| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ricardo Schmidt, Björn Welzel, Wolfgang Lösche. Effects of season, daytime, sex, and stress on the incidence, latency, frequency, severity, and duration of neonatal seizures in a rat model of birth asphyxia. Epilepsy & behavior : E&B. vol 147. 2023-09-20. PMID:37729684. |
acute stress induced an increase in hippocampal microglia density in sham-exposed rat pups, which may have an additive effect on microglia activation induced by asphyxia. |
2023-09-20 |
2023-10-07 |
human |
| Afzal Misrani, Sidra Tabassum, Zai-Yong Zhang, Shao-Hua Tan, Cheng Lon. Urolithin A Prevents Sleep-deprivation-induced Neuroinflammation and Mitochondrial Dysfunction in Young and Aged Mice. Molecular neurobiology. 2023-09-19. PMID:37725214. |
in the hippocampus of young (3 months-old) and aged (12 months-old) mice subjected to 24 h sd, pretreatment with ua prevented the activation of microglia and astrocytes, nf-κb-nlrp3 signaling and il-1β, il6, tnf-α cytokine production, thus ameliorating neuroinflammation. |
2023-09-19 |
2023-10-07 |
mouse |
| Eleni H Moschonas, Tyler S Ranellone, Vincent J Vozzella, Piper L Rennerfeldt, Corina O Bondi, Ellen M Annas, Rachel A Bittner, Dana M Tamura, Rithika I Reddy, Rithik R Eleti, Jeffrey P Cheng, Jessica M Jarvis, Ericka L Fink, Anthony E Klin. Efficacy of a music-based intervention in a preclinical model of traumatic brain injury: An initial foray into a novel and non-pharmacological rehabilitative therapy. Experimental neurology. 2023-09-19. PMID:37726048. |
music also reduced cortical lesion volume and activated microglia but increased resting microglia and hippocampal bdnf expression. |
2023-09-19 |
2023-10-07 |
rat |
| Dandan Xu, Yayun Xu, Xinran Gao, Mengyu Yan, Chen Zhang, Xian Wu, Qingrong Xia, Jinfang G. Potential value of Interleukin-6 as a diagnostic biomarker in human MDD and the antidepressant effect of its receptor antagonist tocilizumab in lipopolysaccharide-challenged rats. International immunopharmacology. vol 124. issue Pt B. 2023-09-17. PMID:37717319. |
moreover, tocilizumab could alleviate the "inflammatory storm" and impaired hippocampal synaptic plasticity in lps-challenged depression rats, inhibiting the hyperactivation of astrocyte and microglia, decreasing the peripheral and central abundance of il-6, crp, and tnf-α, and balancing the hippocampal expression levels of synaptic plasticity-associated proteins and key molecular in wnt/β-catenin signaling pathway. |
2023-09-17 |
2023-10-07 |
human |
| Blessing A Obafemi, Isaac A Adedara, Joao B T Roch. Neurotoxicity of ochratoxin A: Molecular mechanisms and neurotherapeutic strategies. Toxicology. 2023-09-14. PMID:37709162. |
specifically, the neurotoxic mechanisms associated with ochratoxin a exposure were unequivocally unraveled in vitro using human neuroblastoma sh-sy5y cells, mouse hippocampal ht22 cells, human astrocyte (nha-sv40lt) cells and microglia cells as well as in vivo using mammalian and non-mammalian models. |
2023-09-14 |
2023-10-07 |
mouse |
| Feng Zhang, Ruo-Lin Cao, Peng Liu, Tian-Yan Chi, Xue-Fei Ji, Zhong-Hui Zheng, Guo-Liang Chen, Li-Bo Zo. The bexarotene derivative OAB-14 ameliorates cognitive decline in APP/PS1 transgenic mice by suppressing microglia-mediated neuroinflammation through the PPAR-γ pathway. International immunopharmacology. vol 124. issue Pt A. 2023-09-11. PMID:37696142. |
simultaneously, oab-14 dramatically inhibited the activation of microglia in the cerebral cortex and hippocampus of ad mice and dose-dependently downregulated the expression of nuclear factor kappa b (nf-κb) and nod-like receptor protein 3 (nlrp3) in the cerebral cortex. |
2023-09-11 |
2023-10-07 |
mouse |
| Lin Wei, Xiaowen Yang, Jie Wang, Zhixiao Wang, Qiguang Wang, Yan Ding, Aiqing Y. H3K18 lactylation of senescent microglia potentiates brain aging and Alzheimer's disease through the NFκB signaling pathway. Journal of neuroinflammation. vol 20. issue 1. 2023-09-11. PMID:37697347. |
