| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kaelin Sbrocco, Ella Borgenheimer, Ying Zhang, Mike Koob, Marija Cvetanovi. Cerebellar contribution to cognitive deficits and prefrontal cortex dysfunction in Spinocerebellar Ataxia Type 1 (SCA1). bioRxiv : the preprint server for biology. 2024-07-19. PMID:39026827. |
spinocerebellar ataxia type 1 (sca1), is an inherited, fatal neurodegenerative disease caused by an abnormal expansion of glutamine (q) encoding cag repeats in the gene ataxin-1 (atxn1) and characterized by severe loss of purkinje cells (pcs) in the cerebellum. |
2024-07-19 |
2024-07-21 |
mouse |
| Lin-Yan Huang, Yi-Ning Liu, Jie Chen, Hai-Xue Zhu, Li-Li Li, Zhi-Yan Liang, Jin-Xiu Song, Yu-Jie Li, Zhao-Li Hu, Dieter Demon, Andy Wullaert, Wan Wang, Su-Hua Q. Caspase-12 is Expressed in Purkinje Neurons and Prevents Psychiatric-Like Behavior in Mice. Molecular neurobiology. 2024-07-18. PMID:39023795. |
strikingly, these reporter mice showed that caspase-12 is expressed explicitly in purkinje neurons of the cerebellum. |
2024-07-18 |
2024-07-20 |
mouse |
| Kim M Gruver, Jenny W Y Jiao, Eviatar Fields, Sen Song, Per Jesper Sjöström, Alanna J Wat. Structured connectivity in the output of the cerebellar cortex. Nature communications. vol 15. issue 1. 2024-07-09. PMID:38982047. |
in the cerebellum, the major output of the cerebellar cortex are synapses made from purkinje cells onto neurons in the cerebellar nuclei, yet little has been known about the spatial organization of these synapses. |
2024-07-09 |
2024-07-12 |
mouse |
| Hisako Nakayama, Taisuke Miyazaki, Manabu Abe, Maya Yamazaki, Yoshinobu Kawamura, Myeongjeong Choo, Kohtarou Konno, Shinya Kawata, Naofumi Uesaka, Kouichi Hashimoto, Mariko Miyata, Kenji Sakimura, Masahiko Watanabe, Masanobu Kan. Direct and indirect pathways for heterosynaptic interaction underlying developmental synapse elimination in the mouse cerebellum. Communications biology. vol 7. issue 1. 2024-07-04. PMID:38961250. |
in the neonatal mouse cerebellum, purkinje cells (pcs) receive excitatory synaptic inputs from multiple climbing fibers (cfs) and synapses from all but one cf are eliminated by around postnatal day 20. |
2024-07-04 |
2024-07-08 |
mouse |
| Hélène Cwerman-Thibault, Vassilissa Malko-Baverel, Gwendoline Le Guilloux, Isabel Torres-Cuevas, Edward Ratcliffe, Djmila Mouri, Virginie Mignon, Bruno Saubaméa, Odile Boespflug-Tanguy, Pierre Gressens, Marisol Corral-Debrinsk. Harlequin mice exhibit cognitive impairment, severe loss of Purkinje cells and a compromised bioenergetic status due to the absence of Apoptosis Inducing Factor. Biochimica et biophysica acta. Molecular basis of disease. 2024-06-19. PMID:38897257. |
we evaluated the progression of cerebellar degeneration in harlequin mice, especially for purkinje cells and its relationship with bioenergetics failure and behavioral damage. |
2024-06-19 |
2024-06-22 |
mouse |
| Martha G Garcia-Garcia, Akash Kapoor, Oluwatobi Akinwale, Lina Takemaru, Tony Hyun Kim, Casey Paton, Ashok Litwin-Kumar, Mark J Schnitzer, Liqun Luo, Mark J Wagne. A cerebellar granule cell-climbing fiber computation to learn to track long time intervals. Neuron. 2024-06-13. PMID:38870929. |
in classical cerebellar learning, purkinje cells (pkcs) associate climbing fiber (cf) error signals with predictive granule cells (grcs) that were active just prior (∼150 ms). |
2024-06-13 |
2024-06-16 |
mouse |
| Yuhao Yan, Timothy H Murph. Decoding state-dependent cortical-cerebellar cellular functional connectivity in the mouse brain. Cell reports. vol 43. issue 6. 2024-06-12. PMID:38865245. |
