| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I Mendez, K Elisevich, B Flumerfel. Substance P synaptic interactions with GABAergic and dopaminergic neurons in rat substantia nigra: an ultrastructural double-labeling immunocytochemical study. Brain research bulletin. vol 28. issue 4. 1992-08-05. PMID:1377584. |
substance p-positive terminals also formed synapses with cell bodies and dendrites of th-positive, dopaminergic neurons in the pars compacta and pars reticulata. |
1992-08-05 |
2023-08-11 |
rat |
| F Lisovoski, C Haby, E Borrelli, C Schleef, M O Revel, C Hindelang, J Zwille. Induction of D2 dopamine receptor mRNA synthesis in a 6-hydroxydopamine parkinsonian rat model. Brain research bulletin. vol 28. issue 5. 1992-08-05. PMID:1535533. |
by injecting 6-hydroxydopamine into the pars compacta of the substantia nigra, we produced a hemiparkinsonian rat model in which there is almost complete destruction of the dopaminergic nigrostriatal pathway but sparing of the dopaminergic mesolimbic system. |
1992-08-05 |
2023-08-11 |
rat |
| R J Care. Pavlovian conditioning of L-dopa induced movement. Psychopharmacology. vol 107. issue 2-3. 1992-07-30. PMID:1615121. |
using the unilateral 6-hydroxydopamine (6-ohda) substantia nigra pars compacta (snc) lesion rat model and a pavlovian conditioning protocol, the present investigation determined that the contralateral rotation response induced by the antiparkinsonian dopaminergic drug l-dopa can become conditioned to exteroceptive test environment stimuli. |
1992-07-30 |
2023-08-11 |
rat |
| X Gu, A L Blatz, D C Germa. Subtypes of substantia nigra dopaminergic neurons revealed by apamin: autoradiographic and electrophysiological studies. Brain research bulletin. vol 28. issue 3. 1992-06-29. PMID:1350500. |
it was demonstrated that a) specific binding of radiolabeled apamin was found within the dopaminergic cell regions of the substantia nigra pars compacta, and ventral tegmental area (2.7-4.7 fmol/mg tissue); b) the firing patterns of less than half of the dopaminergic neurons were changed from a regular pattern to that of a burster with concentrations as low as 1 nm, but the firing patterns of many neurons were not changed by the drug; and c) blockade of the sk channel did not interfere with the inhibitory effects of dopamine on dopaminergic neuronal impulse flow, indicating that the known hyperpolarizing effects mediated by this dopamine receptor are not importantly mediated via the sk channel. |
1992-06-29 |
2023-08-11 |
mouse |
| M Diana, G Mereu, A Mura, F Fadda, N Passino, G Gess. Low doses of gamma-hydroxybutyric acid stimulate the firing rate of dopaminergic neurons in unanesthetized rats. Brain research. vol 566. issue 1-2. 1992-06-23. PMID:1814536. |
administration of gamma-hydroxybutyric acid (ghb) at the doses of 50-400 mg/kg produced a dose-related stimulation (10-56%) of the firing rate of dopaminergic (da) neurons in the pars compacta of the substantia nigra. |
1992-06-23 |
2023-08-11 |
rat |
| C W Shult. Future perfect? Presymptomatic diagnosis, neural transplantation, and trophic factors. Neurologic clinics. vol 10. issue 2. 1992-06-17. PMID:1584189. |
trophic factors and transplantation enabled researchers to begin to develop and implement strategies to protect remaining dopaminergic neurons in the substantia nigra pars compacta and to restore dopaminergic innervation in the striatum. |
1992-06-17 |
2023-08-11 |
Not clear |
| G M Pasinetti, H H Osterburg, A B Kelly, S Kohama, D G Morgan, J F Reinhard, R H Stellwagen, C E Finc. Slow changes of tyrosine hydroxylase gene expression in dopaminergic brain neurons after neurotoxin lesioning: a model for neuron aging. Brain research. Molecular brain research. vol 13. issue 1-2. 1992-06-05. PMID:1374506. |
