| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael Donovan, Morgan Frentz, Anakaren Romero Lozano, Shripriya Rao, Madeline Rodriguez, Linda J Noble-Haeusslei. The Emerging Landscape of the Cerebellum after a Pediatric Traumatic Brain Injury: From Diaschisis to Sociality. Advances in neurobiology. vol 42. 2024-10-21. PMID:39432042. |
in the adult brain, preclinical studies have revealed acute as well as progressive loss of purkinje cells in the cerebellum coincident with microglial activation. |
2024-10-21 |
2024-10-23 |
Not clear |
| Niraj Kumar Singh, Pranjul Singh, Prachi Varshney, Ashini Singh, Bharat Bhusha. Multimodal action of phosphodiesterase 5 inhibitors against neurodegenerative disorders: An update review. Journal of biochemical and molecular toxicology. vol 38. issue 11. 2024-10-19. PMID:39425458. |
phosphodiesterase type 5 (pde5) is an enzyme primarily found in the smooth muscle of the corpus cavernosum and also highly expressed in the substantia nigra, cerebellum, caudate, hippocampal regions and cerebellar purkinje cells, responsible for selectively breaking down cyclic guanosine monophosphate (cgmp) into 5'-gmp and regulate intracellular cgmp levels. |
2024-10-19 |
2024-10-21 |
Not clear |
| Shuyang Jin, Court Hul. Reward-driven cerebellar climbing fiber activity influences both neural and behavioral learning. bioRxiv : the preprint server for biology. 2024-10-17. PMID:39416023. |
to test how cfs operate during reward-guided behavior, and evaluate the role of reward-related cf activity in learning, we have measured cf responses in purkinje cells of the lateral cerebellum during a pavlovian task using 2-photon calcium imaging. |
2024-10-17 |
2024-10-19 |
Not clear |
| Isabel Atienza-Navarro, Angel Del Marco, Maria de Los Angeles Garcia-Perez, Alvaro Raya-Marin, Carmen Gil, Ana Martinez, Isabel Benavente-Fernandez, Simon Lubian-Lopez, Monica Garcia-Alloz. VP3.15 reduces acute cerebellum damage after germinal matrix-intraventricular hemorrhage of the preterm newborn. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 180. 2024-10-16. PMID:39413619. |
in our hands, the induction of unilateral gm-ivh to p7 cd1 mice results in a short-term (p14) compromise of the cerebellar neuronal population and purkinje cells arborization, an increase of microglia burden in the nuclei and an overall increase of punctuate cerebellar hemorrhages. |
2024-10-16 |
2024-10-19 |
mouse |
| Isabel Atienza-Navarro, Angel Del Marco, Maria de Los Angeles Garcia-Perez, Alvaro Raya-Marin, Carmen Gil, Ana Martinez, Isabel Benavente-Fernandez, Simon Lubian-Lopez, Monica Garcia-Alloz. VP3.15 reduces acute cerebellum damage after germinal matrix-intraventricular hemorrhage of the preterm newborn. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 180. 2024-10-16. PMID:39413619. |
importantly, treatment with vp3.15 significantly reduces neuronal loss, purkinje cells simplification, the presence of cerebellar hemorrhages, as well as hyperactivity. |
2024-10-16 |
2024-10-19 |
mouse |
| Leah K Manning, Emily Winkenwerder, Louise Baskind, Katie L M Eager, Cali E Willet, Ben Porebski, Brendon A O'Rourke, Imke Tammen, Marina Gimeno, Pedro Pinczowsk. A novel missense variant in the Veterinary pathology. 2024-10-12. PMID:39394905. |
the cerebellar vermis had disorganized, thin, and hypocellular gray matter with frequent ectopic purkinje cells, while identifiable folia were largely absent within the hemispheres. |
2024-10-12 |
2024-10-15 |
Not clear |
