| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sumit Sarkar, Edward Lu, James Raymick, Joseph Hanig, Qiang G. ERK/MAP Kinase Activation is Evident in Activated Microglia of the Striatum and Substantia Nigra in an Acute and Chronically-Induced Mouse Model of Parkinson's Disease. Current neurovascular research. vol 15. issue 4. 2019-07-30. PMID:30468126. |
dopaminergic neurons originating in the midbrain project to the striatum (caudate-putamen-cpu). |
2019-07-30 |
2023-08-13 |
mouse |
| Lifeng Qiu, Mei-Chih Liao, Allen K Chen, Shunhui Wei, Shaoping Xie, Shaul Reuveny, Zhi Dong Zhou, Walter Hunziker, Eng King Tan, Steve K W Oh, Li Zen. Immature Midbrain Dopaminergic Neurons Derived from Floor-Plate Method Improve Cell Transplantation Therapy Efficacy for Parkinson's Disease. Stem cells translational medicine. vol 6. issue 9. 2019-06-27. PMID:28650520. |
immature midbrain dopaminergic neurons derived from floor-plate method improve cell transplantation therapy efficacy for parkinson's disease. |
2019-06-27 |
2023-08-13 |
mouse |
| Petros Stathakos, Natalia Jimenez-Moreno, Lucy Crompton, Paul Nistor, Maeve A Caldwell, Jon D Lan. Imaging Autophagy in hiPSC-Derived Midbrain Dopaminergic Neuronal Cultures for Parkinson's Disease Research. Methods in molecular biology (Clifton, N.J.). vol 1880. 2019-06-24. PMID:30610703. |
imaging autophagy in hipsc-derived midbrain dopaminergic neuronal cultures for parkinson's disease research. |
2019-06-24 |
2023-08-13 |
human |
| Petros Stathakos, Natalia Jimenez-Moreno, Lucy Crompton, Paul Nistor, Maeve A Caldwell, Jon D Lan. Imaging Autophagy in hiPSC-Derived Midbrain Dopaminergic Neuronal Cultures for Parkinson's Disease Research. Methods in molecular biology (Clifton, N.J.). vol 1880. 2019-06-24. PMID:30610703. |
in pd, a class of dopaminergic neurons in the ventral midbrain (mdans) is affected. |
2019-06-24 |
2023-08-13 |
human |
| Fabiano Araújo Tofoli, Ana Teresa Silva Semeano, Ágatha Oliveira-Giacomelli, Maria Carolina Bittencourt Gonçalves, Merari F R Ferrari, Lygia Veiga Pereira, Henning Ulric. Midbrain Dopaminergic Neurons Differentiated from Human-Induced Pluripotent Stem Cells. Methods in molecular biology (Clifton, N.J.). vol 1919. 2019-06-14. PMID:30656624. |
midbrain dopaminergic neurons differentiated from human-induced pluripotent stem cells. |
2019-06-14 |
2023-08-13 |
mouse |
| Fabiano Araújo Tofoli, Ana Teresa Silva Semeano, Ágatha Oliveira-Giacomelli, Maria Carolina Bittencourt Gonçalves, Merari F R Ferrari, Lygia Veiga Pereira, Henning Ulric. Midbrain Dopaminergic Neurons Differentiated from Human-Induced Pluripotent Stem Cells. Methods in molecular biology (Clifton, N.J.). vol 1919. 2019-06-14. PMID:30656624. |
the work with midbrain dopaminergic neurons (mdan) differentiation might seem to be hard. |
2019-06-14 |
2023-08-13 |
mouse |
| Leah C Beauchamp, Jacky Chan, Lin W Hung, Benjamin S Padman, Laura J Vella, Xiang M Liu, Bradley Coleman, Ashley I Bush, Michael Lazarou, Andrew F Hill, Laura Jacobson, Kevin J Barnha. Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease. Acta neuropathologica communications. vol 6. issue 1. 2019-06-04. PMID:29976255. |
parkinson's disease is diagnosed upon the presentation of motor symptoms, resulting from substantial degeneration of dopaminergic neurons in the midbrain. |
2019-06-04 |
