| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W Tripanichkul, D Stanic, J Drago, D I Finkelstein, M K Horn. D2 Dopamine receptor blockade results in sprouting of DA axons in the intact animal but prevents sprouting following nigral lesions. The European journal of neuroscience. vol 17. issue 5. 2003-05-15. PMID:12653979. |
haloperidol administration caused a 57% increase in dopaminergic terminal tree size (measured as terminal density per substantia nigra pars compacta neuron) and an increase of glia in the striatum. |
2003-05-15 |
2023-08-12 |
Not clear |
| W Tripanichkul, D Stanic, J Drago, D I Finkelstein, M K Horn. D2 Dopamine receptor blockade results in sprouting of DA axons in the intact animal but prevents sprouting following nigral lesions. The European journal of neuroscience. vol 17. issue 5. 2003-05-15. PMID:12653979. |
by examining the effect of administering haloperidol at varying times following a lesion, we concluded that a switch in the effect of d2 dopamine receptor blockade occurred after dopaminergic synapses began to form in the striatum. |
2003-05-15 |
2023-08-12 |
Not clear |
| Todd B Sherer, Ranjita Betarbet, Jin Ho Kim, J Timothy Greenamyr. Selective microglial activation in the rat rotenone model of Parkinson's disease. Neuroscience letters. vol 341. issue 2. 2003-05-15. PMID:12686372. |
extensive microglial activation, determined by ox-42-ir, occurred in striatum and nigra of rotenone-treated animals, and was prominent before anatomical evidence of dopaminergic lesions. |
2003-05-15 |
2023-08-12 |
rat |
| N Bhattacharya, M K Chhetri, K L Mukherjee, A Baran Ghosh, B Krishna Samanta, R Mitra, M Bhattacharya, S Bhattacharya, T Bandopadhyay. Can human fetal cortical brain tissue transplant (up to 20 weeks) sustain its metabolic and oxygen requirements in a heterotopic site outside the brain? A study of 12 volunteers with Parkinson's disease. Clinical and experimental obstetrics & gynecology. vol 29. issue 4. 2003-05-06. PMID:12635741. |
stereotactic placement of dopaminergic neurons in the caudate-putamen (striatum), is being attempted in centers of excellence and has proved to be beneficial. |
2003-05-06 |
2023-08-12 |
human |
| Rajappa S Kenchappa, Vijayalakshmi Ravindranat. Glutaredoxin is essential for maintenance of brain mitochondrial complex I: studies with MPTP. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 17. issue 6. 2003-04-21. PMID:12594173. |
1-methyl-4-phenyl-1,2,3,6,tetrahydro-pyridine (mptp), the neurotoxin that causes parkinson's disease-like symptoms in primates and dopaminergic cell loss in mice, acts through the inhibition of complex i. regeneration of complex i activity in the striatum occurs concurrently with increase in glutaredoxin activity, 4 h after the neurotoxic insult, and is mediated through activation of activating protein-1. |
2003-04-21 |
2023-08-12 |
mouse |
| Marc G Reyes, Francesco Faraldi, Robert Rydman, Charles Ce Wan. Decreased nigral neuromelanin in Alzheimer's disease. Neurological research. vol 25. issue 2. 2003-04-17. PMID:12635519. |
we speculated that the decreased amount of neuromelanin in nigral neuronal cell bodies could have resulted from neurofibrillary degeneration, retrograde degeneration from damage of nigral dopaminergic terminals in the striatum by the beta amyloid protein of the diffuse plaques and possibly transneuronal degeneration from damage of cell bodies or dendrites of nigral neurons by their plaque- and tangle-ravaged striatal, neocortical and other subcortical nigral connections. |
2003-04-17 |
2023-08-12 |
Not clear |
