| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G L Bernardini, X Gu, D C Germa. Nucleus A10 dopaminergic neurons in inbred mouse strains: firing rate and autoreceptor sensitivity are independent of the number of cells in the nucleus. Brain research bulletin. vol 27. issue 2. 1992-01-13. PMID:1742603. |
it was observed that the autoreceptors on mouse dopaminergic neurons exhibit pharmacological properties of dopamine autoreceptors; activation of the autoreceptor produced a marked inhibition (50-70%) in cell firing rate by quinpirole (10(-8) m), ly-141865 (10(-7) m), (+)-3-(3-hydroxyphenyl)-n-n-propyl-piperidine (10(-6) m), propyl-norapomorphine (10(-5) m) and dopamine (10(-4) m), and this inhibition was blocked or reversed by specific dopamine d2 receptor antagonists [(-) sulpiride and spiroperidol, 10(-6) m]. |
1992-01-13 |
2023-08-11 |
mouse |
| M T Martin-Iverso. Chronic treatment with D1 and D2 dopamine receptor agonists: combined treatments interact to differentially affect brain levels of monoamines. Naunyn-Schmiedeberg's archives of pharmacology. vol 344. issue 3. 1992-01-09. PMID:1683687. |
in addition, recent hypotheses of the possible pathogenesis of this disorder have suggested that metabolism of dopamine by monoamine oxidase in the presynaptic terminal may contribute to the loss of dopaminergic cells, through the production of reactive by-products. |
1992-01-09 |
2023-08-11 |
rat |
| E Arenas, J Alberch, J Marsa. Dopaminergic system mediates only delta-opiate inhibition of endogenous acetylcholine release evoked by glutamate from rat striatal slices. Neuroscience. vol 42. issue 3. 1992-01-02. PMID:1683474. |
furthermore, these results suggest that the inhibition by delta-opiate agonists could be the result of dopamine release from dopaminergic terminals and its action on d2 receptors. |
1992-01-02 |
2023-08-11 |
rat |
| T M Shih, T A Koviak, B R Capaci. Anticonvulsants for poisoning by the organophosphorus compound soman: pharmacological mechanisms. Neuroscience and biobehavioral reviews. vol 15. issue 3. 1991-12-31. PMID:1683477. |
we also found that at anticonvulsant doses biperiden and trihexyphenidyl each significantly reversed the effects of soman on striatal levels of dopac and hva, the metabolites of dopamine, and have concluded that in addition to actions on muscarinic receptors, the anticonvulsant effects of these anticholinergics in soman poisoning may be partially related to their actions on the striatal dopaminergic system. |
1991-12-31 |
2023-08-11 |
rat |
| S Sigala, P Rizzonelli, E Zanelli, A Forgione, C Missale, P Span. Low doses of l-sulpiride down-regulate striatal and cortical dopamine receptors and beta-adrenoceptors. European journal of pharmacology. vol 199. issue 2. 1991-12-30. PMID:1683290. |
taken together these data suggest that cortical noradrenergic terminals may be endowed with dopamine d2 receptors controlling norepinephrine release and that blockade of this dopaminergic inhibitory modulation may be involved in the antidepressant effects of l-sulpiride. |
1991-12-30 |
2023-08-11 |
Not clear |
| J L Góngora-Alfaro, S Hernández-López, D Martínez-Fong, J L Brassart, J Aceve. Activation of nigral M1 and M2 muscarinic receptors produces opposing effects on striatal 3,4-dihydroxyphenylacetic acid measured by in vivo voltammetry. Brain research. vol 554. issue 1-2. 1991-12-26. PMID:1933315. |
these results indicate the existence of two types of muscarinic receptors on dopaminergic neurons, whose activation produces opposing effects on dopamine metabolism in neostriatum. |
1991-12-26 |
2023-08-11 |
rat |
