| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S M Waters, C S Konkoy, T P Davi. Haloperidol and apomorphine differentially affect neuropeptidase activity. The Journal of pharmacology and experimental therapeutics. vol 277. issue 1. 1996-06-06. PMID:8613907. |
in view of the interaction between mesocorticolimbic dopamine neurons and neuropeptides, e.g., substance p, neurotensin and enkephalins, neuroleptic-induced alterations in the activities of neuropeptidases, and thus neuropeptide metabolism can, in turn, play a role in modulating midbrain dopaminergic activity. |
1996-06-06 |
2023-08-12 |
rat |
| K Krieglstein, C Suter-Crazzolara, G Hötten, J Pohl, K Unsicke. Trophic and protective effects of growth/differentiation factor 5, a member of the transforming growth factor-beta superfamily, on midbrain dopaminergic neurons. Journal of neuroscience research. vol 42. issue 5. 1996-04-30. PMID:8600306. |
trophic and protective effects of growth/differentiation factor 5, a member of the transforming growth factor-beta superfamily, on midbrain dopaminergic neurons. |
1996-04-30 |
2023-08-12 |
human |
| K Krieglstein, C Suter-Crazzolara, G Hötten, J Pohl, K Unsicke. Trophic and protective effects of growth/differentiation factor 5, a member of the transforming growth factor-beta superfamily, on midbrain dopaminergic neurons. Journal of neuroscience research. vol 42. issue 5. 1996-04-30. PMID:8600306. |
we show here that gdf5 is expresed in the developing cns including the mesencephalon and acts as a neurotrophic, survival promoting molecule for rat dopaminergic midbrain neurons, which degenerate in parkinson's disease. |
1996-04-30 |
2023-08-12 |
human |
| K Krieglstein, C Suter-Crazzolara, G Hötten, J Pohl, K Unsicke. Trophic and protective effects of growth/differentiation factor 5, a member of the transforming growth factor-beta superfamily, on midbrain dopaminergic neurons. Journal of neuroscience research. vol 42. issue 5. 1996-04-30. PMID:8600306. |
recombinant human gdf5 supports dopaminergic neurons, dissected at embryonic day (e) 14 and cultured for 8 days under serum-free conditions, to almost the same extent as tgf-beta 3, and is as effective as glial cell line-derived neurotrophic factor (gdnf), two established trophic factors for midbrain dopaminergic neurons. |
1996-04-30 |
2023-08-12 |
human |
| B Brugg, P P Michel, Y Agid, M Ruber. Ceramide induces apoptosis in cultured mesencephalic neurons. Journal of neurochemistry. vol 66. issue 2. 1996-04-03. PMID:8592146. |
the death of dopaminergic and other neurons in primary cultures of the mesencephalon could be induced by treatment with ceramide, as in lymphocytes where it mediates activation by the cytokines tumor necrosis factor-alpha and interleukin-1 beta of a novel sphingomyelin-dependent signaling pathway leading to apoptosis. |
1996-04-03 |
2023-08-12 |
Not clear |
| M B Mattammal, J H Haring, H D Chung, G Raghu, R Stron. An endogenous dopaminergic neurotoxin: implication for Parkinson's disease. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 4. issue 3. 1996-03-15. PMID:8581559. |
the toxicity of dopal for dopaminergic neurons was investigated using rat neostriatal synaptosomes, pc-12 cells and cultures of fetal rat dissociated mesencephalon. |
1996-03-15 |
2023-08-12 |
rat |
| R von Coelln, K Unsicker, K Krieglstei. Screening of interleukins for survival-promoting effects on cultured mesencephalic dopaminergic neurons from embryonic rat brain. Brain research. Developmental brain research. vol 89. issue 1. 1996-03-14. PMID:8575089. |
in order to evaluate the neurotrophic potential that interleukins may have for nigrostriatal dopaminergic neurons, we have applied the interleukins 1 alpha, 1 beta, and 2 through 12 to cultures of e14 rat midbrain floor cells enriched for dopaminergic neurons. |
1996-03-14 |
2023-08-12 |
rat |
| J Rohrbacher, K Krieglstein, S Honerkamp, A Lewen, U Misgel. 5,7-Dihydroxytryptamine uptake discriminates living serotonergic cells from dopaminergic cells in rat midbrain culture. Neuroscience letters. vol 199. issue 3. 1996-03-13. PMID:8577399. |
5,7-dihydroxytryptamine uptake discriminates living serotonergic cells from dopaminergic cells in rat midbrain culture. |
1996-03-13 |
2023-08-12 |
rat |
| S N Haber, H Ryoo, C Cox, W L. Subsets of midbrain dopaminergic neurons in monkeys are distinguished by different levels of mRNA for the dopamine transporter: comparison with the mRNA for the D2 receptor, tyrosine hydroxylase and calbindin immunoreactivity. The Journal of comparative neurology. vol 362. issue 3. 1996-03-12. PMID:8576447. |
subsets of midbrain dopaminergic neurons in monkeys are distinguished by different levels of mrna for the dopamine transporter: comparison with the mrna for the d2 receptor, tyrosine hydroxylase and calbindin immunoreactivity. |
1996-03-12 |
2023-08-12 |
monkey |
| B H Steensen, S Nedergaard, K Ostergaard, J D Lamber. Electrophysiological characterization of dopaminergic and non-dopaminergic neurones in organotypic slice cultures of the rat ventral mesencephalon. Experimental brain research. vol 106. issue 2. 1996-03-07. PMID:8566185. |
