All Relations between purkinje and cerebellum

Publication Sentence Publish Date Extraction Date Species
Yuhao Yan, Timothy H Murph. Decoding state-dependent cortical-cerebellar cellular functional connectivity in the mouse brain. Cell reports. vol 43. issue 6. 2024-06-12. PMID:38865245. these cortical-cerebellar connectivity features are observed in mossy fibers and purkinje cells as well as neurons in different cerebellar lobules, albeit with variations across cell types and regions. 2024-06-12 2024-06-15 mouse
Jennifer L Fessler, Megan A Stiles, Martin-Paul Agbaga, Mohiuddin Ahmad, David M Sherr. The Spinocerebellar Ataxia 34-Causing W246G ELOVL4 Mutation Does Not Alter Cerebellar Neuron Populations in a Rat Model. Cerebellum (London, England). 2024-06-08. PMID:38850484. to test whether w246g elovl4 altered neuronal generation or survival in the cerebellum, we compared the numbers of purkinje cells, unipolar brush cells, molecular layer interneurons, granule and displaced granule cells in the cerebellum of wildtype, heterozygous, and homozygous sca34-ki rats at four months of age, when motor impairment is already present. 2024-06-08 2024-06-11 human
D González-Tapia, N Vázquez-Hernández, F Urmeneta-Ortiz, N Navidad-Hernandez, M Lazo-Yepez, A Tejeda-Martínez, M Flores-Soto, I González-Burgo. 3-Acetylpyridine-induced ataxic-like motor impairments are associated with plastic changes in the Purkinje cells of the rat cerebellum. Neurologia. vol 39. issue 5. 2024-06-03. PMID:38830720. 3-acetylpyridine-induced ataxic-like motor impairments are associated with plastic changes in the purkinje cells of the rat cerebellum. 2024-06-03 2024-06-06 rat
D González-Tapia, N Vázquez-Hernández, F Urmeneta-Ortiz, N Navidad-Hernandez, M Lazo-Yepez, A Tejeda-Martínez, M Flores-Soto, I González-Burgo. 3-Acetylpyridine-induced ataxic-like motor impairments are associated with plastic changes in the Purkinje cells of the rat cerebellum. Neurologia. vol 39. issue 5. 2024-06-03. PMID:38830720. in addition, in purkinje cells from lobules v-vii of the cerebellar vermis studied by the golgi method, the density of dendritic spines decreased, especially the thin and mushroom types. 2024-06-03 2024-06-06 rat
D González-Tapia, N Vázquez-Hernández, F Urmeneta-Ortiz, N Navidad-Hernandez, M Lazo-Yepez, A Tejeda-Martínez, M Flores-Soto, I González-Burgo. 3-Acetylpyridine-induced ataxic-like motor impairments are associated with plastic changes in the Purkinje cells of the rat cerebellum. Neurologia. vol 39. issue 5. 2024-06-03. PMID:38830720. findings suggest a limited capacity of purkinje cells to acquire and consolidate afferent excitatory inputs and an aberrant, rigid profile in the movement-related output patterns of purkinje neurons that likely contributes to the motor-related impairments characteristic of cerebellar ataxias. 2024-06-03 2024-06-06 rat
Rhydham Karnik, Aliasgar Vohra, Mahamadtezib Khatri, Nilay Dalvi, Hitarthi S Vyas, Helly Shah, Sujitsinh Gohil, Smit Kanojiya, Ranjitsinh Devka. Diet/photoperiod mediated changes in cerebellar clock genes causes locomotor shifts and imperative changes in BDNF-TrkB pathway. Neuroscience letters. 2024-05-31. PMID:38821201. nuclear pyknosis of purkinje cells, their derangement and inflammation were the hallmark of cerebellar tissue of all the three experimental groups. 2024-05-31 2024-06-02 Not clear
