| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying He, Man-Shu Zou, Ting-Ting Ren, Ping Li, Yang Liu, Yuan-Shan Ha. [Therapeutic effect and mechanism of Xiaoyao Kangai Jieyu Recipe on mice with breast cancer related depression through regulating COX pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 14. 2023-07-20. PMID:37475079. |
compared with the model group, the positive drug group and the xkjr group presented an improvement in depressive behaviors, a decrease in the contents of il-1β, il-18, cox-2 and eprs in hippocampus, and an alleviation in the activation of hippocampal microglia and neuronal damage; the tumor suppression rates of positive drug and xkjr were 40.32% and 48.83%, respectively, suggesting a lower tumor growth rate than that of the model group. |
2023-07-20 |
2023-08-14 |
mouse |
| Ying He, Man-Shu Zou, Ting-Ting Ren, Ping Li, Yang Liu, Yuan-Shan Ha. [Therapeutic effect and mechanism of Xiaoyao Kangai Jieyu Recipe on mice with breast cancer related depression through regulating COX pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 14. 2023-07-20. PMID:37475079. |
in summary, xkjr may improve hippocampal microglia activation and neuronal damage in mice with breast cancer related depression through activating cox signaling pathway. |
2023-07-20 |
2023-08-14 |
mouse |
| Masato Kobayashi, Nobuhiro Moro, Atsuo Yoshino, Takahiro Kumagawa, Katsunori Shijo, Takeshi Maeda, Hideki Oshim. Inhibition of P2X4 and P2X7 receptors improves histological and behavioral outcomes after experimental traumatic brain injury in rats. Experimental and therapeutic medicine. vol 26. issue 2. 2023-07-17. PMID:37456165. |
in the cci-5-bdbd, cci-az11645373, and cci-5-bdbd + az11645373 groups, expression of activated microglia was suppressed in the ipsilateral cortex and hippocampus 3 days after the cci. |
2023-07-17 |
2023-08-14 |
rat |
| Amanda Moya-Gómez, Lena Pérez Font, Andreea Burlacu, Yeranddy A Alpizar, Miriam Marañón Cardonne, Bert Brône, Annelies Bronckaer. Extremely Low-Frequency Electromagnetic Stimulation (ELF-EMS) Improves Neurological Outcome and Reduces Microglial Reactivity in a Rodent Model of Global Transient Stroke. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37446295. |
next, we studied microglial cells migration and, in organotypic hippocampal brain slices, we assessed neuronal survival and microglia reactivity. |
2023-07-14 |
2023-08-14 |
Not clear |
| Amanda Moya-Gómez, Lena Pérez Font, Andreea Burlacu, Yeranddy A Alpizar, Miriam Marañón Cardonne, Bert Brône, Annelies Bronckaer. Extremely Low-Frequency Electromagnetic Stimulation (ELF-EMS) Improves Neurological Outcome and Reduces Microglial Reactivity in a Rodent Model of Global Transient Stroke. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37446295. |
it also improved neuronal survival and decreased glia reactivity in the hippocampus, with microglia showing the first signs of treatment effect. |
2023-07-14 |
2023-08-14 |
Not clear |
| Miquel Martin, Matteo M Pusceddu, Joan Teichenné, Teresa Negra, Alan Connolly, Xavier Escoté, Helena Torrell Galceran, Adrià Cereto Massagué, Iris Samarra Mestre, Antoni Del Pino Rius, Jordi Romero-Gimenez, Cristina Egea, Juan Maria Alcaide-Hidalgo, Josep Maria Del Ba. Preventive Treatment with Astaxanthin Microencapsulated with Spirulina Powder, Administered in a Dose Range Equivalent to Human Consumption, Prevents LPS-Induced Cognitive Impairment in Rats. Nutrients. vol 15. issue 13. 2023-07-14. PMID:37447181. |
our results demonstrate that lps modified long-term memory in the mwm and increased microglia activation in the hippocampus and prefrontal cortex. |
2023-07-14 |
2023-08-14 |
human |
