| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Yoshida, H Takahashi, K Sato, H Higuchi, T Shimiz. Biperiden hydrochlorate ameliorates dystonia of rats produced by microinjection of sigma ligands into the red nucleus. Pharmacology, biochemistry, and behavior. vol 67. issue 3. 2001-04-19. PMID:11164078. |
the results also suggest that not only dopaminergic and cholinergic systems but also sigma system, and not only the striatum but also the red nucleus, may play an important role in the pathophysiology of nad. |
2001-04-19 |
2023-08-12 |
rat |
| J F Chen, R Moratalla, F Impagnatiello, D K Grandy, B Cuellar, M Rubinstein, M A Beilstein, E Hackett, J S Fink, M J Low, E Ongini, M A Schwarzschil. The role of the D(2) dopamine receptor (D(2)R) in A(2A) adenosine receptor (A(2A)R)-mediated behavioral and cellular responses as revealed by A(2A) and D(2) receptor knockout mice. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 4. 2001-04-19. PMID:11172060. |
the a(2a)r is largely coexpressed with d(2)rs and enkephalin mrna in the striatum where it modulates dopaminergic activity. |
2001-04-19 |
2023-08-12 |
mouse |
| J Booij, P Bergmans, A Winogrodzka, J D Speelman, E C Wolter. Imaging of dopamine transporters with [123I]FP-CIT SPECT does not suggest a significant effect of age on the symptomatic threshold of disease in Parkinson's disease. Synapse (New York, N.Y.). vol 39. issue 2. 2001-04-19. PMID:11180497. |
with natural aging there is loss of dopaminergic cells in the substantia nigra and, consequently, loss of dopamine transporters in the striatum. |
2001-04-19 |
2023-08-12 |
Not clear |
| M A McCoy, P B Young, A J Hudson, G Davison, D G Kenned. Regional brain monoamine concentrations and their alterations in bovine hypomagnesaemic tetany experimentally induced by a magnesium-deficient diet. Research in veterinary science. vol 69. issue 3. 2001-04-12. PMID:11124104. |
however, there was no significant change in da concentrations in the corpus striatum (the main dopaminergic region in the brain) associated with hypomagnesaemia. |
2001-04-12 |
2023-08-12 |
cattle |
| G Page, M Peeters, M Najimi, J M Maloteaux, E Herman. Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes. Journal of neurochemistry. vol 76. issue 5. 2001-04-05. PMID:11238713. |
based on the close relationship between glutamatergic and dopaminergic systems in the striatum, we investigated the modulation of the dat activity by metabotropic glutamate receptors (mglurs). |
2001-04-05 |
2023-08-12 |
rat |
| K Kannari, H Yamato, H Shen, M Tomiyama, T Suda, M Matsunag. Activation of 5-HT(1A) but not 5-HT(1B) receptors attenuates an increase in extracellular dopamine derived from exogenously administered L-DOPA in the striatum with nigrostriatal denervation. Journal of neurochemistry. vol 76. issue 5. 2001-04-05. PMID:11238719. |
in order to determine whether l-dopa-derived extracellular dopamine (da) in the striatum with dopaminergic denervation is affected by activation of serotonin autoreceptors (5-ht(1a) and 5-ht(1b) receptors), we applied in vivo brain microdialysis technique to 6-hydroxydopamine-lesioned rats and examined the effects of the selective 5-ht(1a) receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and the selective 5-ht(1b) receptor agonist cgs-12066 a on l-dopa-derived extracellular da levels. |
2001-04-05 |
2023-08-12 |
rat |
| A Petersen, O Hansson, M Emgård, P Brundi. Grafting of nigral tissue hibernated with tirilazad mesylate and glial cell line-derived neurotrophic factor. Cell transplantation. vol 9. issue 5. 2001-03-29. PMID:11144955. |
as only around 5-10% of embryonic dopaminergic neurons survive grafting into the adult striatum, it is considered necessary to use multiple donor embryos. |
2001-03-29 |
2023-08-12 |
human |
| G Glavan, R Zorec, K Babic, D Sket, M Zivi. Dopaminergic regulation of synaptotagmin I and IV mRNAs in hemiparkinsonian rats. Neuroreport. vol 11. issue 18. 2001-03-29. PMID:11192626. |
here we investigate whether dopaminergic regulation of syt i and syt iv expression could play a role in the hypersensitive striatum of rats with unilateral lesions of dopaminergic nigrostriatal neurons with 6-hydroxydopamine. |
2001-03-29 |
2023-08-12 |
rat |
| G Glavan, R Zorec, K Babic, D Sket, M Zivi. Dopaminergic regulation of synaptotagmin I and IV mRNAs in hemiparkinsonian rats. Neuroreport. vol 11. issue 18. 2001-03-29. PMID:11192626. |
we show that chronic dopaminergic denervation resulted in a small down-regulation of striatal syt i mrna, whereas acute treatment with skf-82958, a dopamine d1 receptor agonist, induced a massive syt iv mrna upregulation in the striatum on the lesioned side. |
2001-03-29 |
2023-08-12 |
rat |
| A Meldrum, S B Dunnett, B J Everit. Role of corticostriatal and nigrostriatal inputs in malonate-induced striatal toxicity. Neuroreport. vol 12. issue 1. 2001-03-22. PMID:11201098. |
we found that malonate-induced striatal toxicity was significantly reduced following lesions of either the glutamatergic or dopaminergic afferents to the striatum. |
2001-03-22 |
2023-08-12 |
Not clear |