Ting-Feng Lin, Silas E Busch, Christian Hanse. Intrinsic and synaptic determinants of receptive field plasticity in Purkinje cells of the mouse cerebellum. Nature communications. vol 15. issue 1. 2024-05-31. PMID:38821918. intrinsic and synaptic determinants of receptive field plasticity in purkinje cells of the mouse cerebellum. 2024-05-31 2024-06-02 mouse
b' Eirik Tveit Solheim, Yola Gerking, Torbj\xf8rn Kr\xe5kenes, Ida Herdlev\xe6r, Even Birkeland, Cecilie Totland, Fiona Dick, Christian Alexander Vedele. Multi-omics profiling reveals dysregulated ribosome biogenesis and impaired cell proliferation following knockout of CDR2L. BMC cancer. vol 24. issue 1. 2024-05-28. PMID:38802745.' cerebellar degeneration-related (cdr) proteins are associated with paraneoplastic cerebellar degeneration (pcd) - a rare, neurodegenerative disease caused by tumour-induced autoimmunity against neural antigens resulting in degeneration of purkinje neurons in the cerebellum. 2024-05-28 2024-05-31 Not clear
Xiaolin Liang, Meng Gong, Zhikai Wang, Jie Wang, Weiwei Guo, Aoling Cai, Zhenye Yang, Xing Liu, Fuqiang Xu, Wei Xiong, Chuanhai Fu, Xiangting Wan. LncRNA TubAR complexes with TUBB4A and TUBA1A to promote microtubule assembly and maintain myelination. Cell discovery. vol 10. issue 1. 2024-05-23. PMID:38769343. tubar knockdown in mouse cerebellum causes loss of oligodendrocytes and purkinje cells, demyelination, and decreased locomotor activity. 2024-05-23 2024-05-27 mouse
D Alwyn Dart, Charlotte L Bevan, Pinar Uysal-Onganer, Wen Guo Jian. Analysis of androgen receptor expression and activity in the mouse brain. Scientific reports. vol 14. issue 1. 2024-05-15. PMID:38750183. ar-driven luciferase activity and distinct nuclear staining for ar were seen in several key brain areas including the thalamus, hypothalamus, olfactory bulb, cerebral cortex, purkinje cells of the cerebellum and the hindbrain. 2024-05-15 2024-05-27 mouse
Yuxin Zhang, Xiaoqing Pei, Lingyang Jing, Qingyu Zhang, Hongfeng Zha. Lead induced cerebellar toxicology of developmental Japanese quail (Coturnix japonica) via oxidative stress-based Nrf2/Keap1 pathway inhibition and glutathione-mediated apoptosis signaling activation. Environmental pollution (Barking, Essex : 1987). vol 352. 2024-05-10. PMID:38718965. the results showed pb caused cerebellar microstructural damages charactered by deformation of neuroglia cells, granule cells and purkinje cells with nissl body changes. 2024-05-10 2024-05-27 Not clear
Joan S Baize. Neuroanatomy of autism: what is the role of the cerebellum? Cerebral cortex (New York, N.Y. : 1991). vol 34. issue 13. 2024-05-02. PMID:38696597. both neuropathological and imaging studies found differences in the cerebellum in autism spectrum disorder, the most widely documented being a decreased density of purkinje cells in the cerebellar cortex. 2024-05-02 2024-05-05 Not clear
Anna Niewiadomska-Cimicka, Lorraine Fievet, Magdalena Surdyka, Ewelina Jesion, Céline Keime, Elisabeth Singer, Aurélie Eisenmann, Zaneta Kalinowska-Poska, Hoa Huu Phuc Nguyen, Agnieszka Fiszer, Maciej Figiel, Yvon Trottie. AAV-Mediated CAG-Targeting Selectively Reduces Polyglutamine-Expanded Protein and Attenuates Disease Phenotypes in a Spinocerebellar Ataxia Mouse Model. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673939. polyq-expanded sca proteins are toxic for cerebellar neurons, with purkinje cells (pcs) being the most vulnerable. 2024-04-27 2024-04-29 mouse
