| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anant Bahadur Patel, Pandichelvam Veeraiah, Mohammad Shameem, Jerald Mahesh Kumar, Kamal Sab. Impaired GABAergic and glutamatergic neurometabolic activity in aged mice brain as measured by FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 2. 2021-07-15. PMID:33543543. |
in this study, we have investigated mitochondrial tca cycle and neurotransmitter cycle fluxes associated with glutamatergic, gabaergic neurons and astroglia in the cerebral cortex and hippocampus of young (6 months) and aged (24 months) c57bl6 mice by using |
2021-07-15 |
2023-08-13 |
mouse |
| Justin N Siemian, Sarah Sarsfield, Yeka Apont. Glutamatergic fast-spiking parvalbumin neurons in the lateral hypothalamus: Electrophysiological properties to behavior. Physiology & behavior. vol 221. 2021-06-21. PMID:32289319. |
however, new methods that allow systematic characterization of the cytoarchitectural organization, connectivity, activity patterns, neurotransmitter nature, and function of genetically-distinct cell types have revealed populations of parvalbumin-positive neurons that are glutamatergic. |
2021-06-21 |
2023-08-13 |
Not clear |
| Carlos Gonzalez-Islas, Miguel Angel Garcia-Bereguiain, Peter Wenne. Homeostatic Recovery of Embryonic Spinal Activity Initiated by Compensatory Changes in Resting Membrane Potential. eNeuro. vol 7. issue 4. 2021-06-18. PMID:32540879. |
it remains unclear what mechanisms mediate this early recovery (first hours) after neurotransmitter blockade, or even if the same mechanisms are triggered following gabaergic and glutamatergic antagonists. |
2021-06-18 |
2023-08-13 |
chicken |
| Haiyang Wang, Lanxiang Liu, Xuechen Rao, Benhua Zeng, Ying Yu, Chanjuan Zhou, Li Zeng, Peng Zheng, Juncai Pu, Shaohua Xu, Ke Cheng, Hanping Zhang, Ping Ji, Hong Wei, Peng Xi. Integrated phosphoproteomic and metabolomic profiling reveals perturbed pathways in the hippocampus of gut microbiota dysbiosis mice. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:33051451. |
these phosphorylation dysregulations were consistently associated with glutamatergic neurotransmitter system disturbances. |
2021-06-18 |
2023-08-13 |
mouse |
| Bettina Moritz, Ariana E Schmitz, Ana Lúcia S Rodrigues, Alcir L Dafre, Mauricio P Cunh. The role of vitamin C in stress-related disorders. The Journal of nutritional biochemistry. vol 85. 2021-05-31. PMID:32745879. |
interestingly, the modulation of monoaminergic and glutamatergic neurotransmitter systems is postulated as pivotal target for the antidepressant and anxiolytic effects of this vitamin. |
2021-05-31 |
2023-08-13 |
Not clear |
| Miao Zhang, Shangxin Song, Di Zhao, Jie Shi, Xinglian Xu, Guanghong Zhou, Chunbao L. High intake of chicken and pork proteins aggravates high-fat-diet-induced inflammation and disorder of hippocampal glutamatergic system. The Journal of nutritional biochemistry. vol 85. 2021-05-31. PMID:32827667. |
thus, compared with a low-protein diet (20%), a high-chicken or -pork-protein diet (40%) under a high-fat background could alter the balance between glutamatergic system and neurotransmitter and have a stronger effect on the interactions between hippocampal glutamatergic system and egcs. |
2021-05-31 |
2023-08-13 |
rat |
| Alaa M Hammad, Ghadeer M S Swiss, F Scott Hall, Suhair Hikmat, Youssef Sari, T M Al-Qirim, H A Amaw. Ceftriaxone Reduces Waterpipe Tobacco Smoke Withdrawal-induced Anxiety in rats via Modulating the Expression of TNF-α/NFĸB, Nrf2, and GLT-1. Neuroscience. vol 463. 2021-05-19. PMID:33836247. |
tobacco exposure has been linked to neuroinflammation and adaptive/maladaptive changes in neurotransmitter systems, including in glutamatergic systems. |
2021-05-19 |
2023-08-13 |
rat |
| Delaram Eslimi Esfahani, Mohammad Reza Zarrindas. Cholestasis and behavioral disorders. Gastroenterology and hepatology from bed to bench. vol 14. issue 2. 2021-05-13. PMID:33968336. |
