| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huu Hoang, Shinichiro Tsutsumi, Masanori Matsuzaki, Masanobu Kano, Keisuke Toyama, Kazuo Kitamura, Mitsuo Kawat. Predictive reward-prediction errors of climbing fiber inputs integrate modular reinforcement learning with supervised learning. PLoS computational biology. vol 21. issue 3. 2025-03-17. PMID:40096178. |
assuming bidirectional parallel-fiber purkinje-cell synaptic plasticity, we constructed a cerebellar neural-network model with 5,000 spiking neurons of granule cells, purkinje cells, cerebellar nuclei neurons, and inferior olive neurons. |
2025-03-17 |
2025-03-20 |
mouse |
| Maryam Abolghasemi, Ali Shamsara, Masoumeh Nozari, Rana Eftekhar-Vaghefi, Masoumeh Baghalishahi, Ali Sarhadi Roodbari, Mohammad Reza Afarines. Protective effects of omega-3 against procarbazine-induced brain damage in the cerebellum and CA1 Hippocampus of male rats: a focus on oxidative stress mechanisms. Metabolic brain disease. vol 40. issue 3. 2025-03-15. PMID:40088343. |
also, cell degeneration in pyramidal cells of the ca1 region and purkinje cells in the cerebellum, along with measuring serum oxidant and antioxidant levels to gauge treatment impact on brain functions. |
2025-03-15 |
2025-03-18 |
rat |
| Yuqin Yin, Kathleen Z He, Jane Kirby, Ishraq A Haque, Xin Tan. Visualizing the Cellular and Subcellular Distribution of Fms-like Tyrosine Kinase 3 (Flt3) and Other Neuronal Proteins Using Alkaline Phosphatase (AP) Immunolabeling. International journal of molecular sciences. vol 26. issue 5. 2025-03-13. PMID:40076904. |
combining ap-polymer-based immunohistochemistry (ap-ihc) for flt3 with conventional immunostaining of cell type marker proteins revealed parvalbumin- and calbindin-positive purkinje cells to be the main cell type expressing flt3 in the cerebellum. |
2025-03-13 |
2025-03-15 |
mouse |
| Cooper Atterton, Alexandra Pelenyi, Justin Jones, Laura Currey, Majd Al-Khalily, Lucinda Wright, Mikki Doonan, David Knight, Nyoman D Kurniawan, Shaun Walters, Stefan Thor, Michael Pipe. The Hippo effector TEAD1 regulates postnatal murine cerebellar development. Brain structure & function. vol 230. issue 3. 2025-03-11. PMID:40064689. |
the importance of tead1 expression for cerebellar development was investigated using a conditional ablation approach, which revealed a range of developmental deficits in tead1 mutants, including an underdeveloped cerebellum, morphological defects in bergmann glia and purkinje neurons, as well as granule neuron migration defects. |
2025-03-11 |
2025-03-13 |
Not clear |
| Yilin Lyu, Yumei Zhan. Ginkgo biloba Extract Improves Dendritic Spine Injury in Cerebellar Purkinje Cells Induced by MPTP in Mice by Regulating the PLK2-SPAR Pathway. Synapse (New York, N.Y.). vol 79. issue 2. 2025-03-11. PMID:40066946. |
purkinje cells (pcs) are the only efferent neurons present in the cerebellum, and dendritic spines in pcs are considered the key structures for transmitting neuronal excitatory signals. |
2025-03-11 |
2025-03-14 |
mouse |
| Momoka Hikosaka, Md Sorwer Alam Parvez, Yuki Yamawaki, Souichi Oe, Yuan Liang, Yayoi Wada, Yukie Hirahara, Taro Koike, Hirohiko Imai, Naoya Oishi, Sina M Schalbetter, Asuka Kumagai, Mari Yoshida, Takeshi Sakurai, Masaaki Kitada, Urs Meyer, Shuh Narumiya, Gen Ohtsuk. Maternal immune activation followed by peripubertal stress combinedly produce reactive microglia and confine cerebellar cognition. Communications biology. vol 8. issue 1. 2025-03-03. PMID:40033126. |
reduced excitability of remaining purkinje cells, cerebellum-involved brain-wide functional dysconnectivity, and behavioral abnormalities indicate cerebellar cognitive dysfunctions in 2hit animals, which are ameliorated by both systemic and cerebellum-specific microglia replacement. |
