| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pamela J McMillan, Sylvia S White, Allyn Franklin, J Lynne Greenup, James B Leverenz, Murray A Raskind, Patricia Szo. Differential response of the central noradrenergic nervous system to the loss of locus coeruleus neurons in Parkinson's disease and Alzheimer's disease. Brain research. vol 1373. 2011-05-03. PMID:21147074. |
tyrosine hydroxylase (th) and dopamine β-hydroxylase (dbh) mrna expression in postmortem lc tissue of control and age-matched pd subjects demonstrated a significant reduction in the number of noradrenergic neurons in the lc of pd subjects. |
2011-05-03 |
2023-08-12 |
human |
| D Tomasi, N D Volkow, G J Wang, R Wang, F Telang, E C Caparelli, C Wong, M Jayne, J S Fowle. Methylphenidate enhances brain activation and deactivation responses to visual attention and working memory tasks in healthy controls. NeuroImage. vol 54. issue 4. 2011-05-02. PMID:21029780. |
this suggests that mph (presumably by amplifying dopamine and noradrenergic signaling) modulates cognition in part through its effects on dan and dmn. |
2011-05-02 |
2023-08-12 |
human |
| J Park, B J Aragona, B M Kile, R M Carelli, R M Wightma. In vivo voltammetric monitoring of catecholamine release in subterritories of the nucleus accumbens shell. Neuroscience. vol 169. issue 1. 2011-03-04. PMID:20451589. |
however, fscv cannot distinguish between dopamine and norepinephrine, and caudal regions of the nac shell receive noradrenergic projections. |
2011-03-04 |
2023-08-12 |
rat |
| Marina R Picciott. Galanin and addiction. Experientia supplementum (2012). vol 102. 2011-03-01. PMID:21299070. |
this is consistent with studies showing that galanin decreases activity-evoked dopamine release in striatal slices and decreases the firing rate of noradrenergic neurons in locus coeruleus, areas involved in drug reward and withdrawal, respectively. |
2011-03-01 |
2023-08-12 |
mouse |
| Jason P Schroeder, Debra A Cooper, Jesse R Schank, Megan A Lyle, Meriem Gaval-Cruz, Yvonne E Ogbonmwan, Nikita Pozdeyev, Kimberly G Freeman, P Michael Iuvone, Gaylen L Edwards, Philip V Holmes, David Weinshenke. Disulfiram attenuates drug-primed reinstatement of cocaine seeking via inhibition of dopamine β-hydroxylase. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 12. 2011-02-16. PMID:20736996. |
we hypothesized that disulfiram's inhibition of dopamine β-hydroxylase (dbh), the catecholamine biosynthetic enzyme that converts dopamine (da) to norepinephrine (ne) in noradrenergic neurons, underlies the drug's ability to treat cocaine dependence. |
2011-02-16 |
2023-08-12 |
rat |
| Kasia Radwanska, Evgenij Nikolaev, Leszek Kaczmare. Central noradrenergic lesion induced by DSP-4 impairs the acquisition of avoidance reactions and prevents molecular changes in the amygdala. Neurobiology of learning and memory. vol 94. issue 3. 2011-01-27. PMID:20650329. |
we found that dsp-4 treatment depleted the expression of the norepinephrine marker dopamine -hydroxylase (dbh) in the locus coeruleus and its projection area, the basolateral nucleus of the amygdala, confirming locus coeruleus noradrenergic lesion in the experimental animals. |
2011-01-27 |
2023-08-12 |
rat |
| Tai-Xiang Xu, Qi Ma, Roger D Spealman, Wei-Dong Ya. Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperdopaminergic mutant. Journal of neurochemistry. vol 115. issue 6. 2011-01-04. PMID:20969573. |
in contrast, amphetamine-induced ltp impairment was prevented by inhibition of post-synaptic protein phosphatase-1, a downstream target of pka signaling, or by blockade of either d(1) - or d(2)-class dopamine, but not noradrenergic, receptors. |
2011-01-04 |
2023-08-12 |
mouse |
