| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xingyu Yang, Ziwei Yu, Li An, Xinyue Jing, Mengqian Yuan, Tiancheng Xu, Zhi Yu, Bin Xu, Mengjiang L. Electroacupuncture stimulation ameliorates cognitive impairment induced by long-term high-fat diet by regulating microglial BDNF. Brain research. vol 1825. 2023-12-17. PMID:38103878. |
studies have shown that hfd activates hippocampal microglia and induces hippocampal inflammation, which is an important factor for cognitive impairment. |
2023-12-17 |
2023-12-21 |
mouse |
| Xingyu Yang, Ziwei Yu, Li An, Xinyue Jing, Mengqian Yuan, Tiancheng Xu, Zhi Yu, Bin Xu, Mengjiang L. Electroacupuncture stimulation ameliorates cognitive impairment induced by long-term high-fat diet by regulating microglial BDNF. Brain research. vol 1825. 2023-12-17. PMID:38103878. |
overexcitation of peripheral inflammasome complexes induces hippocampal microglia apoptosis, which hinders the effects of es. |
2023-12-17 |
2023-12-21 |
mouse |
| Ya-Ya Du, Ting Sun, Qi Yang, Qing-Qing Liu, Jia-Min Li, Le Yang, Lan-Xin Lu. Therapeutic Potential of Kaempferol against Sleep Deprivation-Induced Cognitive Impairment: Modulation of Neuroinflammation and Synaptic Plasticity Disruption in Mice. ACS pharmacology & translational science. vol 6. issue 12. 2023-12-14. PMID:38093836. |
immunofluorescence investigations emphasized diminished activation of astrocytes and reduced the proliferation of microglia in the hippocampus of mice subjected to sd. |
2023-12-14 |
2023-12-17 |
mouse |
| Anna M Fiorito, Eric Fakra, Guillaume Sescousse, El Chérif Ibrahim, Romain Re. Molecular mapping of a core transcriptional signature of microglia-specific genes in schizophrenia. Translational psychiatry. vol 13. issue 1. 2023-12-13. PMID:38092734. |
we report evidence of a widespread transcriptional alteration of microglia genes both in brain tissues (we observed a decreased expression in the cerebellum, associative striatum, hippocampus, and parietal cortex of individuals with schizophrenia compared with healthy controls) and whole blood (characterized by a mixed altered expression pattern). |
2023-12-13 |
2023-12-17 |
human |
| Xiao-Xiang Tan, Hong-Yu Dai, Juan Yao, Jia-Jia Wang, Yu-Chen Dai, Tian-Hao Zhang, Li-Li Qiu, Jie Su. Hippocampal estrogens rescued the decline of synaptic plasticity after surgery and anesthesia by inhibiting microglia overactivation. Behavioural brain research. 2023-12-06. PMID:38056710. |
hippocampal estrogens rescued the decline of synaptic plasticity after surgery and anesthesia by inhibiting microglia overactivation. |
2023-12-06 |
2023-12-10 |
Not clear |
| Xiao-Xiang Tan, Hong-Yu Dai, Juan Yao, Jia-Jia Wang, Yu-Chen Dai, Tian-Hao Zhang, Li-Li Qiu, Jie Su. Hippocampal estrogens rescued the decline of synaptic plasticity after surgery and anesthesia by inhibiting microglia overactivation. Behavioural brain research. 2023-12-06. PMID:38056710. |
this study aimed to determine whether suppressing microglia overactivation by hippocampal estrogens can rescue the decrease of synaptic plasticity after surgery and anesthesia. |
2023-12-06 |
2023-12-10 |
Not clear |
| R De Simone, M A Ajmone-Cat, A M Tartaglione, G Calamandrei, L Minghett. Maternal suboptimal selenium intake and low-level lead exposure affect offspring's microglial immune profile and its reactivity to a subsequent inflammatory hit. Scientific reports. vol 13. issue 1. 2023-12-05. PMID:38052845. |
we found an overall higher basal expression of inflammatory markers in neonatal brains, as well as in purified microglia and organotypic hippocampal slice cultures, from the subopt se offspring. |
2023-12-05 |
2023-12-10 |
rat |