2023-08-13 |
mouse |
| Leah C Beauchamp, Jacky Chan, Lin W Hung, Benjamin S Padman, Laura J Vella, Xiang M Liu, Bradley Coleman, Ashley I Bush, Michael Lazarou, Andrew F Hill, Laura Jacobson, Kevin J Barnha. Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease. Acta neuropathologica communications. vol 6. issue 1. 2019-06-04. PMID:29976255. |
there is limited information about non-motor impairments and there is a need for directed research into these early pathogenic cellular pathways that precede extensive dopaminergic death in the midbrain. |
2019-06-04 |
2023-08-13 |
mouse |
| Vukasin M Jovanovic, Ahmad Salti, Hadas Tilleman, Ksenija Zega, Marin M Jukic, Hongyan Zou, Roland H Friedel, Nilima Prakash, Sandra Blaess, Frank Edenhofer, Claude Brodsk. BMP/SMAD Pathway Promotes Neurogenesis of Midbrain Dopaminergic Neurons The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 7. 2019-06-03. PMID:29321139. |
bmp/smad pathway promotes neurogenesis of midbrain dopaminergic neurons the embryonic formation of midbrain dopaminergic (mda) neurons |
2019-06-03 |
2023-08-13 |
Not clear |
| Spyridon Theofilopoulos, Willy Antoni Abreu de Oliveira, Shanzheng Yang, Eylan Yutuc, Ahmed Saeed, Jonas Abdel-Khalik, Abbe Ullgren, Angel Cedazo-Minguez, Ingemar Björkhem, Yuqin Wang, William J Griffiths, Ernest Arena. 24( The Journal of biological chemistry. vol 294. issue 11. 2019-05-30. PMID:30655290. |
24( the liver x receptors lxrα/nr1h3 and lxrβ/nr1h2 are ligand-dependent nuclear receptors critical for midbrain dopaminergic (mda) neuron development. |
2019-05-30 |
2023-08-13 |
Not clear |
| Angel J Santiago-Lope. A Repulsive Environment Induces Neurodegeneration of Midbrain Dopaminergic Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 6. 2019-05-29. PMID:29438033. |
a repulsive environment induces neurodegeneration of midbrain dopaminergic neurons. |
2019-05-29 |
2023-08-13 |
Not clear |
| Krishnapriya Madhu Varier, Thangarajan Sumath. Hinokitiol Offers Neuroprotection Against 6-OHDA-Induced Toxicity in SH-SY5Y Neuroblastoma Cells by Downregulating mRNA Expression of MAO/α-Synuclein/LRRK2/PARK7/PINK1/PTEN Genes. Neurotoxicity research. vol 35. issue 4. 2019-05-23. PMID:30569287. |
parkinson's disease (pd) remarks its pathology by affecting the patient's movements and postural instability by dopaminergic loss in the substantia nigra of midbrain. |
2019-05-23 |
2023-08-13 |
Not clear |
| Martin Tik, Ronald Sladky, Caroline Di Bernardi Luft, David Willinger, André Hoffmann, Michael J Banissy, Joydeep Bhattacharya, Christian Windischberge. Ultra-high-field fMRI insights on insight: Neural correlates of the Aha!-moment. Human brain mapping. vol 39. issue 8. 2019-05-21. PMID:29665228. |
besides the finding on cortical involvement of the left anterior middle temporal gyrus (amtg), here we showed for the first time robust subcortical activity changes related to insightful problem solving in the bilateral thalamus, hippocampus, and the dopaminergic midbrain comprising ventral tegmental area (vta), nucleus accumbens (nacc), and caudate nucleus. |
2019-05-21 |
2023-08-13 |
human |
| Florian Groessl, Thomas Munsch, Susanne Meis, Johannes Griessner, Joanna Kaczanowska, Pinelopi Pliota, Dominic Kargl, Sylvia Badurek, Klaus Kraitsy, Arash Rassoulpour, Johannes Zuber, Volkmar Lessmann, Wulf Haubensa. Dorsal tegmental dopamine neurons gate associative learning of fear. Nature neuroscience. vol 21. issue 7. 2019-05-16. PMID:29950668. |
