| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chen-Meng Qiao, Wei Quan, Yu Zhou, Gu-Yu Niu, Hui Hong, Jian Wu, Li-Ping Zhao, Ting Li, Chun Cui, Wei-Jiang Zhao, Yan-Qin She. Orally Induced High Serum Level of Trimethylamine N-oxide Worsened Glial Reaction and Neuroinflammation on MPTP-Induced Acute Parkinson's Disease Model Mice. Molecular neurobiology. 2023-06-02. PMID:37266763. |
furthermore, immunofluorescence, elisa, and rt-qpcr results of the hippocampus also showed that high serum tmao significantly promoted the activation of microglia and astrocytes in the dentate gyrus, increased the levels of tnf-α and il-1β, and upregulated gene expression of m1 microglia-related markers (including cd16, cd32, and inos) and a2 astrocyte-related markers (including s100a10, ptx3, and emp1) in mrna levels. |
2023-06-02 |
2023-08-14 |
mouse |
| Zengyu Zhang, Zimin Guo, Pengpeng Jin, Hualan Yang, Mengting Hu, Yuan Zhang, Zhilan Tu, Shuangxing Ho. Transcriptome Profiling of Hippocampus After Cerebral Hypoperfusion in Mice. Journal of molecular neuroscience : MN. 2023-06-02. PMID:37266840. |
increased inflammatory cells, particularly microglia, often parallel hypoperfusion-induced gray matter damage such as hippocampal lesions, but the exact mechanism remains largely unknown. |
2023-06-02 |
2023-08-14 |
mouse |
| David J Braun, Hilaree N Frazier, Verda A Davis, Meggie J Coleman, Colin B Rogers, Linda J Van Eldi. Early chronic suppression of microglial p38α in a model of Alzheimer's disease does not significantly alter amyloid-associated neuropathology. PloS one. vol 18. issue 5. 2023-06-01. PMID:37256881. |
however, this manipulation did significantly increase hippocampal levels of soluble aβ42 and reduce colocalization of iba1 and 6e10 in a subset of microglia in close proximity to plaques. |
2023-06-01 |
2023-08-14 |
mouse |
| Kevin Sanchez, Sienna L Wu, Reha Kakkar, Jeffrey S Darling, Claire S Harper, Laura K Fonke. Ovariectomy in mice primes hippocampal microglia to exacerbate behavioral sickness responses. Brain, behavior, & immunity - health. vol 30. 2023-05-31. PMID:37256192. |
ovariectomy in mice primes hippocampal microglia to exacerbate behavioral sickness responses. |
2023-05-31 |
2023-08-14 |
mouse |
| Zhourui Wu, Ran Zhu, Yan Yu, Jianjie Wang, Xiao Hu, Wei Xu, Yilong Ren, Chen Li, Zhili Zeng, Bin Ma, Ning Xie, Gufa Lin, Bei Ma, Rongrong Zhu, Keqiang Ye, Liming Chen. Spinal cord injury-activated C/EBPβ-AEP axis mediates cognitive impairment through APP C586/Tau N368 fragments spreading. Progress in neurobiology. 2023-05-31. PMID:37257680. |
elevated c/ebpβ level, as well as microglia population and inflammatory cytokines were also noticed in the cortex and hippocampus of sci mice. |
2023-05-31 |
2023-08-14 |
mouse |
| Arielle J D Hay, Amanda S Latham, Genova Mumford, Amelia D Hines, Sydney Risen, Elizabeth Gordon, Connor Siebenaler, Vincenzo S Gilberto, Mark D Zabel, Julie A Moren. Intranasally delivered mesenchymal stromal cells decrease glial inflammation early in prion disease. Frontiers in neuroscience. vol 17. 2023-05-30. PMID:37250395. |
admsc treatment promoted a quiescent state in hippocampal microglia by inducing changes in both number and morphology. |
2023-05-30 |
2023-08-14 |
mouse |
| Giacomo Gravina, Maryam Ardalan, Tetyana Chumak, Halfdan Rydbeck, Xiaoyang Wang, Carl Joakim Ek, Carina Mallar. Transcriptome network analysis links perinatal Staphylococcus epidermidis infection to microglia reprogramming in the immature hippocampus. Glia. 2023-05-29. PMID:37246946. |
transcriptome network analysis links perinatal staphylococcus epidermidis infection to microglia reprogramming in the immature hippocampus. |
2023-05-29 |
2023-08-14 |
mouse |