2025-03-03 |
2025-03-06 |
mouse |
| Maxime Beau, David J Herzfeld, Francisco Naveros, Marie E Hemelt, Federico D'Agostino, Marlies Oostland, Alvaro Sánchez-López, Young Yoon Chung, Michael Maibach, Stephen Kyranakis, Hannah N Stabb, M Gabriela Martínez Lopera, Agoston Lajko, Marie Zedler, Shogo Ohmae, Nathan J Hall, Beverley A Clark, Dana Cohen, Stephen G Lisberger, Dimitar Kostadinov, Court Hull, Michael Häusser, Javier F Medin. A deep learning strategy to identify cell types across species from high-density extracellular recordings. Cell. 2025-03-01. PMID:40023155. |
we combine optogenetics and pharmacology using the cerebellum as a testbed to generate a curated ground-truth library of electrophysiological properties for purkinje cells, molecular layer interneurons, golgi cells, and mossy fibers. |
2025-03-01 |
2025-03-05 |
Not clear |
| Samuel P Brown, Achintya K Jena, Joanna J Osko, Joseph L Ransdel. Tsc1 deletion in Purkinje neurons disrupts the axon initial segment, impairing excitability and cerebellar function. Neurobiology of disease. 2025-02-27. PMID:40015654. |
tsc1 deletion in purkinje neurons disrupts the axon initial segment, impairing excitability and cerebellar function. |
2025-02-27 |
2025-03-02 |
mouse |
| Chih-Chun Lin, Ke-Chu Fang, Ilaria Balbo, Ting-Yu Liang, Chia-Wei Liu, Wen-Chuan Liu, Yi-Mei Wang, Yen-Ling Hung, Kai-Chien Yang, Scott Kun Geng, Chun-Lun Ni, Christopher P Driscoll, David S Ruff, Ami Kumar, Nadia Amokrane, Natasha Desai, Phyllis L Faust, Elan D Louis, Sheng-Han Kuo, Ming-Kai Pa. Reduced cerebellar rhythm by climbing fiber denervation is linked to motor rhythm deficits in mice and ataxia severity in patients. Science translational medicine. vol 17. issue 787. 2025-02-26. PMID:40009696. |
correspondingly, two patients with inferior olive pathology, the brain site that provides cfs to purkinje cells, presented with ataxia and cerebellar rhythm loss. |
2025-02-26 |
2025-03-01 |
mouse |
| YingXiang Wang, HaoTian Wu, Jian Gu, Jia Wan. Paraneoplastic Neurologic Syndrome Associated with Fallopian Tube Cancer: A Case Report. Case reports in oncology. vol 18. issue 1. 2025-02-21. PMID:39980509. |
paraneoplastic cerebellar degeneration, a subtype of pns, involved an immune-mediated attack on cerebellar purkinje cells, resulting in a series of cerebellar symptoms. |
2025-02-21 |
2025-02-23 |
Not clear |
| Yong-Rui Piao, Mei-Rui Li, Ming-Ze Sun, Yang Liu, Chao-Yue Chen, Chun-Ping Chu, Yuki Todo, Zheng Tang, Chun-Yan Wang, Wen-Zhe Jin, De-Lai Qi. Estradiol Enhances Cerebellar Molecular Layer Interneuron-Purkinje Cell Synaptic Transmission and Improves Motor Learning Through ER-β in Vivo in Mice. Cerebellum (London, England). vol 24. issue 2. 2025-02-20. PMID:39979512. |
in this study, we investigated the effects of e2 on synaptic transmission between cerebellar molecular layer interneurons (mlis) and purkinje cells (pcs) in urethane-anesthetized mice. |
2025-02-20 |
2025-02-23 |
mouse |
| A A Smith, B B Singh, C Silva, D E F Suzuk. Cerebellar Abiotrophy in a Quarter Horse Foal. Journal of equine veterinary science. 2025-02-17. PMID:39961496. |
cerebellar abiotrophy is a neurodegenerative disease that affects the purkinje cells of the cerebellum, resulting in premature neuronal death. |
2025-02-17 |
2025-02-23 |
Not clear |
| Abdulaziz M Al-Garni, Sara A Hosny, Faris Almasabi, Ayed A Shati, Norah M Alzamil, Asmaa M ShamsEldeen, Asmaa A El-Shafei, Fahaid Al-Hashem, Hind Zafrah, Amro Maarouf, Bahjat Al-Ani, Ismaeel Bin-Jaliah, Samaa S Kama. Identifying iNOS and glycogen as biomarkers for degenerated cerebellar purkinje cells in autism spectrum disorder: Protective effects of erythropoietin and zinc sulfate. PloS one. vol 20. issue 2. 2025-02-13. PMID:39946495. |
