| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S J Crocker, W R Lamba, P D Smith, S M Callaghan, R S Slack, H Anisman, D S Par. c-Jun mediates axotomy-induced dopamine neuron death in vivo. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 23. 2001-12-07. PMID:11687617. |
ad.c-jundn also delayed the degeneration of dopaminergic nigral axons in the striatum after mfb axotomy. |
2001-12-07 |
2023-08-12 |
Not clear |
| E Shamir, Y Barak, I Shalman, M Laudon, N Zisapel, R Tarrasch, A Elizur, R Weizma. Melatonin treatment for tardive dyskinesia: a double-blind, placebo-controlled, crossover study. Archives of general psychiatry. vol 58. issue 11. 2001-12-07. PMID:11695951. |
the pineal hormone melatonin is a potent antioxidant and attenuates dopaminergic activity in the striatum and dopamine release from the hypothalamus. |
2001-12-07 |
2023-08-12 |
Not clear |
| K R Sidell, S J Olson, J J Ou, Y Zhang, V Amarnath, T J Montin. Cysteine and mercapturate conjugates of oxidized dopamine are in human striatum but only the cysteine conjugate impedes dopamine trafficking in vitro and in vivo. Journal of neurochemistry. vol 79. issue 3. 2001-12-07. PMID:11701754. |
here we investigated map enzymes and products in the midbrain and striatum of control individuals and patients with dementia with lewy bodies (dlb) who had less severe dopaminergic degeneration than pd patients and who were not treated with l-dopa. |
2001-12-07 |
2023-08-12 |
human |
| K R Sidell, S J Olson, J J Ou, Y Zhang, V Amarnath, T J Montin. Cysteine and mercapturate conjugates of oxidized dopamine are in human striatum but only the cysteine conjugate impedes dopamine trafficking in vitro and in vivo. Journal of neurochemistry. vol 79. issue 3. 2001-12-07. PMID:11701754. |
these results indicate that while cys-da is not increased in striatum of patients with mild dopaminergic neurodegeneration, it may interfere with uptake of da in patients with advanced pd. |
2001-12-07 |
2023-08-12 |
human |
| Q Wang, J P Jolly, J D Surmeier, B M Mullah, M S Lidow, C M Bergson, J D Robisha. Differential dependence of the D1 and D5 dopamine receptors on the G protein gamma 7 subunit for activation of adenylylcyclase. The Journal of biological chemistry. vol 276. issue 42. 2001-12-04. PMID:11500503. |
underscoring the physiological relevance of these findings, single cell reverse transcriptase-polymerase chain reaction analysis revealed that the d(1) dopamine receptor and the g protein gamma(7) subunit are coordinately expressed in substance p containing neurons in rat striatum, suggesting that the g protein gamma(7) subunit may be a new target for drugs to selectively alter dopaminergic signaling within the brain. |
2001-12-04 |
2023-08-12 |
human |
| J Q Wang, Y S La. Dose-related alteration in nitric oxide synthase mRNA expression induced by amphetamine and the full D1 dopamine receptor agonist SKF-82958 in mouse striatum. Neuroscience letters. vol 311. issue 1. 2001-12-04. PMID:11585554. |
these data indicate that constitutive nnos expression in nitric oxide-producing neurons of the mouse striatum is regulated by dopaminergic transmission. |
2001-12-04 |
2023-08-12 |
mouse |
| B M Campbell, P J Gresch, P D Walke. Neonatal dopamine depletion reveals a synergistic mechanism of mRNA regulation that is mediated by dopamine(D1) and serotonin(2) receptors and is targeted to tachykinin neurons of the dorsomedial striatum. Neuroscience. vol 105. issue 3. 2001-11-01. PMID:11516832. |