| Giacomo Gravina, Maryam Ardalan, Tetyana Chumak, Halfdan Rydbeck, Xiaoyang Wang, Carl Joakim Ek, Carina Mallar. Transcriptome network analysis links perinatal Staphylococcus epidermidis infection to microglia reprogramming in the immature hippocampus. Glia. 2023-05-29. PMID:37246946. |
we employed morphological, transcriptomic and physiological methods to extensively characterize microglia in the immature hippocampus following s. epidermidis infection. |
2023-05-29 |
2023-08-14 |
mouse |
| Ha-Yeun Chung, Jonathan Wickel, Nina Hahn, Nils Mein, Meike Schwarzbrunn, Philipp Koch, Mihai Ceanga, Holger Haselmann, Carolin Baade-Büttner, Nikolai von Stackelberg, Nina Hempel, Lars Schmidl, Marco Groth, Nico Andreas, Juliane Götze, Sina M Coldewey, Michael Bauer, Christian Mawrin, Justina Dargvainiene, Frank Leypoldt, Stephan Steinke, Zhao-Qi Wang, Michael Hust, Christian Gei. Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in sepsis-associated encephalopathy. Science advances. vol 9. issue 21. 2023-05-26. PMID:37235660. |
we identified microglia and c1q complement activation in hippocampal autopsy tissue of patients with sepsis and increased c1q-mediated synaptic pruning in a murine polymicrobial sepsis model. |
2023-05-26 |
2023-08-14 |
mouse |
| Ha-Yeun Chung, Jonathan Wickel, Nina Hahn, Nils Mein, Meike Schwarzbrunn, Philipp Koch, Mihai Ceanga, Holger Haselmann, Carolin Baade-Büttner, Nikolai von Stackelberg, Nina Hempel, Lars Schmidl, Marco Groth, Nico Andreas, Juliane Götze, Sina M Coldewey, Michael Bauer, Christian Mawrin, Justina Dargvainiene, Frank Leypoldt, Stephan Steinke, Zhao-Qi Wang, Michael Hust, Christian Gei. Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in sepsis-associated encephalopathy. Science advances. vol 9. issue 21. 2023-05-26. PMID:37235660. |
unbiased transcriptomics of hippocampal tissue and isolated microglia derived from septic mice revealed an involvement of the innate immune system, complement activation, and up-regulation of lysosomal pathways during sae in parallel to neuronal and synaptic damage. |
2023-05-26 |
2023-08-14 |
mouse |
| Ali Nouraeineja. The functional and structural changes in the hippocampus of COVID-19 patients. Acta neurologica Belgica. 2023-05-24. PMID:37226033. |
covid-19 activates microglia in the hippocampus and induces a cns cytokine storm, leading to loss of hippocampal neurogenesis. |
2023-05-24 |
2023-08-14 |
human |
| Yulong Wu, Zhouyan Dong, Xinze Jiang, Lei Qu, Wei Zhou, Xu Sun, Jiangshan Hou, Hongmei Xu, Mei Chen. Gut Microbiota Taxon-Dependent Transformation of Microglial M1/M2 Phenotypes Underlying Mechanisms of Spatial Learning and Memory Impairment after Chronic Methamphetamine Exposure. Microbiology spectrum. 2023-05-22. PMID:37212669. |
here, we investigated the impact of the gut microbiota on the phenotype status of microglia (microglial phenotypes m1 and microglial m2) and their secreting factors, the subsequent hippocampal neural processes, and the resulting influence on spatial learning and memory of chronically meth-exposed mice. |
2023-05-22 |
2023-08-14 |
mouse |
| Hyun Joo Shin, Kyung Eun Kim, Eun Ae Jeong, Hyeong Seok An, So Jeong Lee, Jaewoong Lee, Gu Seob Ro. Amyloid β oligomer promotes microglial galectin-3 and astrocytic lipocalin-2 levels in the hippocampus of mice fed a high-fat diet. Biochemical and biophysical research communications. vol 667. 2023-05-18. PMID:37201358. |
sholl analysis of iba-1-positive microglia showed retraction of microglial ramifications in the hippocampus of hfd-fed diabetic mice. |
2023-05-18 |
2023-08-14 |
mouse |
| Song-Ji Li, Min-Hui Ma, Jun-Mei Li, Xiao-Yu Lu, Cheng-Biao Lu, Shi-Fen Zhou, Lin-Xuan Zhang, Meng-Qing Li, Tong-Ze Shao, Su-Ping Bai, Xiao-Xin Yan, Fang Li, Chang-Qi L. CNTN1 Aggravates Neuroinflammation and Triggers Cognitive Deficits in Male Mice by Boosting Crosstalk between Microglia and Astrocytes. Aging and disease. 2023-05-17. PMID:37196127. |