| Hi-Joon Park, Sabina Lim, Wan-Seok Joo, Chang-Shik Yin, Hyang-Sook Lee, Hye-Jung Lee, Jung Chul Seo, Kanghyun Leem, Yang-Sun Son, Youn-Jung Kim, Chang-Ju Kim, Yong-Sik Kim, Joo-Ho Chun. Acupuncture prevents 6-hydroxydopamine-induced neuronal death in the nigrostriatal dopaminergic system in the rat Parkinson's disease model. Experimental neurology. vol 180. issue 1. 2003-04-17. PMID:12668152. |
however, acupunctural treatment resulted in the enhanced survival of dopaminergic neurons in the sn (21.4% loss) and their terminals in the dorsolateral striatum. |
2003-04-17 |
2023-08-12 |
rat |
| Fu-Ming Zhou, Charles Wilson, John A Dan. Muscarinic and nicotinic cholinergic mechanisms in the mesostriatal dopamine systems. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 9. issue 1. 2003-04-16. PMID:12580337. |
the striatum and its dense dopaminergic innervation originating in the midbrain, primarily from the substantia nigra pars compacta and the ventral tegmental area, compose the mesostriatal dopamine (da) systems. |
2003-04-16 |
2023-08-12 |
Not clear |
| Fu-Ming Zhou, Charles Wilson, John A Dan. Muscarinic and nicotinic cholinergic mechanisms in the mesostriatal dopamine systems. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 9. issue 1. 2003-04-16. PMID:12580337. |
the dopaminergic projections from the ventral tegmental area to the striatum participate more in the processes that shape behaviors leading to reward, and addictive drugs act upon this mesolimbic system. |
2003-04-16 |
2023-08-12 |
Not clear |
| Fu-Ming Zhou, Charles Wilson, John A Dan. Muscarinic and nicotinic cholinergic mechanisms in the mesostriatal dopamine systems. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 9. issue 1. 2003-04-16. PMID:12580337. |
especially in the striatum, the dense mingling of dopaminergic and cholinergic constituents enables potent interactions. |
2003-04-16 |
2023-08-12 |
Not clear |
| Fu-Ming Zhou, Charles Wilson, John A Dan. Muscarinic and nicotinic cholinergic mechanisms in the mesostriatal dopamine systems. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 9. issue 1. 2003-04-16. PMID:12580337. |
evidence indicates that cholinergic and dopaminergic systems work together to produce the coordinated functioning of the striatum. |
2003-04-16 |
2023-08-12 |
Not clear |
| Heike Franke, Nathalie Schelhorn, Peter Ille. Dopaminergic neurons develop axonal projections to their target areas in organotypic co-cultures of the ventral mesencephalon and the striatum/prefrontal cortex. Neurochemistry international. vol 42. issue 5. 2003-04-09. PMID:12510026. |
mesencephalic dopaminergic neurons are known to project to the prefrontal cortex (pfc) and the striatum (str). |
2003-04-09 |
2023-08-12 |
rat |
| B Florán, C Barajas, L Florán, D Erlij, J Aceve. Adenosine A1 receptors control dopamine D1-dependent [(3)H]GABA release in slices of substantia nigra pars reticulata and motor behavior in the rat. Neuroscience. vol 115. issue 3. 2003-04-07. PMID:12435413. |
adenosine appears to modulate the dopaminergic control in striatum, where an inhibitory interaction between adenosine and dopamine receptors has been demonstrated. |
2003-04-07 |
2023-08-12 |
rat |
| P E Batchelor, M J Porritt, P Martinello, C L Parish, G T Liberatore, G A Donnan, D W Howell. Macrophages and Microglia Produce Local Trophic Gradients That Stimulate Axonal Sprouting Toward but Not beyond the Wound Edge. Molecular and cellular neurosciences. vol 21. issue 3. 2003-03-31. PMID:12498785. |
in this study, using dopaminergic sprouting in the injured striatum as a model system, we have examined the relationship of periwound sprouting fibers to reactive glia and macrophages. |
