| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ahmet Özdemir, Belgin Sever, Mehlika Dilek Altıntop, Elif Kaya Tilki, Miriş Dikme. Design, Synthesis, and Neuroprotective Effects of a Series of Pyrazolines against 6-Hydroxydopamine-Induced Oxidative Stress. Molecules (Basel, Switzerland). vol 23. issue 9. 2018-11-12. PMID:30150574. |
parkinson's disease (pd) is a chronic, progressive, and age-related neurodegenerative disorder characterized by the loss of midbrain dopaminergic neurons caused by the accumulation of free radicals and oxidative stress. |
2018-11-12 |
2023-08-13 |
Not clear |
| Xiao-Yu Cheng, Si-Yue Li, Cheng-Jie Mao, Mei-Xia Wang, Jing Chen, Fen Wang, Guang-Hui Wang, Wen-Bin Deng, Xiao-Kang Li, Chun-Feng Li. Serum Response Factor Promotes Dopaminergic Neuron Survival via Activation of Beclin 1-Dependent Autophagy. Neuroscience. vol 371. 2018-11-09. PMID:29196028. |
the ablation of srf renders the midbrain dopaminergic (da) neurons vulnerable to 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine-induced neurotoxicity, however, the underlying mechanisms remain poorly understood. |
2018-11-09 |
2023-08-13 |
rat |
| Luqing Wei, Xiao Hu, Yonggui Yuan, Weiguo Liu, Hong Che. Abnormal ventral tegmental area-anterior cingulate cortex connectivity in Parkinson's disease with depression. Behavioural brain research. vol 347. 2018-11-05. PMID:29530489. |
the present study used resting-state fmri and seed-based functional connectivity of putative dopaminergic midbrain regions (i.e., substantia nigra (sn) and ventral tegmental area (vta)) to investigate the circuit-related abnormalities in pd with depression. |
2018-11-05 |
2023-08-13 |
Not clear |
| Luqing Wei, Xiao Hu, Yonggui Yuan, Weiguo Liu, Hong Che. Abnormal ventral tegmental area-anterior cingulate cortex connectivity in Parkinson's disease with depression. Behavioural brain research. vol 347. 2018-11-05. PMID:29530489. |
these results have provided potential circuit-level biomarkers of depression in pd, and suggested that resting state functional connectivity of midbrain dopaminergic nuclei may be useful for understanding the underlying pathology in pd with depression. |
2018-11-05 |
2023-08-13 |
Not clear |
| Bo Fu, Xie-Chuan Weng, Jing Wang, Tao Huang, Bin Wang, Shi-de Lin, Shao-Jun Li. [The impact of electrophysiology of central dopaminergic neurons and the depression-state induced by chronic neuropathic pain]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 32. issue 5. 2018-10-18. PMID:29931842. |
to explore the underlying electrophysiological mechanism of depression induced by chronic pain in dopaminergic neurons in midbrain ventral tegmental area (vta) of rats. |
2018-10-18 |
2023-08-13 |
rat |
| Martina Pfeffer, Zuzana Zimmermann, Suzana Gispert, Georg Auburger, Horst-Werner Korf, Charlotte von Gal. Impaired Photic Entrainment of Spontaneous Locomotor Activity in Mice Overexpressing Human Mutant α-Synuclein. International journal of molecular sciences. vol 19. issue 6. 2018-10-17. PMID:29865270. |
pd is characterized by a progressive degeneration of the dorsal vagal nucleus and midbrain dopaminergic neurons together with an imbalance of many other neurotransmitters. |
2018-10-17 |
2023-08-13 |
mouse |
| Maroof M Adil, Gonçalo M C Rodrigues, Rishikesh U Kulkarni, Antara T Rao, Nicole E Chernavsky, Evan W Miller, David V Schaffe. Efficient generation of hPSC-derived midbrain dopaminergic neurons in a fully defined, scalable, 3D biomaterial platform. Scientific reports. vol 7. 2018-10-15. PMID:28091566. |
efficient generation of hpsc-derived midbrain dopaminergic neurons in a fully defined, scalable, 3d biomaterial platform. |
2018-10-15 |
2023-08-13 |
rat |
| Maroof M Adil, Gonçalo M C Rodrigues, Rishikesh U Kulkarni, Antara T Rao, Nicole E Chernavsky, Evan W Miller, David V Schaffe. Efficient generation of hPSC-derived midbrain dopaminergic neurons in a fully defined, scalable, 3D biomaterial platform. Scientific reports. vol 7. 2018-10-15. PMID:28091566. |
for example, there have been major recent advances in the generation of midbrain dopaminergic (mda) neurons from stem cells for parkinson's disease (pd) therapy; however, production of these cells typically involves undefined components and difficult to scale 2d culture formats. |
2018-10-15 |
2023-08-13 |
rat |
| Mohammed Abdel-Rahman, Rania A Galhom, Wael Amin Nasr El-Din, Mona H Mohammed Ali, Alaa El-Din Saad Abdel-Hami. Therapeutic efficacy of olfactory stem cells in rotenone induced Parkinsonism in adult male albino rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 103. 2018-10-15. PMID:29864896. |
rotenone; widely used insecticide has a neurodegenerative effect on the dopaminergic cells of substantia nigra (sn) of midbrain producing parkinsonism. |