in this study, we quantified the levels of lactic acid in senescent microglia, and hippocampus tissues of naturally aged mice and ad mice models (fad |
2023-09-11 |
2023-10-07 |
mouse |
| Hong Zhuang, Qian Li, Congli Sun, Dan Xu, Guangming Gan, Chenchen Zhang, Chen Chen, Yang Yuan, Linchen Liu, Yu Xiao, Xiuting Yao, Conghui Wang, Xiaoming Kang, Chenxi Yang, Jingyi Zhao, Wenhao Chen, Jiatang Wang, Jinyu Li, Caichen Luo, Jie Wang, Xirui Jia, Zhehao Yu, Lijie Li. Voluntary wheel exercise ameliorates cognitive impairment, hippocampal neurodegeneration and microglial abnormalities preceded by demyelination in a male mouse model of noise-induced hearing loss. Brain, behavior, and immunity. 2023-09-08. PMID:37683962. |
pretreatment with the glucocorticoid receptor antagonist ru486 before stressful noise exposure partially mitigated the early activation of hippocampal microglia, which were present at 7 days post noise exposure (7dpn), but had no impact on later microglial aberrations, hippocampal neurodegeneration, or cognitive decline exhibited at 1 month post noise exposure (1mpn). |
2023-09-08 |
2023-10-07 |
mouse |
| Hong Zhuang, Qian Li, Congli Sun, Dan Xu, Guangming Gan, Chenchen Zhang, Chen Chen, Yang Yuan, Linchen Liu, Yu Xiao, Xiuting Yao, Conghui Wang, Xiaoming Kang, Chenxi Yang, Jingyi Zhao, Wenhao Chen, Jiatang Wang, Jinyu Li, Caichen Luo, Jie Wang, Xirui Jia, Zhehao Yu, Lijie Li. Voluntary wheel exercise ameliorates cognitive impairment, hippocampal neurodegeneration and microglial abnormalities preceded by demyelination in a male mouse model of noise-induced hearing loss. Brain, behavior, and immunity. 2023-09-08. PMID:37683962. |
our results indicated that accelerated cognitive deterioration and hippocampal neuroplastic decline following nihl are most likely driven by the maladaptive response of hippocampal microglia to myelin damage secondary to hearing loss, and we also demonstrated the potential of voluntary physical exercise as a promising and cost-effective strategy to alleviate the detrimental impact of aphl on cognitive function and thus curtail the high and continuously increasing global burden of dementia. |
2023-09-08 |
2023-10-07 |
mouse |
| Fang Qiu, Changchun Zeng, Yuqiang Liu, Haobo Pan, Changneng K. J147 ameliorates sepsis-induced depressive-like behaviors in mice by attenuating neuroinflammation through regulating the TLR4/NF-κB signaling pathway. Journal of molecular histology. 2023-09-07. PMID:37676534. |
we investigated the effects of j147 on lipopolysaccharide (lps)-induced neuroinflammatory, depressive-like behaviors, and the toll-like receptor 4 (tlr4)/nuclear factor-κb (nf-κb) signal pathway in the mouse hippocampus and microglia (bv2 cells). |
2023-09-07 |
2023-10-07 |
mouse |
| Mingxie Ni, Meng Zheng, Bingran Chen, Xu Lu, Hui Zhao, Tao Zhu, Li Cheng, Han Han, Ting Ye, Huijun Liu, Ying Ye, Chao Huang, Xiaomei Yua. Microglial stimulation triggered by intranasal lipopolysaccharide administration produces antidepressant-like effect through ERK1/2-mediated BDNF synthesis in the hippocampus. Neuropharmacology. 2023-09-07. PMID:37678448. |
we recently reported that reversing the chronic stress-induced decline of microglia in the dentate gyrus (dg) of the hippocampus by intraperitoneal injection of a low dose of lipopolysaccharide (lps) ameliorated depression-like behavior in chronically stressed mice. |
2023-09-07 |
2023-10-07 |
mouse |
| Mingxie Ni, Meng Zheng, Bingran Chen, Xu Lu, Hui Zhao, Tao Zhu, Li Cheng, Han Han, Ting Ye, Huijun Liu, Ying Ye, Chao Huang, Xiaomei Yua. Microglial stimulation triggered by intranasal lipopolysaccharide administration produces antidepressant-like effect through ERK1/2-mediated BDNF synthesis in the hippocampus. Neuropharmacology. 2023-09-07. PMID:37678448. |
these results demonstrate that stimulation of hippocampal microglia by intranasal lps administration can induce antidepressant effects via erk1/2-dependent synthesis of bdnf protein, providing hope for the development of new strategies for the treatment of depression. |
2023-09-07 |
2023-10-07 |
mouse |
