| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Iván Ballasch, Esther García-García, Cristina Vila, Anna Pérez-González, Anna Sancho-Balsells, Jéssica Fernández, David Soto, Mar Puigdellívol, Xavier Gasull, Jordi Alberch, Manuel J Rodríguez, Josep M Canals, Albert Giral. Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration. Brain, behavior, and immunity. 2023-01-26. PMID:36702234. |
by characterizing the ikzf1 deficient mice, we observed that these mice displayed spatial learning deficits, impaired hippocampal ca3-ca1 long-term potentiation, and decreased spine density in pyramidal neurons of the ca1, which correlates with an increased expression of synaptic markers within microglia. |
2023-01-26 |
2023-08-14 |
mouse |
| Iván Ballasch, Esther García-García, Cristina Vila, Anna Pérez-González, Anna Sancho-Balsells, Jéssica Fernández, David Soto, Mar Puigdellívol, Xavier Gasull, Jordi Alberch, Manuel J Rodríguez, Josep M Canals, Albert Giral. Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration. Brain, behavior, and immunity. 2023-01-26. PMID:36702234. |
additionally, these ikzf1 deficient microglia exhibited a severe abnormal morphology in the hippocampus, which is accompanied by astrogliosis, an aberrant composition of the inflammasome, and an altered expression of disease-associated microglia molecules. |
2023-01-26 |
2023-08-14 |
mouse |
| Iván Ballasch, Esther García-García, Cristina Vila, Anna Pérez-González, Anna Sancho-Balsells, Jéssica Fernández, David Soto, Mar Puigdellívol, Xavier Gasull, Jordi Alberch, Manuel J Rodríguez, Josep M Canals, Albert Giral. Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration. Brain, behavior, and immunity. 2023-01-26. PMID:36702234. |
since the lack of ikzf1 in mice appears to induce the internalization of synaptic markers within microglia, and severe gliosis we then analyzed hippocampal ikzf1 levels in several models of neurological disorders. |
2023-01-26 |
2023-08-14 |
mouse |
| Du Zheng, Hongwei Wang, Youfa Zhou, Yeru Chen, Gang Che. Ac-YVAD-cmk ameliorated sevoflurane-induced cognitive dysfunction and revised mitophagy impairment. PloS one. vol 18. issue 1. 2023-01-25. PMID:36696410. |
the cleaved caspase-1 was demonstrated in microglia of hippocampus. |
2023-01-25 |
2023-08-14 |
mouse |
| Xiaorong Wu, Shiqi Li, Meijia Zhang, Shengjun Bai, Yangyue Ni, Qiaoqiao Xu, Yun Fan, Chuncheng Lu, Zhipeng Xu, Chenbo Ji, Guizhen Du, Yufeng Qi. Early-life bisphenol AP exposure impacted neurobehaviors in adulthood through microglial activation in mice. Chemosphere. 2023-01-25. PMID:36696922. |
besides, single-nucleus rna-sequencing (snrna-seq) showed bpap exposure altered the transcriptome of microglia in hippocampus. |
2023-01-25 |
2023-08-14 |
mouse |
| Xiaorong Wu, Shiqi Li, Meijia Zhang, Shengjun Bai, Yangyue Ni, Qiaoqiao Xu, Yun Fan, Chuncheng Lu, Zhipeng Xu, Chenbo Ji, Guizhen Du, Yufeng Qi. Early-life bisphenol AP exposure impacted neurobehaviors in adulthood through microglial activation in mice. Chemosphere. 2023-01-25. PMID:36696922. |
mechanistically, bpap exposure induced inflammations in hippocampus through upregulating iba-1 and activating the microglia. |
2023-01-25 |
2023-08-14 |
mouse |
| Xiaorong Wu, Shiqi Li, Meijia Zhang, Shengjun Bai, Yangyue Ni, Qiaoqiao Xu, Yun Fan, Chuncheng Lu, Zhipeng Xu, Chenbo Ji, Guizhen Du, Yufeng Qi. Early-life bisphenol AP exposure impacted neurobehaviors in adulthood through microglial activation in mice. Chemosphere. 2023-01-25. PMID:36696922. |
