| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicolas X Tritsch, Won-Jong Oh, Chenghua Gu, Bernardo L Sabatin. Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis. eLife. vol 3. 2015-11-10. PMID:24843012. |
these findings therefore indicate that gaba co-release is a general feature of midbrain dopaminergic neurons that relies on gaba uptake from the extracellular milieu as opposed to de novo synthesis. |
2015-11-10 |
2023-08-13 |
Not clear |
| Panojot Bifsha, Jianqi Yang, Rory A Fisher, Jacques Droui. Rgs6 is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra. PLoS genetics. vol 10. issue 12. 2015-11-06. PMID:25501001. |
parkinson disease (pd) is characterized by the preferential, but poorly understood, vulnerability to degeneration of midbrain dopaminergic (mda) neurons in the ventral substantia nigra compacta (vsnc). |
2015-11-06 |
2023-08-13 |
mouse |
| Elisabeth Piccart, Nicholas A Courtney, Sarah Y Branch, Christopher P Ford, Michael J Beckstea. Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 31. 2015-11-05. PMID:26245975. |
neurotensin induces presynaptic depression of d2 dopamine autoreceptor-mediated neurotransmission in midbrain dopaminergic neurons. |
2015-11-05 |
2023-08-13 |
mouse |
| Elisabeth Piccart, Nicholas A Courtney, Sarah Y Branch, Christopher P Ford, Michael J Beckstea. Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 31. 2015-11-05. PMID:26245975. |
activity of midbrain dopaminergic neurons is under strict control of inhibitory d2 autoreceptors. |
2015-11-05 |
2023-08-13 |
mouse |
| Elisabeth Piccart, Nicholas A Courtney, Sarah Y Branch, Christopher P Ford, Michael J Beckstea. Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 31. 2015-11-05. PMID:26245975. |
application of the modulatory peptide neurotensin (nt) to midbrain dopaminergic neurons transiently increases activity by decreasing d2 dopamine autoreceptor function, yet little is known about the mechanisms that underlie long-lasting effects. |
2015-11-05 |
2023-08-13 |
mouse |
| K Schawkat, S Di Santo, S Seiler, A D Ducray, H R Widme. Loss of Nogo-A-expressing neurons in a rat model of Parkinson's disease. Neuroscience. vol 288. 2015-10-29. PMID:25554426. |
immunohistochemical analyses of normal adult rat brain showed a distinct expression of nogo-a in the ventral mesencephalon, with the highest level in the substantia nigra pars compacta (snc) where it co-localized with dopaminergic neurons. |
2015-10-29 |
2023-08-13 |
rat |
| Jae-Ick Kim, Subhashree Ganesan, Sarah X Luo, Yu-Wei Wu, Esther Park, Eric J Huang, Lu Chen, Jun B Din. Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons. Science (New York, N.Y.). vol 350. issue 6256. 2015-10-28. PMID:26430123. |
aldehyde dehydrogenase 1a1 mediates a gaba synthesis pathway in midbrain dopaminergic neurons. |
2015-10-28 |
2023-08-13 |
Not clear |
| Johanna Neuner, Saak V Ovsepian, Mario Dorostkar, Severin Filser, Aayush Gupta, Stylianos Michalakis, Martin Biel, Jochen Herm. Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb. Nature communications. vol 5. 2015-10-27. PMID:24867427. |
although the role of noxious α-synuclein (α-syn) in the degeneration of midbrain dopaminergic neurons and associated motor deficits of parkinson's disease is recognized, its impact on non-motor brain circuits and related symptoms remains elusive. |
2015-10-27 |
2023-08-13 |
mouse |
| Ahmed Sharaf, Belal Rahhal, Björn Spittau, Eleni Rouss. Localization of reelin signaling pathway components in murine midbrain and striatum. Cell and tissue research. vol 359. issue 2. 2015-10-27. PMID:25418135. |
reelin was expressed intracellularly and extracellularly in midbrain mesencephalic dopaminergic (mda) neurons of newborns. |
2015-10-27 |
2023-08-13 |
mouse |
| Ahmed Sharaf, Belal Rahhal, Björn Spittau, Eleni Rouss. Localization of reelin signaling pathway components in murine midbrain and striatum. Cell and tissue research. vol 359. issue 2. 2015-10-27. PMID:25418135. |
the loss of apoer2 and vldlr expression in the mature midbrain and striatum implies that reelin functions are restricted to migratory events and early postnatal maturation and are dispensable for the maintenance of dopaminergic neurons. |
2015-10-27 |
2023-08-13 |
mouse |
| Tracy Ho, Andrew I Jobling, Ursula Greferath, Trinette Chuang, Archana Ramesh, Erica L Fletcher, Kirstan A Vesse. Vesicular expression and release of ATP from dopaminergic neurons of the mouse retina and midbrain. Frontiers in cellular neuroscience. vol 9. 2015-10-27. PMID:26500494. |
vesicular expression and release of atp from dopaminergic neurons of the mouse retina and midbrain. |
2015-10-27 |
2023-08-13 |
mouse |