2003-03-31 |
2023-08-12 |
Not clear |
| Abigail Snyder-Keller, Ruchira Chandra, Yili Lin, Ellen Siobhan Mitchel. Basal EGR-1 (zif268, NGFI-A, Krox-24) expression in developing striatal patches: role of dopamine and glutamate. Brain research. vol 958. issue 2. 2003-03-27. PMID:12470865. |
thus, egr-1 expression in the developing striatum appears to be driven first by dopaminergic afferents, and then later in development by excitatory glutamatergic afferents. |
2003-03-27 |
2023-08-12 |
Not clear |
| Charles W Bradberr. Dose-dependent effect of ethanol on extracellular dopamine in mesolimbic striatum of awake rhesus monkeys: comparison with cocaine across individuals. Psychopharmacology. vol 165. issue 1. 2003-03-20. PMID:12474120. |
it has been hypothesized that ethanol reward is mediated via increased dopaminergic neurotransmission in mesolimbic striatum, as is the case for cocaine. |
2003-03-20 |
2023-08-12 |
monkey |
| Eloisa Carreño-Müller, Antonio J Herrera, Rocio M de Pablos, Mayka Tomás-Camardiel, José L Venero, Josefina Cano, Alberto Machad. Thrombin induces in vivo degeneration of nigral dopaminergic neurones along with the activation of microglia. Journal of neurochemistry. vol 84. issue 5. 2003-03-19. PMID:12603843. |
moreover, selective damage to dopaminergic neurones was produced after thrombin injection, evidenced by loss of tyrosine hydroxylase immunostaining and tyrosine hydroxylase mrna-expressing cell bodies, and the unaltered transcription of glutamic acid decarboxylase mrna in the sn and striatum. |
2003-03-19 |
2023-08-12 |
Not clear |
| John McGrath, Elishia Lintz, Barry J Hoffer, Greg A Gerhardt, E Matthew Quintero, Ann-Charlotte Granhol. Adeno-associated viral delivery of GDNF promotes recovery of dopaminergic phenotype following a unilateral 6-hydroxydopamine lesion. Cell transplantation. vol 11. issue 3. 2003-02-25. PMID:12075987. |
within 4 weeks of a single intrastriatal injection of raav-gdnf, unilaterally lesioned animals exhibited significant behavioral recovery, which correlated with increased expression of dopaminergic markers in the substantia nigra, the medial forebrain bundle, and the striatum. |
2003-02-25 |
2023-08-12 |
rat |
| V P Chekhonin, S V Lebedev, T B Dmitrieva, V P Baklaushev, E A Savchenko, I P Lazarenko, O I Gurina, V V Belopaso. [Criteria of efficiency of transplantation of embryonic nervous tissue preparations in rats with 6-OHDA-impaired dopaminergic nigrostriatal system]. Patologicheskaia fiziologiia i eksperimental'naia terapiia. issue 3. 2003-02-24. PMID:12462177. |
effectiveness of transplantation of cells from embryonal nervous tissue of the ventral mesencephalon (vm ent) and striatum (str ent) by apomorphin-induced motor asymmetry (apo-test), consolidation of the transplant (the degree of glyal reaction and amount of dopaminergic neurons) and blood serum levels of gfap was studied for 3 months in wistar rats with 6-ohda-impaired dopaminergic nigrostriatal system. |
2003-02-24 |
2023-08-12 |
rat |
| V P Chekhonin, S V Lebedev, T B Dmitrieva, V P Baklaushev, E A Savchenko, I P Lazarenko, O I Gurina, V V Belopaso. [Criteria of efficiency of transplantation of embryonic nervous tissue preparations in rats with 6-OHDA-impaired dopaminergic nigrostriatal system]. Patologicheskaia fiziologiia i eksperimental'naia terapiia. issue 3. 2003-02-24. PMID:12462177. |
separate transplantation of vm ent in the lateral ventricle and str ent in the striatum had no positive effect on recovery of the dopaminergic nigrostriatal system. |
2003-02-24 |
2023-08-12 |
rat |