the cerebellum is the major part of the human brain affected by asd and is associated with a substantial reduction in the number of purkinje cells. |
2025-02-13 |
2025-02-16 |
human |
| Abdulaziz M Al-Garni, Sara A Hosny, Faris Almasabi, Ayed A Shati, Norah M Alzamil, Asmaa M ShamsEldeen, Asmaa A El-Shafei, Fahaid Al-Hashem, Hind Zafrah, Amro Maarouf, Bahjat Al-Ani, Ismaeel Bin-Jaliah, Samaa S Kama. Identifying iNOS and glycogen as biomarkers for degenerated cerebellar purkinje cells in autism spectrum disorder: Protective effects of erythropoietin and zinc sulfate. PloS one. vol 20. issue 2. 2025-02-13. PMID:39946495. |
asd-like features were developed in the model group, as evidenced by cerebellum damage (degeneration of purkinje cells) and cerebellar dysfunction (behavioral impairment). |
2025-02-13 |
2025-02-16 |
human |
| Elizabeth Mercado Ayón, Ellarie Talgo, Liam Flatley, Jennifer Coulman, David R Lync. Neurochemical alterations in the cerebellum in Friedreich's Ataxia mouse models. Experimental neurology. 2025-02-04. PMID:39904419. |
the precise impact of frataxin deficiency on the cerebellum including purkinje cells remains unclear. |
2025-02-04 |
2025-02-07 |
mouse |
| Elizabeth Mercado Ayón, Ellarie Talgo, Liam Flatley, Jennifer Coulman, David R Lync. Neurochemical alterations in the cerebellum in Friedreich's Ataxia mouse models. Experimental neurology. 2025-02-04. PMID:39904419. |
in the present work, we examined the biochemical and structural properties of the cerebellum and purkinje cells in the doxycycline-inducible (frdakd) and the knock-in/knockout (kiko) mouse models of frda. |
2025-02-04 |
2025-02-07 |
mouse |
| Elizabeth Mercado Ayón, Ellarie Talgo, Liam Flatley, Jennifer Coulman, David R Lync. Neurochemical alterations in the cerebellum in Friedreich's Ataxia mouse models. Experimental neurology. 2025-02-04. PMID:39904419. |
overall, we observed dysregulated levels of glutamate receptors and transporters in the kiko and frdakd mice models of friedreich ataxia, suggesting the importance of frataxin in maintaining purkinje cells and cerebellar integrity along with synaptic properties. |
2025-02-04 |
2025-02-07 |
mouse |
| Ami Kumar, Yi-Mei Wang, Ming-Kai Pan, Sheng-Han Ku. Protocol for recording physiological signals from the human cerebellum using electroencephalography. STAR protocols. vol 6. issue 1. 2025-01-27. PMID:39869480. |
as purkinje cells of the cerebellum have a very fast firing rate, techniques with high temporal resolution are required to capture cerebellar physiology. |
2025-01-27 |
2025-01-30 |
human |
| Dan Li, Shuijing Cao, Yanrong Chen, Yueyan Liu, Kugeng Huo, Zhuangqi Shi, Shuxin Han, Liecheng Wan. Distribution and functional significance of KLF15 in mouse cerebellum. Molecular brain. vol 18. issue 1. 2025-01-22. PMID:39838470. |
klf15 was detected highly expressed in the cerebellum and enriched in purkinje cells, with a significant increase in klf15 expression between 15 and 20 days of neural development. |
2025-01-22 |
2025-01-24 |
mouse |
| Dan Li, Shuijing Cao, Yanrong Chen, Yueyan Liu, Kugeng Huo, Zhuangqi Shi, Shuxin Han, Liecheng Wan. Distribution and functional significance of KLF15 in mouse cerebellum. Molecular brain. vol 18. issue 1. 2025-01-22. PMID:39838470. |
therefore, our study aims to elucidate the relationship between klf15 and purkinje cells in mice, may provide a new research idea for the developmental mechanism of the mouse cerebellum. |
2025-01-22 |
2025-01-24 |
mouse |