| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H L Kimmel, B E Garrett, S G Holtzma. Effects of acute and chronic morphine on rotational behavior in nigral-lesioned rats. Pharmacology, biochemistry, and behavior. vol 52. issue 2. 1996-03-11. PMID:8577807. |
stimulation of mu-opioid receptors located on dopaminergic neurons in the striatum and the nucleus accumbens increases dopamine release, which may account for some of the behavioral effects of morphine. |
1996-03-11 |
2023-08-12 |
rat |
| D B Miller, J P O'Callagha. The role of temperature, stress, and other factors in the neurotoxicity of the substituted amphetamines 3,4-methylenedioxymethamphetamine and fenfluramine. Molecular neurobiology. vol 11. issue 1-3. 1996-03-07. PMID:8561961. |
amphetamines (amps) can cause long-term depletions in striatal dopamine (da) and serotonin (5-ht), and these decrements are often accepted as prima facie evidence of amp-induced damage to the dopaminergic and serotonergic projections to striatum. |
1996-03-07 |
2023-08-12 |
mouse |
| J Sautter, A Kupsch, W H Oertel, C D Ear. [Neuronal transplantation in animal models of Parkinson disease: in vivo voltammetry, tissue cryopreservation and immunology]. Zentralblatt fur Neurochirurgie. vol 56. issue 4. 1996-03-07. PMID:8571694. |
neuronal transplantation of dopaminergic embryonic ventral mesencephalic cells aims at replacing the lost striatal dopamine in parkinson's disease. |
1996-03-07 |
2023-08-12 |
Not clear |
| J Sautter, A Kupsch, W H Oertel, C D Ear. [Neuronal transplantation in animal models of Parkinson disease: in vivo voltammetry, tissue cryopreservation and immunology]. Zentralblatt fur Neurochirurgie. vol 56. issue 4. 1996-03-07. PMID:8571694. |
finally, we established in vivo voltammetry to measure dopamine release from the graft and effects of the grafts on related parts of the dopaminergic system in the living animal. |
1996-03-07 |
2023-08-12 |
Not clear |
| K L Marek, J P Seibyl, S S Zoghbi, Y Zea-Ponce, R M Baldwin, B Fussell, D S Charney, C van Dyck, P B Hoffer, R P Inni. [123I] beta-CIT/SPECT imaging demonstrates bilateral loss of dopamine transporters in hemi-Parkinson's disease. Neurology. vol 46. issue 1. 1996-02-23. PMID:8559382. |
these data demonstrate that spect imaging of the dopamine transporter with [123i] beta-cit can identify patients with pd at the onset of motor symptoms and suggest that this technique also may be useful in identifying individuals with developing dopaminergic pathology before onset of motor symptoms. |
1996-02-23 |
2023-08-12 |
human |
| D W Howells, J Y Wong, A J Churchyard, G A Donna. Leukaemia inhibitory factor prevents injury induced proliferation of striatal dopamine uptake sites. Neuroreport. vol 6. issue 14. 1996-02-22. PMID:8547584. |
the injury associated with implantation of an inert gelatin matrix (gel foam) into normal mouse striatum induces a long-lived increase in binding of [3h]mazindol to presynaptic dopamine uptake sites, probably due to proliferation of striatal dopaminergic terminals. |
1996-02-22 |
2023-08-12 |
mouse |
| C S Planeta, R DeLucia, M L Aizenstei. The behavioral sensitization induced by fencamfamine is not related to plasma drug levels. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 28. issue 6. 1996-02-22. PMID:8547850. |
fencamfamine (fcf) is a cns stimulant that facilitates central dopaminergic transmission primarily through blockade of dopamine uptake. |
1996-02-22 |
2023-08-12 |
rat |
| S Harder, H Baas, S Rietbroc. Concentration-effect relationship of levodopa in patients with Parkinson's disease. Clinical pharmacokinetics. vol 29. issue 4. 1996-02-22. PMID:8549026. |
thus, without dopamine storage acting as a buffer between levodopa metabolism and dopaminergic effect, the decline in motor response closely follows the decrease in levodopa concentrations. |
1996-02-22 |
2023-08-12 |
Not clear |
| M J Nirenberg, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 2. 1996-02-22. PMID:8551328. |
the dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons. |
1996-02-22 |
2023-08-12 |
rat |
| M J Nirenberg, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 2. 1996-02-22. PMID:8551328. |
dat also can transport dopamine neurotoxins and has been implicated in the selective vulnerability of nigrostriatal dopaminergic neurons in major models of parkinson's disease. |
1996-02-22 |
2023-08-12 |
rat |
| M J Nirenberg, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 2. 1996-02-22. PMID:8551328. |
these findings support the proposed topological model for dat and suggest that this transporter is strategically located to facilitate uptake of dopamine and neurotoxins into distal dendritic and axonal processes of nigrostriatal dopaminergic neurons. |