these findings add a new module to the midbrain dopaminergic circuit architecture underlying associative reinforcement learning and identify vpdrd neurons as a critical component of pavlovian fear conditioning. |
2019-05-16 |
2023-08-13 |
Not clear |
| Atsushi Noritake, Taihei Ninomiya, Masaki Isod. Social reward monitoring and valuation in the macaque brain. Nature neuroscience. vol 21. issue 10. 2019-05-16. PMID:30224807. |
medial prefrontal cortex neurons selectively monitored self-reward and partner-reward information, whereas midbrain dopaminergic neurons integrated this information into a subjective value. |
2019-05-16 |
2023-08-13 |
monkey |
| Atsushi Noritake, Taihei Ninomiya, Masaki Isod. Social reward monitoring and valuation in the macaque brain. Nature neuroscience. vol 21. issue 10. 2019-05-16. PMID:30224807. |
recordings of local field potentials revealed that responses to reward-predictive stimuli in medial prefrontal cortex started before those in dopaminergic midbrain nuclei and that neural information flowed predominantly in a medial prefrontal cortex-to-midbrain direction. |
2019-05-16 |
2023-08-13 |
monkey |
| Luke T Coddington, Joshua T Dudma. The timing of action determines reward prediction signals in identified midbrain dopamine neurons. Nature neuroscience. vol 21. issue 11. 2019-05-16. PMID:30323275. |
the activity of midbrain dopaminergic neurons is thought to convey a critical teaching signal: reward-prediction error. |
2019-05-16 |
2023-08-13 |
mouse |
| Luke T Coddington, Joshua T Dudma. The timing of action determines reward prediction signals in identified midbrain dopamine neurons. Nature neuroscience. vol 21. issue 11. 2019-05-16. PMID:30323275. |
although reward-prediction error signals are thought to be essential to learning, little is known about the dynamic changes in the activity of midbrain dopaminergic neurons as animals learn about novel sensory cues and appetitive rewards. |
2019-05-16 |
2023-08-13 |
mouse |
| Sarah A McClymont, Paul W Hook, Alexandra I Soto, Xylena Reed, William D Law, Samuel J Kerans, Eric L Waite, Nicole J Briceno, Joey F Thole, Michael G Heckman, Nancy N Diehl, Zbigniew K Wszolek, Cedric D Moore, Heng Zhu, Jennifer A Akiyama, Diane E Dickel, Axel Visel, Len A Pennacchio, Owen A Ross, Michael A Beer, Andrew S McCallio. Parkinson-Associated SNCA Enhancer Variants Revealed by Open Chromatin in Mouse Dopamine Neurons. American journal of human genetics. vol 103. issue 6. 2019-05-14. PMID:30503521. |
the progressive loss of midbrain (mb) dopaminergic (da) neurons defines the motor features of parkinson disease (pd), and modulation of risk by common variants in pd has been well established through genome-wide association studies (gwass). |
2019-05-14 |
2023-08-13 |
mouse |
| Guo-Qing Wang, Bei Zhang, Xue-Mei He, Dai-Di Li, Jing-Shan Shi, Feng Zhan. Naringenin targets on astroglial Nrf2 to support dopaminergic neurons. Pharmacological research. vol 139. 2019-05-14. PMID:30527894. |
in primary rat midbrain neuron-glia co-cultures, nar conferred neurotrophic effects to support dopaminergic (da) neurons survival in the concentration- and time-dependent manners. |
2019-05-14 |
2023-08-13 |
rat |