| Yi Luo, Keyi Lv, Zhulin Du, Dandan Zhang, Mei Chen, Jing Luo, Lian Wang, Tianyao Liu, Hong Gong, Xiaotang Fa. Minocycline improves autism-related behaviors by modulating microglia polarization in a mouse model of autism. International immunopharmacology. vol 122. 2023-07-13. PMID:37441807. |
we also found that minocycline improved neurogenesis and inhibited microglia activation in the hippocampus of btbr mice. |
2023-07-13 |
2023-08-14 |
mouse |
| Wei Xiong, Rongzi Li, Boying Li, Xifan Wang, Huihui Wang, Yanan Sun, Xiaoyu Wang, Yixuan Li, Fazheng Re. Nobiletin Mitigates D-Galactose-Induced Memory Impairment via Improving Hippocampal Neurogenesis in Mice. Nutrients. vol 15. issue 9. 2023-07-11. PMID:37432372. |
furthermore, it downregulated the pro-inflammatory mediators il-1 β, il-6, and pp65 (by 42.2%, 22.9%, and 46.4% of those in the d-galactose treated group, respectively) in the hippocampus and blocked microglia and astrocyte activation. |
2023-07-11 |
2023-08-14 |
mouse |
| María Inmaculada Infantes-López, Andrea Nieto-Quero, Patricia Chaves-Peña, Emma Zambrana-Infantes, Manuel Cifuentes, Javier Márquez, Carmen Pedraza, Margarita Pérez-Martí. New insights into hypothalamic neurogenesis disruption after acute and intense stress: implications for microglia and inflammation. Frontiers in neuroscience. vol 17. 2023-07-10. PMID:37425000. |
acute and chronic stress is known to cause alterations in neurogenesis and microglia in classical adult neurogenic regions such as the hippocampus. |
2023-07-10 |
2023-08-14 |
mouse |
| Susanna Kemppainen, Nadine Huber, Roosa-Maria Willman, Ana Zamora, Petra Mäkinen, Henna Martiskainen, Mari Takalo, Annakaisa Haapasalo, Tomás Sobrino, Manuel Antonio González Gómez, Yolanda Piñeiro, José Rivas, Uwe Himmelreich, Mikko Hiltune. Organotypic Hippocampal Slice Cultures from Adult Tauopathy Mice and Theragnostic Evaluation of Nanomaterial Phospho-TAU Antibody-Conjugates. Cells. vol 12. issue 10. 2023-07-06. PMID:37408256. |
adult hippocampal slices retained intact hippocampal layers, astrocytes, and functional microglia during culturing. |
2023-07-06 |
2023-08-14 |
mouse |
| Maiko Inoue, Takashi Tanida, Tomohiro Kondo, Shigeo Takenaka, Takayuki Nakajim. Oxygen-glucose deprivation-induced glial cell reactivity in the rat primary neuron-glia co-culture. The Journal of veterinary medical science. 2023-07-05. PMID:37407448. |
this study examined the ogd-induced changes in the expression level of astrocytes and microglia marker proteins and immunoreactivity for ki-67, a marker protein for cell proliferation, using rat primary hippocampal neuron-glia co-culture (ngc) cells. |
2023-07-05 |
2023-08-14 |
rat |
| Zoë A P Williams, Joanna Kasia Szyszkowicz, Natasha Osborne, Bshaier Allehyany, Christophe Nadon, Maryann Chinonye Udechukwu, Ana Santos, Marie-Claude Aude. Sex-specific effects of voluntary wheel running on behavior and the gut microbiota-immune-brain axis in mice. Brain, behavior, & immunity - health. vol 30. 2023-07-03. PMID:37396336. |
gene expression of pro-inflammatory cytokines, microglia activation-related genes, and tight junction proteins was determined in the jejunum and the hippocampus, while microbiota composition and predicted function were verified in cecum contents. |
2023-07-03 |
2023-08-14 |
mouse |
| Xi Chen, Qian-Qian Cui, Xiao-Hai Hu, Jian Ye, Zi-Cun Liu, Yuan-Xi Mei, Fang Wang, Zhuang-Li Hu, Jian-Guo Che. CD200 in dentate gyrus improves depressive-like behaviors of mice through enhancing hippocampal neurogenesis via alleviation of microglia hyperactivation. Journal of neuroinflammation. vol 20. issue 1. 2023-06-30. PMID:37391731. |
cd200 in dentate gyrus improves depressive-like behaviors of mice through enhancing hippocampal neurogenesis via alleviation of microglia hyperactivation. |
2023-06-30 |
2023-08-14 |
mouse |
| Gideon Opeyemi Ayilara, Bamidele Victor Owoyel. Neuroinflammation and microglial expression in brains of social-isolation rearing model of schizophrenia. IBRO neuroscience reports. vol 15. 2023-06-27. PMID:37359498. |