the mechanisms underlying these cognitive deficits could be attributed to hippocampal microglia and astrocyte activation, which led to aberrant expression of excitatory amino acid transporters (eaat)1/eaat2. |
2023-05-17 |
2023-08-14 |
mouse |
| Dongli Meng, Mengzhe Yang, Huiliang Zhang, Lun Zhang, Haiyue Song, Yi Liu, Yi Zeng, Bo Yang, Xiaochuan Wang, Yu Chen, Rong Li. Microglia activation mediates circadian rhythm disruption-induced cognitive impairment in mice. Journal of neuroimmunology. vol 379. 2023-05-17. PMID:37196595. |
in the brain, crd resulted in neuroinflammation, which was characterized by microglia activation and increased pro-inflammatory cytokine production, impairments in neurogenesis and reduction of synaptic proteins in the hippocampus. |
2023-05-17 |
2023-08-14 |
mouse |
| Xiaoyu Dong, Dongxue Zha. Ferulic acid as a therapeutic agent in depression: Evidence from preclinical studies. CNS neuroscience & therapeutics. 2023-05-15. PMID:37183361. |
the mechanisms are achieved by enhancing monoamine oxidase a (moa) activity, inhibiting microglia activation and inflammatory factor release, anti-oxidative stress, promoting hippocampal nerve regeneration, increasing brain-derived neurotrophic factor secretion, regulating gut microbiome, and activating protein kinase b/collapsin response mediator protein 2 (akt/crmp2) signaling pathway. |
2023-05-15 |
2023-08-14 |
human |
| Giulia Bivona, Matilda Iemmolo, Giulio Ghers. CX3CL1 Pathway as a Molecular Target for Treatment Strategies in Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175935. |
however, some other putative mechanisms underlying the pathogenesis of the disease have been proposed, including inflammation in the brain, microglia activation, impaired hippocampus neurogenesis and alterations in the production and release of neurotrophic factors. |
2023-05-14 |
2023-08-14 |
Not clear |
| Ekaterina V Pershina, Irina Yu Chernomorets, Dmitry A Fedorov, Vladimir I Arkhipo. Pharmacological Modulation of Excitotoxicity through the Combined Use of NMDA Receptor Inhibition and Group III mGlu Activation Reduces TMT-Induced Neurodegeneration in the Rat Hippocampus. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175959. |
the results of immunohistochemical studies confirmed a significant activation of microglia in the hippocampus three weeks after tmt injection. |
2023-05-14 |
2023-08-14 |
rat |
| Ekaterina V Pershina, Irina Yu Chernomorets, Dmitry A Fedorov, Vladimir I Arkhipo. Pharmacological Modulation of Excitotoxicity through the Combined Use of NMDA Receptor Inhibition and Group III mGlu Activation Reduces TMT-Induced Neurodegeneration in the Rat Hippocampus. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175959. |
moreover, in the ca1 field of the hippocampus of the animals of the mem + vu group, the amount of such microglia was close to the control. |
2023-05-14 |
2023-08-14 |
rat |
| Kazuki Nakanishi, Kosuke Norimatsu, Akira Tani, Teruki Matsuoka, Ryoma Matsuzaki, Syogo Kakimoto, Nao Nojima, Yuta Tachibe, Yuki Kato, Masaki Inadome, Riho Kitazato, Shotaro Otsuka, Seiya Takada, Megumi Sumizono, Harutoshi Sakakim. Effects of early exercise intervention and exercise cessation on neuronal loss and neuroinflammation in a senescence-accelerated mouse prone 8. Neuroscience letters. 2023-05-14. PMID:37182575. |
age-related cognitive decline was prevented in the lt-ex group compared with the no-ex group through the suppression of neuronal loss, enhanced brain-derived neurotrophic factor (bdnf), and inhibition of neuroinflammation corresponding to reduced m1 and increased m2 microglia in the hippocampus. |
2023-05-14 |
2023-08-14 |
mouse |