| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Castañeda, D E Moss, S D Oddie, I Q Whisha. THC does not affect striatal dopamine release: microdialysis in freely moving rats. Pharmacology, biochemistry, and behavior. vol 40. issue 3. 1992-05-14. PMID:1725460. |
the hypothesis that cannabinoids potentiate the motor effects of neuroleptics and produce their abuse potential by stimulating dopaminergic activity was tested by measuring the ability of thc to increase extracellular dopamine concentrations. |
1992-05-14 |
2023-08-11 |
rat |
| E L Gardner, J H Lowinso. Marijuana's interaction with brain reward systems: update 1991. Pharmacology, biochemistry, and behavior. vol 40. issue 3. 1992-05-14. PMID:1806947. |
the most pervasive commonality amongst noncannabinoid drugs of abuse is that they enhance electrical brain stimulation reward and act as direct or indirect dopamine agonists in the reward relevant dopaminergic projections of the medial forebrain bundle (mfb). |
1992-05-14 |
2023-08-11 |
Not clear |
| A Brouard, D Pelaprat, C Dana, M Vial, A M Lhiaubet, W Rostèn. Mesencephalic dopaminergic neurons in primary cultures express functional neurotensin receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 12. issue 4. 1992-05-06. PMID:1348274. |
th-immunoreactive neurons were characterized as dopaminergic neurons by their ability to take up dopamine in a benztropine- and nomifensine-sensitive manner. |
1992-05-06 |
2023-08-11 |
rat |
| D J Calcagnetti, M D Schechte. Conditioned place aversion following the central administration of a novel dopamine release inhibitor CGS 10746B. Pharmacology, biochemistry, and behavior. vol 40. issue 2. 1992-05-04. PMID:1687164. |
numerous drugs of abuse that elevate brain extracellular dopamine concentrations by either increasing the firing rate of dopaminergic neurons or producing dopamine release have been shown to reliably condition a preference for place. |
1992-05-04 |
2023-08-11 |
rat |
| S M Aquiloniu. What has PET told us about Parkinson's disease? Acta neurologica Scandinavica. Supplementum. vol 136. 1992-04-21. PMID:1801535. |
these results indicate that the striatal dopaminergic terminals are relatively preserved in pd as compared to the extreme reductions of dopamine in this region post mortem. |
1992-04-21 |
2023-08-11 |
human |
| L Orelan. Monoamine oxidase, dopamine and Parkinson's disease. Acta neurologica Scandinavica. Supplementum. vol 136. 1992-04-21. PMID:1801538. |
1.4.3.4) are of obvious interest in relation to parkinson's disease and its treatment with the irreversible and selective mao-b inhibitor l-deprenyl and are discussed in this review: 1) to what extent the two forms of mao are of importance for the deamination of dopamine and to what degree mao localised inside and outside of dopaminergic nerve terminals contributes 2) the kinetics of the mao-protein, i.e. |
1992-04-21 |
2023-08-11 |
Not clear |
| U K Rinn. New strategies in the treatment of early Parkinson's disease. Acta neurologica Scandinavica. Supplementum. vol 136. 1992-04-21. PMID:1801545. |
as a new treatment strategy it appears advisable to initiate the dopaminergic treatment in early parkinson's disease by using initially selegiline and a dopamine agonist and by adding levodopa when the therapeutic response is insufficient. |
1992-04-21 |
2023-08-11 |
Not clear |
| R Spanagel, A Herz, T S Shippenber. Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 6. 1992-04-17. PMID:1347943. |
employing the technique of in vivo microdialysis and the administration of highly selective opioid ligands, the present study demonstrates the existence of tonically active and functionally opposing mu and kappa opioid systems that regulate dopamine release in the nucleus accumbens, the major terminal area of a10 dopaminergic neurons. |
1992-04-17 |
2023-08-11 |
Not clear |
| R Spanagel, A Herz, T S Shippenber. Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 6. 1992-04-17. PMID:1347943. |
thus, stimulation of mu-type receptors in the ventral tegmental area, the site of origin of a10 dopaminergic neurons, increases dopamine release whereas the selective blockade of this opioid receptor type results in a significant decrease in basal dopamine release. |
1992-04-17 |
2023-08-11 |
Not clear |
| A C Linthorst, H De Lang, W De Jong, D H Verstee. Effect of the dopamine D2 receptor agonist quinpirole on the in vivo release of dopamine in the caudate nucleus of hypertensive rats. European journal of pharmacology. vol 201. issue 2-3. 1992-04-16. PMID:1686754. |
the present findings on changes in dopaminergic neurotransmission and d2 autoreceptor-mediated modulation of dopamine release in genetically hypertensive rats but not in rats with experimentally induced hypertension provide further evidence for the hypothesis that alterations in the nigrostriatal dopamine system may be involved in the initiation of the development of spontaneous hypertension. |
1992-04-16 |
2023-08-11 |
rat |
| Y Akiyama, A Ito, K Koshimura, T Ohue, S Yamagata, S Miwa, H Kikuch. Effects of transient forebrain ischemia and reperfusion on function of dopaminergic neurons and dopamine reuptake in vivo in rat striatum. Brain research. vol 561. issue 1. 1992-04-16. PMID:1797339. |