it has been hypothesized that dopamine(d1) and serotonin(2) receptors become sensitized to agonist-mediated regulation of gene expression following loss of dopaminergic innervation to the striatum. |
2001-11-01 |
2023-08-12 |
rat |
| b' M Huotari, M Passlin, H L Nordberg, M Forsberg, S Kotisaari, L Tuomisto, F Shintani, K F Tanaka, I Reenil\\xc3\\xa4, K Laitinen, P T M\\xc3\\xa4nnist\\xc3\\xb. Effect of intracerebral 6-nitronoradrenaline, an endogenous catechol-O-methyltransferase (COMT) inhibitor, on striatal dopamine metabolism in anaesthetised rats. Journal of neuroscience methods. vol 109. issue 1. 2001-10-25. PMID:11489299.' |
whether endogenous 6-nitronoradrenaline can be formed also in vivo in the striatum and act as a regulator of dopaminergic tone remains to be determined. |
2001-10-25 |
2023-08-12 |
rat |
| A Gjedd. [Receptor mapping in living human beings by means of positron emission tomography]. Ugeskrift for laeger. vol 163. issue 38. 2001-10-25. PMID:11577527. |
pet has revealed loss of dopaminergic terminals and dopamine synthetic capacity in parkinson's disease, mptp intoxication, and lesch-nyhan's syndrome; release of dopamine after administration of cocaine and amphetamine, and in motor activity and cognition; increased synaptic dopamine and release of dopamine, and the 70-90% neuroleptic occupancy of dopamine receptors in the striatum, in patients with schizophrenia; loss of muscarinic and nicotinergic receptors in alzheimer's disease, and benzodiazepine and opiate receptors in stroke, epilepsy, and huntington's chorea; altered opiate receptors in chronic pain and drug abuse; and release of opiates in analgesia; but changes in serotonin synthesis, transport, and binding in affective or psychotic disorders remain elusive. |
2001-10-25 |
2023-08-12 |
human |
| R A Jeyasingham, A L Baird, A Meldrum, S B Dunnet. Differential effects of unilateral striatal and nigrostriatal lesions on grip strength, skilled paw reaching and drug-induced rotation in the rat. Brain research bulletin. vol 55. issue 4. 2001-10-18. PMID:11543955. |
lateralised motor deficits associated with basal ganglia dysfunction were compared in separate groups of rats receiving unilateral 6-hydroxydopamine-induced lesions of the dopaminergic nigrostriatal pathway, quinolinic acid-induced lesions of the striatum, or sham control injections. |
2001-10-18 |
2023-08-12 |
rat |
| Y He, S Appel, W L. Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum. Brain research. vol 909. issue 1-2. 2001-10-11. PMID:11478935. |
to determine the role of immune/inflammatory factors in dopaminergic cell degeneration in parkinsonian substantia nigra, we assayed tyrosine hydroxylase (th)-positive immunoreactive neuronal numbers with stereologic techniques and cd11b-positive immunoreactive microglial profiles following 6-hydroxydopamine (6-ohda) injection into ipsilateral striatum of mice. |
2001-10-11 |
2023-08-12 |
mouse |
| E Valjent, C Pagès, M Rogard, M J Besson, R Maldonado, J Caboch. Delta 9-tetrahydrocannabinol-induced MAPK/ERK and Elk-1 activation in vivo depends on dopaminergic transmission. The European journal of neuroscience. vol 14. issue 2. 2001-10-11. PMID:11553284. |
however, blockade of dopaminergic (da) d1 receptors by administration of sch 23390, prior to thc, totally prevents erk activation in the striatum, thus demonstrating a critical involvement of da systems in thc-induced erk activation. |
2001-10-11 |
2023-08-12 |
Not clear |
| S J Crocker, N Wigle, P Liston, C S Thompson, C J Lee, D Xu, S Roy, D W Nicholson, D S Park, A MacKenzie, R G Korneluk, G S Robertso. NAIP protects the nigrostriatal dopamine pathway in an intrastriatal 6-OHDA rat model of Parkinson's disease. The European journal of neuroscience. vol 14. issue 2. 2001-10-11. PMID:11553289. |