| Stefanie Tasevski, Hwa Kyung Nam, Amanda Ghannam, Sara Moughni, Tia Atoui, Yara Mashal, Nan Hatch, Zhi Zhan. Tissue nonspecific alkaline phosphatase deficiency impairs Purkinje cell development and survival in a mouse model of infantile hypophosphatasia. Neuroscience. 2024-10-06. PMID:39369942. |
the main objective of this study was to investigate the roles of tnap in cerebellar development and function, with a particular focus on purkinje cells, in a mouse model of infantile hpp. |
2024-10-06 |
2024-10-09 |
mouse |
| Mauricio Torres, Brent Pederson, Hui Wang, Liangguang L Lin, Huilun Wang, Amara Bugarin-Lapuz, Zhen Zhao, Ling Q. Purkinje Cell-specific Deficiency in SEL1L-HRD1 Endoplasmic Reticulum-Associated Degradation Causes Progressive Cerebellar Ataxia in Mice. JCI insight. 2024-10-01. PMID:39352758. |
lastly, loss of purkinje cells is associated with a secondary neurodegeneration of granular cells, as well as robust activation of astrocytes and proliferation of microglia, in the cerebellum of sel1lpcp2cre mice. |
2024-10-01 |
2024-10-05 |
mouse |
| Ziyad W Sultan, Marion Najac, Indira M Rama. Control of action potential afterdepolarizations in the inferior olive by inactivating A-type currents through K The Journal of physiology. 2024-09-20. PMID:39303148. |
broader adps support more spikes in climbing fibre axons and evoke longer bursts of complex spikes in purkinje cells, which affect the magnitude and sign of cerebellar synaptic plasticity. |
2024-09-20 |
2024-09-23 |
mouse |
| Jennifer N Jahncke, Eric Schnell, Kevin M Wrigh. Distinct functional domains of Dystroglycan regulate inhibitory synapse formation and maintenance in cerebellar Purkinje cells. bioRxiv : the preprint server for biology. 2024-09-11. PMID:39257744. |
while dystroglycan is required to maintain inhibitory synapses from cerebellar molecular layer interneurons (mlis) onto purkinje cells (pcs) whether initial synaptogenesis during development is dependent on dystroglycan has not been examined. |
2024-09-11 |
2024-09-13 |
Not clear |
| Chigure Suzuki, Junji Yamaguchi, Shun Mitsui, Takahito Sanada, Juan Alejandro Oliva Trejo, Soichirou Kakuta, Kenichi Tanaka, Yukari Suda, Taku Hatano, Nobutaka Hattori, Isei Tanida, Yasuo Uchiyam. Direct evidence for ultrastructures of the α-synuclein-associated synaptic vesicle pool in presynaptic terminals. Biochimica et biophysica acta. Molecular basis of disease. vol 1870. issue 8. 2024-09-05. PMID:39233262. |
α-synuclein-mkate2 accumulated in presynaptic terminals, particularly between purkinje cells in the cerebellum and neurons in cerebellar nuclei. |
2024-09-05 |
2024-09-08 |
mouse |
| Simon Bossi, Hervé Daniel, Heather McLea. Interplay between metabotropic glutamate type 4 and adenosine type 1 receptors modulate synaptic transmission in the cerebellar cortex. Frontiers in pharmacology. vol 15. 2024-08-30. PMID:39211784. |
the synapses between parallel fibers and purkinje cells play a pivotal role in cerebellar function. |
2024-08-30 |
2024-09-04 |
mouse |
| Simon Bossi, Hervé Daniel, Heather McLea. Interplay between metabotropic glutamate type 4 and adenosine type 1 receptors modulate synaptic transmission in the cerebellar cortex. Frontiers in pharmacology. vol 15. 2024-08-30. PMID:39211784. |
employing a combination of whole-cell patch clamp recordings of purkinje cells and parallel fiber presynaptic fluorometric calcium measurements in acute rat and mouse cerebellar cortical slices, our results reveal functional interactions between these receptor types. |
2024-08-30 |
2024-09-04 |
mouse |