Ke Zhang, Zhen Yang, Michael A Gaffield, Garrett G Gross, Don B Arnold, Jason M Christi. Molecular layer disinhibition unlocks climbing-fiber-instructed motor learning in the cerebellum. bioRxiv : the preprint server for biology. 2024-04-26. PMID:38654827. climbing fibers supervise cerebellar learning by providing signals to purkinje cells (pcs) that instruct adaptive changes to mistakenly performed movements. 2024-04-26 2024-04-28 mouse
Jay S Pi, Mohammad Amin Fakharian, Paul Hage, Ehsan Sedaghat-Nejad, Salomon Z Muller, Reza Shadmeh. The olivary input to the cerebellum dissociates sensory events from movement plans. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 17. 2024-04-17. PMID:38630714. neurons in the inferior olive are thought to anatomically organize the purkinje cells (p-cells) of the cerebellum into computational modules, but what is computed by each module? 2024-04-17 2024-04-20 human
C'iana P Cooper, Liam H Cheng, Jafar A Bhatti, Edward L Rivera, Derek Huell, Cristina Banuelos, Evelyn J Perez, Jeffrey M Long, Peter R Rap. Cerebellum Purkinje cell vulnerability in aged rats with memory impairment. The Journal of comparative neurology. vol 532. issue 4. 2024-04-12. PMID:38605461. to interrogate potential substrates of the relationship between cerebellar structure and memory in aging, here we target the purkinje cells (pcs). 2024-04-12 2024-04-14 rat
Emre Kul, Uchechi Okoroafor, Amanda Dougherty, Lauren Palkovic, Hao Li, Paula Valiño-Ramos, Leah Aberman, Samuel M Youn. Development of adenoviral vectors that transduce Purkinje cells and other cerebellar cell-types in the cerebellum of a humanized mouse model. Molecular therapy. Methods & clinical development. vol 32. issue 2. 2024-04-12. PMID:38605812. development of adenoviral vectors that transduce purkinje cells and other cerebellar cell-types in the cerebellum of a humanized mouse model. 2024-04-12 2024-04-14 mouse
Emre Kul, Uchechi Okoroafor, Amanda Dougherty, Lauren Palkovic, Hao Li, Paula Valiño-Ramos, Leah Aberman, Samuel M Youn. Development of adenoviral vectors that transduce Purkinje cells and other cerebellar cell-types in the cerebellum of a humanized mouse model. Molecular therapy. Methods & clinical development. vol 32. issue 2. 2024-04-12. PMID:38605812. using a "humanized" hcd46 mouse model, we demonstrate these ad vectors transduce cerebellar cell types, including purkinje cells, that are refractory to ad5 transduction. 2024-04-12 2024-04-14 mouse
Aïda Padilla-Ferrer, Alex Carrete, Anne Simon, Delphine Meffre, Mehrnaz Jafarian-Tehran. A disintegrin and Metalloprotease 10 expression within the murine central nervous system. Brain research. 2024-03-28. PMID:38548249. we observed adam10 expression through the whole cns, with a strong expression in the hippocampus, in the hypothalamus and in the cerebral and piriform cortex in the brain, in the purkinje and in granular cell layers in the cerebellum and in the spinal cord to a lower extent. 2024-03-28 2024-03-31 mouse
Tariq Zaman, Daniel Vogt, Jeremy Prokop, Qusai Abdulkhaliq Alsabia, Gabriel Simms, April Stafford, Bryan W Luikart, Michael R William. Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje cells. eLife. vol 12. 2024-03-27. PMID:38536959. kit is enriched in molecular layer interneurons (mlis) of the cerebellar cortex (i.e., stellate and basket cells), while cerebellar kit ligand is selectively expressed by a target of their inhibition, purkinje cells (pcs). 2024-03-27 2024-03-30 mouse