these cortical-cerebellar connectivity features are observed in mossy fibers and purkinje cells as well as neurons in different cerebellar lobules, albeit with variations across cell types and regions. |
2024-06-12 |
2024-06-15 |
mouse |
| Jennifer L Fessler, Megan A Stiles, Martin-Paul Agbaga, Mohiuddin Ahmad, David M Sherr. The Spinocerebellar Ataxia 34-Causing W246G ELOVL4 Mutation Does Not Alter Cerebellar Neuron Populations in a Rat Model. Cerebellum (London, England). 2024-06-08. PMID:38850484. |
to test whether w246g elovl4 altered neuronal generation or survival in the cerebellum, we compared the numbers of purkinje cells, unipolar brush cells, molecular layer interneurons, granule and displaced granule cells in the cerebellum of wildtype, heterozygous, and homozygous sca34-ki rats at four months of age, when motor impairment is already present. |
2024-06-08 |
2024-06-11 |
human |
| D González-Tapia, N Vázquez-Hernández, F Urmeneta-Ortiz, N Navidad-Hernandez, M Lazo-Yepez, A Tejeda-Martínez, M Flores-Soto, I González-Burgo. 3-Acetylpyridine-induced ataxic-like motor impairments are associated with plastic changes in the Purkinje cells of the rat cerebellum. Neurologia. vol 39. issue 5. 2024-06-03. PMID:38830720. |
3-acetylpyridine-induced ataxic-like motor impairments are associated with plastic changes in the purkinje cells of the rat cerebellum. |
2024-06-03 |
2024-06-06 |
rat |
| D González-Tapia, N Vázquez-Hernández, F Urmeneta-Ortiz, N Navidad-Hernandez, M Lazo-Yepez, A Tejeda-Martínez, M Flores-Soto, I González-Burgo. 3-Acetylpyridine-induced ataxic-like motor impairments are associated with plastic changes in the Purkinje cells of the rat cerebellum. Neurologia. vol 39. issue 5. 2024-06-03. PMID:38830720. |
in addition, in purkinje cells from lobules v-vii of the cerebellar vermis studied by the golgi method, the density of dendritic spines decreased, especially the thin and mushroom types. |
2024-06-03 |
2024-06-06 |
rat |
| D González-Tapia, N Vázquez-Hernández, F Urmeneta-Ortiz, N Navidad-Hernandez, M Lazo-Yepez, A Tejeda-Martínez, M Flores-Soto, I González-Burgo. 3-Acetylpyridine-induced ataxic-like motor impairments are associated with plastic changes in the Purkinje cells of the rat cerebellum. Neurologia. vol 39. issue 5. 2024-06-03. PMID:38830720. |
findings suggest a limited capacity of purkinje cells to acquire and consolidate afferent excitatory inputs and an aberrant, rigid profile in the movement-related output patterns of purkinje neurons that likely contributes to the motor-related impairments characteristic of cerebellar ataxias. |
2024-06-03 |
2024-06-06 |
rat |
| Rhydham Karnik, Aliasgar Vohra, Mahamadtezib Khatri, Nilay Dalvi, Hitarthi S Vyas, Helly Shah, Sujitsinh Gohil, Smit Kanojiya, Ranjitsinh Devka. Diet/photoperiod mediated changes in cerebellar clock genes causes locomotor shifts and imperative changes in BDNF-TrkB pathway. Neuroscience letters. 2024-05-31. PMID:38821201. |
nuclear pyknosis of purkinje cells, their derangement and inflammation were the hallmark of cerebellar tissue of all the three experimental groups. |
2024-05-31 |
2024-06-02 |
Not clear |
| Ting-Feng Lin, Silas E Busch, Christian Hanse. Intrinsic and synaptic determinants of receptive field plasticity in Purkinje cells of the mouse cerebellum. Nature communications. vol 15. issue 1. 2024-05-31. PMID:38821918. |
intrinsic and synaptic determinants of receptive field plasticity in purkinje cells of the mouse cerebellum. |
2024-05-31 |
2024-06-02 |
mouse |