| Mustafa Ozkaraca, Selcuk Ozdemir, Selim Comakli, Mehmet Ozkan Timurka. Roles of apoptosis and autophagy in natural rabies infections. Veterinarni medicina. vol 67. issue 1. 2024-08-22. PMID:39169958. |
lc3b immunopositivity was detected in the cytoplasm of the purkinje cells in the cerebellum of the cows, horses and donkeys, and also in the cytoplasm of the neurons in the cornu ammonis of the dogs and cats. |
2024-08-22 |
2024-08-24 |
Not clear |
| Ioannis Mavroudis, Foivos Petridi. Neuropathological findings in essential tremor. Folia neuropathologica. 2024-08-21. PMID:39165215. |
two brain areas have been consistently found to present neuropathological alterations in patients with et: the brainstem, for presence of lewy bodies or neuronal depletion, and the cerebellum, regarding purkinje cells' morphology and density. |
2024-08-21 |
2024-08-23 |
Not clear |
| Guochao Yang, Yinghong Yang, Zhihong Song, Liping Chen, Fengjiao Liu, Ying Li, Shaofei Jiang, Saisai Xue, Jie Pei, Yan Wu, Yuanlin He, Bo Chu, Haitao W. Spliceosomal GTPase Eftud2 deficiency-triggered ferroptosis leads to Purkinje cell degeneration. Neuron. 2024-08-17. PMID:39153477. |
here, we demonstrate that specific ablation of eftud2 in cerebellar purkinje cells (pcs) in mice results in severe ferroptosis, pc degeneration, dyskinesia, and cerebellar atrophy, which recapitulates phenotypes observed in patients with mfdm. |
2024-08-17 |
2024-08-20 |
mouse |
| Riya Elizabeth Thomas, Franziska Mudlaff, Kyra Schweers, W Todd Farmer, Aparna Suvratha. Heterogeneity in slow synaptic transmission diversifies Purkinje cell timing. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-08-15. PMID:39147589. |
here, we describe a previously unappreciated form of synaptic heterogeneity at parallel fiber synapses to purkinje cells in the mouse cerebellum (both sexes). |
2024-08-15 |
2024-08-18 |
mouse |
| Shuangchan Wu, Pingting Liu, Marija Cvetanovic, Wensheng Li. Endoplasmic reticulum associated degradation preserves neurons viability by maintaining endoplasmic reticulum homeostasis. Frontiers in neuroscience. vol 18. 2024-08-14. PMID:39135735. |
moreover, we found that cerebellar and hippocampal atrophy in these mice resulted from degeneration of purkinje neurons and hippocampal neurons, respectively. |
2024-08-14 |
2024-08-16 |
mouse |
| Omnia I Ismail, Hala Mohamed Hassani. Ameliorative effects of gallic acid on tebuconazole-induced adverse effects in the cerebellum of adult albino rats: histopathological and immunohistochemical evidence. Ultrastructural pathology. 2024-08-06. PMID:39105544. |
teb exposure led to neuronal damage in the form of degenerated purkinje cells with vacuolated cytoplasm, areas of lost purkinje cells, the basket cells appeared vacuolated with degenerated neuropil, the granule cells clumped with congested areas between them, dilated cerebellar islands, weak positive bcl2 immunoreactions in the purkinje cells, and numerous gfap-positive astrocytes. |
2024-08-06 |
2024-08-08 |
rat |
| Yuki Yoshioka, Yong Huang, Xiaocen Jin, Kien Xuan Ngo, Tomohiro Kumaki, Meihua Jin, Saori Toyoda, Sumire Takayama, Maiko Inotsume, Kyota Fujita, Hidenori Homma, Toshio Ando, Hikari Tanaka, Hitoshi Okazaw. PQBP3 prevents senescence by suppressing PSME3-mediated proteasomal Lamin B1 degradation. The EMBO journal. 2024-08-05. PMID:39103492. |
consistently, knock-in mice expressing mutant atxn1 exhibit decreased nuclear pqbp3 and a senescence phenotype in purkinje cells of the cerebellum. |
2024-08-05 |
2024-08-08 |
mouse |