| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Lin, M D Ginsberg, R Busto, W D Dietric. Sequential analysis of subacute and chronic neuronal, astrocytic and microglial alterations after transient global ischemia in rats. Acta neuropathologica. vol 95. issue 5. 1998-07-13. PMID:9600598. |
in the ca1 hippocampus, a decreased number of normal neurons was seen at 1 week post ischemia, together with a significant increase in immunoreactive microglia at that time; the latter normalized after 2 weeks. |
1998-07-13 |
2023-08-12 |
rat |
| H Neumann, T Misgeld, K Matsumuro, H Wekerl. Neurotrophins inhibit major histocompatibility class II inducibility of microglia: involvement of the p75 neurotrophin receptor. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 10. 1998-06-19. PMID:9576961. |
we studied the conditions leading to the induction of mhc class ii molecules in microglia by using explant cultures of neonatal rat hippocampus, a model of interacting neuronal networks. |
1998-06-19 |
2023-08-12 |
rat |
| H Neumann, T Misgeld, K Matsumuro, H Wekerl. Neurotrophins inhibit major histocompatibility class II inducibility of microglia: involvement of the p75 neurotrophin receptor. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 10. 1998-06-19. PMID:9576961. |
interferon-gamma (ifn-gamma)-dependent mhc class ii inducibility in microglia cells was very low, but strongly increased in the hippocampal slices after the blockade of neuronal activity by neurotoxins [tetrodotoxin (ttx), omega-conotoxin] or glutamate antagonists. |
1998-06-19 |
2023-08-12 |
rat |
| Y Kitamur. [Functional activation of glial cells in early and delayed episodes of the brain damage]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 111. issue 3. 1998-06-05. PMID:9583078. |
the microinjection of interferon-gamma and lipopolysaccharide into rat hippocampus induced mhc class ii and inos in microglia. |
1998-06-05 |
2023-08-12 |
rat |
| Y Kitamur. [Functional activation of glial cells in early and delayed episodes of the brain damage]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 111. issue 3. 1998-06-05. PMID:9583078. |
subsequently, neuronal cell death occurred in the hippocampus, but cell death was undetectable in both microglia and astrocytes that expressed ho-1. |
1998-06-05 |
2023-08-12 |
rat |
| T Stojkovic, C Colin, F Le Saux, C Jacqu. Specific pattern of nitric oxide synthase expression in glial cells after hippocampal injury. Glia. vol 22. issue 4. 1998-05-05. PMID:9517565. |
despite the large expression of nos detected by nadph-diaphorase histochemistry after lesioning the hippocampus, immunostaining for inos was confined to microglia. |
1998-05-05 |
2023-08-12 |
mouse |
| T Yamada, Y Yoshiyama, N Kawaguchi, A Ichinose, T Iwaki, S Hirose, W A Jefferie. Possible roles of transglutaminases in Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 9. issue 2. 1998-05-05. PMID:9524802. |
on the other hand, few factor-xiiia-positive microglia were found in the parietal cortices from non-neurological cases, but moderate numbers were found in their hippocampal tissues. |
1998-05-05 |
2023-08-12 |
human |
| B Hauss-Wegrzyniak, P Dobrzanski, J D Stoehr, G L Wen. Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease. Brain research. vol 780. issue 2. 1998-05-04. PMID:9507169. |
chronic infusion of lps (0.25 microgram/h) into the 4th ventricle for four weeks produced (1) an increase in the number of glial fibrillary acidic protein-positive activated astrocytes and ox-6-positive reactive microglia distributed throughout the brain, with the greatest increase occurring within the temporal lobe, particularly the hippocampus, (2) an induction in interleukin-1 beta, tumor necrosis factor-alpha and beta-amyloid precursor protein mrna levels within the basal forebrain region and hippocampus, (3) the degeneration of hippocampal ca3 pyramidal neurons, and (4) a significant impairment in spatial memory as determined by decreased spontaneous alternation behavior on a t-maze. |
1998-05-04 |
2023-08-12 |
rat |
| E L Conway, A L Gundlach, J A Crave. Temporal changes in glial fibrillary acidic protein messenger RNA and [3H]PK11195 binding in relation to imidazoline-I2-receptor and alpha 2-adrenoceptor binding in the hippocampus following transient global forebrain ischaemia in the rat. Neuroscience. vol 82. issue 3. 1998-04-09. PMID:9483537. |
in this study the spatial changes in glial fibrillary acidic protein messenger rna levels in the hippocampus have been mapped four, eight, 12, 16 and 20 days following 10 min of global forebrain ischaemia in the rat and related to changes in [3h]pk11195 binding to peripheral benzodiazepine receptors, a putative marker of activated microglia. |
1998-04-09 |
2023-08-12 |
rat |
| Y Kitamura, M Furukawa, Y Matsuoka, I Tooyama, H Kimura, Y Nomura, T Taniguch. In vitro and in vivo induction of heme oxygenase-1 in rat glial cells: possible involvement of nitric oxide production from inducible nitric oxide synthase. Glia. vol 22. issue 2. 1998-04-09. PMID:9537834. |