electrophysiological characterization of dopaminergic and non-dopaminergic neurones in organotypic slice cultures of the rat ventral mesencephalon. |
1996-03-07 |
2023-08-12 |
rat |
| J W Fawcett, R A Barker, S B Dunnet. Dopaminergic neuronal survival and the effects of bFGF in explant, three dimensional and monolayer cultures of embryonic rat ventral mesencephalon. Experimental brain research. vol 106. issue 2. 1996-03-07. PMID:8566192. |
dopaminergic neuronal survival and the effects of bfgf in explant, three dimensional and monolayer cultures of embryonic rat ventral mesencephalon. |
1996-03-07 |
2023-08-12 |
rat |
| J W Fawcett, R A Barker, S B Dunnet. Dopaminergic neuronal survival and the effects of bFGF in explant, three dimensional and monolayer cultures of embryonic rat ventral mesencephalon. Experimental brain research. vol 106. issue 2. 1996-03-07. PMID:8566192. |
dissociation of the tissue by itself caused the death of approximately 30% of dopaminergic neurones, as judged by the difference in cell counts between the intact embryonic day 14 (e14) mesencephalon, and cells dissociated then packed into tubes. |
1996-03-07 |
2023-08-12 |
rat |
| A M Di Giulio, B Tenconi, M L Malosio, L Vergani, A Bertelli, A Gori. Perinatal morphine. I: Effects on synapsin and neurotransmitter systems in the brain. Journal of neuroscience research. vol 42. issue 4. 1996-03-05. PMID:8568934. |
no effect of morphine on 5-ht and ne is observed, while the dopaminergic system is mainly affected in the mesencephalon. |
1996-03-05 |
2023-08-12 |
rat |
| Q Y Zhou, R D Palmite. Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic. Cell. vol 83. issue 7. 1996-02-21. PMID:8548806. |
midbrain dopaminergic neurons, their projections, and most characteristics of their target neurons in the striatum appeared normal. |
1996-02-21 |
2023-08-12 |
mouse |
| W Trojniar, M Staszewsk. Bilateral lesions of the pedunculopontine tegmental nucleus affect feeding induced by electrical stimulation of the ventral tegmental area. Acta neurobiologiae experimentalis. vol 55. issue 3. 1996-02-20. PMID:8553913. |
the pedunculopontine tegmental nucleus (ppn) is anatomically connected with dopaminergic cells in the ventral mesencephalon, which are known to participate in the regulation of various adaptive appetitive behaviours. |
1996-02-20 |
2023-08-12 |
Not clear |
| G H Tjon, T J De Vries, P Nestby, G Wardeh, A H Mulder, A N Schoffelmee. Intermittent and chronic morphine treatment induces long-lasting changes in delta-opioid receptor-regulated acetylcholine release in rat striatum and nucleus accumbens. European journal of pharmacology. vol 283. issue 1-3. 1996-01-18. PMID:7498306. |
therefore, we hypothesize that an enhanced (re)activity of striatal and accumbal cholinergic neurons, which are regulated by dopaminergic neurons of the ventral mesencephalon, may represent a long-lasting neuroadaptive effect of morphine (and possibly other drugs of abuse) playing a crucial role in behavioral sensitization associated with enhanced vulnerability to drugs of abuse. |
1996-01-18 |
2023-08-12 |
rat |
| S A Bayer, K V Wills, L C Triarhou, B Ghett. Time of neuron origin and gradients of neurogenesis in midbrain dopaminergic neurons in the mouse. Experimental brain research. vol 105. issue 2. 1996-01-18. PMID:7498372. |
time of neuron origin and gradients of neurogenesis in midbrain dopaminergic neurons in the mouse. |
1996-01-18 |
2023-08-12 |
mouse |
| S A Bayer, K V Wills, L C Triarhou, B Ghett. Time of neuron origin and gradients of neurogenesis in midbrain dopaminergic neurons in the mouse. Experimental brain research. vol 105. issue 2. 1996-01-18. PMID:7498372. |
using tyrosine hydroxylase immunostaining combined with [3h]thymidine autoradiography, the time of origin of dopaminergic midbrain neurons in the retrorubral field, the substantia nigra pars compacta, the ventral tegmental area, and the interfascicular nucleus was determined in postnatal day 20 mice. |
1996-01-18 |
2023-08-12 |
mouse |
| S A Bayer, K V Wills, L C Triarhou, B Ghett. Time of neuron origin and gradients of neurogenesis in midbrain dopaminergic neurons in the mouse. Experimental brain research. vol 105. issue 2. 1996-01-18. PMID:7498372. |
these findings indicate that mouse and rat brains have nearly identical developmental patterns in the midbrain, and neurogenetic gradients in dopaminergic neurons are similar to those found in nissl studies in rats. |
1996-01-18 |
2023-08-12 |
mouse |
| S A Bayer, K V Wills, L C Triarhou, J D Thomas, B Ghett. Systematic differences in time of dopaminergic neuron origin between normal mice and homozygous weaver mutants. Experimental brain research. vol 105. issue 2. 1996-01-18. PMID:7498373. |
immunocytochemical labeling for tyrosine hydroxylase and [3h]thymidine autoradiography were combined in wild-type mice and in mice homozygous for the weaver mutant gene (wv) to see whether the neurogenetic patterns of midbrain dopaminergic neurons was normal in the mutants and whether the degeneration of dopaminergic neurons was linked to their time of origin. |
1996-01-18 |
2023-08-12 |
mouse |