| Heliana de Barros Fernandes, Bruna da Silva Oliveira, Caroline Amaral Machado, Brener Cunha Carvalho, Eliana Cristina de Brito Toscano, Maria Carolina M da Silva, Érica Leandro Marciano Vieira, Antônio Carlos Pinheiro de Oliveira, Antônio Lúcio Teixeira, Aline Silva de Miranda, Aristóbolo Mendes da Silv. Behavioral, neurochemical and neuroimmune features of RasGEF1b deficient mice. Progress in neuro-psychopharmacology & biological psychiatry. 2023-12-04. PMID:38048936. |
in addition, morphological alterations were observed in rasgef1b deficient microglia along with decreased levels of hippocampal bdnf. |
2023-12-04 |
2023-12-10 |
mouse |
| Wenrong Wen, Jingsheng Zhou, Chang'an Zhan, Jun Wan. Microglia as a Game Changer in Epilepsy Comorbid Depression. Molecular neurobiology. 2023-12-04. PMID:38048030. |
activated microglia released cytokines like il-6 and il-1β, orchestrating neuroinflammation especially in the hippocampus, worsening both depression and epilepsy. |
2023-12-04 |
2023-12-10 |
Not clear |
| Yuan Qi, Xuehang Wang, Yaoxin Zhang, Yue Leng, Xiaoting Liu, Xiyan Wang, Dan Wu, Ji Wang, Weihong Mi. Walnut-Derived Peptide Improves Cognitive Impairment in Colitis Mice Induced by Dextran Sodium Sulfate via the Microbiota-Gut-Brain Axis (MGBA). Journal of agricultural and food chemistry. 2023-12-01. PMID:38039336. |
furthermore, lp-5 ameliorated hippocampal neuron damage and protected blood-brain barrier (bbb) integrity by downregulating microglia marker protein iba-1, increasing tj protein expression, and restoring the deterioration of synaptic proteins. |
2023-12-01 |
2023-12-10 |
mouse |
| Yongri Hong, Caichuan Wei, Miaoying Fu, Xinyang Li, Haiju Zhang, Baozhen Ya. MCC950 alleviates seizure severity and angiogenesis by inhibiting NLRP3/ IL-1β signaling pathway-mediated pyroptosis in mouse model of epilepsy. International immunopharmacology. vol 126. 2023-12-01. PMID:38039716. |
in addition, immunofluorescence staining, rt-qpcr, and western blot demonstrated that mcc950 inhibited the expression of the nlrp3 inflammasome and its related proteins in microglia, whereas microangiogenesis was found to be increased in the cerebral cortex and hippocampus of epileptic mice, and these effects could be reversed by mcc950. |
2023-12-01 |
2023-12-10 |
mouse |
| Antara Rao, Nuo Chen, Min Joo Kim, Jessica Blumenfeld, Oscar Yip, Yanxia Hao, Zherui Liang, Maxine R Nelson, Nicole Koutsodendris, Brian Grone, Leo Ding, Seo Yeon Yoon, Patrick Arriola, Yadong Huan. Microglia Depletion Reduces Human Neuronal APOE4-Driven Pathologies in a Chimeric Alzheimer's Disease Model. bioRxiv : the preprint server for biology. 2023-11-28. PMID:38014339. |
specifically, we transplanted homozygous apoe4, isogenic apoe3, and apoe-knockout (apoe-ko) induced pluripotent stem cell (ipsc)-derived human neurons into the hippocampus of human apoe3 or apoe4 knock-in mice, and depleted microglia in half the chimeric mice. |
2023-11-28 |
2023-11-29 |
mouse |
| Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Sing. S1PR2 inhibition mitigates cognitive deficit in diabetic mice by modulating microglial activation via Akt-p53-TIGAR pathway. International immunopharmacology. vol 126. 2023-11-27. PMID:38011768. |
it further enhanced anti-inflammatory microglia in the hippocampus and prefrontal cortex (pfc), as evidenced by increased arg-1, cd206, and ym-1 levels and decreased inos, cd16, and mhcii levels. |
2023-11-27 |
2023-11-29 |
mouse |
| Qian Xiao, Jiaojiao Wang, Qiuyun Tian, Na Tian, Qi Tian, Xin He, Yutian Wang, Zhifang Don. Uric Acid Mitigates Cognitive Deficits via TFEB-Mediated Microglial Autophagy in Mice Models of Alzheimer's Disease. Molecular neurobiology. 2023-11-26. PMID:38008888. |
