| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Angela Cruz-Hernandez, Zeynep Sena Agim, Paola C Montenegro, George P McCabe, Jean-Christophe Rochet, Jason R Canno. Selective dopaminergic neurotoxicity of three heterocyclic amine subclasses in primary rat midbrain neurons. Neurotoxicology. vol 65. 2019-03-27. PMID:29408373. |
selective dopaminergic neurotoxicity of three heterocyclic amine subclasses in primary rat midbrain neurons. |
2019-03-27 |
2023-08-13 |
rat |
| Angela Cruz-Hernandez, Zeynep Sena Agim, Paola C Montenegro, George P McCabe, Jean-Christophe Rochet, Jason R Canno. Selective dopaminergic neurotoxicity of three heterocyclic amine subclasses in primary rat midbrain neurons. Neurotoxicology. vol 65. 2019-03-27. PMID:29408373. |
using e17 rat primary midbrain cultures, we tested dopaminergic and non-dopaminergic neurotoxicity elicited by the following compounds: 2-amino-3-methylimidazo[4,5-f]quinoline (iq), 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (meiq), 2-amino-3,8-dimethylmidazo[4,5-f]quinoxaline (meiqx), 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (4,8-dimeiqx), phip, 1-methyl-9h-pyrido[3,4-b]indole (harmane), 9h-pyrido[3,4-b]indole (norharmane) and 2-amino-9h-pyrido[2,3-b]indole (aαc) at concentrations ranging from 100 nm-5 μm. |
2019-03-27 |
2023-08-13 |
rat |
| Su-Rong Yang, Zhen-Zhen Hu, Yan-Jia Luo, Ya-Nan Zhao, Huan-Xin Sun, Dou Yin, Chen-Yao Wang, Yu-Dong Yan, Dian-Ru Wang, Xiang-Shan Yuan, Chen-Bo Ye, Wei Guo, Wei-Min Qu, Yoan Cherasse, Michael Lazarus, Yu-Qiang Ding, Zhi-Li Huan. The rostromedial tegmental nucleus is essential for non-rapid eye movement sleep. PLoS biology. vol 16. issue 4. 2019-03-27. PMID:29652889. |
the rostromedial tegmental nucleus (rmtg), also called the gabaergic tail of the ventral tegmental area, projects to the midbrain dopaminergic system, dorsal raphe nucleus, locus coeruleus, and other regions. |
2019-03-27 |
2023-08-13 |
rat |
| Su-Rong Yang, Zhen-Zhen Hu, Yan-Jia Luo, Ya-Nan Zhao, Huan-Xin Sun, Dou Yin, Chen-Yao Wang, Yu-Dong Yan, Dian-Ru Wang, Xiang-Shan Yuan, Chen-Bo Ye, Wei Guo, Wei-Min Qu, Yoan Cherasse, Michael Lazarus, Yu-Qiang Ding, Zhi-Li Huan. The rostromedial tegmental nucleus is essential for non-rapid eye movement sleep. PLoS biology. vol 16. issue 4. 2019-03-27. PMID:29652889. |
electrophysiological experiments combined with optogenetics showed a direct inhibitory connection between the terminals of rmtg neurons and midbrain dopaminergic neurons. |
2019-03-27 |
2023-08-13 |
rat |
| Shane V Hegarty, Sean L Wyatt, Laura Howard, Elke Stappers, Danny Huylebroeck, Aideen M Sullivan, Gerard W O'Keeff. Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation. Scientific reports. vol 7. issue 1. 2019-03-25. PMID:28819210. |
zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation. |
2019-03-25 |
2023-08-13 |
mouse |
| Shane V Hegarty, Sean L Wyatt, Laura Howard, Elke Stappers, Danny Huylebroeck, Aideen M Sullivan, Gerard W O'Keeff. Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation. Scientific reports. vol 7. issue 1. 2019-03-25. PMID:28819210. |
midbrain dopaminergic neurons project via the nigrostriatal pathway to the striatum to regulate voluntary movement. |
2019-03-25 |
2023-08-13 |
mouse |
| Shane V Hegarty, Sean L Wyatt, Laura Howard, Elke Stappers, Danny Huylebroeck, Aideen M Sullivan, Gerard W O'Keeff. Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation. Scientific reports. vol 7. issue 1. 2019-03-25. PMID:28819210. |
while the specification and differentiation of these neurons have been extensively studied, the molecular mechanisms that regulate midbrain dopaminergic axon growth and target innervation are less clear. |
2019-03-25 |
2023-08-13 |
mouse |
| Shane V Hegarty, Sean L Wyatt, Laura Howard, Elke Stappers, Danny Huylebroeck, Aideen M Sullivan, Gerard W O'Keeff. Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation. Scientific reports. vol 7. issue 1. 2019-03-25. PMID:28819210. |
here we show that the transcription factor zeb2 cell-autonomously represses smad signalling to limit midbrain dopaminergic axon growth and target innervation. |
2019-03-25 |
2023-08-13 |
mouse |
| Shane V Hegarty, Sean L Wyatt, Laura Howard, Elke Stappers, Danny Huylebroeck, Aideen M Sullivan, Gerard W O'Keeff. Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation. Scientific reports. vol 7. issue 1. 2019-03-25. PMID:28819210. |
zeb2 levels are downregulated in the embryonic rodent midbrain during the period of dopaminergic axon growth, when bmp pathway components are upregulated. |
2019-03-25 |
2023-08-13 |
mouse |
| Shane V Hegarty, Sean L Wyatt, Laura Howard, Elke Stappers, Danny Huylebroeck, Aideen M Sullivan, Gerard W O'Keeff. Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation. Scientific reports. vol 7. issue 1. 2019-03-25. PMID:28819210. |