| Tai-Xiang Xu, Qi Ma, Roger D Spealman, Wei-Dong Ya. Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperdopaminergic mutant. Journal of neurochemistry. vol 115. issue 6. 2011-01-04. PMID:20969573. |
unexpectedly, amphetamine restored the loss of ltp in dopamine transporter-knockout mice primarily by activation of the noradrenergic system. |
2011-01-04 |
2023-08-12 |
mouse |
| Juliano C Capra, Mauricio P Cunha, Daniele G Machado, Andrea D E Zomkowski, Beatriz G Mendes, Adair Roberto S Santos, Moacir G Pizzolatti, Ana Lúcia S Rodrigue. Antidepressant-like effect of scopoletin, a coumarin isolated from Polygala sabulosa (Polygalaceae) in mice: evidence for the involvement of monoaminergic systems. European journal of pharmacology. vol 643. issue 2-3. 2010-12-28. PMID:20599906. |
the results indicate that its antidepressant-like effect is dependent on the serotonergic (5-ht(2a) receptors), noradrenergic (alpha(1)- and alpha(2)-adrenoceptors) and dopaminergic (dopamine d(1) and d(2) receptors) systems. |
2010-12-28 |
2023-08-12 |
mouse |
| Benoit Forget, Carrie Wertheim, Paola Mascia, Abhiram Pushparaj, Steven R Goldberg, Bernard Le Fol. Noradrenergic alpha1 receptors as a novel target for the treatment of nicotine addiction. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 8. 2010-09-17. PMID:20357760. |
although dopamine has been extensively implicated in the rewarding effects of nicotine, noradrenergic systems may have a larger role than previously suspected. |
2010-09-17 |
2023-08-12 |
rat |
| Benoit Forget, Carrie Wertheim, Paola Mascia, Abhiram Pushparaj, Steven R Goldberg, Bernard Le Fol. Noradrenergic alpha1 receptors as a novel target for the treatment of nicotine addiction. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 8. 2010-09-17. PMID:20357760. |
this study evaluated the role of noradrenergic alpha(1) receptors in nicotine and food self-administration and relapse, nicotine discrimination, and nicotine-induced dopamine release in the nucleus accumbens in rats. |
2010-09-17 |
2023-08-12 |
rat |
| T Hökfelt, L G Elfvin, R Elde, M Schultzberg, M Goldstein, R Luf. Occurrence of somatostatin-like immunoreactivity in some peripheral sympathetic noradrenergic neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 74. issue 8. 2010-06-29. PMID:16592433. |
the noradrenergic nature of these cells was established by "staining" of the same or consecutive sections with antiserum to dopamine beta-hydroxylase [dopamine beta-monooxygenase; 3,4-dihydroxyphenylethylamine, ascorbate:oxygen oxidoreductase (beta-hydroxylating), ec 1.14.17.1], the enzyme converting dopamine to noradrenaline (norepinephrine). |
2010-06-29 |
2023-08-12 |
Not clear |
| Paola Devoto, Giovanna Flor. On the origin of cortical dopamine: is it a co-transmitter in noradrenergic neurons? Current neuropharmacology. vol 4. issue 2. 2010-06-09. PMID:18615131. |
on the origin of cortical dopamine: is it a co-transmitter in noradrenergic neurons? |
2010-06-09 |
2023-08-12 |
rat |
| Paola Devoto, Giovanna Flor. On the origin of cortical dopamine: is it a co-transmitter in noradrenergic neurons? Current neuropharmacology. vol 4. issue 2. 2010-06-09. PMID:18615131. |
on the other hand, drugs selectively acting on dopaminergic transmission produced modest changes in extracellular da in mpfc, and had no effect on the occipital or parietal cortex.acute administration of morphine did not increase da levels in the pfc (where na is diminished), in contrast with augmented dopaminergic neuronal activity; moreover, during morphine withdrawal both da and na levels increased, in spite of a diminished dopaminergic activity, both increases being antagonised by clonidine but not quinpirole administration.extensive 6-hydroxy dopamine lesion of the ventral tegmental area (vta) decreases below 95% of control both intra- and extracellular da and dopac in the nucleus accumbens, but only partially or not significantly in the mpfc and parietal cortex.the above evidence points to a common origin for na and da in the cerebral cortex and suggests the possible utility of noradrenergic system modulation as a target for drugs with potential clinical efficacy on cognitive functions. |