it has been reported that after he, all classical neurotransmitter systems such as opioidergic, dopaminergic, cholinergic, gabaergic, adrenergic, serotonergic, and glutamatergic systems can be altered. |
2021-05-13 |
2023-08-13 |
Not clear |
| Suelen Baggio, Kamila Zenki, Alberto Martins Silva, Thainá Garbino Dos Santos, Giovana Rech, Gabriela Lazzarotto, Renato Dutra Dias, Ben Hur Mussulini, Eduardo Pacheco Rico, Diogo Losch de Oliveir. Fetal alcohol spectrum disorders model alters the functionality of glutamatergic neurotransmission in adult zebrafish. Neurotoxicology. vol 78. 2021-04-21. PMID:32173352. |
therefore, the aim of the present study was to evaluate the functionality of the glutamatergic neurotransmitter system in an adult zebrafish fasd model. |
2021-04-21 |
2023-08-13 |
zebrafish |
| Simon C Johnson, Ernst-Bernhard Kayser, Rebecca Bornstein, Julia Stokes, Alessandro Bitto, Kyung Yeon Park, Amanda Pan, Grace Sun, Daniel Raftery, Matt Kaeberlein, Margaret M Sedensky, Philip G Morga. Regional metabolic signatures in the Ndufs4(KO) mouse brain implicate defective glutamate/α-ketoglutarate metabolism in mitochondrial disease. Molecular genetics and metabolism. vol 130. issue 2. 2021-04-06. PMID:32331968. |
together, our findings are consistent with mtor inhibition alleviating disease by increasing availability of α-ketoglutarate, which is both an efficient mitochondrial complex i substrate in ndufs4(ko) and an important metabolite related to neurotransmitter metabolism in glutamatergic neurons. |
2021-04-06 |
2023-08-13 |
mouse |
| Gregory H Jones, Carola Rong, Aisha S Shariq, Abhinav Mishra, Rodrigo Machado-Vieir. Intracellular Signaling Cascades in Bipolar Disorder. Current topics in behavioral neurosciences. vol 48. 2021-03-31. PMID:32860212. |
in this chapter, we review a wide range of intracellular mechanisms including mitochondrial energetics, calcium signaling, neuroinflammation, the microbiome, neurotransmitter metabolism, glycogen synthase kinase 3-beta (gsk3β), protein kinase c (pkc) and diacylglycerol (dag), and neurotrophins (especially bdnf), as well as the glutamatergic, dopaminergic, purinergic, and neurohormonal systems. |
2021-03-31 |
2023-08-13 |
Not clear |
| Koen Cuypers, Anouk Marsma. Transcranial magnetic stimulation and magnetic resonance spectroscopy: Opportunities for a bimodal approach in human neuroscience. NeuroImage. vol 224. 2021-03-29. PMID:32987106. |
particularly the mrs-detectable metabolites glutamate, the major excitatory neurotransmitter, and gamma-aminobutyric acid (gaba), the major inhibitory neurotransmitter, are of interest when combining tms and mrs. tms is a non-invasive brain stimulation technique that can be applied either as a neuromodulation or neurostimulation tool, specifically targeting glutamatergic and gabaergic mechanisms. |
2021-03-29 |
2023-08-13 |
human |
| Nikolay N Dygalo, Tatyana S Kalinina, Galina T Shishkin. Stress-induced expression pattern of glutamate signaling genes associated with anhedonia. Stress (Amsterdam, Netherlands). vol 23. issue 6. 2021-03-24. PMID:32814471. |
in general, changes in expression of multiple genes involved in glutamatergic neurotransmission in the forebrain and brainstem regions suggest that stress-induced anhedonia may result from the network dysfunction of this neurotransmitter system. |
2021-03-24 |
2023-08-13 |
human |
| Mohammad Naderi, Pankaj Puar, Mahtab Zonouzi-Marand, Douglas P Chivers, Som Niyogi, Raymond W M Kwon. A comprehensive review on the neuropathophysiology of selenium. The Science of the total environment. vol 767. 2021-02-26. PMID:33445002. |
a wealth of evidence has shown that exposure to excess se may compromise the normal functioning of various key proteins, neurotransmitter systems (the glutamatergic, dopaminergic, serotonergic, and cholinergic systems), and signaling molecules involved in the control and regulation of cognitive, behavioral, and neuroendocrine functions. |