consequently there is dopaminergic hyperinnervation of the striatum, without an increase in the numbers of midbrain dopaminergic neurons, in conditional zeb2 (nestin-cre based) knockout mice. |
2019-03-25 |
2023-08-13 |
mouse |
| Shane V Hegarty, Sean L Wyatt, Laura Howard, Elke Stappers, Danny Huylebroeck, Aideen M Sullivan, Gerard W O'Keeff. Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation. Scientific reports. vol 7. issue 1. 2019-03-25. PMID:28819210. |
therefore, these findings reveal a new mechanism for the regulation of midbrain dopaminergic axon growth during central nervous system development. |
2019-03-25 |
2023-08-13 |
mouse |
| José Luis Pérez-López, Rubén Contreras-López, Josué O Ramírez-Jarquín, Fatuel Tecuapetl. Direct Glutamatergic Signaling From Midbrain Dopaminergic Neurons Onto Pyramidal Prefrontal Cortex Neurons. Frontiers in neural circuits. vol 12. 2019-03-25. PMID:30210308. |
direct glutamatergic signaling from midbrain dopaminergic neurons onto pyramidal prefrontal cortex neurons. |
2019-03-25 |
2023-08-13 |
Not clear |
| Xiaolai Zhou, Björn Spitta. Lipopolysaccharide-Induced Microglia Activation Promotes the Survival of Midbrain Dopaminergic Neurons In Vitro. Neurotoxicity research. vol 33. issue 4. 2019-03-20. PMID:29188488. |
lipopolysaccharide-induced microglia activation promotes the survival of midbrain dopaminergic neurons in vitro. |
2019-03-20 |
2023-08-13 |
Not clear |
| Gunasingh J Masilamoni, Yoland Smit. Metabotropic glutamate receptors: targets for neuroprotective therapies in Parkinson disease. Current opinion in pharmacology. vol 38. 2019-03-14. PMID:29605730. |
preclinical studies have revealed that specific mglur subtypes mediate significant neuroprotective effects that reduce toxin-induced midbrain dopaminergic neuronal death in animal models of pd. |
2019-03-14 |
2023-08-13 |
human |
| Gunasingh J Masilamoni, Yoland Smit. Metabotropic glutamate receptors: targets for neuroprotective therapies in Parkinson disease. Current opinion in pharmacology. vol 38. 2019-03-14. PMID:29605730. |
it is noteworthy that these protective effects extend beyond midbrain dopaminergic neurons to include other monoaminergic cell groups for some mglurs. |
2019-03-14 |
2023-08-13 |
human |
| Franziska Knolle, Anna O Ermakova, Azucena Justicia, Paul C Fletcher, Nico Bunzeck, Emrah Düzel, Graham K Murra. Brain responses to different types of salience in antipsychotic naïve first episode psychosis: An fMRI study. Translational psychiatry. vol 8. issue 1. 2019-03-14. PMID:30242202. |
previous research utilising reward learning or anticipation paradigms has demonstrated cortical and subcortical abnormalities in people with psychosis, specifically in the prefrontal cortex, the dopaminergic midbrain and the striatum. |
2019-03-14 |
2023-08-13 |
human |
| Franziska Knolle, Anna O Ermakova, Azucena Justicia, Paul C Fletcher, Nico Bunzeck, Emrah Düzel, Graham K Murra. Brain responses to different types of salience in antipsychotic naïve first episode psychosis: An fMRI study. Translational psychiatry. vol 8. issue 1. 2019-03-14. PMID:30242202. |
however, little is known about possible abnormalities across different forms of salience processing in psychosis patients, and whether any such abnormalities involve the dopaminergic midbrain. |
2019-03-14 |
2023-08-13 |
human |
| Kyle Denton, Yongchao Mou, Chong-Chong Xu, Dhruvi Shah, Jaerak Chang, Craig Blackstone, Xue-Jun L. Impaired mitochondrial dynamics underlie axonal defects in hereditary spastic paraplegias. Human molecular genetics. vol 27. issue 14. 2019-03-12. PMID:29726929. |
in patient ipsc-derived telencephalic glutamatergic and midbrain dopaminergic neurons, neurite number, length and branching are significantly reduced, recapitulating disease-specific phenotypes. |
2019-03-12 |
2023-08-13 |
Not clear |
| Ching-Long Lai, Chun-Chung Lu, Hui-Ching Lin, Yueh-Feng Sung, Yi-Pin Wu, Jau-Shyong Hong, Giia-Sheun Pen. Valproate is protective against 6-OHDA-induced dopaminergic neurodegeneration in rodent midbrain: A potential role of BDNF up-regulation. Journal of the Formosan Medical Association = Taiwan yi zhi. vol 118. issue 1 Pt 3. 2019-03-12. PMID:30031602. |
valproate is protective against 6-ohda-induced dopaminergic neurodegeneration in rodent midbrain: a potential role of bdnf up-regulation. |
2019-03-12 |
2023-08-13 |
Not clear |
| Yutaka Mine, Toshihiko Momiyama, Takuro Hayashi, Takeshi Kawas. Grafted Miniature-Swine Neural Stem Cells of Early Embryonic Mesencephalic Neuroepithelial Origin can Repair the Damaged Neural Circuitry of Parkinson's Disease Model Rats. Neuroscience. vol 386. 2019-03-11. PMID:29932984. |
although recent progress in the use of human ips cell-derived midbrain dopaminergic progenitors is remarkable, alternatives are essential in the strategies of treatment of basal-ganglia-related diseases. |
2019-03-11 |
2023-08-13 |
human |