| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrew Oster, Philippe Faure, Boris S Gutki. Mechanisms for multiple activity modes of VTA dopamine neurons. Frontiers in computational neuroscience. vol 9. 2015-08-18. PMID:26283955. |
midbrain ventral segmental area (vta) dopaminergic neurons send numerous projections to cortical and sub-cortical areas, and diffusely release dopamine (da) to their targets. |
2015-08-18 |
2023-08-13 |
Not clear |
| Beatriz Raposo Corradini, Priscila Iamashita, Edilaine Tampellini, José Marcelo Farfel, Lea Tenenholz Grinberg, Carlos Alberto Moreira-Filh. Complex network-driven view of genomic mechanisms underlying Parkinson's disease: analyses in dorsal motor vagal nucleus, locus coeruleus, and substantia nigra. BioMed research international. vol 2014. 2015-08-12. PMID:25525598. |
parkinson's disease (pd)—classically characterized by severe loss of dopaminergic neurons in the substantia nigra pars compacta—has a caudal-rostral progression, beginning in the dorsal motor vagal nucleus and, in a less extent, in the olfactory system, progressing to the midbrain and eventually to the basal forebrain and the neocortex. |
2015-08-12 |
2023-08-13 |
Not clear |
| Jose A Morales-Garcia, Sandra Alonso-Gil, Carmen Gil, Ana Martinez, Angel Santos, Ana Perez-Castill. Phosphodiesterase 7 inhibition induces dopaminergic neurogenesis in hemiparkinsonian rats. Stem cells translational medicine. vol 4. issue 6. 2015-08-12. PMID:25925836. |
parkinson's disease is characterized by a loss of dopaminergic neurons in a specific brain region, the ventral midbrain. |
2015-08-12 |
2023-08-13 |
rat |
| Ernest Arenas, Mark Denham, J Carlos Villaescus. How to make a midbrain dopaminergic neuron. Development (Cambridge, England). vol 142. issue 11. 2015-08-10. PMID:26015536. |
midbrain dopaminergic (mda) neuron development has been an intense area of research during recent years. |
2015-08-10 |
2023-08-13 |
human |
| Lanying Song, Gino Cortopass. Mitochondrial complex I defects increase ubiquitin in substantia nigra. Brain research. vol 1594. 2015-08-04. PMID:25446449. |
parkinson׳s disease (pd) is the second most common neurodegenerative disorder in the developed world, and is characterized by the loss of dopaminergic (da) neurons in the substantia nigra (sn) of midbrain. |
2015-08-04 |
2023-08-13 |
mouse |
| Candan Depboylu, Martin Klietz, Lukas Maurer, Wolfgang H Oertel, Kazuto Kobayashi, Eberhard Weihe, Günter U Höglinger, Martin K-H Schäfe. Transcriptional and structural plasticity of tyrosine hydroxylase expressing neurons in both striatum and nucleus accumbens following dopaminergic denervation. Journal of chemical neuroanatomy. vol 61-62. 2015-07-31. PMID:25451178. |
thus, permanent dopaminergic pathway injury induces both transcriptional as well as structural plasticity of th expressing neurons in striatal and accumbal target areas of ventral midbrain dopaminergic neurons. |
2015-07-31 |
2023-08-13 |
mouse |
| Ulrika Nordströma, Geneviève Beauvais, Anamitra Ghosh, Baby Chakrapani Pulikkaparambil Sasidharan, Martin Lundblad, Julia Fuchs, Rajiv L Joshi, Jack W Lipton, Andrew Roholt, Satish Medicetty, Timothy N Feinstein, Jennifer A Steiner, Martha L Escobar Galvis, Alain Prochiantz, Patrik Brundi. Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's disease. Neurobiology of disease. vol 73. 2015-07-29. PMID:25281317. |
in line with these findings, we detected an up-regulation of the mtor pathway, concurrent with a downregulation of the autophagic marker lc3b, in ventral midbrain and nigral dopaminergic neurons of the en1(+/-) mice. |