in conclusion, early-life exposure to bpap impaired neurobehaviors in adult offspring accompanied with excessive activation of hippocampal microglia. |
2023-01-25 |
2023-08-14 |
mouse |
| Renrui Lu, Li Zhang, Huihui Wang, Meng Li, Weisheng Feng, Xiaoke Zhen. Echinacoside exerts antidepressant-like effects through enhancing BDNF-CREB pathway and inhibiting neuroinflammation Frontiers in pharmacology. vol 13. 2023-01-23. PMID:36686689. |
in conclusion, echinacoside may be beneficial for the treatment of depression diseases through regulating the microglia balance by inhibiting the polarization of microglia to m1 phenotype, and improving hippocampal neurogenesis by the creb-bdnf signaling pathway. |
2023-01-23 |
2023-08-14 |
mouse |
| Ran Zhang, Meixuan Chen, Zhongfang Deng, Lingchao Kong, Bing Shen, Lesha Zhan. Delta Opioid Peptide Targets Brain Microvascular Endothelial Cells Reducing Apoptosis to Relieve Hypoxia-Ischemic/Reperfusion Injury. Pharmaceutics. vol 15. issue 1. 2023-01-21. PMID:36678674. |
the co-localization results showed that bmecs, but not astrocytes, microglia, or neurons, presented mostly tunel-positive signals, especially in the dentate gyrus (dg) area of the hippocampus. |
2023-01-21 |
2023-08-14 |
rat |
| Ekaterina Kurilova, Maria Sidorova, Oksana Tuchin. Single Prolonged Stress Decreases the Level of Adult Hippocampal Neurogenesis in C57BL/6, but Not in House Mice. Current issues in molecular biology. vol 45. issue 1. 2023-01-20. PMID:36661521. |
we suppose that decreased microglia levels in the hippocampus of c57bl/6 compared to house mice might be one of the reasons for their sensitivity to a single prolonged stress. |
2023-01-20 |
2023-08-14 |
mouse |
| Yawen Zhang, Rui Ma, Qian Deng, Wencheng Wang, Chi Cao, Chunyang Yu, Shulin Li, Lei Shi, Jianying Tia. S-adenosylmethionine Improves Cognitive Impairment in D-galactose-Induced Brain Aging by Inhibiting Oxidative Stress and Neuroinflammation. Journal of chemical neuroanatomy. 2023-01-12. PMID:36632907. |
sam reduced neuronal cell loss, increased brain-derived neurotrophic factor level in the hippocampus, inhibited amyloid-β level and microglia activation, as well as pro-inflammatory factors levels in the hippocampus and serum. |
2023-01-12 |
2023-08-14 |
rat |
| Zhong Luo, Meng Xu, Linhai Zhang, Haiqing Zhang, Zucai Xu, Zhongxiang X. Glycyrrhizin regulates the HMGB1/P38MAPK signalling pathway in status epilepticus. Molecular medicine reports. vol 27. issue 2. 2023-01-12. PMID:36633134. |
in the hippocampus, the protein expression levels of hmgb1 were assessed using western blotting, the neuronal damage was evaluated using haematoxylin and eosin staining and transmission electron microscopy, and the activation of microglia was assessed using immunochemistry and immunofluorescence. |
2023-01-12 |
2023-08-14 |
rat |
| Megan Goyal, Andrea S Bordt, Jay Neitz, David W Marsha. Trogocytosis of neurons and glial cells by microglia in a healthy adult macaque retina. Scientific reports. vol 13. issue 1. 2023-01-12. PMID:36635325. |
in the mouse hippocampus, microglia engulf small pieces of axons and presynaptic terminals via a process called trogocytosis. |
2023-01-12 |
2023-08-14 |
mouse |
| Yuanduo Liu, Hongying Ma, Yangyang Wang, Boxu Ren, Lian Liu, Anbang Sun, Fengru Tan. Neonatal exposure to low-dose X-ray causes behavioral defects and abnormal hippocampal development in mice. IUBMB life. 2023-01-11. PMID:36629313. |