1996-02-22 |
2023-08-12 |
rat |
| Q Y Zhou, R D Palmite. Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic. Cell. vol 83. issue 7. 1996-02-21. PMID:8548806. |
mice unable to synthesize dopamine (da) specifically in dopaminergic neurons were created by inactivating the tyrosine hydroxylase (th) gene then by restoring th function in noradrenergic cells. |
1996-02-21 |
2023-08-12 |
mouse |
| K E Sabol, J B Richards, K Layton, L S Seide. Amphetamine analogs have differential effects on DRL 36-s schedule performance. Psychopharmacology. vol 121. issue 1. 1996-02-07. PMID:8539341. |
consistent with in vitro and in vivo release studies, the differential results of these five drugs on drl 36-s schedule performance suggest a predominant dopamine role for amph and meth, a predominant serotonin role for fen, and different degrees of combined dopaminergic and serotonergic roles for mdma and pca in the mediation of the task. |
1996-02-07 |
2023-08-12 |
Not clear |
| J W Kebabian, P J Blanchet, P Bedar. The D-1 dopamine receptor: past, present and future an idiosyncratic review. Progress in neuro-psychopharmacology & biological psychiatry. vol 19. issue 5. 1996-02-07. PMID:8539418. |
the loss of the dopaminergic innervation and the subsequent repeated exposure to dopamine (derived from the exogenous dopa administered to the subjects) alters the response properties of the basal ganglia circuitry so that stimulation of dopamine receptors now elicits the dyskinetic movements. |
1996-02-07 |
2023-08-12 |
human |
| J M Trugma. D1/D2 actions of dopaminergic drugs studied with [14C]-2-deoxyglucose autoradiography. Progress in neuro-psychopharmacology & biological psychiatry. vol 19. issue 5. 1996-02-07. PMID:8539420. |
the marked d1-mediated rcgu increase in the snr ipsilateral to the dopamine depletion contrasts with the modest increase seen on the contralateral side and in naive rats, suggesting that the enhanced rcgu response to d1 stimulation is an index of dopaminergic supersensitivity. |
1996-02-07 |
2023-08-12 |
rat |
| M Asanuma, N Ogawa, S Nishibayashi, M Kawai, Y Kondo, E Iwat. Protective effects of pergolide on dopamine levels in the 6-hydroxydopamine-lesioned mouse brain. Archives internationales de pharmacodynamie et de therapie. vol 329. issue 2. 1996-02-06. PMID:8540762. |
therefore, pergolide could normalize the decreased dopamine synthesis or storage, and has a neuroprotective effect against dopaminergic dysfunction induced by the neurotoxin, 6-hydroxydopamine. |
1996-02-06 |
2023-08-12 |
mouse |
| M R Weed, W L Woolverto. The reinforcing effects of dopamine D1 receptor agonists in rhesus monkeys. The Journal of pharmacology and experimental therapeutics. vol 275. issue 3. 1996-02-01. PMID:8531104. |
central dopaminergic systems have been implicated in the reinforcing effects of a number of stimuli, including drugs of abuse; however, the role of dopamine d1 receptors remains controversial. |
1996-02-01 |
2023-08-12 |
monkey |
| J L Andersson, G G Nomikos, M Marcus, P Hertel, J M Mathé, T H Svensso. Ritanserin potentiates the stimulatory effects of raclopride on neuronal activity and dopamine release selectivity in the mesolimbic dopaminergic system. Naunyn-Schmiedeberg's archives of pharmacology. vol 352. issue 4. 1996-02-01. PMID:8532065. |
ritanserin potentiates the stimulatory effects of raclopride on neuronal activity and dopamine release selectivity in the mesolimbic dopaminergic system. |
1996-02-01 |
2023-08-12 |
rat |
| J L Andersson, G G Nomikos, M Marcus, P Hertel, J M Mathé, T H Svensso. Ritanserin potentiates the stimulatory effects of raclopride on neuronal activity and dopamine release selectivity in the mesolimbic dopaminergic system. Naunyn-Schmiedeberg's archives of pharmacology. vol 352. issue 4. 1996-02-01. PMID:8532065. |
the atypical profile of clozapine and some other new antipsychotic drugs has been attributed to a relatively selective effect on the mesolimbic dopaminergic system, as well as to their potent serotonin 5-ht2 receptor antagonism and high ratio of 5-ht2 to dopamine d2 receptor affinities. |
1996-02-01 |
2023-08-12 |
rat |
| X H Wang, P Levitt, D R Grayson, E H Murph. Intrauterine cocaine exposure of rabbits: persistent elevation of GABA-immunoreactive neurons in anterior cingulate cortex but not visual cortex. Brain research. vol 689. issue 1. 1996-01-30. PMID:8528704. |
in addition, acc receives dense dopaminergic innervation and cocaine's action in inhibiting the re-uptake of dopamine is believed to underly the rewarding properties of cocaine. |
1996-01-30 |
2023-08-12 |
rabbit |