2015-07-29 |
2023-08-13 |
mouse |
| Yael Mandelblat-Cerf, Liora Las, Natalia Denisenko, Michale S Fe. A role for descending auditory cortical projections in songbird vocal learning. eLife. vol 3. 2015-07-28. PMID:24935934. |
in this study, we report several findings suggesting that song evaluation involves an avian 'cortical' area previously shown to project to the dopaminergic midbrain and other downstream targets. |
2015-07-28 |
2023-08-13 |
Not clear |
| Yael Mandelblat-Cerf, Liora Las, Natalia Denisenko, Michale S Fe. A role for descending auditory cortical projections in songbird vocal learning. eLife. vol 3. 2015-07-28. PMID:24935934. |
our findings suggest that auditory cortical areas may guide learning by transmitting song evaluation signals to the dopaminergic midbrain and/or other subcortical targets. |
2015-07-28 |
2023-08-13 |
Not clear |
| Sheng-Ming Yin, Dan Zhao, De-Qin Yu, Sheng-Long Li, Dong An, Yan Peng, Hong Xu, Yi-Ping Sun, Dong-Mei Wang, Jie Zhao, Wan-Qin Zhan. Neuroprotection by scorpion venom heat resistant peptide in 6-hydroxydopamine rat model of early-stage Parkinson's disease. Sheng li xue bao : [Acta physiologica Sinica]. vol 66. issue 6. 2015-07-26. PMID:25516514. |
three weeks after 6-ohda injection, the immunoreactivity of dopaminergic neurons were detected by immunohistochemistry staining, and the ultrastructure of neuronal mitochondria in midbrain was observed by electron microscope. |
2015-07-26 |
2023-08-13 |
rat |
| Sheng-Ming Yin, Dan Zhao, De-Qin Yu, Sheng-Long Li, Dong An, Yan Peng, Hong Xu, Yi-Ping Sun, Dong-Mei Wang, Jie Zhao, Wan-Qin Zhan. Neuroprotection by scorpion venom heat resistant peptide in 6-hydroxydopamine rat model of early-stage Parkinson's disease. Sheng li xue bao : [Acta physiologica Sinica]. vol 66. issue 6. 2015-07-26. PMID:25516514. |
the results showed that 6-ohda reduced the optical density of dopaminergic neurons, induced damage of mitochondrial ultrastructure of midbrain neurons, decreased sod activity, increased mao-b activity and mda content, and reduced the antioxidant ability of the serum. |
2015-07-26 |
2023-08-13 |
rat |
| Gael Le Douaron, Fanny Schmidt, Majid Amar, Hanane Kadar, Lucila Debortoli, Alexandra Latini, Blandine Séon-Méniel, Laurent Ferrié, Patrick Pierre Michel, David Touboul, Alain Brunelle, Rita Raisman-Vozari, Bruno Figadèr. Neuroprotective effects of a brain permeant 6-aminoquinoxaline derivative in cell culture conditions that model the loss of dopaminergic neurons in Parkinson disease. European journal of medicinal chemistry. vol 89. 2015-07-24. PMID:25462259. |
parkinson disease is a neurodegenerative disorder of aging, characterized by disabling motor symptoms resulting from the loss of midbrain dopaminergic neurons and the decrease of dopamine in the striatum. |
2015-07-24 |
2023-08-13 |
mouse |
| Gael Le Douaron, Fanny Schmidt, Majid Amar, Hanane Kadar, Lucila Debortoli, Alexandra Latini, Blandine Séon-Méniel, Laurent Ferrié, Patrick Pierre Michel, David Touboul, Alain Brunelle, Rita Raisman-Vozari, Bruno Figadèr. Neuroprotective effects of a brain permeant 6-aminoquinoxaline derivative in cell culture conditions that model the loss of dopaminergic neurons in Parkinson disease. European journal of medicinal chemistry. vol 89. 2015-07-24. PMID:25462259. |
to evaluate the neuroprotective activity of these molecules, we used midbrain cultures and various experimental conditions that promote dopaminergic cell loss. |
2015-07-24 |
2023-08-13 |
mouse |
