| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiao Meng, Pengming Pan, Gengshuo Guo, Anqi Chen, Xiangbao Meng, Heli Li. Transient CSF1R inhibition ameliorates behavioral deficits in Cntnap2 knockout and valproic acid-exposed mouse models of autism. Journal of neuroinflammation. vol 21. issue 1. 2024-10-19. PMID:39425203. |
at the cellular level, plx5622 restores the morphology and/or number of microglia in the somatosensory cortex, striatum, and hippocampal ca1 regions of the two models. |
2024-10-19 |
2024-10-21 |
mouse |
| Diogo Carregosa, Natasa Loncarevic-Vasiljkovic, Raquel Feliciano, Diogo Moura-Louro, César S Mendes, Cláudia Nunes Dos Santo. Locomotor and gait changes in the LPS model of neuroinflammation are correlated with inflammatory cytokines in blood and brain. Journal of inflammation (London, England). vol 21. issue 1. 2024-10-08. PMID:39379968. |
additionally, in rotarod, lps administration led to a significant decrease in the distance achieved, while in the mousewalker, lps led to a reduction in average velocity.lps induced a decrease in microglia ramification index in the motor cortex and the striatum, while surprisingly a reduction in microglia number was observed in the motor cortex.the concentrations of thirteen cytokines in the blood were significantly altered, while only cxcl1, ccl22, ccl17, g-csf, and il-12p40 were changed in the brain. |
2024-10-08 |
2024-10-11 |
mouse |
| Amanda J Bullert, Hui Wang, Morgan J Linahon, Michael S Chimenti, Andrea Adamcakova-Dodd, Xueshu Li, Michael E Dailey, Aloysius J Klingelhutz, James A Ankrum, Hanna E Stevens, Peter S Thorne, Hans-Joachim Lehmle. Effects of 28-Day Nose-Only Inhalation of PCB52 (2,2',5,5'-Tetrachlorobiphenyl) on the Brain Transcriptome. Toxicology. 2024-10-06. PMID:39369937. |
no significant differences were observed by immunohistochemical evaluation in the density and percent area of total cells, astrocytes, or microglia in the striatum and cerebellar cortex. |
2024-10-06 |
2024-10-09 |
rat |
| Alma Karen Lomeli-Lepe, José Luis Castañeda-Cabral, Mónica E Ureña-Guerrero, Graciela Gudiño Cabrera, Silvia Josefina López-Pére. Bee Venom Reduces Early Inflammation and Oxidative Stress Associated with Lipopolysaccharide-induced Alpha-synuclein in the Substantia Nigra-striatum Axis. Cell biochemistry and biophysics. 2024-09-29. PMID:39342536. |
we examined whether bv (1.5 mg/kg by acupoint injection st36 six times every 48 h) could change the α-syn and th expression measured by western blotting, also, observed the activation of microglia and astrocytes by immunofluorescence, quantified the proinflammatory cytokines levels of tumoral necrosis factor-α (tnf-α) and interleukin-1β (il-1β) by enzyme-linked immunosorbent assay (elisa), and estimated the lipid peroxidation and the activity of superoxide dismutase (sod) and catalase (cat) by colorimetric kits in lps-treated rats (2.5 µg by a single dose intranigral injection) in substantia nigra (sn) and striatum (str) brain areas. |
2024-09-29 |
2024-10-01 |
rat |
| Jianjian Dong, Guanghai Xiang, Xiaoxue Xia, Lewen Xu, Peihua Wen, Chenchen Xu, Yin Xu, Yushuang Su, Yanze Song, Haiyang Tong, Qingjun Zhu, Yongzhu Han, Yongsheng Han, Nan Cheng, Haoyi Wang, Hong Zho. Aberrant copper metabolism and hepatic inflammation cause neurological manifestations in a mouse model of Wilson's disease. Journal of neuroinflammation. vol 21. issue 1. 2024-09-28. PMID:39334421. |
microglia in the striatum and cortex exhibit significant activation, shorter processes, and decreased branch points. |
2024-09-28 |
2024-10-01 |
mouse |
| Sang Hwan Lee, Eun-Jin Bae, Dayana Perez-Acuna, Min Kyo Jung, Jong Won Han, Inhee Mook-Jung, Seung-Jae Le. Amyloid-β-activated microglia can induce compound proteinopathies. Brain : a journal of neurology. 2024-08-28. PMID:39194073. |
here, we show that transplantation of amyloid-β oligomer-activated microglia into the striatum of naïve mice was sufficient to generate all the features of alzheimer's disease, including widespread tauopathy and synucleinopathy, gliosis, neuroinflammation, synapse loss, neuronal death, and cognitive and motor deficits. |
2024-08-28 |
2024-08-30 |
mouse |