in in vivo rat hippocampus, microinjection of lps plus ifn-gamma, or snap after 24 h also induced ho-1 immunoreactivity in reactive microglia and astrocytes. |
1998-04-09 |
2023-08-12 |
rat |
| A G Woods, K M Guthrie, M A Kurlawalla, C M Gal. Deafferentation-induced increases in hippocampal insulin-like growth factor-1 messenger RNA expression are severely attenuated in middle aged and aged rats. Neuroscience. vol 83. issue 3. 1998-04-02. PMID:9483550. |
insulin-like growth factor-1 may play a role in sprouting because it (i) promotes axonal growth, (ii) is expressed at elevated levels by microglia just prior to sprouting onset, and (iii) is expressed with better spatiotemporal correspondence to hippocampal sprouting than other trophic factors examined. |
1998-04-02 |
2023-08-12 |
rat |
| A D Rogove, S E Tsirk. Neurotoxic responses by microglia elicited by excitotoxic injury in the mouse hippocampus. Current biology : CB. vol 8. issue 1. 1998-03-24. PMID:9427623. |
neurotoxic responses by microglia elicited by excitotoxic injury in the mouse hippocampus. |
1998-03-24 |
2023-08-12 |
mouse |
| E Garcion, L Sindji, C Montero-Menei, C Andre, P Brachet, F Darc. Expression of inducible nitric oxide synthase during rat brain inflammation: regulation by 1,25-dihydroxyvitamin D3. Glia. vol 22. issue 3. 1998-03-24. PMID:9482214. |
after stab lesion, inos mrnas, expressed at 5 h mainly in cells in the interventricular junction and in a few cells in brain parenchyma, were no more detectable from 15 h onwards, whereas the protein was faintly expressed in parenchymal cells at 15 h and 24 h. in contrast, after lps injection, inos-mrnas were detected from 5 to 24 h. inos-immunoreactivity was highly induced and sequentially observed first in choroid plexus and ependymal cells at 5 h, in monocytes and activated/reactive microglia at 15 h and 24 h, and finally in astrocytes at 72 h. in order to investigate potential regulatory effects of 1,25-dihydroxyvitamin d3 (1,25-d3) on inos expression, we have delivered this hormone with lps or buffer into the rat hippocampus. |
1998-03-24 |
2023-08-12 |
rat |
| T Kita, L Liu, N Tanaka, Y Kinoshit. The expression of tumor necrosis factor-alpha in the rat brain after fluid percussive injury. International journal of legal medicine. vol 110. issue 6. 1998-01-22. PMID:9387012. |
by immunoelectron microscopy, tnf alpha reactions were detected in the lysosomes of microglia accumulated at the impact site of the cortex 30 min after impact, and 1 h after impact these reactions were mainly detected at the glial cells (such as microglia and astrocytes) in the hippocampus and parasagittal cortex. |
1998-01-22 |
2023-08-12 |
rat |
| U Boschert, M Muda, M Camps, R Dickinson, S Arkinstal. Induction of the dual specificity phosphatase PAC1 in rat brain following seizure activity. Neuroreport. vol 8. issue 14. 1997-11-26. PMID:9331917. |
recurrent seizure activity leads to delayed neuronal death as well as to inflammatory responses involving microglia in hippocampal subfields ca1, ca3 and ca4. |
1997-11-26 |
2023-08-12 |
rat |
| U Boschert, M Muda, M Camps, R Dickinson, S Arkinstal. Induction of the dual specificity phosphatase PAC1 in rat brain following seizure activity. Neuroreport. vol 8. issue 14. 1997-11-26. PMID:9331917. |
at this time pac1 mrna was also expressed in white matter microglia as well as in microglia invading the damaged hippocampus. |
1997-11-26 |
2023-08-12 |
rat |
| J D Miller, J Cummings, G A Maresh, D G Walker, G M Castillo, C Ngo, K Kimata, M G Kinsella, T N Wight, A D Sno. Localization of perlecan (or a perlecan-related macromolecule) to isolated microglia in vitro and to microglia/macrophages following infusion of beta-amyloid protein into rodent hippocampus. Glia. vol 21. issue 2. 1997-11-26. PMID:9336237. |
localization of perlecan (or a perlecan-related macromolecule) to isolated microglia in vitro and to microglia/macrophages following infusion of beta-amyloid protein into rodent hippocampus. |
1997-11-26 |
2023-08-12 |
human |
| C Solà, J M Tusell, J Serratos. Calmodulin is expressed by reactive microglia in the hippocampus of kainic acid-treated mice. Neuroscience. vol 81. issue 3. 1997-11-24. PMID:9316022. |
calmodulin is expressed by reactive microglia in the hippocampus of kainic acid-treated mice. |
1997-11-24 |
2023-08-12 |
mouse |
| Y Sakurai-Yamashita, M Niwa, K Yamashita, Y Kataoka, A Himeno, K Shigematsu, K Tsutsumi, K Taniyam. Endothelin receptors in kainic acid-induced neural lesions of rat brain. Neuroscience. vol 81. issue 2. 1997-10-29. PMID:9300442. |
microglia were present in the area with "punched hole-figure" and in the hippocampus pyramidal cell layer with neuronal death. |
1997-10-29 |
2023-08-12 |
rat |
| K Sugaya, M Reeves, M McKinne. Topographic associations between DNA fragmentation and Alzheimer's disease neuropathology in the hippocampus. Neurochemistry international. vol 31. issue 2. 1997-09-02. PMID:9220460. |
in hippocampal sections prepared to visualize glia, dna fragmentation was not observed in gfap-positive astrocytes, but some ox-42-positive microglia exhibited tunel signals. |
1997-09-02 |
2023-08-12 |
human |