| b' Eirik Tveit Solheim, Yola Gerking, Torbj\xf8rn Kr\xe5kenes, Ida Herdlev\xe6r, Even Birkeland, Cecilie Totland, Fiona Dick, Christian Alexander Vedele. Multi-omics profiling reveals dysregulated ribosome biogenesis and impaired cell proliferation following knockout of CDR2L. BMC cancer. vol 24. issue 1. 2024-05-28. PMID:38802745.' |
cerebellar degeneration-related (cdr) proteins are associated with paraneoplastic cerebellar degeneration (pcd) - a rare, neurodegenerative disease caused by tumour-induced autoimmunity against neural antigens resulting in degeneration of purkinje neurons in the cerebellum. |
2024-05-28 |
2024-05-31 |
Not clear |
| Xiaolin Liang, Meng Gong, Zhikai Wang, Jie Wang, Weiwei Guo, Aoling Cai, Zhenye Yang, Xing Liu, Fuqiang Xu, Wei Xiong, Chuanhai Fu, Xiangting Wan. LncRNA TubAR complexes with TUBB4A and TUBA1A to promote microtubule assembly and maintain myelination. Cell discovery. vol 10. issue 1. 2024-05-23. PMID:38769343. |
tubar knockdown in mouse cerebellum causes loss of oligodendrocytes and purkinje cells, demyelination, and decreased locomotor activity. |
2024-05-23 |
2024-05-27 |
mouse |
| D Alwyn Dart, Charlotte L Bevan, Pinar Uysal-Onganer, Wen Guo Jian. Analysis of androgen receptor expression and activity in the mouse brain. Scientific reports. vol 14. issue 1. 2024-05-15. PMID:38750183. |
ar-driven luciferase activity and distinct nuclear staining for ar were seen in several key brain areas including the thalamus, hypothalamus, olfactory bulb, cerebral cortex, purkinje cells of the cerebellum and the hindbrain. |
2024-05-15 |
2024-05-27 |
mouse |
| Yuxin Zhang, Xiaoqing Pei, Lingyang Jing, Qingyu Zhang, Hongfeng Zha. Lead induced cerebellar toxicology of developmental Japanese quail (Coturnix japonica) via oxidative stress-based Nrf2/Keap1 pathway inhibition and glutathione-mediated apoptosis signaling activation. Environmental pollution (Barking, Essex : 1987). vol 352. 2024-05-10. PMID:38718965. |
the results showed pb caused cerebellar microstructural damages charactered by deformation of neuroglia cells, granule cells and purkinje cells with nissl body changes. |
2024-05-10 |
2024-05-27 |
Not clear |
| Joan S Baize. Neuroanatomy of autism: what is the role of the cerebellum? Cerebral cortex (New York, N.Y. : 1991). vol 34. issue 13. 2024-05-02. PMID:38696597. |
both neuropathological and imaging studies found differences in the cerebellum in autism spectrum disorder, the most widely documented being a decreased density of purkinje cells in the cerebellar cortex. |
2024-05-02 |
2024-05-05 |
Not clear |
| Anna Niewiadomska-Cimicka, Lorraine Fievet, Magdalena Surdyka, Ewelina Jesion, Céline Keime, Elisabeth Singer, Aurélie Eisenmann, Zaneta Kalinowska-Poska, Hoa Huu Phuc Nguyen, Agnieszka Fiszer, Maciej Figiel, Yvon Trottie. AAV-Mediated CAG-Targeting Selectively Reduces Polyglutamine-Expanded Protein and Attenuates Disease Phenotypes in a Spinocerebellar Ataxia Mouse Model. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673939. |
polyq-expanded sca proteins are toxic for cerebellar neurons, with purkinje cells (pcs) being the most vulnerable. |
2024-04-27 |
2024-04-29 |
mouse |
| Ke Zhang, Zhen Yang, Michael A Gaffield, Garrett G Gross, Don B Arnold, Jason M Christi. Molecular layer disinhibition unlocks climbing-fiber-instructed motor learning in the cerebellum. bioRxiv : the preprint server for biology. 2024-04-26. PMID:38654827. |
climbing fibers supervise cerebellar learning by providing signals to purkinje cells (pcs) that instruct adaptive changes to mistakenly performed movements. |
2024-04-26 |
2024-04-28 |
mouse |