| Yanan Wu, Kaiyi Zhou, Baiyang Liu, Jindong Xu, Liming Lei, Jiaqi Hu, Xiao Cheng, Feng Zhong, Sheng Wan. Glial Activation, Mitochondrial Imbalance, and Akt/mTOR Signaling May Be Potential Mechanisms of Cognitive Impairment in Heart Failure Mice. Neurotoxicity research. 2023-09-05. PMID:37668877. |
hf group cued fear memory, spatial memory, and learning impairment, accompanied by activation of glial cells (astrocytes, microglia, and oligodendrocytes) in the hippocampus. |
2023-09-05 |
2023-09-07 |
mouse |
| Zhen Mei, Jiaqi Liu, Jason P Schroeder, David Weinshenker, Duc M Duong, Nicholas T Seyfried, Yujing Li, Peng Jin, Aliza P Wingo, Thomas S Wing. Lowering hippocampal miR-29a expression slows cognitive decline and reduces beta-amyloid deposition in 5xFAD mice. Research square. 2023-08-30. PMID:37645711. |
mir-29a sponge expression significantly reduced hippocampal beta-amyloid deposition in 5xfad mice and lowered astrocyte and microglia activation in both 5xfad and wt mice. |
2023-08-30 |
2023-09-07 |
mouse |
| Heying Zhong, Xiaojuan Ran, Bin Chen, Yiqiang Xiong, Xiangdi Y. Apamin, an SK2 Inhibitor, Attenuated Neonatal Sevoflurane Exposures Caused Cognitive Deficits in Mice through the Regulation of Hippocampal Neuroinflammation. ACS chemical neuroscience. 2023-08-30. PMID:37647501. |
apamin inhibited m1-type polarization but promoted m2-type polarization of microglia after neonatal sevoflurane exposures in the hippocampus. |
2023-08-30 |
2023-09-07 |
mouse |
| Ruizhuo Chen, Brandy N Routh, Jillian E Straetker, Cecily R Gibson, Aidan S Weitzner, Kiersten S Bell, Andrew D Gaudet, Laura K Fonke. Microglia depletion ameliorates neuroinflammation, anxiety-like behavior, and cognitive deficits in a sex-specific manner in Rev-erbα knockout mice. Brain, behavior, and immunity. 2023-08-30. PMID:37648007. |
surprisingly, these increases were only fully reversed by microglia depletion in the male but not female rko hippocampus. |
2023-08-30 |
2023-09-07 |
mouse |
| Chen Chen, Tao Zhu, Lifen Gong, Zhe Hu, Hao Wei, Jianchen Fan, Donghui Lin, Xiaojun Wang, Junyu Xu, Xinyan Dong, Yifan Wang, Ningxiao Xia, Linghui Zeng, Peifang Jiang, Yicheng Xi. Trpm2 deficiency in microglia attenuates neuroinflammation during epileptogensis by upregulating autophagy via the AMPK/mTOR pathway. Neurobiology of disease. 2023-08-30. PMID:37648036. |
trpm2 knockout in microglia attenuated kainic acid (ka)-induced glial activation, inflammatory cytokines production and hippocampal paroxysmal discharges, whereas trpm2 knockout in astrocytes exhibited no significant effects. |
2023-08-30 |
2023-09-07 |
Not clear |
| Sarah R Ocañas, Kevin D Pham, Jillian E J Cox, Alex W Keck, Sunghwan Ko, Felix A Ampadu, Hunter L Porter, Victor A Ansere, Adam Kulpa, Collyn M Kellogg, Adeline H Machalinski, Manu A Thomas, Zsabre Wright, Ana J Chucair-Elliott, Willard M Freema. Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer's disease. Journal of neuroinflammation. vol 20. issue 1. 2023-08-16. PMID:37587511. |
here, we examined and compared transcriptomic and translatomic sex effects in young and old murine hippocampal microglia. |
2023-08-16 |
2023-09-07 |
mouse |
| He Li, Tianyuan Ye, Xingyang Liu, Rui Guo, Xiuzhao Yang, Yangyi Li, Dongmei Qi, Yihua Wei, Yifan Zhu, Lei Wen, Xiaorui Chen. The role of signaling crosstalk of microglia in hippocampus on progression of ageing and Alzheimer's disease. Journal of pharmaceutical analysis. vol 13. issue 7. 2023-08-14. PMID:37577391. |
the role of signaling crosstalk of microglia in hippocampus on progression of ageing and alzheimer's disease. |
2023-08-14 |
2023-08-16 |
mouse |
| Xue Wang, Ya-Jin Shi, Ting-Yuan Niu, Ting-Ting Chen, Han-Bing Li, Su-Hui Wu, Gen-Lin L. Neuroprotective effect of 20 (S) - Protopanaxadiol (PPD) attenuates NLRP3 inflammasome-mediated microglial pyroptosis in vascular dementia rats. Neuroscience letters. 2023-08-14. PMID:37579868. |
ppd significantly reduced the cerebral infarction area and the activation of microglia in the cortex and hippocampal dg, ca1, and ca3 area. |
2023-08-14 |
2023-09-07 |
rat |