2018-10-15 |
2023-08-13 |
rat |
| Md Solayman, Md Asiful Islam, Fahmida Alam, Md Ibrahim Khalil, Mohammad Amjad Kamal, Siew Hua Ga. Natural Products Combating Neurodegeneration: Parkinson's Disease. Current drug metabolism. vol 18. issue 1. 2018-10-01. PMID:27396919. |
parkinson's disease (pd) is characterized by neurodegeneration and a progressive functional impairment of the midbrain nigral dopaminergic neurons. |
2018-10-01 |
2023-08-13 |
Not clear |
| Hardy J Rideout, Diane B R. LRRK2 and the "LRRKtosome" at the Crossroads of Programmed Cell Death: Clues from RIP Kinase Relatives. Advances in neurobiology. vol 14. 2018-09-25. PMID:28353285. |
however, the mechanism(s) by which expression of mutant forms of lrrk2 lead to the death of dopaminergic neurons of the ventral midbrain remains largely uncharacterized. |
2018-09-25 |
2023-08-13 |
Not clear |
| Hardy J Rideout, Diane B R. LRRK2 and the "LRRKtosome" at the Crossroads of Programmed Cell Death: Clues from RIP Kinase Relatives. Advances in neurobiology. vol 14. 2018-09-25. PMID:28353285. |
however, since the expression of lrrk2 is comparatively quite low in ventral midbrain dopaminergic neurons, the possibility exists that non-cell autonomous signaling also contributes to the loss of these neurons. |
2018-09-25 |
2023-08-13 |
Not clear |
| Aliya Iftikhar Sarwa. Trazodone and Parkinsonism: The Link Strengthens. Clinical neuropharmacology. vol 41. issue 3. 2018-09-13. PMID:29634584. |
although generally considered safe, it can potentially inhibit midbrain dopaminergic neurotransmission leading to the emergence of extrapyramidal adverse effects. |
2018-09-13 |
2023-08-13 |
Not clear |
| Bumpei Samata, Daisuke Doi, Kaneyasu Nishimura, Tetsuhiro Kikuchi, Akira Watanabe, Yoshimasa Sakamoto, Jungo Kakuta, Yuichi Ono, Jun Takahash. Purification of functional human ES and iPSC-derived midbrain dopaminergic progenitors using LRTM1. Nature communications. vol 7. 2018-09-05. PMID:27739432. |
purification of functional human es and ipsc-derived midbrain dopaminergic progenitors using lrtm1. |
2018-09-05 |
2023-08-13 |
human |
| Bumpei Samata, Daisuke Doi, Kaneyasu Nishimura, Tetsuhiro Kikuchi, Akira Watanabe, Yoshimasa Sakamoto, Jungo Kakuta, Yuichi Ono, Jun Takahash. Purification of functional human ES and iPSC-derived midbrain dopaminergic progenitors using LRTM1. Nature communications. vol 7. 2018-09-05. PMID:27739432. |
human induced pluripotent stem cells (ipscs) can provide a promising source of midbrain dopaminergic (mda) neurons for cell replacement therapy for parkinson's disease (pd). |
2018-09-05 |
2023-08-13 |
human |
| Shuhei Takahashi, Akinori Hisatsune, Yuki Kurauchi, Takahiro Seki, Hiroshi Katsuk. Polysulfide protects midbrain dopaminergic neurons from MPP Journal of pharmacological sciences. vol 137. issue 1. 2018-09-05. PMID:29709269. |
polysulfide protects midbrain dopaminergic neurons from mpp polysulfides are endogenous sulfur-containing molecular species that may regulate various cellular functions. |
2018-09-05 |
2023-08-13 |
rat |
| G I McNamara, B A Davis, M Browne, T Humby, J W Dalley, J Xia, R M John, A R Isle. Dopaminergic and behavioural changes in a loss-of-imprinting model of Cdkn1c. Genes, brain, and behavior. vol 17. issue 2. 2018-08-30. PMID:28857482. |
however, cdkn1c also plays an important role in the brain, being key to the appropriate proliferation and differentiation of midbrain dopaminergic neurons. |
2018-08-30 |
2023-08-13 |
Not clear |
| Francesco Rigoli, Karl J Friston, Raymond J Dola. Neural processes mediating contextual influences on human choice behaviour. Nature communications. vol 7. 2018-08-27. PMID:27535770. |
these findings suggest that context-sensitive choice is driven by a brain circuit involving hippocampus and dopaminergic midbrain. |
2018-08-27 |
2023-08-13 |
human |
| Guangxin Chen, Juxiong Liu, Liqiang Jiang, Xin Ran, Dewei He, Yuhang Li, Bingxu Huang, Wei Wang, Shoupeng F. Galangin Reduces the Loss of Dopaminergic Neurons in an LPS-Evoked Model of Parkinson's Disease in Rats. International journal of molecular sciences. vol 19. issue 1. 2018-08-20. PMID:29267220. |
parkinson's disease (pd) is caused by the loss of dopaminergic (da) neurons in the midbrain substantia nigra (sn). |
2018-08-20 |
2023-08-13 |
rat |
| Hanna Oh-Descher, Jeffrey M Beck, Silvia Ferrari, Marc A Sommer, Tobias Egne. Probabilistic inference under time pressure leads to a cortical-to-subcortical shift in decision evidence integration. NeuroImage. vol 162. 2018-07-25. PMID:28882633. |
this strategic change in decision-making was associated with an increased involvement of the dopaminergic midbrain, striatum, thalamus, and cerebellum in representing and integrating cue values. |
2018-07-25 |
2023-08-13 |
human |