| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francesca L'Episcopo, Cataldo Tirolo, Nunzio Testa, Salvatore Caniglia, Maria Concetta Morale, Maria Francesca Serapide, Stefano Pluchino, Bianca Marchett. Wnt/β-catenin signaling is required to rescue midbrain dopaminergic progenitors and promote neurorepair in ageing mouse model of Parkinson's disease. Stem cells (Dayton, Ohio). vol 32. issue 8. 2015-10-07. PMID:24648001. |
wnt/β-catenin signaling is required for specification and neurogenesis of midbrain dopaminergic (mda) neurons, the pivotal neuronal population that degenerates in parkinson's disease (pd), and in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) mouse model of pd. |
2015-10-07 |
2023-08-12 |
mouse |
| Robert A McGovern, Andrew K Chan, Charles B Mikell, John P Sheehy, Vincent P Ferrera, Guy M McKhan. Human substantia nigra neurons encode decision outcome and are modulated by categorization uncertainty in an auditory categorization task. Physiological reports. vol 3. issue 9. 2015-09-29. PMID:26416969. |
while classic temporal difference reinforcement models assume midbrain dopaminergic neurons underlie the prediction error required to learn boundary location, these neurons also demonstrate a robust response to nonreward incentive stimuli. |
2015-09-29 |
2023-08-13 |
human |
| Anna Pertek, Florian Meier, Martin Irmler, Johannes Beckers, Stavroula Skylaki, Max Endele, Wolfgang Wurst, Nilima Prakash, Ralf Küh. Simple derivation of transgene-free iPS cells by a dual recombinase approach. Molecular biotechnology. vol 56. issue 8. 2015-09-28. PMID:24677035. |
as shown by a reporter ipsc line for the differentiation into midbrain dopaminergic neurons, the dual recombinase approach offers a simple and efficient way to derive transgene-free ipscs for studying disease mechanisms and cell replacement therapies. |
2015-09-28 |
2023-08-12 |
Not clear |
| Martin J Kelly, Gerard W O'Keeffe, Aideen M Sulliva. Viral vector delivery of neurotrophic factors for Parkinson's disease therapy. Expert reviews in molecular medicine. vol 17. 2015-09-28. PMID:25997719. |
parkinson's disease (pd) is a neurodegenerative disorder characterised by the progressive loss of midbrain dopaminergic neurons, which causes motor impairments. |
2015-09-28 |
2023-08-13 |
Not clear |
| Sandeep Vasant More, Dong-Kug Cho. Promising cannabinoid-based therapies for Parkinson's disease: motor symptoms to neuroprotection. Molecular neurodegeneration. vol 10. 2015-09-25. PMID:25888232. |
parkinson's disease (pd) is a slow insidious neurological disorder characterized by a loss of dopaminergic neurons in the midbrain. |
2015-09-25 |
2023-08-13 |
Not clear |
| Jennifer Kaufling, Gary Aston-Jone. Persistent Adaptations in Afferents to Ventral Tegmental Dopamine Neurons after Opiate Withdrawal. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 28. 2015-09-24. PMID:26180204. |
protracted opiate withdrawal is accompanied by altered responsiveness of midbrain dopaminergic (da) neurons, including a loss of da cell response to morphine, and by behavioral alterations, including affective disorders. |
2015-09-24 |
2023-08-13 |
rat |
| Juho Joutsa, Jarkko Johansson, Marko Seppänen, Tommi Noponen, Valtteri Kaasine. Dorsal-to-Ventral Shift in Midbrain Dopaminergic Projections and Increased Thalamic/Raphe Serotonergic Function in Early Parkinson Disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 56. issue 7. 2015-09-22. PMID:25952735. |
dorsal-to-ventral shift in midbrain dopaminergic projections and increased thalamic/raphe serotonergic function in early parkinson disease. |
2015-09-22 |
2023-08-13 |
Not clear |
| Kenneth K B Tan, Jason Y Tann, Sharvari R Sathe, Seok Hong Goh, Dongliang Ma, Eyleen L K Goh, Evelyn K F Yi. Enhanced differentiation of neural progenitor cells into neurons of the mesencephalic dopaminergic subtype on topographical patterns. Biomaterials. vol 43. 2015-09-21. PMID:25591959. |
parkinson's disease (pd) is a neurodegenerative disease attributed to the loss of midbrain dopaminergic (da) neurons. |
2015-09-21 |
2023-08-13 |
Not clear |
| Ramon Sotomayor-Zarate, Gonzalo Cruz, Georgina M Renard, Pedro Espinosa, Victor D Ramire. Sex hormones and brain dopamine functions. Central nervous system agents in medicinal chemistry. vol 14. issue 2. 2015-09-18. PMID:25540983. |
the purpose of this thematic issue is to present the state of art concerning the effects of sex hormones on the neurochemical regulation of dopaminergic midbrain areas involved in neurobiological and pathological processes, such as addiction to drugs of abuse. |
2015-09-18 |
2023-08-13 |
Not clear |
| Ramon Sotomayor-Zarate, Gonzalo Cruz, Georgina M Renard, Pedro Espinosa, Victor D Ramire. Sex hormones and brain dopamine functions. Central nervous system agents in medicinal chemistry. vol 14. issue 2. 2015-09-18. PMID:25540983. |
