on the c3 zone of the cerebellar anterior lobe, will present and discuss recent data of the cutaneous pf input to purkinje cells, interneurons and golgi cells as well as novel forms of pf plasticity. |
2003-08-20 |
2023-08-12 |
Not clear |
| Osamu Saitoh, Ikuo Masuho, Masayuki Itoh, Hideki Abe, Keiichiro Komori, Megumi Odagir. Distribution of regulator of G protein signaling 8 (RGS8) protein in the cerebellum. Cerebellum (London, England). vol 2. issue 2. 2003-08-20. PMID:12880183. |
in situ hybridization analysis showed a highly dense expression of rgs8 mrna in purkinje cells of the cerebellum in rat brain. |
2003-08-20 |
2023-08-12 |
rat |
| Kristin L Schaller, John H Caldwel. Expression and distribution of voltage-gated sodium channels in the cerebellum. Cerebellum (London, England). vol 2. issue 1. 2003-08-20. PMID:12882229. |
electrophysiological studies suggest that nav1.6 is responsible for spontaneous firing and bursting features in purkinje cells, but the specialized functions of the other subunits in the cerebellum remain unknown. |
2003-08-20 |
2023-08-12 |
Not clear |
| Daniel L Tolbert, Teresa L Knigh. Persistence of spinocerebellar afferent topography following hereditary Purkinje cell degeneration. Cerebellum (London, England). vol 2. issue 1. 2003-08-20. PMID:12882232. |
cerebellar purkinje neurons play a significant role in the development and early maintenance of cerebellar afferent topography. |
2003-08-20 |
2023-08-12 |
rat |
| Motohiko Takemura, Nobue Kitanaka, Junichi Kitanak. Signal transduction by histamine in the cerebellum and its modulation by N-methyltransferase. Cerebellum (London, England). vol 2. issue 1. 2003-08-20. PMID:12882233. |
h2 receptors are expressed in the purkinje cells and granule cells of guinea pig; and (3) the application of histamine to the slices of guinea pig or rat cerebellar cortex elicits an increase in the turnover of phosphoinositides, so h1 receptors in the cerebellum are functional. |
2003-08-20 |
2023-08-12 |
mouse |
| Wei-Jung A Chen, Russell B Edwards, Roland D Romero, Scott E Parnell, Rebecca J Mon. Long-term nicotine exposure reduces Purkinje cell number in the adult rat cerebellar vermis. Neurotoxicology and teratology. vol 25. issue 3. 2003-08-19. PMID:12757829. |
the long-term nicotine treatment regimen did result in a significant loss of mature purkinje cells in the cerebellum, however, such a loss of purkinje cells was not nicotine dose-related. |
2003-08-19 |
2023-08-12 |
rat |
| Wei-Jung A Chen, Russell B Edwards, Roland D Romero, Scott E Parnell, Rebecca J Mon. Long-term nicotine exposure reduces Purkinje cell number in the adult rat cerebellar vermis. Neurotoxicology and teratology. vol 25. issue 3. 2003-08-19. PMID:12757829. |
these findings indicated that the mature adult cerebellum is susceptible to the damaging effects of nicotine in depleting purkinje cells in the cerebellum. |
2003-08-19 |
2023-08-12 |
rat |
| Roy V Sillitoe, Manuel Hulliger, Richard Dyck, Richard Hawke. Antigenic compartmentation of the cat cerebellar cortex. Brain research. vol 977. issue 1. 2003-08-14. PMID:12788507. |
in the cat cerebellum the somata of most purkinje cells express zebrin ii but parasagittal stripes may still be delineated owing to the alternating high and low zebrin ii expression levels in the dendritic arbors. |
2003-08-14 |
2023-08-12 |
cat |
| Marco Martina, Gui Lan Yao, Bruce P Bea. Properties and functional role of voltage-dependent potassium channels in dendrites of rat cerebellar Purkinje neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 13. 2003-08-14. PMID:12843273. |
we characterized the properties and functional roles of voltage-dependent potassium channels in the dendrites of purkinje neurons studied in rat cerebellar slices. |
2003-08-14 |
2023-08-12 |
rat |
| S Zheng, Z Zu. Isoflurane preconditioning reduces purkinje cell death in an in vitro model of rat cerebellar ischemia. Neuroscience. vol 118. issue 1. 2003-08-13. PMID:12676141. |
we monitored survival of purkinje cells in rat cerebellar slices to test the hypothesis that isoflurane preconditioning reduces ischemia-induced neuronal death. |
2003-08-13 |
2023-08-12 |
rat |
| Yukihiro Takayasu, Masae Iino, Nobuhiko Furuya, Seiji Ozaw. Muscarine-induced increase in frequency of spontaneous EPSCs in Purkinje cells in the vestibulo-cerebellum of the rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 15. 2003-08-13. PMID:12867503. |
to clarify the functional roles of cholinergic mossy fibers in the vestibulo-cerebellum, we investigated the effects of acetylcholine (ach) on the membrane electrical properties of both granule cells and purkinje cells in slices of the cerebellar vermis of the rat using whole-cell patch-clamp techniques. |
2003-08-13 |
2023-08-12 |
rat |
| Manuel Yepes, Elizabeth Moore, Sharron A N Brown, Heather N Hanscom, Elizabeth P Smith, Daniel A Lawrence, Jeffrey A Winkle. Progressive ankylosis (Ank) protein is expressed by neurons and Ank immunohistochemical reactivity is increased by limbic seizures. Laboratory investigation; a journal of technical methods and pathology. vol 83. issue 7. 2003-08-12. PMID:12861042. |
in this study, we demonstrate that ank is expressed primarily in human brain neurons, with the highest levels of expression observed in the thalamus, the iii and v cortical layers, the purkinje cells of the cerebellum, clusters of cells in the dorsal portion of the pons and midbrain, and neurons of the anterior horn of the spinal cord. |
2003-08-12 |
2023-08-12 |
mouse |
| T C Frank, M C Nunley, H D Sons, R Ramon, L C Abbot. Fluoro-jade identification of cerebellar granule cell and purkinje cell death in the alpha1A calcium ion channel mutant mouse, leaner. Neuroscience. vol 118. issue 3. 2003-08-08. PMID:12710975. |
previous studies have shown that leaner cerebellar purkinje cells die in a specific pattern that appears to be influenced by functional and anatomical boundaries of the cerebellum. |
2003-08-08 |
2023-08-12 |
mouse |
| Elisabetta Ciani, Michela Frenquelli, Antonio Contestabil. Developmental expression of the cell cycle and apoptosis controlling gene, Lot1, in the rat cerebellum and in cultures of cerebellar granule cells. Brain research. Developmental brain research. vol 142. issue 2. 2003-08-01. PMID:12711370. |
in the adult cerebellum, the overall low lot1 level was essentially associated with purkinje cells. |
2003-08-01 |
2023-08-12 |
rat |