furthermore, ua activated microglia and upregulated the autophagy-related proteins such as lc3ii/i ratio, beclin-1, and lamp1 in the hippocampus of ad model mice. |
2023-11-26 |
2023-11-28 |
mouse |
| Caio Matheus Santos da Silva Calado, Raul Manhães-de-Castro, Sabrina da Conceição Pereira, Vanessa da Silva Souza, Leticia Nicoly Ferreira Barbosa, Osmar Henrique Dos Santos Junior, Claudia Jacques Lagranha, Pedro Alberto Romero Juárez, Luz Torner, Omar Guzmán-Quevedo, Ana Elisa Toscan. Resveratrol Reduces Neuroinflammation and Hippocampal Microglia Activation and Protects Against Impairment of Memory and Anxiety-Like Behavior in Experimental Cerebral Palsy. Molecular neurobiology. 2023-11-24. PMID:38001357. |
resveratrol reduces neuroinflammation and hippocampal microglia activation and protects against impairment of memory and anxiety-like behavior in experimental cerebral palsy. |
2023-11-24 |
2023-11-28 |
rat |
| Caio Matheus Santos da Silva Calado, Raul Manhães-de-Castro, Sabrina da Conceição Pereira, Vanessa da Silva Souza, Leticia Nicoly Ferreira Barbosa, Osmar Henrique Dos Santos Junior, Claudia Jacques Lagranha, Pedro Alberto Romero Juárez, Luz Torner, Omar Guzmán-Quevedo, Ana Elisa Toscan. Resveratrol Reduces Neuroinflammation and Hippocampal Microglia Activation and Protects Against Impairment of Memory and Anxiety-Like Behavior in Experimental Cerebral Palsy. Molecular neurobiology. 2023-11-24. PMID:38001357. |
the cps group showed an increase in the activated microglia and a reduction in cell proliferation in the hippocampus, while cpr animals showed a reduction of activated microglia and an increase in cell proliferation. |
2023-11-24 |
2023-11-28 |
rat |
| Jie Gao, Huiping Zhang, Leiying Zhou, Jiaqi Liu, Enba Zhuo, Yujun Shen, Xuesheng Liu, Qiying She. MANF Alleviates Sevoflurane-Induced Cognitive Impairment in Neonatal Mice by Modulating Microglial Activation and Polarization. Molecular neurobiology. 2023-11-22. PMID:37989984. |
finally, the recombinant human manf (rhmanf, 20 μg) protein was intraperitoneally administrated to neonatal mice before the sevoflurane anesthesia and the cognitive function, levels of pro-inflammatory cytokine and synapse-associated protein psd95, the status of neural apoptosis, microglia activation and oxidative stress in hippocampus of the mice were investigated. |
2023-11-22 |
2023-11-29 |
mouse |
| Jie Gao, Huiping Zhang, Leiying Zhou, Jiaqi Liu, Enba Zhuo, Yujun Shen, Xuesheng Liu, Qiying She. MANF Alleviates Sevoflurane-Induced Cognitive Impairment in Neonatal Mice by Modulating Microglial Activation and Polarization. Molecular neurobiology. 2023-11-22. PMID:37989984. |
the sevoflurane anesthesia increased the expression of endogenous manf in the hippocampus, especially in microglia. |
2023-11-22 |
2023-11-29 |
mouse |
| Jie Gao, Huiping Zhang, Leiying Zhou, Jiaqi Liu, Enba Zhuo, Yujun Shen, Xuesheng Liu, Qiying She. MANF Alleviates Sevoflurane-Induced Cognitive Impairment in Neonatal Mice by Modulating Microglial Activation and Polarization. Molecular neurobiology. 2023-11-22. PMID:37989984. |
mko upregulated the expression of tumor necrosis factor-α (tnf-α), accelerated the neural apoptosis and the activation of microglia in hippocampus in young mice. |
2023-11-22 |
2023-11-29 |
mouse |
| Zhen Mei, Jiaqi Liu, Jason P Schroeder, David Weinshenker, Duc M Duong, Nicholas T Seyfried, Yujing Li, Peng Jin, Aliza P Wingo, Thomas S Wing. Lowering Hippocampal miR-29a Expression Slows Cognitive Decline and Reduces Beta-Amyloid Deposition in 5×FAD Mice. Molecular neurobiology. 2023-11-22. PMID:37989983. |
mir-29a sponge significantly reduced hippocampal beta-amyloid deposition in 5×fad mice and lowered astrocyte and microglia activation in both 5×fad and wt mice. |
2023-11-22 |
2023-11-29 |
mouse |