here, we show that adenovirally mediated expression of neuronal apoptosis inhibitor protein (naip) ameliorates the loss of nigrostriatal function following intrastriatal 6-ohda administration by attenuating the death of dopamine neurons and dopaminergic fibres in the striatum. |
2001-10-11 |
2023-08-12 |
rat |
| X G Xia, T Harding, M Weller, A Bieneman, J B Uney, J B Schul. Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 18. 2001-10-04. PMID:11504916. |
in mice, adenoviral gene transfer of the jnk binding domain of jnk-interacting protein-1 (a scaffold protein and inhibitor of jnk) inhibited this cascade downstream of mkk4 phosphorylation, blocked jnk, c-jun, and caspase activation, the death of dopaminergic neurons, and the loss of catecholamines in the striatum. |
2001-10-04 |
2023-08-12 |
mouse |
| J E Johansen, V L Teixeira, C Johansson, P Serrão, P O Berggren, P Soares-Da-Silva, M Schalling, A M Bertorell. Altered dopaminergic transmission in the anorexic anx/anx mouse striatum. Neuroreport. vol 12. issue 12. 2001-10-04. PMID:11522958. |
altered dopaminergic transmission in the anorexic anx/anx mouse striatum. |
2001-10-04 |
2023-08-12 |
mouse |
| M Kato, K Ishida, T Chuma, K Abe, T Shigenaga, K Taguchi, T Miyatak. beta-Phenylethylamine modulates acetylcholine release in the rat striatum: involvement of a dopamine D(2) receptor mechanism. European journal of pharmacology. vol 418. issue 1-2. 2001-09-27. PMID:11334866. |
furthermore, the dopaminergic system, through the dopamine d(2) receptor, is involved in the locally applied beta-phenylethylamine-induced decrease in acetylcholine in the striatum. |
2001-09-27 |
2023-08-12 |
rat |
| S Cantagrel, P Gressens, S Bodard, A L Suc, J Laugier, D Guilloteau, S Chalo. mRNA D(2) dopaminergic receptor expression after hypoxia-ischemia in rat immature brain. Biology of the neonate. vol 80. issue 1. 2001-09-27. PMID:11474153. |
previous studies have shown a reduction of dopaminergic d(2) receptors (d(2)r) in the striatum after hypoxia-ischemia in newborn rats. |
2001-09-27 |
2023-08-12 |
rat |
| H Yamato, K Kannari, H Shen, T Suda, M Matsunag. Fluoxetine reduces L-DOPA-derived extracellular DA in the 6-OHDA-lesioned rat striatum. Neuroreport. vol 12. issue 6. 2001-09-13. PMID:11338177. |
we investigated the effect of fluoxetine, a selective serotonin reuptake inhibitor (ssri), on l-dopa-derived extracellular dopamine (da) levels in the striatum of rats with nigrostriatal dopaminergic denervation using in vivo microdialysis. |
2001-09-13 |
2023-08-12 |
rat |
| C D Earl, A Marburger, J Sautter, W H Oertel, R Morgenster. The development of dopamine overflow from foetal nigral grafts in the intact rat striatum and their influence on contralateral striatal dopamine overflow. Neurochemistry international. vol 39. issue 2. 2001-09-13. PMID:11408095. |
in this study, cell suspensions of foetal rat ventral mesencephalic dopaminergic tissue were grafted to the intact (non-lesioned) striatum of adult rats. |
2001-09-13 |
2023-08-12 |
rat |
| V M Goettl, T A Wemlinger, A E Colvin, N H Neff, M Hadjiconstantino. Motoric behavior in aged rats treated with GM1. Brain research. vol 906. issue 1-2. 2001-09-13. PMID:11430865. |
gm1 ganglioside partially restores pre-synaptic dopaminergic markers and the number and morphology of dopaminergic neurons in the midbrain and striatum of sprague--dawley aged rats. |
2001-09-13 |
2023-08-12 |
rat |