| Pablo Berríos-Cárcamo, Sarah Núñez, Justine Castañeda, Javiera Gallardo, María Rosa Bono, Fernando Ezque. Two-Month Voluntary Ethanol Consumption Promotes Mild Neuroinflammation in the Cerebellum but Not in the Prefrontal Cortex, Hippocampus, or Striatum of Mice. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673763. |
we found a significant increase in mcp1 mrna levels in the cerebellum of mice that consumed ethanol compared to controls, whereas no significant changes were observed in the prefrontal cortex, hippocampus, or striatum or in microglia isolated from the hippocampus and striatum. |
2024-04-27 |
2024-04-29 |
mouse |
| Mingjie Zhang, Congyan Duan, Weifang Lin, Honghua Wu, Lu Chen, Hong Guo, Minyu Yu, Qi Liu, Yaling Nie, Hong Wang, Shaoxia Wan. Levistilide A Exerts a Neuroprotective Effect by Suppressing Glucose Metabolism Reprogramming and Preventing Microglia Polarization Shift: Implications for Parkinson's Disease. Molecules (Basel, Switzerland). vol 29. issue 4. 2024-02-24. PMID:38398662. |
in vivo experiments further corroborated these findings, demonstrating that la mitigated the death of th-positive dopaminergic neurons and reduced microglia activation in the ventral snpc brain region of the midbrain and the striatum. |
2024-02-24 |
2024-02-26 |
Not clear |
| Rikang Wang, Zhi Liang, Xiaoyan Xue, Hua Mei, Lianru Ji, Bocheng Wang, Wenjin Chen, Chao Gao, Shun Yuan, Tao Wu, Hui Qi, Suifa Hu, Li Yi, Yonggui Song, Rifang Liao, Baodong Che. Microglial FoxO3a deficiency ameliorates ferroptosis-induced brain injury of intracerebral haemorrhage via regulating autophagy and heme oxygenase-1. Journal of cellular and molecular medicine. vol 28. issue 1. 2024-01-24. PMID:37890842. |
furthermore, the microglia activation in the striatum showed significant along with a high expression level of foxo3a in the ich mice. |
2024-01-24 |
2024-01-26 |
mouse |
| Rikang Wang, Zhi Liang, Xiaoyan Xue, Hua Mei, Lianru Ji, Bocheng Wang, Wenjin Chen, Chao Gao, Shun Yuan, Tao Wu, Hui Qi, Suifa Hu, Li Yi, Yonggui Song, Rifang Liao, Baodong Che. Microglial FoxO3a deficiency ameliorates ferroptosis-induced brain injury of intracerebral haemorrhage via regulating autophagy and heme oxygenase-1. Journal of cellular and molecular medicine. vol 28. issue 1. 2024-01-24. PMID:37890842. |
we found that conditional knockout of foxo3a in microglia in mice alleviated neurological deficits and microglia activation as well as ferroptosis-induced striatum injury in the autologous blood-induced ich model. |
2024-01-24 |
2024-01-26 |
mouse |
| Max Gentenaar, Fleur L Meulmeester, Ximaine R van der Burg, Anna T Hoekstra, Hazel Hunt, Jan Kroon, Willeke M C van Roon-Mom, Onno C Meije. Glucocorticoid receptor antagonist CORT113176 attenuates motor and neuropathological symptoms of Huntington's disease in R6/2 mice. Experimental neurology. 2024-01-12. PMID:38216109. |
it also restored hd-related parameters including astrocyte markers in both the dorsolateral striatum and the hippocampus, and microglia markers in the hippocampus. |
2024-01-12 |
2024-01-15 |
mouse |
| Maria João Nunes, Andreia Neves Carvalho, Alexandra I Rosa, Paula A Videira, Maria João Gama, Elsa Rodrigues, Margarida Castro-Calda. Altered expression of Sialyl Lewis X in experimental models of Parkinson's disease. Journal of molecular medicine (Berlin, Germany). 2024-01-10. PMID:38197965. |
importantly, our results show that mptp triggers the presentation of more proteins decorated with slex in mouse cortex and striatum in a time-dependent manner, as well as increased mrna expression of its rate-limiting enzyme fucosyltransferase 7. slex is expressed in neurons, including dopaminergic neurons, and microglia. |
2024-01-10 |
2024-01-13 |
mouse |
| Ge Shi, Chunhui Zhang, Xinghua Bai, Jian Sun, KaiDong Wang, Qi Meng, Yang Li, Guiling Hu, Rong Hu, Qian Cai, Min Huan. A potential mechanism clue to the periodic storm from microglia activation and progressive neuron damage induced by paraquat exposure. Environmental toxicology. 2024-01-08. PMID:38189626. |
in addition, we observed the fluorescence intensity enhancement of iba-1 activated microglia with released pro-inflammatory, all ahead of both the damage of dopaminergic neurons in the substantia nigra and corpus striatum of the brain. |
2024-01-08 |