| A Meldrum, S B Dunnett, B J Everit. Role of corticostriatal and nigrostriatal inputs in malonate-induced striatal toxicity. Neuroreport. vol 12. issue 1. 2001-03-22. PMID:11201098. |
these data suggest that malonate-induced toxicity in the striatum depends upon the integrity of interactive influences from both glutamatergic and dopaminergic afferents. |
2001-03-22 |
2023-08-12 |
Not clear |
| S Z Imam, G D Newport, Y Itzhak, J L Cadet, F Islam, W Slikker, S F Al. Peroxynitrite plays a role in methamphetamine-induced dopaminergic neurotoxicity: evidence from mice lacking neuronal nitric oxide synthase gene or overexpressing copper-zinc superoxide dismutase. Journal of neurochemistry. vol 76. issue 3. 2001-03-15. PMID:11158245. |
to assess the role of peroxynitrite in meth-induced dopaminergic, we investigated the production of 3-nitrotyrosine (3-nt) in the mouse striatum. |
2001-03-15 |
2023-08-12 |
mouse |
| A K Halladay, Y Yue, L Michna, D A Widmer, G C Wagner, R Zho. Regulation of EphB1 expression by dopamine signaling. Brain research. Molecular brain research. vol 85. issue 1-2. 2001-03-08. PMID:11146119. |
these animals also showed an increase in ephb1 signal density, but only in the dopaminergic terminal areas in the cortex and striatum. |
2001-03-08 |
2023-08-12 |
mouse |
| M Aoi, I Date, S Tomita, T Ohmot. Single or continuous injection of glial cell line-derived neurotrophic factor in the striatum induces recovery of the nigrostriatal dopaminergic system. Neurological research. vol 22. issue 8. 2001-03-08. PMID:11149247. |
single or continuous injection of glial cell line-derived neurotrophic factor in the striatum induces recovery of the nigrostriatal dopaminergic system. |
2001-03-08 |
2023-08-12 |
rat |
| K R Pennypacker, X Yang, M N Gordon, S Benkovic, D Miller, J P O'Callagha. Long-term induction of Fos-related antigen-2 after methamphetamine-, methylenedioxymethamphetamine-, 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine- and trimethyltin-induced brain injury. Neuroscience. vol 101. issue 4. 2001-03-01. PMID:11113340. |
methamphetamine and methylenedioxymethamphetamine, agents which cause degeneration of dopaminergic nerve terminals in the striatum of the mouse, cause an increase in fos-related antigen-2 immunoreactivity which begins at three days post-treatment and returns to basal levels by days 5 and 15, respectively. |
2001-03-01 |
2023-08-12 |
mouse |
| J Rodríguez-Pallares, H J Caruncho, A Muñoz, M J Guerra, J L Labandeira-Garcí. GABAA receptor subunit expression in intrastriatal ventral mesencephalic transplants. Experimental brain research. vol 135. issue 3. 2001-03-01. PMID:11146811. |
these results show that mesencephalic tissue ectopically grafted into the striatum develops a pattern of gabaa receptor expression similar to that normally expressed in situ, and particularly that the grafted dopaminergic neurons express similar gabaa receptors, including the alpha 3 subunit. |
2001-03-01 |
2023-08-12 |
Not clear |
| O Eberhardt, R V Coelln, S Kugler, J Lindenau, S Rathke-Hartlieb, E Gerhardt, S Haid, S Isenmann, C Gravel, A Srinivasan, M Bahr, M Weller, J Dichgans, J B Schul. Protection by synergistic effects of adenovirus-mediated X-chromosome-linked inhibitor of apoptosis and glial cell line-derived neurotrophic factor gene transfer in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 24. 2001-02-22. PMID:11124990. |
in contrast, the combination of adenoviral gene transfer of xiap and of the glial cell line-derived neurotrophic factor to the striatum provides synergistic effects, rescuing dopaminergic snpc neurons from cell death and maintaining their nigrostriatal terminals. |
2001-02-22 |
2023-08-12 |
mouse |
| K Ozawa, D S Fan, Y Shen, S Muramatsu, K Fujimoto, K Ikeguchi, M Ogawa, M Urabe, A Kume, I Nakan. Gene therapy of Parkinson's disease using adeno-associated virus (AAV) vectors. Journal of neural transmission. Supplementum. issue 58. 2001-02-22. PMID:11128607. |
parkinson's disease (pd) is characterized by the progressive loss of the dopaminergic neurons in the substantia nigra and a severe decrease in dopamine in the striatum. |
2001-02-22 |
2023-08-12 |
rat |
| A Kaelin-Lang, P Liniger, A Probst, T Lauterburg, J M Burgunde. Adenosine A2A receptor gene expression in the normal striatum and after 6-OH-dopamine lesion. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 8-9. 2001-02-15. PMID:11041267. |
in the rat striatum, expression of a2a receptors was not significantly altered after lesion of the dopaminergic pathways with 6-oh-dopamine even though enkephalin gene expression was up-regulated. |
2001-02-15 |
2023-08-12 |
mouse |
| M Nomoto, S Kaseda, S Iwata, T Shimizu, T Fukuda, S Nakagaw. The metabolic rate and vulnerability of dopaminergic neurons, and adenosine dynamics in the cerebral cortex, nucleus accumbens, caudate nucleus, and putamen of the common marmoset. Journal of neurology. vol 247 Suppl 5. 2001-02-15. PMID:11081800. |
the increase of adenosine metabolism suggested that cholinergic neurons in the striatum receive inhibitory inputs from nigrostriatal dopaminergic neurons. |
2001-02-15 |
2023-08-12 |
marmoset |