we also discuss evidence of how neonatal exposure to sex hormones or endocrine disrupting chemicals can produce long-term changes on the neurochemical regulation of dopaminergic neurons in the limbic and midbrain areas. |
2015-09-18 |
2023-08-13 |
Not clear |
| Shane V Hegarty, Aideen M Sullivan, Gerard W O'Keeff. Roles for the TGFβ superfamily in the development and survival of midbrain dopaminergic neurons. Molecular neurobiology. vol 50. issue 2. 2015-09-11. PMID:24504901. |
roles for the tgfβ superfamily in the development and survival of midbrain dopaminergic neurons. |
2015-09-11 |
2023-08-12 |
Not clear |
| Shane V Hegarty, Aideen M Sullivan, Gerard W O'Keeff. Roles for the TGFβ superfamily in the development and survival of midbrain dopaminergic neurons. Molecular neurobiology. vol 50. issue 2. 2015-09-11. PMID:24504901. |
the adult midbrain contains 75% of all dopaminergic neurons in the cns. |
2015-09-11 |
2023-08-12 |
Not clear |
| Jia-Qing Yan, Yu-He Yuan, Yan-Na Gao, Ju-Yang Huang, Kai-Li Ma, Yan Gao, Wan-Qing Zhang, Xiao-Feng Guo, Nai-Hong Che. Overexpression of human E46K mutant α-synuclein impairs macroautophagy via inactivation of JNK1-Bcl-2 pathway. Molecular neurobiology. vol 50. issue 2. 2015-09-11. PMID:24833599. |
parkinson's disease (pd) is pathologically characterized by selective loss of dopaminergic neurons in the midbrain and the existence of intracellular protein inclusions termed lewy bodies, largely composed of α-synuclein. |
2015-09-11 |
2023-08-13 |
human |
| Jennifer M Wenzel, Noah A Rauscher, Joseph F Cheer, Erik B Oleso. A role for phasic dopamine release within the nucleus accumbens in encoding aversion: a review of the neurochemical literature. ACS chemical neuroscience. vol 6. issue 1. 2015-09-10. PMID:25491156. |
indeed, a number of studies suggest that midbrain dopaminergic cells are inhibited by the presentation of negative or fearful stimuli, while others report no change, or even an increase, in their activity. |
2015-09-10 |
2023-08-13 |
Not clear |
| Xiaolai Zhou, Tanja Zöller, Kerstin Krieglstein, Björn Spitta. TGFβ1 inhibits IFNγ-mediated microglia activation and protects mDA neurons from IFNγ-driven neurotoxicity. Journal of neurochemistry. vol 134. issue 1. 2015-09-09. PMID:25827682. |
finally, we demonstrate that tgfβ1 is capable of protecting midbrain dopaminergic (mda) neurons from ifnγ-driven neurotoxicity in mixed neuron-glia cultures derived from embryonic day 14 (e14) midbrain tissue. |
2015-09-09 |
2023-08-13 |
Not clear |
| Xiaolai Zhou, Tanja Zöller, Kerstin Krieglstein, Björn Spitta. TGFβ1 inhibits IFNγ-mediated microglia activation and protects mDA neurons from IFNγ-driven neurotoxicity. Journal of neurochemistry. vol 134. issue 1. 2015-09-09. PMID:25827682. |
in mixed neuron-glia cultures, tgfβ1 protects midbrain dopaminergic (mda) neurons from ifnγ-induced neurotoxicity. |
2015-09-09 |
2023-08-13 |
Not clear |
| Sushruta Koppula, Hemant Kumar, Sandeep Vasant More, Byung Wook Kim, In Su Kim, Dong Kug Cho. Recent advances on the neuroprotective potential of antioxidants in experimental models of Parkinson's disease. International journal of molecular sciences. vol 13. issue 8. 2015-08-31. PMID:22949883. |
parkinson's disease (pd), a neurodegenerative movement disorder of the central nervous system (cns) is characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta region of the midbrain. |
2015-08-31 |
2023-08-12 |
Not clear |
| Kurt Braunlich, Carol Sege. The basal ganglia. Wiley interdisciplinary reviews. Cognitive science. vol 4. issue 2. 2015-08-26. PMID:26304191. |
through its connections with widespread cortical areas and with dopaminergic midbrain areas, the basal ganglia are well situated to integrate patterns of cortical input with the dopaminergic reward signal originating in the midbrain. |
2015-08-26 |
2023-08-13 |
Not clear |
| Daniel García-Pérez, Roger López-Bellido, Juana M Hidalgo, Raquel E Rodríguez, Maria Luisa Laorden, Cristina Núñez, Maria Victoria Milané. Morphine regulates Argonaute 2 and TH expression and activity but not miR-133b in midbrain dopaminergic neurons. Addiction biology. vol 20. issue 1. 2015-08-24. PMID:23927484. |
morphine regulates argonaute 2 and th expression and activity but not mir-133b in midbrain dopaminergic neurons. |
2015-08-24 |
2023-08-12 |
rat |
| Paula L Croxson, Mark E Walton, Erie D Boorman, Matthew F S Rushworth, David M Bannerma. Unilateral medial frontal cortex lesions cause a cognitive decision-making deficit in rats. The European journal of neuroscience. vol 40. issue 12. 2015-08-20. PMID:25348059. |
in contrast, rats with unilateral dopaminergic midbrain lesions did exhibit a motoric turning bias, but were unimpaired on the effort-based decision-making task. |
2015-08-20 |
2023-08-13 |
rat |