| Meisam Mohammadi, Mohammad Nasehi, Mohammad-Reza Zarrindas. Modulation of the effects of the cannabinoid agonist, ACPA, on spatial and non-spatial novelty detection in mice by dopamine D1 receptor drugs infused into the basolateral amygdala. Behavioural brain research. vol 280. 2015-07-24. PMID:25476564. |
the amygdala is a major target of midbrain dopaminergic neurons and is implicated in learning and memory processes. |
2015-07-24 |
2023-08-13 |
mouse |
| Chris M Woodard, Brian A Campos, Sheng-Han Kuo, Melissa J Nirenberg, Michael W Nestor, Matthew Zimmer, Eugene V Mosharov, David Sulzer, Hongyan Zhou, Daniel Paull, Lorraine Clark, Eric E Schadt, Sergio Pablo Sardi, Lee Rubin, Kevin Eggan, Mathew Brock, Scott Lipnick, Mahendra Rao, Stephen Chang, Aiqun Li, Scott A Noggl. iPSC-derived dopamine neurons reveal differences between monozygotic twins discordant for Parkinson's disease. Cell reports. vol 9. issue 4. 2015-07-21. PMID:25456120. |
utilizing fluorescence-activated cell sorting, we obtained a homogenous population of "footprint-free" ipsc-derived midbrain dopaminergic (mda) neurons. |
2015-07-21 |
2023-08-13 |
Not clear |
| Richard G Carroll, Emilie Hollville, Seamus J Marti. Parkin sensitizes toward apoptosis induced by mitochondrial depolarization through promoting degradation of Mcl-1. Cell reports. vol 9. issue 4. 2015-07-21. PMID:25456142. |
because parkin mutations occur in parkinson's disease, a condition associated with the death of dopaminergic neurons in the midbrain, wild-type parkin is thought to promote neuronal survival. |
2015-07-21 |
2023-08-13 |
Not clear |
| Prem Prakash Tripathi, Yuri Bozz. The role of dopaminergic and serotonergic systems in neurodevelopmental disorders: a focus on epilepsy and seizure susceptibility. BioImpacts : BI. vol 5. issue 2. 2015-07-20. PMID:26191504. |
dopaminergic and serotonergic neurons, located in midbrain and hindbrain regions respectively, diffusely innervate several forebrain areas including limbic system, contributing in regulating several physiological functions. |
2015-07-20 |
2023-08-13 |
Not clear |
| Soonbong Baek, Hwan Choi, Jongpil Ki. Ebf3-miR218 regulation is involved in the development of dopaminergic neurons. Brain research. vol 1587. 2015-07-17. PMID:25192643. |
the development of midbrain dopaminergic (da) neurons is a complex process that requires the precise spatial and temporal expression of numerous genes. |
2015-07-17 |
2023-08-13 |
Not clear |
| Harry S Xenias, Osvaldo Ibáñez-Sandoval, Tibor Koós, James M Teppe. Are striatal tyrosine hydroxylase interneurons dopaminergic? The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 16. 2015-07-16. PMID:25904808. |
fluorescence immunocytochemistry in enhanced green fluorescent protein (egfp)-th mice revealed colocalization of da, l-amino acid decarboxylase, the da transporter, and vesicular monoamine transporter-2 with egfp in midbrain dopaminergic neurons but not in any of the striatal egfp-th interneurons. |
2015-07-16 |
2023-08-13 |
mouse |
| Haiyin Wu, Brian O'Neill, Dawn D Han, Keerthi Thirtamara-Rajamani, Yanlin Wang, Howard H G. Restoration of cocaine stimulation and reward by reintroducing wild type dopamine transporter in adult knock-in mice with a cocaine-insensitive dopamine transporter. Neuropharmacology. vol 86. 2015-07-14. PMID:24835281. |
in summary, cocaine induced locomotion and reward can be restored in fully developed dat-ci mice, and cocaine inhibition of dat expressed in dopaminergic neurons originated from the ventral midbrain mediates cocaine reward and stimulation. |
2015-07-14 |
2023-08-13 |
mouse |