| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Nestby, G H Tjon, D T Visser, B Drukarch, J E Leysen, A H Mulder, A N Schoffelmee. Intermittent morphine treatment causes long-term desensitization of functional dopamine D2 receptors in rat striatum. European journal of pharmacology. vol 294. issue 2-3. 1996-10-23. PMID:8750744. |
it is suggested that such a desensitization of dopamine d2 receptors on dopaminergic nerve terminals as well as on cholinergic interneurons may play a pivotal role in the long-lasting nature of behavioural sensitization upon cessation of treatment with morphine and possibly other drugs of abuse. |
1996-10-23 |
2023-08-12 |
rat |
| O Benkert, F Müller-Siecheneder, H Wetze. Dopamine agonists in schizophrenia: a review. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 5 Suppl. 1996-10-23. PMID:8775758. |
synthesis and release of dopamine as well as firing rates of dopaminergic neurons are controlled by stimulation of autoreceptors via a negative feedback regulation. |
1996-10-23 |
2023-08-12 |
Not clear |
| O Benkert, F Müller-Siecheneder, H Wetze. Dopamine agonists in schizophrenia: a review. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 5 Suppl. 1996-10-23. PMID:8775758. |
dopamine autoreceptor agonists like pramipexole, roxindole, talipexole and opc-4392 as well as partial agonists like terguride and sdz hdc 912 have been tested in positive schizophrenic symptomatology in order to reduce the postulated excess of central dopaminergic activity. |
1996-10-23 |
2023-08-12 |
Not clear |
| J P Doucet, Y Nakabeppu, P J Bedard, B T Hope, E J Nestler, B J Jasmin, J S Chen, M J Iadarola, M St-Jean, N Wigle, P Blanchet, R Grondin, G S Robertso. Chronic alterations in dopaminergic neurotransmission produce a persistent elevation of deltaFosB-like protein(s) in both the rodent and primate striatum. The European journal of neuroscience. vol 8. issue 2. 1996-10-22. PMID:8714707. |
chronic haloperidol administration also selectively elevated expression of these fos-related antigens, suggesting that their induction after dopaminergic denervation is mediated by reduced activation of d2-like dopamine receptors. |
1996-10-22 |
2023-08-12 |
rat |
| K M Kim, Y Nakajima, S Nakajim. G protein-coupled inward rectifier modulated by dopamine agonists in cultured substantia nigra neurons. Neuroscience. vol 69. issue 4. 1996-10-22. PMID:8848103. |
dopamine release from dopaminergic neurons in the substantia nigra plays an important role in regulating their activity. |
1996-10-22 |
2023-08-12 |
Not clear |
| T Hertzberg, T Brosenitsch, D M Kat. Depolarizing stimuli induce high levels of dopamine synthesis in fetal rat sensory neurons. Neuroreport. vol 7. issue 1. 1996-10-17. PMID:8742459. |
although dopaminergic traits are normally detectable in only 10-20% of ganglion neurones, exposure to depolarizing concentrations of potassium chloride (40 mm) or veratridine (10 microm) in culture induced tyrosine hydroxylase expression in 100% of petrosal neurons and a 10-fold increase in dopamine content. |
1996-10-17 |
2023-08-12 |
rat |
| Y Odagaki, S Dasgupta, K Fux. Additivity and non-additivity between dopamine-, norepinephrine-, carbachol- and GABA-stimulated GTPase activity. European journal of pharmacology. vol 291. issue 3. 1996-10-16. PMID:8719408. |
this lack of additivity was apparently due to stimulation of the same dopamine d2 receptors by both dopamine and norepinephrine, since norepinephrine-stimulated high-affinity gtpase activity could be inhibited by dopaminergic but not adrenergic antagonists. |
1996-10-16 |
2023-08-12 |
mouse |
| N B Saul'skai. [Monoamine metabolism in the rat striatum during actions on the nucleus accumbens]. Fiziologicheskii zhurnal imeni I.M. Sechenova. vol 82. issue 2. 1996-10-16. PMID:8768127. |
data indicated that the n.acc exerts an inhibitory influence on the metabolism of dopamine in the str, the influence being under control of dopaminergic system of the n.acc. |
1996-10-16 |
2023-08-12 |
rat |
| M Ebadi, S K Srinivasan, M D Bax. Oxidative stress and antioxidant therapy in Parkinson's disease. Progress in neurobiology. vol 48. issue 1. 1996-10-16. PMID:8830346. |
the loss of dopaminergic neurons in parkinson's disease results in enhanced metabolism of dopamine, augmenting the formation of h2o2, thus leading to generation of highly neurotoxic hydroxyl radicals (oh.). |
1996-10-16 |
2023-08-12 |
human |
| M Ebadi, S K Srinivasan, M D Bax. Oxidative stress and antioxidant therapy in Parkinson's disease. Progress in neurobiology. vol 48. issue 1. 1996-10-16. PMID:8830346. |
new approaches designed to attenuate the effects of oxidative stress and to provide neuroprotection of striatal dopaminergic neurons in parkinson's disease include blocking dopamine transporter by mazindol, blocking nmda receptors by dizocilpine maleate, enhancing the survival of neurons by giving brain-derived neurotrophic factors, providing antioxidants such as vitamin e, or inhibiting monoamine oxidase b (mao-b) by selegiline. |
1996-10-16 |
2023-08-12 |
human |