| So-Young Bang, So Hee Kwon, Sang-Hoon Yi, Sang Ah Yi, Eun Kyung Park, Jae-Cheol Lee, Choon-Gon Jang, Jueng Soo You, Sang-Hun Lee, Jeung-Whan Ha. Epigenetic activation of the Foxa2 gene is required for maintaining the potential of neural precursor cells to differentiate into dopaminergic neurons after expansion. Stem cells and development. vol 24. issue 4. 2015-10-26. PMID:25233056. |
dysregulation of forkhead box protein a2 (foxa2) expression in fetal ventral mesencephalon (vm)-derived neural precursor cells (npcs) appears to be associated with the loss of their potential to differentiate into dopaminergic (da) neurons after mitogenic expansion in vitro, hindering their efficient use as a transplantable cell source. |
2015-10-26 |
2023-08-13 |
Not clear |
| Shuntaro Kohnomi, Shiro Konish. Multiple actions of a D₃ dopamine receptor agonist, PD128907, on GABAergic inhibitory transmission between medium spiny neurons in mouse nucleus accumbens shell. Neuroscience letters. vol 600. 2015-10-19. PMID:26033184. |
the nucleus accumbens (nac) plays a crucial role in pathophysiological responses, such as reward-related behaviors, addiction, depression and schizophrenia, through activation of dopaminergic system in the midbrain area. |
2015-10-19 |
2023-08-13 |
mouse |
| Haigang Gu, Roman M Lazarenko, Dmitry Koktysh, Lorraine Iacovitti, Qi Zhan. A Stem Cell-Derived Platform for Studying Single Synaptic Vesicles in Dopaminergic Synapses. Stem cells translational medicine. vol 4. issue 8. 2015-10-16. PMID:26025981. |
midbrain culture has been one of the most valuable preparations for the subcellular investigation of dopaminergic transmission; however, the paucity and fragility of cultured dopaminergic neurons limits their use for live cell imaging. |
2015-10-16 |
2023-08-13 |
Not clear |
| Haigang Gu, Roman M Lazarenko, Dmitry Koktysh, Lorraine Iacovitti, Qi Zhan. A Stem Cell-Derived Platform for Studying Single Synaptic Vesicles in Dopaminergic Synapses. Stem cells translational medicine. vol 4. issue 8. 2015-10-16. PMID:26025981. |
we report a more efficient procedure to reliably generate dopamine neurons from embryonic stem cells, and it yields more dopamine neurons with more dopaminergic axon projections than midbrain culture does. |
2015-10-16 |
2023-08-13 |
Not clear |
| Pascaline Aimé, Xiaotian Sun, Neela Zareen, Apeksha Rao, Zachary Berman, Laura Volpicelli-Daley, Paulette Bernd, John F Crary, Oren A Levy, Lloyd A Green. Trib3 Is Elevated in Parkinson's Disease and Mediates Death in Parkinson's Disease Models. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 30. 2015-10-16. PMID:26224857. |
trib3 protein is also upregulated in cellular models of pd, including neuronal pc12 cells and rat dopaminergic ventral midbrain neurons treated with 6-ohda, 1-methyl-4-phenylpyridinium (mpp+), or α-synuclein fibrils (αsyn). |
2015-10-16 |
2023-08-13 |
human |
| Pascaline Aimé, Xiaotian Sun, Neela Zareen, Apeksha Rao, Zachary Berman, Laura Volpicelli-Daley, Paulette Bernd, John F Crary, Oren A Levy, Lloyd A Green. Trib3 Is Elevated in Parkinson's Disease and Mediates Death in Parkinson's Disease Models. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 30. 2015-10-16. PMID:26224857. |
trib3 overexpression is sufficient to promote neuronal death; conversely, trib3 knockdown protects neuronal pc12 cells as well as ventral midbrain dopaminergic neurons from 6-ohda, mpp+, or αsyn. |
2015-10-16 |
2023-08-13 |
human |
| Celia van der Merwe, Zahra Jalali Sefid Dashti, Alan Christoffels, Ben Loos, Soraya Bardie. Evidence for a common biological pathway linking three Parkinson's disease-causing genes: parkin, PINK1 and DJ-1. The European journal of neuroscience. vol 41. issue 9. 2015-10-12. PMID:25761903. |
parkinson's disease (pd) is characterised by the loss of dopaminergic neurons in the midbrain. |
2015-10-12 |
2023-08-13 |
drosophila_melanogaster |
| Gábor Debertin, Orsolya Kántor, Tamás Kovács-Öller, Lajos Balogh, Edina Szabó-Meleg, József Orbán, Miklós Nyitrai, Béla Völgy. Tyrosine hydroxylase positive perisomatic rings are formed around various amacrine cell types in the mammalian retina. Journal of neurochemistry. vol 134. issue 3. 2015-10-09. PMID:25940543. |
dopaminergic neurons of the central nervous system are mainly found in nuclei of the midbrain and the hypothalamus that provide subcortical and cortical targets with a rich and divergent innervation. |
2015-10-09 |
2023-08-13 |
mouse |
| Francesca L'Episcopo, Cataldo Tirolo, Nunzio Testa, Salvatore Caniglia, Maria Concetta Morale, Maria Francesca Serapide, Stefano Pluchino, Bianca Marchett. Wnt/β-catenin signaling is required to rescue midbrain dopaminergic progenitors and promote neurorepair in ageing mouse model of Parkinson's disease. Stem cells (Dayton, Ohio). vol 32. issue 8. 2015-10-07. PMID:24648001. |
wnt/β-catenin signaling is required to rescue midbrain dopaminergic progenitors and promote neurorepair in ageing mouse model of parkinson's disease. |
2015-10-07 |
2023-08-12 |
mouse |