effects of transient forebrain ischemia and reperfusion on function of dopaminergic neurons and dopamine reuptake in vivo in rat striatum. |
1992-04-16 |
2023-08-11 |
rat |
| Y Akiyama, A Ito, K Koshimura, T Ohue, S Yamagata, S Miwa, H Kikuch. Effects of transient forebrain ischemia and reperfusion on function of dopaminergic neurons and dopamine reuptake in vivo in rat striatum. Brain research. vol 561. issue 1. 1992-04-16. PMID:1797339. |
to clarify functional changes of dopaminergic neurons and dopamine (da) reuptake during and after ischemia, extracellular da levels in striatum were determined using in vivo brain microdialysis in a 4-vessel occlusion model of male wistar rats with and without pharmacological interventions. |
1992-04-16 |
2023-08-11 |
rat |
| F Larrea, A Escorza, X Valencia, I Méndez, R Schiavon, G Forsbac. Reduced dopaminergic inhibition of thyrotropin release in hyperprolactinemic ovulatory women. Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion. vol 43. issue 4. 1992-04-16. PMID:1798861. |
central dopaminergic activity was investigated by the administration of the dopamine antagonist domperidone to normal women (n = 7) and women with anovulatory (n = 6) and ovulatory hyperprolactinemia (n = 2). |
1992-04-16 |
2023-08-11 |
human |
| V Leviel, B Guibert, J Mallet, N Faucon-Bigue. Induction of tyrosine hydroxylase in the rat substantia nigra by local injection of forskolin. Journal of neuroscience research. vol 30. issue 2. 1992-04-15. PMID:1686787. |
in addition, the decrease of the ratio between dopamine and its first metabolite in the cn and the sn suggested a decreased activity of the dopaminergic nigral cells. |
1992-04-15 |
2023-08-11 |
rat |
| D Casper, C Mytilineou, M Blu. EGF enhances the survival of dopamine neurons in rat embryonic mesencephalon primary cell culture. Journal of neuroscience research. vol 30. issue 2. 1992-04-15. PMID:1839162. |
fluorodeoxyuridine, an agent that is toxic to proliferating cells was able to eliminate the effect of egf on dopamine uptake, suggesting that egf may be increasing dopaminergic cell survival largely through a population of dividing cells. |
1992-04-15 |
2023-08-11 |
rat |
| M S Saporito, R E Heikkila, S K Youngster, W J Nicklas, H M Gelle. Dopaminergic neurotoxicity of 1-methyl-4-phenylpyridinium analogs in cultured neurons: relationship to the dopamine uptake system and inhibition of mitochondrial respiration. The Journal of pharmacology and experimental therapeutics. vol 260. issue 3. 1992-04-13. PMID:1312170. |
dopaminergic neurotoxicity of 1-methyl-4-phenylpyridinium analogs in cultured neurons: relationship to the dopamine uptake system and inhibition of mitochondrial respiration. |
1992-04-13 |
2023-08-11 |
Not clear |
| M S Saporito, R E Heikkila, S K Youngster, W J Nicklas, H M Gelle. Dopaminergic neurotoxicity of 1-methyl-4-phenylpyridinium analogs in cultured neurons: relationship to the dopamine uptake system and inhibition of mitochondrial respiration. The Journal of pharmacology and experimental therapeutics. vol 260. issue 3. 1992-04-13. PMID:1312170. |
the compounds that were potent and selective dopaminergic neurotoxins had high affinity for the dopamine transport system, as measured by their ability to cause dopamine release, and were similar to mpp+ in inhibiting mitochondrial respiration. |
1992-04-13 |
2023-08-11 |
Not clear |
| M S Saporito, R E Heikkila, S K Youngster, W J Nicklas, H M Gelle. Dopaminergic neurotoxicity of 1-methyl-4-phenylpyridinium analogs in cultured neurons: relationship to the dopamine uptake system and inhibition of mitochondrial respiration. The Journal of pharmacology and experimental therapeutics. vol 260. issue 3. 1992-04-13. PMID:1312170. |
this study describes the neurotoxicity of a number of analogs of mpp+ and highlights the importance of the dopamine uptake system and the ability to inhibit mitochondrial respiration as critical processes in conferring selectivity and neurotoxicity, respectively, to mpp+ and analogs, for dopaminergic neurons in culture. |
1992-04-13 |
2023-08-11 |
Not clear |
| X Z Ding, I Mocchett. Dopaminergic regulation of cholecystokinin mRNA content in rat striatum. Brain research. Molecular brain research. vol 12. issue 1-3. 1992-04-13. PMID:1312208. |
the nigrostriatal dopaminergic activity was pharmacologically changed to assess whether dopamine (da) regulates cholecystokinin (cck) mrna steady state in rat striatum. |
1992-04-13 |
2023-08-11 |
rat |
| M Savasta, F Mennicken, M Chritin, D N Abrous, C Feuerstein, M Le Moal, J P Herma. Intrastriatal dopamine-rich implants reverse the changes in dopamine D2 receptor densities caused by 6-hydroxydopamine lesion of the nigrostriatal pathway in rats: an autoradiographic study. Neuroscience. vol 46. issue 3. 1992-04-13. PMID:1532053. |
one month later animals were killed and striatal dopaminergic receptor densities were quantified using autoradiography, the dopaminergic reinnervation of the host striatum being visualized with [3h]gbr 12935, a ligand labelling dopamine uptake sites. |
1992-04-13 |
2023-08-11 |
rat |