however, the number of astrocytes and microglia in the hippocampus was increased the first day after irradiation, and then decreased 21 days later. |
2023-01-11 |
2023-08-14 |
mouse |
| . Expression of Concern: Accumulating Microglia Phagocytose Injured Neurons in Hippocampal Slice Cultures: Involvement of p38 MAP Kinase. PloS one. vol 18. issue 1. 2023-01-11. PMID:36630371. |
expression of concern: accumulating microglia phagocytose injured neurons in hippocampal slice cultures: involvement of p38 map kinase. |
2023-01-11 |
2023-08-14 |
Not clear |
| Julia N Khantakova, Natalia P Bondar, Elena V Antontseva, Vasiliy V Reshetniko. Once induced, it lasts for a long time: the structural and molecular signatures associated with depressive-like behavior after neonatal immune activation. Frontiers in cellular neuroscience. vol 16. 2023-01-09. PMID:36619667. |
analyses of molecular changes have shown that nia leads to an increase in the amount of activated microglia and astroglia in the frontal cortex and hippocampus, an increase in oxidative-stress parameters, a change in stress reactivity of the hpa axis, and an imbalance of cytokines in various regions of the brain, but not in blood plasma, thus confirming the local nature of the inflammation. |
2023-01-09 |
2023-08-14 |
Not clear |
| Huili Jiang, Lu Chen, Yufei Li, Xingzhou Gao, Xinjing Yang, Bingcong Zhao, Yahuan Li, Yu Wang, Xue Yu, Xuhui Zhang, Shixing Feng, Yemao Chai, Hong Meng, Xiujun Ren, Tuya Ba. Effects of acupuncture on regulating the hippocampal inflammatory response in rats exposed to post-traumatic stress disorder. Neuroscience letters. 2023-01-09. PMID:36621587. |
immunofluorescence staining method was used to observe the activation of hippocampal microglia. |
2023-01-09 |
2023-08-14 |
rat |
| Huili Jiang, Lu Chen, Yufei Li, Xingzhou Gao, Xinjing Yang, Bingcong Zhao, Yahuan Li, Yu Wang, Xue Yu, Xuhui Zhang, Shixing Feng, Yemao Chai, Hong Meng, Xiujun Ren, Tuya Ba. Effects of acupuncture on regulating the hippocampal inflammatory response in rats exposed to post-traumatic stress disorder. Neuroscience letters. 2023-01-09. PMID:36621587. |
the results have also shown that acupuncture intervention effectively reversed the activated microglia of the hippocampus in rats. |
2023-01-09 |
2023-08-14 |
rat |
| Ning Jiang, Yiwen Zhang, Caihong Yao, Yupei Liu, Yuzhen Chen, Fang Chen, Yan Wang, Muhammad Iqbal Choudhary, Xinmin Li. Tenuifolin ameliorates the sleep deprivation-induced cognitive deficits. Phytotherapy research : PTR. 2023-01-07. PMID:36608695. |
moreover, ten stimulated the generation of anti-inflammatory cytokines (interleukin-10), lowered the production of pro-inflammatory cytokines (interleukin-1β, interleukin-6, and interleukin-18), and activated microglia, improving antioxidant status in the hippocampus. |
2023-01-07 |
2023-08-14 |
mouse |
| Guo Dongming, Yang Xu, Zhenghai Liu, Yingge Wang, Xiaofan Xu, Li Cai, Suyun Li, Jingwen Zhang, Tianqing Xiong, Wen Yu Cao, Jingyan Lian. IGF2 inhibits hippocampal over-activated microglia and alleviates depression-like behavior in LPS- treated male mice. Brain research bulletin. 2023-01-05. PMID:36603794. |
igf2 inhibits hippocampal over-activated microglia and alleviates depression-like behavior in lps- treated male mice. |
2023-01-05 |
2023-08-14 |
mouse |