furthermore, isolation rearing significantly increased microglia count (p < 0.05) in the hippocampus, nucleus accumbens, and prefrontal cortex, only in the male group. |
2023-06-27 |
2023-08-14 |
mouse |
| Xinmiao Wu, Yuzhu Gao, Cuina Shi, Jianhua Tong, Daqing Ma, Jinchun Shen, Jianjun Yang, Muhuo J. Complement C1q drives microglia-dependent synaptic loss and cognitive impairments in a mouse model of lipopolysaccharide-induced neuroinflammation. Neuropharmacology. 2023-06-25. PMID:37356797. |
collectively, our data provide evidence that activated microglia and complement cascade c1q signaling in the hippocampus may account for synaptic loss and cognitive impairments in a mouse model of neuroinflammation induced by repeated lps injections. |
2023-06-25 |
2023-08-14 |
mouse |
| Yanning Li, Yujie Ma, Lijie Gao, Ting Wang, Yuchen Zhuang, Yuping Zhang, Long Zheng, Xifu Li. Upregulation of microglial Sirt6 and inhibition of microglial activation by vitamin D3 in lipopolysaccharide-stimulated mice and BV-2 cells. Neuroscience. 2023-06-23. PMID:37352968. |
moreover, vitamin d3 promoted microglial sirt6 distribution and attenuated microglia displaying an activated morphology in the hippocampus of lps-stimulated mice. |
2023-06-23 |
2023-08-14 |
mouse |
| Rita Chaaya, Joel R Steele, Brian G Oliver, Hui Chen, Rita Machaalan. Effects of e-vapour and high-fat diet on the immunohistochemical staining of nicotinic acetylcholine receptors, apoptosis, microglia and astrocytes in the adult male mouse hippocampus. Journal of chemical neuroanatomy. 2023-06-21. PMID:37343645. |
effects of e-vapour and high-fat diet on the immunohistochemical staining of nicotinic acetylcholine receptors, apoptosis, microglia and astrocytes in the adult male mouse hippocampus. |
2023-06-21 |
2023-08-14 |
mouse |
| Rui Li, Huiyu Jia, Min Si, Xinwei Li, Zheng Ma, Yu Zhu, Wuyi Sun, Fengqin Zhu, Shengyong Lu. Loureirin B protects against cerebral ischemia/reperfusion injury through modulating M1/M2 microglial polarization via STAT6 / NF-kappaB signaling pathway. European journal of pharmacology. 2023-06-18. PMID:37331681. |
the results showed that lb significantly reduced infarct volume, neurological deficits and neurobehavioral deficits, apparently improved histopathological changes and neuronal loss in cortex and hippocampus of mcao/r rats, markedly decreased the proportion of m1 microglia cells and the level of pro-inflammatory cytokines, and increased the proportion of m2 microglia and the level of anti-inflammatory cytokines both in vivo and in vitro. |
2023-06-18 |
2023-08-14 |
rat |
| Natalia V Gulyaev. Glucocorticoids Orchestrate Adult Hippocampal Plasticity: Growth Points and Translational Aspects. Biochemistry. Biokhimiia. vol 88. issue 5. 2023-06-18. PMID:37331704. |
glucocorticoid hormones ensure the coordinated functioning of key components and mechanisms of hippocampal plasticity: neurogenesis, glutamatergic neurotransmission, microglia and astrocytes, systems of neurotrophic factors, neuroinflammation, proteases, metabolic hormones, neurosteroids. |
2023-06-18 |
2023-08-14 |
Not clear |
| Isabel M Alonso Bellido, Mercedes Posada-Pérez, Francisco Hernández-Rasco, Sandra Vázquez-Reyes, María Cabanillas, Antonio J Herrera, Sara Bachiller, Jesús Soldán-Hidalgo, Ana M Espinosa-Oliva, Bertrand Joseph, Rocío M de Pablos, José L Venero, Rocío Rui. Microglial Caspase-3 is essential for modulating hippocampal neurogenesis. Brain, behavior, and immunity. 2023-06-16. PMID:37327833. |
after the reduction of caspase-3 in microglia, mutant mice showed a reduction of microglia in the hippocampus, especially in the dentate gyrus region, a region inherently associated to neurogenesis. |
2023-06-16 |
2023-08-14 |
mouse |