| G Engberg, T Elebring, H Nissbrand. Deprenyl (selegiline), a selective MAO-B inhibitor with active metabolites; effects on locomotor activity, dopaminergic neurotransmission and firing rate of nigral dopamine neurons. The Journal of pharmacology and experimental therapeutics. vol 259. issue 2. 1991-12-24. PMID:1658311. |
deprenyl (selegiline), a selective mao-b inhibitor with active metabolites; effects on locomotor activity, dopaminergic neurotransmission and firing rate of nigral dopamine neurons. |
1991-12-24 |
2023-08-11 |
Not clear |
| J M Desce, G Godeheu, T Galli, F Artaud, A Chéramy, J Glowinsk. Presynaptic facilitation of dopamine release through D,L-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptors on synaptosomes from the rat striatum. The Journal of pharmacology and experimental therapeutics. vol 259. issue 2. 1991-12-24. PMID:1682483. |
in favor of the existence of glutamate receptors of the ampa type on dopaminergic nerve terminals, the stimulatory effect of ampa (5 x 10(-5) m) on [3h]dopamine release was antagonized by 6,7-dinitroquinoxaline-2,3-dione, 6-cyano-7-nitro-quinoxaline-2,3-dione, tau-d-glutamyl-amino-methyl-sulphonate and tau-d-glutamyl-glycine tested at 10(-4) m. 6,7-dinitroquinoxaline-2,3-dione was the most potent, whereas l-glutamate diethylester was without effect. |
1991-12-24 |
2023-08-11 |
rat |
| A Levy, M J Stillman, T M Rauc. Cyclo (His-Pro), d-amphetamine and striatal dopamine: a microdialysis study. Brain research bulletin. vol 27. issue 1. 1991-12-23. PMID:1933425. |
extracellular levels of dopamine (da) and its metabolites (dopac and hva) were monitored in the striatum of rats using in vivo microdialysis, in an attempt to elucidate the mechanism of cyclo (his-pro) (histidyl-proline-diketopiperazine, chp) on dopaminergic activity. |
1991-12-23 |
2023-08-11 |
rat |
| Y Arai, S K Kim, H Kinemuchi, T Tadano, K Oyama, N Satoh, K Kisar. Inhibition of brain MAO-A and animal behaviour induced by p-hydroxyamphetamine. Brain research bulletin. vol 27. issue 1. 1991-12-23. PMID:1933439. |
intra- and extra-synaptosomal activity of monoamine oxidase-a (mao-a) and -b (mao-b), dopamine (da) and its main metabolites were examined to clarify the mechanism of action(s) of p-hydroxyamphetamine (p-oha) in animal behaviour mediated by central dopaminergic systems. |
1991-12-23 |
2023-08-11 |
mouse |
| Y Tian, K J Lookingland, K E Moor. Contribution of noradrenergic neurons to 3,4-dihydroxyphenylacetic acid concentrations in the regions of the rat brain containing incertohypothalamic dopaminergic neurons. Brain research. vol 555. issue 1. 1991-12-20. PMID:1681993. |
the purpose of this study was to determine the source of 3,4-dihydroxyphenylacetic acid (dopac) in medial zona incerta (mzi) and dorsomedial nucleus (dmn), with the overall aim of ascertaining whether alterations in the concentration of this dopamine (da) metabolite reflect the activity of incertohypothalamic dopaminergic neurons. |
1991-12-20 |
2023-08-11 |
rat |
| C Cerruti, M J Drian, J M Kamenka, A Priva. Localization of dopamine carriers by BTCP, a dopamine uptake inhibitor, on nigral cells cultured in vitro. Brain research. vol 555. issue 1. 1991-12-20. PMID:1681995. |
btcp, n-[1-(2-benzo(b)thiopenyl)cyclohexyl]piperidine, a derivative of phencyclidine, acted as a potent dopamine (da) uptake blocking agent on primary cultures of dopaminergic neurons obtained from substantia nigra (ic50 = 70 nm). |
1991-12-20 |
2023-08-11 |
Not clear |
| R McChesney, S C Sealfon, M Tsutsumi, K W Dong, J L Roberts, C Bancrof. Either isoform of the dopamine D2 receptor can mediate dopaminergic repression of the rat prolactin promoter. Molecular and cellular endocrinology. vol 79. issue 1-3. 1991-12-18. PMID:1834494. |