2010-06-09 |
2023-08-12 |
rat |
| Fleur L Warton, Fleur M Howells, Vivienne A Russel. Increased glutamate-stimulated release of dopamine in substantia nigra of a rat model for attention-deficit/hyperactivity disorder--lack of effect of methylphenidate. Metabolic brain disease. vol 24. issue 4. 2010-04-29. PMID:19821016. |
abnormal dopamine function could be the result of a primary defect in dopamine neurons (neuronal firing, dopamine transporter, synthesis, receptor function) or an indirect result of impaired glutamate and/or noradrenergic regulation of dopamine neurons. |
2010-04-29 |
2023-08-12 |
rat |
| A Erez, J Li, M T Geraghty, S Ben-Shachar, M L Cooper, D E Mensing, K D Vonalt, Z Ou, A N Pursley, A C Chinault, A Patel, S W Cheung, T Saho. Mosaic deletion 11p13 in a child with dopamine beta-hydroxylase deficiency--case report and review of the literature. American journal of medical genetics. Part A. vol 152A. issue 3. 2010-04-12. PMID:20186791. |
dopamine beta-hydroxylase (dbh) deficiency is characterized by a lack of sympathetic noradrenergic function. |
2010-04-12 |
2023-08-12 |
Not clear |
| H Sershen, A Hashim, A Lajth. Differences between nicotine and cocaine-induced conditioned place preferences. Brain research bulletin. vol 81. issue 1. 2010-03-01. PMID:19665529. |
we measured inhibition by four antagonists: mecamylamine, atropine, sch23390, and phentolamine: antagonists respectively of nicotinic, and muscarinic acetylcholine, dopamine d1, and alpha noradrenergic receptors. |
2010-03-01 |
2023-08-12 |
mouse |
| Sudhirkumar U Yanpallewar, Kimberly Fernandes, Swananda V Marathe, Krishna C Vadodaria, Dhanisha Jhaveri, Karen Rommelfanger, Uma Ladiwala, Shanker Jha, Verena Muthig, Lutz Hein, Perry Bartlett, David Weinshenker, Vidita A Vaidy. Alpha2-adrenoceptor blockade accelerates the neurogenic, neurotrophic, and behavioral effects of chronic antidepressant treatment. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 3. 2010-02-05. PMID:20089918. |
these effects persist in dopamine beta-hydroxylase knock-out (dbh(-/-)) mice lacking norepinephrine, supporting a role for alpha(2)-heteroceptors on progenitor cells, rather than alpha(2)-autoreceptors on noradrenergic neurons that inhibit norepinephrine release. |
2010-02-05 |
2023-08-12 |
mouse |
| John Jacob, Robert Storm, Diogo S Castro, Christopher Milton, Patrick Pla, François Guillemot, Carmen Birchmeier, James Brisco. Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain. Development (Cambridge, England). vol 136. issue 14. 2009-09-24. PMID:19542360. |
however, insm1 is dispensable for the expression of a second key noradrenergic biosynthetic enzyme, dopamine beta-hydroxylase, which is instead regulated by ascl1. |
2009-09-24 |
2023-08-12 |
mouse |
| Yan Fan, Jingjing Huang, Niamh Kieran, Meng-Yang Zh. Effects of transcription factors Phox2 on expression of norepinephrine transporter and dopamine beta-hydroxylase in SK-N-BE(2)C cells. Journal of neurochemistry. vol 110. issue 5. 2009-09-21. PMID:19573018. |
in the present study, we examined the possible effect of phox2a/2b on the in vitro expression of the norepinephrine transporter (net) and dopamine beta-hydroxylase (dbh), two important markers of the noradrenergic system. |
2009-09-21 |
2023-08-12 |
human |