2021-02-26 |
2023-08-13 |
Not clear |
| Jason H Y Yeung, Beatriz Calvo-Flores Guzmán, Thulani H Palpagama, Jayarjun Ethiraj, Ying Zhai, Warren P Tate, Katie Peppercorn, Henry J Waldvogel, Richard L M Faull, Andrea Kwakowsk. Amyloid-beta Journal of neurochemistry. vol 155. issue 1. 2021-02-10. PMID:32491248. |
glutamate is the main excitatory brain neurotransmitter and it plays an essential role in the function and health of neurons and neuronal excitability. while previous studies have shown alterations in expression of glutamatergic signaling components in ad, the underlying mechanisms of these changes are not well understood. |
2021-02-10 |
2023-08-13 |
Not clear |
| Shanker Karunanithi, Yong Qi Lin, G Lorenzo Odierna, Hareesh Menon, Juan Mena Gonzalez, G Gregory Neely, Peter G Noakes, Nickolas A Lavidis, Andrew J Moorhouse, Bruno van Swindere. Activity-Dependent Global Downscaling of Evoked Neurotransmitter Release across Glutamatergic Inputs in The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 42. 2021-02-01. PMID:32928887. |
activity-dependent global downscaling of evoked neurotransmitter release across glutamatergic inputs in within mammalian brain circuits, activity-dependent synaptic adaptations, such as synaptic scaling, stabilize neuronal activity in the face of perturbations. |
2021-02-01 |
2023-08-13 |
Not clear |
| Ning Sheng, Hao Zheng, Min Li, Menglin Li, Zhe Wang, Ying Peng, Haibo Yu, Jinlan Zhan. 4,5 caffeoylquinic acid and scutellarin, identified by integrated metabolomics and proteomics approach as the active ingredients of Dengzhan Shengmai, act against chronic cerebral hypoperfusion by regulating glutamatergic and GABAergic synapses. Pharmacological research. vol 152. 2021-01-04. PMID:31926275. |
upon proteomic and metabolomic analysis, we observed a significant response in dzsm therapy from the interconnected neurotransmitter transport pathways including glutamatergic and gabaergic synapses. |
2021-01-04 |
2023-08-13 |
rat |
| Gabriel Crevier-Sorbo, Vladimir V Rymar, Raphael Crevier-Sorbo, Abbas F Sadiko. Thalamostriatal degeneration contributes to dystonia and cholinergic interneuron dysfunction in a mouse model of Huntington's disease. Acta neuropathologica communications. vol 8. issue 1. 2020-12-23. PMID:32033588. |
amongst multiple cellular processes, abnormal neurotransmitter signalling and decreased trophic support from glutamatergic cortical afferents are major mechanisms underlying striatal degeneration. |
2020-12-23 |
2023-08-13 |
mouse |
| Luis Jimenez-Trevino, Leticia Gonzalez-Blanco, Clara Alvarez-Vazquez, Julia Rodriguez-Revuelta, Pilar A Saiz Martine. Glutamine and New Pharmacological Targets to Treat Suicidal Ideation. Current topics in behavioral neurosciences. vol 46. 2020-12-23. PMID:32926351. |
glutamate is the major excitatory neurotransmitter in the central nervous system, and it is linked with the amino acid glutamine through a metabolic relationship of enzymatic compound interconversion and transportation, also known as the glutamate-glutamine cycle.a growing body of evidence suggests involvement of the glutamatergic neurotransmitter system in suicidal behaviours. |
2020-12-23 |
2023-08-13 |
human |
| Benjamin Spurny, Rene Seiger, Philipp Moser, Thomas Vanicek, Murray B Reed, Eva Heckova, Paul Michenthaler, Alim Basaran, Gregor Gryglewski, Manfred Klöbl, Siegfried Trattnig, Siegfried Kasper, Wolfgang Bogner, Rupert Lanzenberge. Hippocampal GABA levels correlate with retrieval performance in an associative learning paradigm. NeuroImage. vol 204. 2020-11-27. PMID:31606475. |
next to the glutamatergic system which contributes to memory formation via long-term potentiation (ltp) and long-term depression (ltd), the main inhibitory neurotransmitter, gaba is crucially involved in neuroplastic processes. |
2020-11-27 |
2023-08-13 |
human |