responses of striatal dopaminergic markers to 6-hydroxydopamine (6-ohda) lesions in rats indicated that the striatal terminals maintained th protein, despite greater than 3-fold loss of th mrna in the substantia nigra pars compacta (snc) cell bodies whose axons project to the striatum. |
1992-06-05 |
2023-08-11 |
rat |
| A Yamada, H Takeuchi, H Miki, T Touge, M Nishiok. [Decreased dopaminergic activity in hepatic encephalopathy in rats with galactosamine-induced acute liver failure]. No to shinkei = Brain and nerve. vol 44. issue 2. 1992-05-26. PMID:1567728. |
therefore, we examined the activities of the dopaminergic neurons of the substantia nigra pars compacta electrophysiologically in control rats and in rats with hepatic encephalopathy induced by galactosamine. |
1992-05-26 |
2023-08-11 |
rat |
| D J Sirinathsinghji, A Kupsch, E Mayer, M Zivin, D Pufal, W H Oerte. Cellular localization of tyrosine hydroxylase mRNA and cholecystokinin mRNA-containing cells in the ventral mesencephalon of the common marmoset: effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Brain research. Molecular brain research. vol 12. issue 1-3. 1992-04-13. PMID:1347634. |
in situ hybridization histochemistry was used to localize tyrosine hydroxylase (th) mrna and cholecystokinin (cck) mrna-expressing cells in the ventral mesencephalon of the common marmoset (callithrix jacchus) and to examine the effects of the dopaminergic (da) neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) on these two populations of neurons in the pars compacta of the substantia nigra (snc) and ventral tegmental area (vta). |
1992-04-13 |
2023-08-11 |
human |
| T Skarsfeld. Electrophysiological profile of the new atypical neuroleptic, sertindole, on midbrain dopamine neurones in rats: acute and repeated treatment. Synapse (New York, N.Y.). vol 10. issue 1. 1992-03-24. PMID:1346943. |
after 3 weeks of treatment sertindole shows an extreme selectivity to inhibit the number of spontaneously active dopaminergic (da) neurones in ventral tegmental area (vta) while leaving the number of active da neurones in substantia nigra pars compacta (snc) unaffected. |
1992-03-24 |
2023-08-11 |
rat |
| F Thibaut, E C Hirsch, R Raisman, F Javoy-Agid, Y Agi. Microtopography of D1 dopaminergic binding sites in the human substantia nigra: an autoradiographic study. Neuroscience. vol 37. issue 2. 1992-03-10. PMID:1983469. |
binding densities were similar in pars compacta and pars reticulata of the substantia nigra, except for a peak value of high [3h]sch 23390 in the pars reticulata, at a level just ventral to a zone of hyperdensity of melanized dopaminergic neurons in the pars compacta. |
1992-03-10 |
2023-08-11 |
human |
| W G Tatton, C E Greenwood, M C Verrier, D P Holland, M M Kwan, F E Biddl. Different rates of age-related loss for four murine monoaminergic neuronal populations. Neurobiology of aging. vol 12. issue 5. 1992-02-21. PMID:1722872. |
the age-related loss of locus coeruleus (lc) noradrenergic neurons, substantia nigra compacta (snc) dopaminergic neurons, dopaminergic retinal amacrine (ram) neurons and raphe serotonergic neurons, identified using antibodies against tyrosine hydroxylase (th) and serotonin (5ht) was investigated in c57b1 mice aged 8 to 104 weeks. |
1992-02-21 |
2023-08-11 |
mouse |
| S A Jones, J R Ellis, A Klegeris, S A Greenfiel. The relationship between visual stimulation, behaviour and continuous release of protein in the substantia nigra. Brain research. vol 560. issue 1-2. 1992-02-11. PMID:1760724. |