either isoform of the dopamine d2 receptor can mediate dopaminergic repression of the rat prolactin promoter. |
1991-12-18 |
2023-08-11 |
rat |
| S Przedborski, V Kostic, V Jackson-Lewis, J L Cadet, R E Burk. Effect of unilateral perinatal hypoxic-ischemic brain injury in the rat on dopamine D1 and D2 receptors and uptake sites: a quantitative autoradiographic study. Journal of neurochemistry. vol 57. issue 6. 1991-12-18. PMID:1834800. |
the absence of changes in [3h]mazindol binding or dopamine levels in the lesioned caudate-putamen indicates that the dopaminergic presynaptic structures are preserved. |
1991-12-18 |
2023-08-11 |
rat |
| D Ben-Shachar, M B Youdi. Intranigral iron injection induces behavioral and biochemical "parkinsonism" in rats. Journal of neurochemistry. vol 57. issue 6. 1991-12-18. PMID:1940919. |
the present study indicates that the nigrostriatal dopamine neurons are susceptible to the presence of ionic iron and thus supports the assumption that iron initiates dopaminergic neurodegeneration in parkinson's disease. |
1991-12-18 |
2023-08-11 |
rat |
| A F Haase, H E Greiner, C A Seyfrie. Neurochemical profile of EMD 45609 (carmoxirole), a dopamine DA2-receptor agonist. Naunyn-Schmiedeberg's archives of pharmacology. vol 343. issue 6. 1991-12-13. PMID:1682817. |
the shallow dose response curves and the submaximal effects obtained for central dopaminergic activity, as reflected in the inhibition of striatal l-dopa accumulation, suggest that emd 45609 is a partial dopamine d2-receptor agonist and in addition, owing to its ionizable structure, passes less readily into the brain than several reference compounds. |
1991-12-13 |
2023-08-11 |
rat |
| S R Kay, R Sandy. Experimental models of schizophrenia. The International journal of neuroscience. vol 58. issue 1-2. 1991-12-04. PMID:1938175. |
positive symptoms are thought to reflect increased dopaminergic activity, which may arise as a compensatory adaptive mechanism to overcome the progressive dopamine loss in the maturing brain. |
1991-12-04 |
2023-08-11 |
Not clear |
| P A Garris, N Ben-Jonatha. Effects of reuptake inhibitors on dopamine release from the stalk-median eminence and posterior pituitary in vitro. Brain research. vol 556. issue 1. 1991-12-03. PMID:1933344. |
similar to other dopaminergic systems, the dopaminergic neurons innervating the stalk-median eminence (sme) and posterior pituitary (pp) possess an uptake mechanism for dopamine (da). |
1991-12-03 |
2023-08-11 |
rat |
| J C Porter, N Aguila-Mansilla, S M Ramin, G P Kozlowski, W Kedziersk. Tyrosine hydroxylase expression in hypothalamic cells: analysis of the roles of adenosine 3',5'-monophosphate- and Ca2+/calmodulin-dependent protein kinases in the action of pituitary cytotropic factor. Endocrinology. vol 129. issue 5. 1991-12-02. PMID:1682136. |
forskolin, an activator of adenylyl cyclase, as well as sp-camp[s] [(sp)-cyclic adenosine 3',5'-monophosphothioate], a camp agonist, and theophylline, an inhibitor of phosphodiesterase activity, stimulate the secretion of dihydroxyphenylalanine (dopa) and dopamine (da), suggesting a role for camp-dependent protein kinase in the secretion of catecholamines by hypothalamic dopaminergic cells. |
1991-12-02 |
2023-08-11 |
Not clear |
| A K Wright, G W Arbuthnott, S B Dunnet. Serotonin hyperinnervation after foetal nigra or raphe transplantation in the neostriatum of adult rats. Neuroscience letters. vol 128. issue 2. 1991-12-02. PMID:1719455. |
these observations suggest that striatal dopamine denervation induces some target-derived trophic factors that stimulate fibre growth from serotonergic as well as dopaminergic neurones. |
1991-12-02 |
2023-08-11 |
rat |