| S P Siva. Dopaminergic regulation of striatonigral tachykinin and dynorphin gene expression: a study with the dopamine uptake inhibitor GBR-12909. Brain research. Molecular brain research. vol 35. issue 1-2. 1996-10-11. PMID:8717356. |
dopaminergic regulation of striatonigral tachykinin and dynorphin gene expression: a study with the dopamine uptake inhibitor gbr-12909. |
1996-10-11 |
2023-08-12 |
rat |
| K Harsanyi, Y Wang, S C Mange. Activation of NMDA receptors produces dopamine-mediated changes in fish retinal horizontal cell light responses. Journal of neurophysiology. vol 75. issue 2. 1996-10-10. PMID:8714640. |
application of the nmda antagonists dl-2-amino-7-phosphonoheptanoic acid-ap-5) or d-2-amino-5-phosphonopentanoic acid-ap-5) (50 microm) blocked the uncoupling action of nmda (100 microm), as did prior application of sch23390, a dopamine d1 antagonist, or prior treatment of the retinas with 6-hydroxydopamine, a procedure that destroys dopaminergic neurons. |
1996-10-10 |
2023-08-12 |
Not clear |
| B K Jin, L Iacovitt. Dopamine differentiation factors increase striatal dopaminergic function in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mice. Journal of neuroscience research. vol 43. issue 3. 1996-10-08. PMID:8714521. |
dopamine differentiation factors increase striatal dopaminergic function in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mice. |
1996-10-08 |
2023-08-12 |
mouse |
| b' K Wedzony, A Czyrak, M Ma\\xc4\\x87kowiak, K Fija\\xc5\\x8. The impact of a competitive and a non-competitive NMDA receptor antagonist on dopaminergic neurotransmission in the rat ventral tegmental area and substantia nigra. Naunyn-Schmiedeberg\'s archives of pharmacology. vol 353. issue 5. 1996-10-08. PMID:8740145.' |
the study compares effects of the competitive and non-competitive nmda receptor antagonists, cgp 40116 and mk-801 respectively, on the metabolism of dopamine and on the density of d-1 and d-2 dopaminergic receptors in the rat ventral tegmental area and substantia nigra. |
1996-10-08 |
2023-08-12 |
rat |
| F L Van Muiswinkel, J G Bol, J M Ruijter, J C Stoof, B Drukarch, H W Steinbusc. Repeated administration of a selective dopamine D2 receptor agonist to 6-OHDA-lesioned rats does not affect the survival and outgrowth of intrastriatal fetal mesencephalic grafts. Experimental brain research. vol 107. issue 1. 1996-10-08. PMID:8751062. |
the objective of the present study was to investigate the effects of chronic activation of dopamine d2 receptors on the development of grafted fetal rat mesencephalic dopaminergic neurons. |
1996-10-08 |
2023-08-12 |
rat |
| F L Van Muiswinkel, J G Bol, J M Ruijter, J C Stoof, B Drukarch, H W Steinbusc. Repeated administration of a selective dopamine D2 receptor agonist to 6-OHDA-lesioned rats does not affect the survival and outgrowth of intrastriatal fetal mesencephalic grafts. Experimental brain research. vol 107. issue 1. 1996-10-08. PMID:8751062. |
it is concluded that long-term concurrent administration of a dopamine d2 receptor agonist for 6 consecutive weeks does not impair the survival and outgrowth of grafted rat fetal mesencephalic dopaminergic neurons. |
1996-10-08 |
2023-08-12 |
rat |
| F Blandini, R H Porter, J T Greenamyr. Glutamate and Parkinson's disease. Molecular neurobiology. vol 12. issue 1. 1996-10-04. PMID:8732541. |
degeneration of dopamine nigral neurons is followed by striatal dopaminergic denervation, which causes a cascade of functional modifications in the activity of basal ganglia nuclei. |
1996-10-04 |
2023-08-12 |
Not clear |
| K Blum, P J Sheridan, R C Wood, E R Braverman, T J Chen, J G Cull, D E Coming. The D2 dopamine receptor gene as a determinant of reward deficiency syndrome. Journal of the Royal Society of Medicine. vol 89. issue 7. 1996-10-04. PMID:8774539. |
the dopaminergic system, and in particular the dopamine d2 receptor, has been profoundly implicated in reward mechanisms in the brain. |
1996-10-04 |
2023-08-12 |
Not clear |
| M Gerlach, M Götz, A Dirr, A Kupsch, B Janetzky, W Oertel, J Sautter, J Schwarz, H Reichmann, P Riedere. Acute MPTP treatment produces no changes in mitochondrial complex activities and indices of oxidative damage in the common marmoset ex vivo one week after exposure to the toxin. Neurochemistry international. vol 28. issue 1. 1996-10-03. PMID:8746763. |
activities of respiratory chain enzymes were measured in crude homogenates of the caudate nucleus, because the probable toxic metabolite of mptp, mpp+, is transported into dopaminergic neurons via the dopamine uptake system in striatal synapses and mitochondria are concentrated in axonal terminals. |
1996-10-03 |
2023-08-12 |
marmoset |
| D L Frederick, J D Alle. Effects of selective dopamine D1- and D2-agonists and antagonists on timing performance in rats. Pharmacology, biochemistry, and behavior. vol 53. issue 4. 1996-09-30. PMID:8801575. |
dopamine (da) d1- and d2-agonists and antagonists were administered at fixed doses to assess putative dopaminergic involvement in timing behavior in rats performing under a peak-interval schedule. |
1996-09-30 |
2023-08-12 |
rat |