2024-01-10 |
mouse |
| Anna M Fiorito, Eric Fakra, Guillaume Sescousse, El Chérif Ibrahim, Romain Re. Molecular mapping of a core transcriptional signature of microglia-specific genes in schizophrenia. Translational psychiatry. vol 13. issue 1. 2023-12-13. PMID:38092734. |
we report evidence of a widespread transcriptional alteration of microglia genes both in brain tissues (we observed a decreased expression in the cerebellum, associative striatum, hippocampus, and parietal cortex of individuals with schizophrenia compared with healthy controls) and whole blood (characterized by a mixed altered expression pattern). |
2023-12-13 |
2023-12-17 |
human |
| Masaki Ishikawa, Yasuko Yamamoto, Bolati Wulaer, Kazuo Kunisawa, Hidetsugu Fujigaki, Tatsuya Ando, Hiroki Kimura, Itaru Kushima, Yuko Arioka, Youta Torii, Akihiro Mouri, Norio Ozaki, Toshitaka Nabeshima, Kuniaki Sait. Indoleamine 2,3-dioxygenase 2 deficiency associates with autism-like behavior via dopaminergic neuronal dysfunction. The FEBS journal. 2023-12-01. PMID:38037233. |
furthermore, decreased abundance of ramified-type microglia resulted in increased dendritic spine density in the striatum of ido2 ko mice. |
2023-12-01 |
2023-12-10 |
mouse |
| Peggy Rentsch, Timothy Egan, Andrea Kuriakose, Sandy Stayte, Bryce Visse. The ratio of M1 to M2 microglia in the striatum determines the severity of L-Dopa-induced dyskinesias. Journal of neurochemistry. 2023-11-02. PMID:37916541. |
the ratio of m1 to m2 microglia in the striatum determines the severity of l-dopa-induced dyskinesias. |
2023-11-02 |
2023-11-08 |
mouse |
| Daniel K Wilton, Kevin Mastro, Molly D Heller, Frederick W Gergits, Carly Rose Willing, Jacyln B Fahey, Arnaud Frouin, Anthony Daggett, Xiaofeng Gu, Yejin A Kim, Richard L M Faull, Suman Jayadev, Ted Yednock, X William Yang, Beth Steven. Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease. Nature medicine. 2023-10-09. PMID:37814059. |
inhibition of this complement-dependent elimination mechanism through administration of a therapeutically relevant c1q function-blocking antibody or genetic ablation of a complement receptor on microglia prevented synapse loss, increased excitatory input to the striatum and rescued the early development of visual discrimination learning and cognitive flexibility deficits in these models. |
2023-10-09 |
2023-10-15 |
Not clear |
| David N King'uyu, Lily Nti-Kyemereh, Jesse L Bonin, Paul J Feustel, Michelle Tram, Katherine C MacNamara, Ashley M Kope. The effect of morphine on rat microglial phagocytic activity: An in vitro study of brain region-, plating density-, sex-, morphine concentration-, and receptor-dependency. Journal of neuroimmunology. vol 384. 2023-09-29. PMID:37774553. |
to examine how morphine impacts microglial phagocytosis, we isolated microglia from adult male and female rat cortex and striatum and plated them in vitro at 10,000 (10k) or 50,000 cells/well densities. |
2023-09-29 |
2023-10-07 |
rat |
| Taisuke Murata, Sho Ishiwa, Xin Lin, Yosuke Nakazawa, Kenji Tago, Megumi Funakoshi-Tag. The citrus flavonoid, nobiletin inhibits neuronal inflammation by preventing the activation of NF-κB. Neurochemistry international. 2023-09-29. PMID:37774798. |
furthermore, the administration of nobiletin significantly suppressed the accumulation of microglia and induction of the mrna expression of ccl2, cxcl1, il-6, and tnfα in the murine brain induced by injecting lps into the striatum. |
2023-09-29 |
2023-10-07 |
mouse |
| Yan Cheng, Rachael Elizabeth Dempsey, Soheil Kazemi Roodsari, Dorela D Shuboni-Mulligan, Olivier George, Larry D Sanford, Ming-Lei Gu. Cocaine Regulates NLRP3 Inflammasome Activity and CRF Signaling in a Region- and Sex-Dependent Manner in Rat Brain. Biomedicines. vol 11. issue 7. 2023-07-29. PMID:37509440. |
to further characterize the effects of cocaine on microglia and neuroimmune signaling in vivo, we utilized the brains from both sexes of outbred rats with cocaine self-administration to explore the activation status of microglia, nod-, lrr-, and pyrin domain-containing protein 3 (nlrp3) inflammasome activity, corticotropin-releasing factor (crf) signaling, and nf-κb levels in the striatum and hippocampus (hp). |
2023-07-29 |
2023-08-14 |
mouse |