in the substantia nigra, a protein (acetylcholinesterase) is secreted from the dendrites of dopaminergic pars compacta neurons, in a noncholinergic capacity. |
1992-02-11 |
2023-08-11 |
Not clear |
| V A Peduto, A Concas, G Santoro, G Biggio, G L Gess. Biochemical and electrophysiologic evidence that propofol enhances GABAergic transmission in the rat brain. Anesthesiology. vol 75. issue 6. 1992-01-06. PMID:1660227. |
in vivo, the effect of propofol was studied using single-unit recording of the electrical activity of both nondopaminergic neurons in the pars reticulata of the substantia nigra (pr neurons) and of dopaminergic neurons in the pars compacta of the substantia nigra (da neurons). |
1992-01-06 |
2023-08-11 |
rat |
| K A Jellinge. Pathology of Parkinson's disease. Changes other than the nigrostriatal pathway. Molecular and chemical neuropathology. vol 14. issue 3. 1992-01-03. PMID:1958262. |
degeneration affects the dopaminergic mesocorticolimbic system, the noradrenergic locus ceruleus (oral parts) and motor vagal nucleus, the serotonergic raphe nuclei, the cholinergic nucleus basalis of meynert, pedunculopontine nucleus pars compacta, westphal-edinger nucleus, and many peptidergic brainstem nuclei. |
1992-01-03 |
2023-08-11 |
Not clear |
| A H Hainsworth, J Röper, R Kapoor, F M Ashcrof. Identification and electrophysiology of isolated pars compacta neurons from guinea-pig substantia nigra. Neuroscience. vol 43. issue 1. 1991-11-15. PMID:1681461. |
the properties of the large multipolar, type a neurons suggest that they form part of the nigrostriatal, dopaminergic population of the pars compacta. |
1991-11-15 |
2023-08-11 |
Not clear |
| J F Chen, Z H Qin, F Szele, G Bai, B Weis. Neuronal localization and modulation of the D2 dopamine receptor mRNA in brain of normal mice and mice lesioned with 6-hydroxydopamine. Neuropharmacology. vol 30. issue 9. 1991-11-06. PMID:1833662. |
these results suggest that the d2 receptor mrna in the substantia nigra pars compacta was localized largely to dopaminergic cell bodies, the terminal projections of which lie in the striatum and codes for d2 autoreceptors and that the d2 receptor mrna of the striatum is in non-dopaminergic cell bodies that are intrinsic to the striatum and probably codes for post-synaptic d2 receptors. |
1991-11-06 |
2023-08-11 |
mouse |
| M Mamela. A model for narcolepsy. Canadian journal of psychology. vol 45. issue 2. 1991-09-20. PMID:1651801. |
pp neurones project to and stimulate the dopaminergic substantia nigra compacta neurones. |
1991-09-20 |
2023-08-11 |
Not clear |
| J P Bolam, C M Francis, Z Henderso. Cholinergic input to dopaminergic neurons in the substantia nigra: a double immunocytochemical study. Neuroscience. vol 41. issue 2-3. 1991-09-13. PMID:1678502. |
in order to determine whether the cholinergic fibres that innervate the substantia nigra make synaptic contact with dopaminergic neurons of the substantia nigra pars compacta, a double immunocytochemical study was carried out in the rat and ferret. |
1991-09-13 |
2023-08-11 |
rat |
| M A Lavín, R Drucker-Colí. Ontogeny of the electrophysiological activity of dopaminergic cells with special reference to the influence of adrenal medullary grafts on aging. Brain research. vol 545. issue 1-2. 1991-08-30. PMID:1860041. |
the purpose of this study was to determine whether the extracellular activity of dopaminergic cells of the substantia nigra pars compacta of wistar rats changes with age, and if so whether ventricular adrenal medullary grafts can influence the electrophysiological activity of the oldest age group. |
1991-08-30 |
2023-08-11 |
rat |